Observation on the effect of <i>pseudomonas aeruginosa</i> preparation in treating refractory seroma after breast cancer surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FENG Xiaojuan ¹ , ZHONG Shanqiong ¹ , ZENG Yuanyuan ¹ , Lü Qing ¹ ,  LI Ka ²

1. Department of Breast Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
2. West China Nursing School of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

LI Ka, Email: likalika127127@163.com

Keywords：

refractory seroma; pseudomonas aeruginosa preparation; breast cancer

DOI：

10.7507/1007-9424.201909126

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the effectiveness and safety of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery.Methods A total of 76 patients with refractory seroma after breast cancer surgery who underwent surgery from October 2018 to August 2019 in our hospital were selected. The subjects were randomly divided into two groups. The patients in the control group (n=36) adopted negative pressure drainage connected with indwelling needle in the lower position of the seroma chamber; on the basis, patients in the experimental group (n=400) were injected with pseudomonas aeruginosa preparation into the seroma chamber. The drainage time, total drainage volume, recurrence rate, and incidence of complications of the two groups were compared.Results There were 4 cases in the experimental group and 3 cases in the control group were lost followed-up, so only 69 cases enrolled in data analysis. The drainage time, total drainage volume, and the recurrence rate of the experimental group were all shorter or less than those of the control group (P<0.05). But there was no significant difference in the incidence of complications between the experimental group and the control group (P>0.05), such as fever, inflamed skin, and infection of incision.Conclusion Pseudomonas aeruginosa preparation is an effective treatment for refractory seroma after breast cancer surgery, which can shorten the drainage time and promote wound healing.

Citation： FENG Xiaojuan, ZHONG Shanqiong, ZENG Yuanyuan, Lü Qing, LI Ka. Observation on the effect of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(3): 304-308. doi: 10.7507/1007-9424.201909126 Copy

1.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	曹欣華, 呂建鑫, 胡浩霖, 等. 不同手術方式對早期乳腺癌患者的術后恢復及并發癥的影響. 東南大學學報: 醫學版, 2018, 37(1): 45-49.
3.	呂淑貞, 李艷萍, 趙霞, 等. 靜脈留置針持續負壓引流治療乳腺癌術后皮下積液. 癌癥進展, 2018, 16(1): 120-122.
4.	van Bastelaar J, Theunissen LLB, Snoeijs MGJ, et al. Flap fixation using tissue glue or sutures appears to reduce seroma aspiration after mastectomy for breast cancer. Clin Breast Cancer, 2017, 17(4): 316-321.
5.	徐青. 乳腺癌術后皮下積液研究現狀及進展. 國際外科學雜志, 2017, 44(3): 195-197.
6.	郭智慧, 羅道蘊, 周慶, 等. 常規處理方案聯合銅綠假單胞菌制劑治療乳腺癌療效的 Meta 分析. 中國普通外科雜志, 2015, 24(5): 669-676.
7.	喻滿成, 王偉, 范威, 等. 皮瓣點式縫合聯合萬特普安防治乳腺癌術后皮下積液療效觀察. 腫瘤防治研究, 2018, 45(3): 163-166.
8.	宋愛琳, 曹農. 銅綠假單胞菌注射液防治乳腺癌術后皮下積液的臨床研究. 遼寧醫學雜志, 2012, 26(2): 57-60.
9.	馬富懿, 王禮泉, 王昌亮, 等. 銅綠假單胞菌注射液在乳腺癌切除術后皮下積液中的臨床應用. 中華腫瘤防治雜志, 2009, 16(14): 1111-1112, 1119.
10.	Isozaki H, Yamamoto Y, Murakami S, et al. Impact of the surgical modality for axillary lymph node dissection on postoperative drainage and seroma formation after total mastectomy. Patient Saf Surg, 2019, 13(1): 20.
11.	Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer. Eur J Surg Oncol, 2004, 30(6): 602-609.
12.	許言, 許貴勤, 胡少鋒. 多點縫合術治療乳腺癌術后頑固性皮下積液 17 例體會. 實用中西醫結合臨床, 2019, 19(1): 150-151.
13.	張祥運. 負壓封閉引流技術在乳且癌術后重度皮下積液中的應用. 中華婦幼臨床醫學雜志: 電子版, 2018, 14(2): 147-150.
14.	van Bastelaar J, Granzier R, van Roozendaal LM, et al. Analysis of TNF-α and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae? Surg Oncol, 2019, 28: 36-41.
15.	Srivastava V, Basu S, Shukla VK. Seroma formation after breast cancer surgery: what we have learned in the last two decades. J Breast Cancer, 2012, 15(4): 373-380.
16.	Woodworth PA, McBoyle MF, Helmer SD, et al. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg, 2000, 66(5): 444-451.
17.	郝凱峰. 乳腺癌改良根治術后皮下積液產生的高危因素及預防措施. 實用癌癥雜志, 2018, 33(4): 686-689.
18.	巫泓生, 廖碧玲, 曹天生, 等. 金葡素治療乳腺癌改良根治術后皮下積液的效果. 臨床醫學, 2019, 39(4): 107-109.
19.	李磊, 阿迪力江?買買提明, 地力木拉提?艾斯木吐拉. 乳腺癌改良根治術后皮下積液與皮瓣壞死的原因及防治探討. 中國普外基礎與臨床雜志, 2015, 26(6): 725-728.
20.	于永政, 胡曉川, 趙輝, 等. 滑石粉懸液治療乳腺癌術后頑固性皮下積液的臨床研究. 臨床外科雜志, 2013, 21(6): 485.
21.	Yang Y, Gao E, Liu X, et al. Effectiveness of OK-432(Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer. Ann Surg Oncol, 2013, 20(5): 1500-1504.
22.	劉鵬熙, 劉曉雁, 歐陽慧英, 等. 生物蛋白膠對乳腺癌術后頑固性皮下積液的治療作用. 中華普通外科雜志, 2004, 19(8): 510.
23.	呂晶. 網格劃痕術用于乳腺癌根治術后頑固性皮下積液的處理. 醫藥論壇雜志, 2011, 32(6): 47-48.
24.	Liu Z, Hou Y, Dong M, et al. 0015 PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of caspases in the human breast cancer cell lines. Breast, 2009, 108(1): 195-206.
25.	Liu ZB, Hou YF, Zhu J, et al. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner. Oncogene, 2010, 29(20): 2996-3009.
26.	Li T, Yang L, Fu SJ, et al. Subcutaneous injections of the mannose-sensitive hemagglutination pilus strain of pseudomonas aeruginosa stimulate host immunity, reduce bladder cancer size and improve tumor survival in mice. Cell Biochem Biophys, 2015, 73(1): 245-252.
27.	Chang J, Liu Y, Han B, et al. Pseudomonas aeruginosa preparation plus chemotherapy for advanced non-small-cell lung cancer: a randomized, multicenter, double-blind phase Ⅲ study. Med Oncol, 2015, 32(5): 139.
28.	Kong D, Liu Y, Li Z, et al. OK-432(Sapylin) reduces seroma formation after axillary lymphadenectomy in breast cancer. J Invest Surg, 2017, 30(1): 1-5.

1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. 曹欣華, 呂建鑫, 胡浩霖, 等. 不同手術方式對早期乳腺癌患者的術后恢復及并發癥的影響. 東南大學學報: 醫學版, 2018, 37(1): 45-49.
3. 呂淑貞, 李艷萍, 趙霞, 等. 靜脈留置針持續負壓引流治療乳腺癌術后皮下積液. 癌癥進展, 2018, 16(1): 120-122.
4. van Bastelaar J, Theunissen LLB, Snoeijs MGJ, et al. Flap fixation using tissue glue or sutures appears to reduce seroma aspiration after mastectomy for breast cancer. Clin Breast Cancer, 2017, 17(4): 316-321.
5. 徐青. 乳腺癌術后皮下積液研究現狀及進展. 國際外科學雜志, 2017, 44(3): 195-197.
6. 郭智慧, 羅道蘊, 周慶, 等. 常規處理方案聯合銅綠假單胞菌制劑治療乳腺癌療效的 Meta 分析. 中國普通外科雜志, 2015, 24(5): 669-676.
7. 喻滿成, 王偉, 范威, 等. 皮瓣點式縫合聯合萬特普安防治乳腺癌術后皮下積液療效觀察. 腫瘤防治研究, 2018, 45(3): 163-166.
8. 宋愛琳, 曹農. 銅綠假單胞菌注射液防治乳腺癌術后皮下積液的臨床研究. 遼寧醫學雜志, 2012, 26(2): 57-60.
9. 馬富懿, 王禮泉, 王昌亮, 等. 銅綠假單胞菌注射液在乳腺癌切除術后皮下積液中的臨床應用. 中華腫瘤防治雜志, 2009, 16(14): 1111-1112, 1119.
10. Isozaki H, Yamamoto Y, Murakami S, et al. Impact of the surgical modality for axillary lymph node dissection on postoperative drainage and seroma formation after total mastectomy. Patient Saf Surg, 2019, 13(1): 20.
11. Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer. Eur J Surg Oncol, 2004, 30(6): 602-609.
12. 許言, 許貴勤, 胡少鋒. 多點縫合術治療乳腺癌術后頑固性皮下積液 17 例體會. 實用中西醫結合臨床, 2019, 19(1): 150-151.
13. 張祥運. 負壓封閉引流技術在乳且癌術后重度皮下積液中的應用. 中華婦幼臨床醫學雜志: 電子版, 2018, 14(2): 147-150.
14. van Bastelaar J, Granzier R, van Roozendaal LM, et al. Analysis of TNF-α and interleukin-6 in seroma of patients undergoing mastectomy with or without flap fixation: is there a predictive value for seroma formation and its sequelae? Surg Oncol, 2019, 28: 36-41.
15. Srivastava V, Basu S, Shukla VK. Seroma formation after breast cancer surgery: what we have learned in the last two decades. J Breast Cancer, 2012, 15(4): 373-380.
16. Woodworth PA, McBoyle MF, Helmer SD, et al. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg, 2000, 66(5): 444-451.
17. 郝凱峰. 乳腺癌改良根治術后皮下積液產生的高危因素及預防措施. 實用癌癥雜志, 2018, 33(4): 686-689.
18. 巫泓生, 廖碧玲, 曹天生, 等. 金葡素治療乳腺癌改良根治術后皮下積液的效果. 臨床醫學, 2019, 39(4): 107-109.
19. 李磊, 阿迪力江?買買提明, 地力木拉提?艾斯木吐拉. 乳腺癌改良根治術后皮下積液與皮瓣壞死的原因及防治探討. 中國普外基礎與臨床雜志, 2015, 26(6): 725-728.
20. 于永政, 胡曉川, 趙輝, 等. 滑石粉懸液治療乳腺癌術后頑固性皮下積液的臨床研究. 臨床外科雜志, 2013, 21(6): 485.
21. Yang Y, Gao E, Liu X, et al. Effectiveness of OK-432(Sapylin) to reduce seroma formation after axillary lymphadenectomy for breast cancer. Ann Surg Oncol, 2013, 20(5): 1500-1504.
22. 劉鵬熙, 劉曉雁, 歐陽慧英, 等. 生物蛋白膠對乳腺癌術后頑固性皮下積液的治療作用. 中華普通外科雜志, 2004, 19(8): 510.
23. 呂晶. 網格劃痕術用于乳腺癌根治術后頑固性皮下積液的處理. 醫藥論壇雜志, 2011, 32(6): 47-48.
24. Liu Z, Hou Y, Dong M, et al. 0015 PA-MSHA inhibits proliferation and induces apoptosis through the up-regulation and activation of caspases in the human breast cancer cell lines. Breast, 2009, 108(1): 195-206.
25. Liu ZB, Hou YF, Zhu J, et al. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner. Oncogene, 2010, 29(20): 2996-3009.
26. Li T, Yang L, Fu SJ, et al. Subcutaneous injections of the mannose-sensitive hemagglutination pilus strain of pseudomonas aeruginosa stimulate host immunity, reduce bladder cancer size and improve tumor survival in mice. Cell Biochem Biophys, 2015, 73(1): 245-252.
27. Chang J, Liu Y, Han B, et al. Pseudomonas aeruginosa preparation plus chemotherapy for advanced non-small-cell lung cancer: a randomized, multicenter, double-blind phase Ⅲ study. Med Oncol, 2015, 32(5): 139.
28. Kong D, Liu Y, Li Z, et al. OK-432(Sapylin) reduces seroma formation after axillary lymphadenectomy in breast cancer. J Invest Surg, 2017, 30(1): 1-5.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Observation on the effect of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content