Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Lingling ¹ , LONG Binbin ² , YANG Yao ¹ , WU Yaqiong ¹ ,  ZHANG Chao ³

1. Department of Dermatology, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;
2. Department of General Surgery Ⅲ, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000,P. R. China;
3. Department of Evidence-Based Medicine Center, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;

Corresponding?author：

ZHANG Chao, Email: 286806931@qq.com

Keywords：

breast cancer; CYP1A1; gene polymorphism; cytochrome P450; meta-analysis

DOI：

10.7507/1007-9424.201908118

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer (BC) in Chinese population.Methods The case-control studies on the correlation between polymorphisms of CYP1A1 MspI and BC in Chinese population were electronically retrieved in online English database (PubMed and Web of Science) and Chinese database (Chinese National Knowledge Infrastructure, Wanfang, and VIP database) from the date of their establishment to December 31, 2018. Two reviewers completed literature screening according to the inclusion and exclusion criteria, data extraction, and methodological quality assessment of the included studies independently. Reman 5.3 software was used to meta-analysis.Results A total 14 case-control studies involving 3 372 cases and 3 510 controls were finally included. The meta-analysis results showed that the CYP1A1 MspI gene polymorphism was associated with BC in Chinese population. Dominant genetic model [OR=1.24, 95%CI was (0.98, 1.58), P=0.08] and heterozygote model [OR=1.11, 95%CI was (0.89, 1.39), P=0.37] had no association with BC in Chinese population, while recessive genetic model [OR=1.66, 95%CI was (1.28, 2.14), P=0.000 1], homozygote model [OR=1.76, 95%CI was (1.26, 2.45), P=0.000 9], and allele contrast genetic model [OR=1.30, 95%CI was (1.08, 1.56), P=0.005] increased the risk of BC in Chinese population.Conclusion It is demonstrated that in Chinese population, CYP1A1 MspI gene polymorphisms related to the risk of BC, recessive genetic model, homozygote model, and allele contrast genetic model might be the risk factor for BC.

Citation： WANG Lingling, LONG Binbin, YANG Yao, WU Yaqiong, ZHANG Chao. Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 846-854. doi: 10.7507/1007-9424.201908118 Copy

1.	World Health Organization. Globocan 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.
2.	Torre LA, Islami F, Siegel RL, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomarkers Prev, 2017, 26(4): 444-457.
3.	陳萬青, 鄭榮壽. 中國女性乳腺癌的發病死亡和生存狀況. 中國腫瘤臨床, 2015, 42(13): 668-674.
4.	師金, 梁迪, 李道娟, 等. 全球女性乳腺癌流行情況研究. 中國腫瘤, 2017, 26(9): 683-690.
5.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6.	Dickson RB, Thompson EW, Lippman ME. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J Steroid Biochem Mol Biol, 1990, 37(3): 305-316.
7.	徐小樂, 靳雅麗, 沈月平. CYP1A1 MspI基因多態性與乳腺癌關系的Meta分析. 蘇州大學學報: 醫學版, 2005, 25(6): 1078-1080.
8.	曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四: 觀察性研究的質量評價工具. 中國循證心血管醫學雜志, 2012, 4(4): 297-299.
9.	張燕舞, 蔣朱明, 王楊, 等. 與轉化醫學有關的臨床研究質量及研究報告質量的評價工具. 中華臨床營養雜志, 2011, 19(1): 1-6.
10.	DerSimonian R, Laird N. Meta-analysis in clinical trials revisited. Contemp Clin Trials, 2015, 45(Pt A): 139-145.
11.	Huang CS, Chern HD, Chang KJ, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res, 1999, 59(19): 4870-4875.
12.	Huang CS, Shen CY, Chang KJ, et al. Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan. Br J Cancer, 1999, 80(11): 1838-1843.
13.	Boyapati SM, Shu XO, Gao YT, et al. Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women. Cancer, 2005, 103(11): 2228-2235.
14.	吐爾遜·買買提, 哈木拉提·吾甫爾, 白嵐, 等. CYP1A1基因3′-UTR6235T-C位點多態性與維醫分型乳腺癌遺傳易感性的關系. 中華醫學雜志, 2011, 91(2): 86-91.
15.	吐爾遜·買買提, 哈木拉提·吾甫爾, 夏坤, 等. CYP1A1、CYP1B1、NET、DAT1單個和聯合基因型與漢族人群乳腺癌易感性的研究. 生命科學研究, 2015, 19(6): 521-529.
16.	崔壯. 雌激素代謝酶相關基因多態性及其它危險因素與乳腺癌關系的病例對照研究. 天津: 天津醫科大學, 2005.
17.	崔壯, 錢碧云, 陳可欣, 等. CYP1A1、GSTT1、GSTM1基因與乳腺癌易感性的病例對照研究. 中國慢性病預防與控制, 2010, 18(3): 249-252.
18.	帕孜來提·阿布都熱西提. CYP1A1基因多態性與新疆維、漢民族女性乳腺癌相關性研究. 烏魯木齊: 新疆醫科大學, 2016.
19.	張明, 高嫦娥, 陳瑩, 等. 彝族乳腺癌遺傳易感性CYP1A1基因MspI多態性的相關性研究. 西部醫學, 2014, 26(12): 1581-1584.
20.	張明, 高嫦娥, 陳瑩, 等. 云南省彝族及漢族乳腺癌遺傳易感性與CYP1A1基因多態性的研究. 實用醫學雜志, 2014, 30(15): 2398-2401.
21.	張珍連, 聞淑娟, 胡欣, 等. ERα PvuⅡ、XbaⅠ及CYP1A1 Msp Ⅰ基因多態性聯合作用與新疆維吾爾族女性乳腺癌發病相關性研究. 中國腫瘤, 2018, 27(3): 234-240.
22.	沈月平. CYP1A1 MspⅠ、ER PvuⅡ、ER XbaⅠ基因多態性與乳腺癌關系的病例-對照研究. 上海: 復旦大學, 2004.
23.	白淑芬, 楊立新, 張愛臣, 等. 乳腺癌患者CYP1A1基因MspⅠ酶切位點多態性的分析. 吉林大學學報: 醫學版, 2009, 35(2): 377-380.
24.	黃燚, 劉丹, 饒紹琴, 等. CYP1A1和CYP1A2基因多態性與漢族女性乳腺癌的關系. 中華乳腺病雜志: 電子版, 2013, 7(5): 345-350.
25.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviewsof Interventions 4.2.5 [updated May 2005]. http://www.cochrane.org/resources/handbook/hbook.htm.
26.	Pastor-Barriuso R, Fernández MF, Casta?o-Vinyals G, et al. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect, 2016, 124(10): 1575-1582.
27.	Upadhyaya A, Smith RA, Chacon-Cortes D, et al. Association of the microRNA-single nucleotide polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: a case control study. Gene, 2016, 576(1 Pt 2): 256-260.
28.	Dai ZM, Kang HF, Zhang WG, et al. The associations of single nucleotide polymorphisms in miR196a2, miR-499, and miR-608 with breast cancer susceptibility: a STROBE-compliant observational study. Medicine (Baltimore), 2016, 95(7): e2826.
29.	Yan R, Cao J, Song C, et al. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol, 2015, 39(6): 978-985.
30.	Yan R, Wang K, Peng R, et al. Genetic variants in lncRNA SRA and risk of breast cancer. Oncotarget, 2016, 7(16): 22486-22496.
31.	Wiels?e M, Gudmundsdottir S, Bonefeld-J?rgensen EC. Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study. Public Health, 2016, 137: 50-58.
32.	Hanf V, Hanf D. Reproduction and breast cancer risk. Breast Care (Basel), 2014, 9(6): 398-405.
33.	Namiranian N, Moradi-Lakeh M, Razavi-Ratki SK, et al. Risk factors of breast cancer in the Eastern Mediterranean Region: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 2014, 15(21): 9535-9541.
34.	Wang X, Li L, Gao J, et al. The association between body size and breast cancer in han women in Northern and Eastern China. Oncologist, 2016, 21(11): 1362-1368.
35.	姜勇, 張梅, 李鎰沖, 等. 2010年我國中心型肥胖流行狀況及腰圍分布特征分析. 中國慢性病預防與控制, 2013, 21(3): 288-291.
36.	倪國華, 張璟, 鄭風田. 中國肥胖流行的現狀與趨勢. 中國食物與營養, 2013, 19(10): 70-74.
37.	Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res, 2016, 40(6): 1166-1181.
38.	Li B, Wang L, Lu MS, et al. Passive smoking and breast cancer risk among non-smoking women: a case-control study in China. PLoS One, 2015, 10(4): e0125894.
39.	Kiruthiga PV, Kannan MR, Saraswathi C, et al. CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India. Asian Pac J Cancer Prev, 2011, 12(8): 2133-2138.
40.	Miyoshi Y, Takahashi Y, Egawa C, et al. Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J, 2002, 8(4): 209-215.
41.	Moreno-Galván M, Herrera-González NE, Robles-Pérez V, et al. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers, 2010, 25(3): 157-163.
42.	Shin A, Kang D, Choi JY, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med, 2007, 39(3): 361-366.

1. World Health Organization. Globocan 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.
2. Torre LA, Islami F, Siegel RL, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomarkers Prev, 2017, 26(4): 444-457.
3. 陳萬青, 鄭榮壽. 中國女性乳腺癌的發病死亡和生存狀況. 中國腫瘤臨床, 2015, 42(13): 668-674.
4. 師金, 梁迪, 李道娟, 等. 全球女性乳腺癌流行情況研究. 中國腫瘤, 2017, 26(9): 683-690.
5. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6. Dickson RB, Thompson EW, Lippman ME. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J Steroid Biochem Mol Biol, 1990, 37(3): 305-316.
7. 徐小樂, 靳雅麗, 沈月平. CYP1A1 MspI基因多態性與乳腺癌關系的Meta分析. 蘇州大學學報: 醫學版, 2005, 25(6): 1078-1080.
8. 曾憲濤, 劉慧, 陳曦, 等. Meta分析系列之四: 觀察性研究的質量評價工具. 中國循證心血管醫學雜志, 2012, 4(4): 297-299.
9. 張燕舞, 蔣朱明, 王楊, 等. 與轉化醫學有關的臨床研究質量及研究報告質量的評價工具. 中華臨床營養雜志, 2011, 19(1): 1-6.
10. DerSimonian R, Laird N. Meta-analysis in clinical trials revisited. Contemp Clin Trials, 2015, 45(Pt A): 139-145.
11. Huang CS, Chern HD, Chang KJ, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res, 1999, 59(19): 4870-4875.
12. Huang CS, Shen CY, Chang KJ, et al. Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan. Br J Cancer, 1999, 80(11): 1838-1843.
13. Boyapati SM, Shu XO, Gao YT, et al. Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women. Cancer, 2005, 103(11): 2228-2235.
14. 吐爾遜·買買提, 哈木拉提·吾甫爾, 白嵐, 等. CYP1A1基因3′-UTR6235T-C位點多態性與維醫分型乳腺癌遺傳易感性的關系. 中華醫學雜志, 2011, 91(2): 86-91.
15. 吐爾遜·買買提, 哈木拉提·吾甫爾, 夏坤, 等. CYP1A1、CYP1B1、NET、DAT1單個和聯合基因型與漢族人群乳腺癌易感性的研究. 生命科學研究, 2015, 19(6): 521-529.
16. 崔壯. 雌激素代謝酶相關基因多態性及其它危險因素與乳腺癌關系的病例對照研究. 天津: 天津醫科大學, 2005.
17. 崔壯, 錢碧云, 陳可欣, 等. CYP1A1、GSTT1、GSTM1基因與乳腺癌易感性的病例對照研究. 中國慢性病預防與控制, 2010, 18(3): 249-252.
18. 帕孜來提·阿布都熱西提. CYP1A1基因多態性與新疆維、漢民族女性乳腺癌相關性研究. 烏魯木齊: 新疆醫科大學, 2016.
19. 張明, 高嫦娥, 陳瑩, 等. 彝族乳腺癌遺傳易感性CYP1A1基因MspI多態性的相關性研究. 西部醫學, 2014, 26(12): 1581-1584.
20. 張明, 高嫦娥, 陳瑩, 等. 云南省彝族及漢族乳腺癌遺傳易感性與CYP1A1基因多態性的研究. 實用醫學雜志, 2014, 30(15): 2398-2401.
21. 張珍連, 聞淑娟, 胡欣, 等. ERα PvuⅡ、XbaⅠ及CYP1A1 Msp Ⅰ基因多態性聯合作用與新疆維吾爾族女性乳腺癌發病相關性研究. 中國腫瘤, 2018, 27(3): 234-240.
22. 沈月平. CYP1A1 MspⅠ、ER PvuⅡ、ER XbaⅠ基因多態性與乳腺癌關系的病例-對照研究. 上海: 復旦大學, 2004.
23. 白淑芬, 楊立新, 張愛臣, 等. 乳腺癌患者CYP1A1基因MspⅠ酶切位點多態性的分析. 吉林大學學報: 醫學版, 2009, 35(2): 377-380.
24. 黃燚, 劉丹, 饒紹琴, 等. CYP1A1和CYP1A2基因多態性與漢族女性乳腺癌的關系. 中華乳腺病雜志: 電子版, 2013, 7(5): 345-350.
25. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviewsof Interventions 4.2.5 [updated May 2005]. http://www.cochrane.org/resources/handbook/hbook.htm.
26. Pastor-Barriuso R, Fernández MF, Casta?o-Vinyals G, et al. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect, 2016, 124(10): 1575-1582.
27. Upadhyaya A, Smith RA, Chacon-Cortes D, et al. Association of the microRNA-single nucleotide polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: a case control study. Gene, 2016, 576(1 Pt 2): 256-260.
28. Dai ZM, Kang HF, Zhang WG, et al. The associations of single nucleotide polymorphisms in miR196a2, miR-499, and miR-608 with breast cancer susceptibility: a STROBE-compliant observational study. Medicine (Baltimore), 2016, 95(7): e2826.
29. Yan R, Cao J, Song C, et al. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol, 2015, 39(6): 978-985.
30. Yan R, Wang K, Peng R, et al. Genetic variants in lncRNA SRA and risk of breast cancer. Oncotarget, 2016, 7(16): 22486-22496.
31. Wiels?e M, Gudmundsdottir S, Bonefeld-J?rgensen EC. Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study. Public Health, 2016, 137: 50-58.
32. Hanf V, Hanf D. Reproduction and breast cancer risk. Breast Care (Basel), 2014, 9(6): 398-405.
33. Namiranian N, Moradi-Lakeh M, Razavi-Ratki SK, et al. Risk factors of breast cancer in the Eastern Mediterranean Region: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 2014, 15(21): 9535-9541.
34. Wang X, Li L, Gao J, et al. The association between body size and breast cancer in han women in Northern and Eastern China. Oncologist, 2016, 21(11): 1362-1368.
35. 姜勇, 張梅, 李鎰沖, 等. 2010年我國中心型肥胖流行狀況及腰圍分布特征分析. 中國慢性病預防與控制, 2013, 21(3): 288-291.
36. 倪國華, 張璟, 鄭風田. 中國肥胖流行的現狀與趨勢. 中國食物與營養, 2013, 19(10): 70-74.
37. Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res, 2016, 40(6): 1166-1181.
38. Li B, Wang L, Lu MS, et al. Passive smoking and breast cancer risk among non-smoking women: a case-control study in China. PLoS One, 2015, 10(4): e0125894.
39. Kiruthiga PV, Kannan MR, Saraswathi C, et al. CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India. Asian Pac J Cancer Prev, 2011, 12(8): 2133-2138.
40. Miyoshi Y, Takahashi Y, Egawa C, et al. Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J, 2002, 8(4): 209-215.
41. Moreno-Galván M, Herrera-González NE, Robles-Pérez V, et al. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers, 2010, 25(3): 157-163.
42. Shin A, Kang D, Choi JY, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med, 2007, 39(3): 361-366.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content