Meta-analysis of the effect of nanocarbon in lymph node dissection of gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PENG Zhihao ,  LI Yuming

Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P. R. China;

Corresponding?author：

LI Yuming, Email: Lym110204@126.com

Keywords：

gastric cancer; nanocarbon; lymph node; meta analysis

DOI：

10.7507/1007-9424.201903089

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the clinical applicability and safety of nanocarbon in patients with gastric cancer, and evaluate its application value in radical gastrectomy.Methods Collectted relevant literatures on radical gastrectomy for nanocarbon scales from the time of construction of the library to February 2019, according to search databases included PubMed, Embase, Cochrane Library, China Journal Full-text Database (CNKI), and Wanfang. The data of lymph node detection, detection time, number of lymph node metastases, and postoperative complications were extracted from the two groups. We systematically evaluated it, and analyzed the two groups by using RevMan 5.3 software.Results We searched 88 articles and selected 10 articles, including 5 randomized controlled trials and 5 case-control studies. There were 784 patients in the nanocarbon group and 695 patients in the non-nanocarbon group. Results of meta analysis on the clinical utility and safety of nanocarbon labeled lymph nodes showed that, the number of lymph node detection, lymph node detection time, and number of lymph node metastases in the nanocarbon group and non-nanocarbon group were statistically significant (P<0.05), they were better in the nanocarbon group. There was no significant difference in postoperative complications between the two groups (P>0.05).Conclusions Nanocarbon has a clear trace effect on lymph nodes of gastric cancer. It can reduce the difficulty of the number of lymph node detection, improve the detection rate of lymph nodes, and avoid blindness during traditional lymph node dissection.

Citation： PENG Zhihao, LI Yuming. Meta-analysis of the effect of nanocarbon in lymph node dissection of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(9): 1093-1100. doi: 10.7507/1007-9424.201903089 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Correa P. Gastric cancer: overview. Gastroenterol Clin North Am, 2013, 42(2): 211-217.
3.	Yang Z, Zhi Q, Wang D, et al. Long noncoding RNA C21orF96 promotes the migration, invasion and lymph node metastasis in gastric cancer. Anticancer Agents Med Chem, 2016, 16(9): 1101-1108.
4.	Zhan HX, Xu JW, Wang L, et al. Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer. World J Surg Oncol, 2015, 13: 105.
5.	Nakamoto J, Torisu R, Aoki R, et al. Clinicopathological evaluation of biological behavior of submucosal invasive gastric carcinomas: relationship among lymph node metastasis, mucin phenotype and proliferative activity. J Med Invest, 2007, 54(1-2): 99-108.
6.	Sarela AI, Turnbull AD, Coit DG, et al. Accurate lymph node staging is of greater prognostic importance than subclassification of the T2 category for gastric adenocarcinoma. Ann Surg Oncol, 2003, 10(7): 783-791.
7.	Estourgie SH, Tanis PJ, Nieweg OE, et al. Should the hunt for internal mammary chain sentinel nodes begin? An evaluation of 150 breast cancer patients. Ann Surg Oncol, 2003, 10(8): 935-941.
8.	van Rijk MC, Tanis PJ, Nieweg OE, et al. Clinical implications of sentinel nodes outside the axilla and internal mammary chain in patients with breast cancer. J Surg Oncol, 2006, 94(4): 281-286.
9.	Cloyd JM, Wapnir IL, Read BM, et al. Indocyanine green and fluorescence lymphangiography for sentinel lymph node identification in cutaneous melanoma. J Surg Oncol, 2014, 110(7): 888-892.
10.	Aziz O, Constantinides V, Tekkis PP, et al. Laparoscopic versus open surgery for rectal cancer: a meta-analysis. Ann Surg Oncol, 2006, 13(3): 413-424.
11.	陳鴻源, 王亞楠, 薛芳沁, 等. 腹腔鏡下靜脈輸液針注射法納米碳淋巴示蹤技術在胃癌根治術中的應用. 中華胃腸外科雜志, 2014, 17(5): 457-460.
12.	洪強, 汪勇, 王建軍, 等. 術前胃鏡下注射法納米碳淋巴結示蹤技術在腹腔鏡胃癌根治術中的應用. 中華醫學雜志, 2017, 97(2): 123-126.
13.	Wang H, Chen MM, Zhu GS, et al. Lymph node mapping with carbon nanoparticles and the risk factors of lymph node metastasis in gastric cancer. J Huazhong Univ Sci Technolog Med Sci, 2016, 36(6): 865-870.
14.	程科. 納米碳淋巴示蹤劑在腹腔鏡輔助進展期胃癌根治術中的應用及評價. 鄭州: 鄭州大學, 2016.
15.	賈榮保. 納米碳示蹤劑的應用對胃癌患者預后的影響. 青島: 青島大學, 2018.
16.	陸曄. 納米碳淋巴示蹤技術在胃癌微創根治手術患者中的應用效果. 陜西醫學雜志, 2015, 44(1): 57-59.
17.	麥麥提·艾合麥提, 劉少壯, 陳成, 等. 術前胃鏡下納米碳標記在腹腔鏡胃癌根治術中的應用價值. 腹腔鏡外科雜志, 2018, 23(1): 31-35.
18.	魏秋亞, 樊勇, 劉永永, 等. 納米炭示蹤技術在腹腔鏡進展期胃癌根治術中的臨床應用. 中國微創外科雜志, 2016, 16(12): 1113-1116.
19.	修乘波, 吳剛, 孫培春. 術前應用納米活性炭對腹腔鏡胃癌根治術治療效果及淋巴結清掃的影響. 癌癥進展, 2018, 16(7): 884-886, 896.
20.	趙玉洲, 韓廣森, 顧焱暉, 等. 胃癌 D2 根治術中納米碳顯影法應用研究. 中華腫瘤防治雜志, 2017, 24(7): 477-480.
21.	Sasako M. Principles of surgical treatment for curable gastric cancer. J Clin Oncol, 2003, 21(23 Suppl): 274s-275s.
22.	Lee HK, Yang HK, Kim WH, et al. Influence of the number of lymph nodes examined on staging of gastric cancer. Br J Surg, 2001, 88(10): 1408-1412.
23.	Smith DD, Schwarz RR, Schwarz RE. Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-population database. J Clin Oncol, 2005, 23(28): 7114-7124.
24.	Son T, Hyung WJ, Lee JH, et al. Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer. Cancer, 2012, 118(19): 4687-4693.
25.	Kikuchi S, Katada N, Sakuramoto S, et al. Factors associated with pN3 stage tumors according to the TNM classification in advanced gastric cancer. Hepatogastroenterology, 2003, 50(53): 1723-1726.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Correa P. Gastric cancer: overview. Gastroenterol Clin North Am, 2013, 42(2): 211-217.
3. Yang Z, Zhi Q, Wang D, et al. Long noncoding RNA C21orF96 promotes the migration, invasion and lymph node metastasis in gastric cancer. Anticancer Agents Med Chem, 2016, 16(9): 1101-1108.
4. Zhan HX, Xu JW, Wang L, et al. Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer. World J Surg Oncol, 2015, 13: 105.
5. Nakamoto J, Torisu R, Aoki R, et al. Clinicopathological evaluation of biological behavior of submucosal invasive gastric carcinomas: relationship among lymph node metastasis, mucin phenotype and proliferative activity. J Med Invest, 2007, 54(1-2): 99-108.
6. Sarela AI, Turnbull AD, Coit DG, et al. Accurate lymph node staging is of greater prognostic importance than subclassification of the T2 category for gastric adenocarcinoma. Ann Surg Oncol, 2003, 10(7): 783-791.
7. Estourgie SH, Tanis PJ, Nieweg OE, et al. Should the hunt for internal mammary chain sentinel nodes begin? An evaluation of 150 breast cancer patients. Ann Surg Oncol, 2003, 10(8): 935-941.
8. van Rijk MC, Tanis PJ, Nieweg OE, et al. Clinical implications of sentinel nodes outside the axilla and internal mammary chain in patients with breast cancer. J Surg Oncol, 2006, 94(4): 281-286.
9. Cloyd JM, Wapnir IL, Read BM, et al. Indocyanine green and fluorescence lymphangiography for sentinel lymph node identification in cutaneous melanoma. J Surg Oncol, 2014, 110(7): 888-892.
10. Aziz O, Constantinides V, Tekkis PP, et al. Laparoscopic versus open surgery for rectal cancer: a meta-analysis. Ann Surg Oncol, 2006, 13(3): 413-424.
11. 陳鴻源, 王亞楠, 薛芳沁, 等. 腹腔鏡下靜脈輸液針注射法納米碳淋巴示蹤技術在胃癌根治術中的應用. 中華胃腸外科雜志, 2014, 17(5): 457-460.
12. 洪強, 汪勇, 王建軍, 等. 術前胃鏡下注射法納米碳淋巴結示蹤技術在腹腔鏡胃癌根治術中的應用. 中華醫學雜志, 2017, 97(2): 123-126.
13. Wang H, Chen MM, Zhu GS, et al. Lymph node mapping with carbon nanoparticles and the risk factors of lymph node metastasis in gastric cancer. J Huazhong Univ Sci Technolog Med Sci, 2016, 36(6): 865-870.
14. 程科. 納米碳淋巴示蹤劑在腹腔鏡輔助進展期胃癌根治術中的應用及評價. 鄭州: 鄭州大學, 2016.
15. 賈榮保. 納米碳示蹤劑的應用對胃癌患者預后的影響. 青島: 青島大學, 2018.
16. 陸曄. 納米碳淋巴示蹤技術在胃癌微創根治手術患者中的應用效果. 陜西醫學雜志, 2015, 44(1): 57-59.
17. 麥麥提·艾合麥提, 劉少壯, 陳成, 等. 術前胃鏡下納米碳標記在腹腔鏡胃癌根治術中的應用價值. 腹腔鏡外科雜志, 2018, 23(1): 31-35.
18. 魏秋亞, 樊勇, 劉永永, 等. 納米炭示蹤技術在腹腔鏡進展期胃癌根治術中的臨床應用. 中國微創外科雜志, 2016, 16(12): 1113-1116.
19. 修乘波, 吳剛, 孫培春. 術前應用納米活性炭對腹腔鏡胃癌根治術治療效果及淋巴結清掃的影響. 癌癥進展, 2018, 16(7): 884-886, 896.
20. 趙玉洲, 韓廣森, 顧焱暉, 等. 胃癌 D2 根治術中納米碳顯影法應用研究. 中華腫瘤防治雜志, 2017, 24(7): 477-480.
21. Sasako M. Principles of surgical treatment for curable gastric cancer. J Clin Oncol, 2003, 21(23 Suppl): 274s-275s.
22. Lee HK, Yang HK, Kim WH, et al. Influence of the number of lymph nodes examined on staging of gastric cancer. Br J Surg, 2001, 88(10): 1408-1412.
23. Smith DD, Schwarz RR, Schwarz RE. Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-population database. J Clin Oncol, 2005, 23(28): 7114-7124.
24. Son T, Hyung WJ, Lee JH, et al. Clinical implication of an insufficient number of examined lymph nodes after curative resection for gastric cancer. Cancer, 2012, 118(19): 4687-4693.
25. Kikuchi S, Katada N, Sakuramoto S, et al. Factors associated with pN3 stage tumors according to the TNM classification in advanced gastric cancer. Hepatogastroenterology, 2003, 50(53): 1723-1726.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Meta-analysis of the effect of nanocarbon in lymph node dissection of gastric cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content