Correlation between cholecystectomy or gallbladder disease and bile reflux gastritis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIAO Gang ¹ , LIU Yanmei ² ,  YU Hong ¹

1. The Second Department of General Surgery, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, P. R. China;
2. Department of Rheumatology, The First Hospital of China Medical University, Shenyang 110004, P. R. China;

Corresponding?author：

YU Hong, Email: yuhong1973@163.com

Keywords：

bile reflux gastritis; cholecystectomy; gallbladder disease; correlation

DOI：

10.7507/1007-9424.201903051

Video：

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Objective To study the relationship among cholecystectomy/gallbladder disease and bile reflux gastritis.Methods A retrospective collection of 123 patients with bile reflux gastritis who were diagnosed as outpatients and hospitalized from January 2014 to February 2019 in Shengjing Hospital Affiliated to China Medical University, and 221 patients with non-biliary reflux gastritis at the same period were collected. According to the gallbladder status, the patients were divided into three groups: gallbladder disease, cholecystectomy, and gallbladder disease-free group. The relationship between gallbladder status and bile reflux gastritis was analyzed.Results Among 123 patients with bile reflux gastritis, there were 22 cases (17.89%) with cholecystectomy and 26 cases (21.14%) with gallbladder disease; 221 cases of non-biliary reflux gastritis with cholecystectomy in 7 cases (3.17%) and gallbladder disease in 30 cases (13.57%). Univariate analysis showed that the gallbladder status was different between the bile reflux gastritis group and the non-biliary reflux gastritis group (χ²=21.089, P<0.001). The study showed that the gallbladder status was related to the occurrence of bile reflux gastritis. In contrast, patients with cholecystectomy and gallbladder disease had a higher risk of occurrence than those with no gallbladder disease (OR>1, P<0.012 5). Independent risk factors were considered by logistic multivariate regression analysis, including cholecystectomy, gallbladder disease, and age (P<0.05).Conclusions There is a correlation between cholecystectomy/gallbladder disease and bile reflux gastritis. Cholecystectomy and gallbladder disease may be the independent risk factors for bile reflux gastritis.

Citation： XIAO Gang, LIU Yanmei, YU Hong. Correlation between cholecystectomy or gallbladder disease and bile reflux gastritis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(9): 1072-1076. doi: 10.7507/1007-9424.201903051 Copy

1.	王愛娜. 膽囊切除術后膽汁反流性胃炎研究進展. 現代消化及介入診療, 2016, 21(2): 372-374.
2.	徐培縣, 高慶香, 李兆勇. 膽囊切除術后膽汁反流的探討. 武警醫學院學報, 2006, 15(1): 57-58.
3.	鄭知強. 曲美布汀在微創膽道術后膽汁反流性胃炎中的療效研究. 四川生理科學雜志, 2017, 39(2): 68-71.
4.	Freedman J, Ye W, N?slund E, et al. Association between cholecystectomy and adenocarcinoma of the esophagus. Gastroenterology, 2001, 121(3): 548-553.
5.	商西丹, 趙新華, 敬長春, 等. 膽汁反流性胃炎與膽囊炎的臨床相關性研究. 中華消化病與影像雜志: 電子版, 2015, 5(5): 234-237.
6.	田野, 譚廣, 陳紅生, 等. 膽囊炎患者腹腔鏡膽囊切除術后胃腸道癥狀的臨床觀察. 臨床合理用藥雜志, 2017, 10(2): 9-11.
7.	Weinert CR, Arnett D, Jacobs D Jr, et al. Relationship between persistence of abdominal symptoms and successful outcome after cholecystectomy. Arch Intern Med, 2000, 160(7): 989-995.
8.	Tsai MC, Huang CC, Kao LT, et al. Increased risk of peptic ulcers following a cholecystectomy for gallstones. Sci Rep, 2016, 6: 30702.
9.	荀林娟, 宋瑞梅, 莊英, 等. 膽囊切除術后膽汁反流性胃炎的研究進展. 實用臨床醫藥雜志, 2018, 22(1): 146-148.
10.	于宏, 王越市, 肖剛, 等. 單孔腹腔鏡膽囊逆行切除術的學習曲線分析. 中國普外基礎與臨床雜志, 2017, 25(6): 750-753.
11.	楊德平, 王榮. 膽囊切除術與膽汁反流性胃炎的相關關系. 江西中醫藥, 2007, 38(11): 33.
12.	蔣飛, 吳愛玲, 顏淵, 等. 胃鏡下觀察膽汁十二指腸胃反流對腹腔鏡膽囊切除術術后惡心嘔吐的影響. 中國當代醫藥, 2018, 25(10): 34-37.
13.	Atak I, Ozdil K, Yücel M, et al. The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia. Hepatogastroenterology, 2012, 59(113): 59-61.
14.	孫丹莉, 張予蜀, 孫士其. 十二指腸胃反流與膽囊切除術關系的臨床研究. 胃腸病學和肝病學雜志, 2002, 11(4): 356-357.
15.	黎可京, 邱小蕾. 雷貝拉唑聯合鋁碳酸鎂治療膽囊切除術并發膽汁反流性胃炎的臨床療效. 臨床合理用藥雜志, 2017, 10(27): 56-57.
16.	Stavraka A, Madan AK, Frantzides CT, et al. Gastric emptying time, not enterogastric reflux, is related to symptoms after upper gastrointestinal/biliary surgery. Am J Surg, 2002, 184(6): 596-599.
17.	王好倫, 連少峰, 王治海, 等. 膽汁反流性胃炎與膽囊炎關系的探討. 蚌埠醫學院學報, 1999, 24(6): 420-421.
18.	劉永鋒, 何三光, 田雨霖, 等. 不同程度膽道感染的壓力變化. 中國醫科大學學報, 1990, 19(4): 275-278.
19.	張舉垚, 張江彬, 林寬仔. 精神心理因素與原發性膽汁反流性胃炎相關性探討. 臨床消化病雜志, 2015, 27(5): 304-306.
20.	常玉英, 黃永輝, 陳波, 等. 膽囊切除術后胃十二指腸黏膜的內鏡病理分析. 西南國防醫藥, 2011, 21(1): 33-35.
21.	趙亞男, 許翠萍. 膽汁反流性胃炎病因病機及診治進展. 世界華人消化雜志, 2018, 26(32): 1886-1892.
22.	Madura JA. Primary bile reflux gastritis: diagnosis and surgical treatment. Am J Surg, 2003, 186(3): 269-273.
23.	徐成棟, 陳曉明, 喇旭, 等. Roux-en-Y胃空腸吻合術在遠端胃切除消化道重建中的應用. 中國普外基礎與臨床雜志, 2014, 21(7): 889-891.
24.	馬有偉, 劉宏斌, 韓曉鵬, 等. 畢Ⅱ式聯合 Braun 吻合與單純畢Ⅱ式吻合在全腹腔鏡下遠端胃癌根治術中的療效比較. 中國普外基礎與臨床雜志, 2016, 23(3): 311-314.
25.	周心明, 梁杏云. 膽汁反流性胃炎臨床分析. 武漢大學學報: 醫學版, 2007, 28(5): 680-682.
26.	李莉, 呂春艷, 徐梅梅, 等. 膽汁反流性胃炎相關問題研究現狀. 中國誤診學雜志, 2012, 12(17): 4540-4541, 4544.
27.	周銀斌, 陳東風. 膽汁反流性胃炎研究現狀. 胃腸病學和肝病學雜志, 2019, 28(6): 689-692.

1. 王愛娜. 膽囊切除術后膽汁反流性胃炎研究進展. 現代消化及介入診療, 2016, 21(2): 372-374.
2. 徐培縣, 高慶香, 李兆勇. 膽囊切除術后膽汁反流的探討. 武警醫學院學報, 2006, 15(1): 57-58.
3. 鄭知強. 曲美布汀在微創膽道術后膽汁反流性胃炎中的療效研究. 四川生理科學雜志, 2017, 39(2): 68-71.
4. Freedman J, Ye W, N?slund E, et al. Association between cholecystectomy and adenocarcinoma of the esophagus. Gastroenterology, 2001, 121(3): 548-553.
5. 商西丹, 趙新華, 敬長春, 等. 膽汁反流性胃炎與膽囊炎的臨床相關性研究. 中華消化病與影像雜志: 電子版, 2015, 5(5): 234-237.
6. 田野, 譚廣, 陳紅生, 等. 膽囊炎患者腹腔鏡膽囊切除術后胃腸道癥狀的臨床觀察. 臨床合理用藥雜志, 2017, 10(2): 9-11.
7. Weinert CR, Arnett D, Jacobs D Jr, et al. Relationship between persistence of abdominal symptoms and successful outcome after cholecystectomy. Arch Intern Med, 2000, 160(7): 989-995.
8. Tsai MC, Huang CC, Kao LT, et al. Increased risk of peptic ulcers following a cholecystectomy for gallstones. Sci Rep, 2016, 6: 30702.
9. 荀林娟, 宋瑞梅, 莊英, 等. 膽囊切除術后膽汁反流性胃炎的研究進展. 實用臨床醫藥雜志, 2018, 22(1): 146-148.
10. 于宏, 王越市, 肖剛, 等. 單孔腹腔鏡膽囊逆行切除術的學習曲線分析. 中國普外基礎與臨床雜志, 2017, 25(6): 750-753.
11. 楊德平, 王榮. 膽囊切除術與膽汁反流性胃炎的相關關系. 江西中醫藥, 2007, 38(11): 33.
12. 蔣飛, 吳愛玲, 顏淵, 等. 胃鏡下觀察膽汁十二指腸胃反流對腹腔鏡膽囊切除術術后惡心嘔吐的影響. 中國當代醫藥, 2018, 25(10): 34-37.
13. Atak I, Ozdil K, Yücel M, et al. The effect of laparoscopic cholecystectomy on the development of alkaline reflux gastritis and intestinal metaplasia. Hepatogastroenterology, 2012, 59(113): 59-61.
14. 孫丹莉, 張予蜀, 孫士其. 十二指腸胃反流與膽囊切除術關系的臨床研究. 胃腸病學和肝病學雜志, 2002, 11(4): 356-357.
15. 黎可京, 邱小蕾. 雷貝拉唑聯合鋁碳酸鎂治療膽囊切除術并發膽汁反流性胃炎的臨床療效. 臨床合理用藥雜志, 2017, 10(27): 56-57.
16. Stavraka A, Madan AK, Frantzides CT, et al. Gastric emptying time, not enterogastric reflux, is related to symptoms after upper gastrointestinal/biliary surgery. Am J Surg, 2002, 184(6): 596-599.
17. 王好倫, 連少峰, 王治海, 等. 膽汁反流性胃炎與膽囊炎關系的探討. 蚌埠醫學院學報, 1999, 24(6): 420-421.
18. 劉永鋒, 何三光, 田雨霖, 等. 不同程度膽道感染的壓力變化. 中國醫科大學學報, 1990, 19(4): 275-278.
19. 張舉垚, 張江彬, 林寬仔. 精神心理因素與原發性膽汁反流性胃炎相關性探討. 臨床消化病雜志, 2015, 27(5): 304-306.
20. 常玉英, 黃永輝, 陳波, 等. 膽囊切除術后胃十二指腸黏膜的內鏡病理分析. 西南國防醫藥, 2011, 21(1): 33-35.
21. 趙亞男, 許翠萍. 膽汁反流性胃炎病因病機及診治進展. 世界華人消化雜志, 2018, 26(32): 1886-1892.
22. Madura JA. Primary bile reflux gastritis: diagnosis and surgical treatment. Am J Surg, 2003, 186(3): 269-273.
23. 徐成棟, 陳曉明, 喇旭, 等. Roux-en-Y胃空腸吻合術在遠端胃切除消化道重建中的應用. 中國普外基礎與臨床雜志, 2014, 21(7): 889-891.
24. 馬有偉, 劉宏斌, 韓曉鵬, 等. 畢Ⅱ式聯合 Braun 吻合與單純畢Ⅱ式吻合在全腹腔鏡下遠端胃癌根治術中的療效比較. 中國普外基礎與臨床雜志, 2016, 23(3): 311-314.
25. 周心明, 梁杏云. 膽汁反流性胃炎臨床分析. 武漢大學學報: 醫學版, 2007, 28(5): 680-682.
26. 李莉, 呂春艷, 徐梅梅, 等. 膽汁反流性胃炎相關問題研究現狀. 中國誤診學雜志, 2012, 12(17): 4540-4541, 4544.
27. 周銀斌, 陳東風. 膽汁反流性胃炎研究現狀. 胃腸病學和肝病學雜志, 2019, 28(6): 689-692.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation between cholecystectomy or gallbladder disease and bile reflux gastritis

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