Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yi ,  ZHAO Xuefeng

Department of General Surgery, The Affiliated Xinhua Hospital of Dalian University, Dalian, Liaoning 116021, P. R. China;

Corresponding?author：

ZHAO Xuefeng, Email: zoserbong@163.com

Keywords：

colorectal cancer; HOXB7 molecule; survival analysis

DOI：

10.7507/1007-9424.201902044

Video：

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Objective To investigate the expression and clinical significance of HOXB7 mRNA and protein in colorectal cancer (CRC) tissues.Methods The expressions of HOXB7 mRNA were evaluated in 6 cases of adjacent colorectal mucosal (ACRM) tissues and 6 cases of CRC tissues by using RT-PCR. The HOXB7 protein expressions were evaluated in 30 cases of ACRM tissues and 98 cases of CRC tissues by using immunohistochemistry. The correlations between the expression of HOXB7 protein, and the clinicopathologic factors or the patient’ survival were analyzed.Results RT-PCR results showed that expression level of HOXB7 mRNA in CRC tissues was significantly higher than that of ACRM tissues (P=0.003). Immunohistochemistry results showed that significantly higher positive-expression rate of HOXB7 protein in CRC tissues compared with ACRM tissues (P<0.05). Positive expression of HOXB7 protein was associated with depth of tumor invasion, lymph node metastasis, and the TNM stage (P<0.05). Kaplan-Meier survival curves showed that positive expression of HOXB7 protein was not inversely correlated with survival of CRC patients (P=0.865).Conclusion Positive expression of HOXB7 protein is a novel biomarker for estimating the progression of CRC, but remains of textual research may be to confirm the significance of HOXB7 protein for prognosis evaluation.

Citation： WANG Yi, ZHAO Xuefeng. Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(6): 673-677. doi: 10.7507/1007-9424.201902044 Copy

1.	鄭榮壽, 孫可欣, 張思維, 等. 2015年中國惡性腫瘤流行情況分析. 中華腫瘤雜志, 2019, 41(1): 19-28.
2.	王錫山. 中美結直腸癌流行病學特征對比及防控策略分析. 中華結直腸疾病電子雜志, 2019, 8(1): 1-5.
3.	康爭春, 蔡慧, 韓一芳, 等. 結直腸癌的早期診斷及生物標志物現狀. 國際外科學雜志, 2017, 44(8): 509-512.
4.	Komatsu H, Iguchi T, Masuda T, et al. HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma. Anticancer Res, 2016, 36(6): 2767-2773.
5.	Monterisi S, Lo Riso P, Russo K, et al. HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 2018, 37(26): 3575-3588.
6.	Soret C, Martin E, Duluc I, et al. Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Lett, 2016, 374(2): 208-215.
7.	Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, et al. miR-196b-5p regulates colorectal cancer cell migration and metastases through interaction with HOXB7 and GALNT5. Clin Cancer Res, 2017, 23(17): 5255-5266.
8.	羅云春, 易文, 姚宇宙, 等. 結直腸癌組織中同源異型盒基因B7蛋白的表達及臨床意義. 重慶醫學, 2018, 47(1): 60-62.
9.	原薇薇, 譚艷, 杜敏, 等. HOXB7基因在肺腺癌中的表達及其臨床意義. 臨床腫瘤學雜志, 2014, 19(11): 987-991.
10.	趙雪峰, 趙美蘭, 許廣大. TMPRSS4在胃癌中的表達及其臨床意義. 中國醫科大學學報, 2018, 47(11): 969-974.
11.	周總光, 楊烈. 結直腸癌外科實驗研究進展與展望. 中華實驗外科雜志, 2012, 29(2): 172-175.
12.	張海鑫, 蘇琪. 精準醫學下結直腸癌研究進展. 中國醫師進修雜志, 2018, 41(9): 848-852.
13.	賀育華, 楊婕, 蔣理立. 結直腸癌術后患者生活質量的研究進展. 中國普外基礎與臨床雜志, 2019, [2019-03-05], http://www.gensurg.cn/article/10.7507/1007-9424.201812095.
14.	鄧艷紅. 結直腸癌的分子分型對臨床個體化治療至關重要. 中華胃腸外科雜志, 2015, 18(10): 994-997.
15.	盧海欣, 黃志輝, 陳佳雅, 等. 結直腸癌化療增敏性研究進展. 國際外科學雜志, 2015, 42(11): 789-792.
16.	Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology, 2007, 50(1): 113-130.
17.	Cantile M, Scognamiglio G, La Sala L, et al. Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers. Int J Mol Sci, 2013, 14(11): 21727-21740.
18.	蘭鴻波, 潘杰, 盧星榕, 等. miR-196b mRNA和HoxB8 mRNA在結直腸癌組織中的表達及其臨床意義. 中國普外基礎與臨床雜志, 2013, 20(4): 400-405.
19.	周旋, 孔令平, 張侖. HOTAIR與腫瘤生物學行為的研究進展. 中國腫瘤臨床, 2016, 43(16): 731-734.
20.	Jin K, Park S, Teo WW, et al. HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance. Cancer Discov, 2015, 5(9): 944-959.
21.	朱克祥, 袁得峰, 張正聰, 等. RNAi結腸癌HOXB7基因表達對癌細胞增殖及凋亡的機制研究. 中國免疫學志, 2018, 34(3): 371-375.
22.	王藝, 張曉微, 房愛春. HOXB7基因對裸鼠結腸癌肺轉移模型的致癌機制研究. 海南醫學, 2018, 29(20): 2816-2819.
23.	Liao WT, Jiang D, Yuan J, et al. HOXB7 as a prognostic factor and mediator of colorectal cancer progression. Clin Cancer Res, 2011, 17(11): 3569-3578.
24.	Iman M, Mostafavi SS, Arab SS, et al. HOXB7 and Hsa-miR-222 as the potential therapeutic candidates for metastatic colorectal cancer. Recent Pat Anticancer Drug Discov, 2016, 11(4): 434-443.
25.	肖海娟, 楊林, 徐鵬飛, 等. 結直腸癌侵襲轉移過程中HOXB7介導Wnt/β-Catenin信號通路作用及機制研究. 中國臨床研究, 2016, 29(11): 1453-1457.
26.	李婷婷. HOXB7激活WnT/β-Catenin信號通路促進結直腸癌侵襲轉移的分子機制. 廣州: 南方醫科大學, 2013.
27.	陳翠敏. HOXB7激活Wnt/β-Catenin信號通路誘導結直腸癌轉移. 廣州: 南方醫科大學, 2012.
28.	郭貞, 焦鋒, 金子良, 等. 轉錄因子HOXB7在腫瘤及相關信號通路中的作用. 腫瘤防治研究, 2015, 42(2): 200-203.

1. 鄭榮壽, 孫可欣, 張思維, 等. 2015年中國惡性腫瘤流行情況分析. 中華腫瘤雜志, 2019, 41(1): 19-28.
2. 王錫山. 中美結直腸癌流行病學特征對比及防控策略分析. 中華結直腸疾病電子雜志, 2019, 8(1): 1-5.
3. 康爭春, 蔡慧, 韓一芳, 等. 結直腸癌的早期診斷及生物標志物現狀. 國際外科學雜志, 2017, 44(8): 509-512.
4. Komatsu H, Iguchi T, Masuda T, et al. HOXB7 expression is a novel biomarker for long-term prognosis after resection of hepatocellular carcinoma. Anticancer Res, 2016, 36(6): 2767-2773.
5. Monterisi S, Lo Riso P, Russo K, et al. HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 2018, 37(26): 3575-3588.
6. Soret C, Martin E, Duluc I, et al. Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Lett, 2016, 374(2): 208-215.
7. Stiegelbauer V, Vychytilova-Faltejskova P, Karbiener M, et al. miR-196b-5p regulates colorectal cancer cell migration and metastases through interaction with HOXB7 and GALNT5. Clin Cancer Res, 2017, 23(17): 5255-5266.
8. 羅云春, 易文, 姚宇宙, 等. 結直腸癌組織中同源異型盒基因B7蛋白的表達及臨床意義. 重慶醫學, 2018, 47(1): 60-62.
9. 原薇薇, 譚艷, 杜敏, 等. HOXB7基因在肺腺癌中的表達及其臨床意義. 臨床腫瘤學雜志, 2014, 19(11): 987-991.
10. 趙雪峰, 趙美蘭, 許廣大. TMPRSS4在胃癌中的表達及其臨床意義. 中國醫科大學學報, 2018, 47(11): 969-974.
11. 周總光, 楊烈. 結直腸癌外科實驗研究進展與展望. 中華實驗外科雜志, 2012, 29(2): 172-175.
12. 張海鑫, 蘇琪. 精準醫學下結直腸癌研究進展. 中國醫師進修雜志, 2018, 41(9): 848-852.
13. 賀育華, 楊婕, 蔣理立. 結直腸癌術后患者生活質量的研究進展. 中國普外基礎與臨床雜志, 2019, [2019-03-05], http://www.gensurg.cn/article/10.7507/1007-9424.201812095.
14. 鄧艷紅. 結直腸癌的分子分型對臨床個體化治療至關重要. 中華胃腸外科雜志, 2015, 18(10): 994-997.
15. 盧海欣, 黃志輝, 陳佳雅, 等. 結直腸癌化療增敏性研究進展. 國際外科學雜志, 2015, 42(11): 789-792.
16. Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology, 2007, 50(1): 113-130.
17. Cantile M, Scognamiglio G, La Sala L, et al. Aberrant expression of posterior HOX genes in well differentiated histotypes of thyroid cancers. Int J Mol Sci, 2013, 14(11): 21727-21740.
18. 蘭鴻波, 潘杰, 盧星榕, 等. miR-196b mRNA和HoxB8 mRNA在結直腸癌組織中的表達及其臨床意義. 中國普外基礎與臨床雜志, 2013, 20(4): 400-405.
19. 周旋, 孔令平, 張侖. HOTAIR與腫瘤生物學行為的研究進展. 中國腫瘤臨床, 2016, 43(16): 731-734.
20. Jin K, Park S, Teo WW, et al. HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance. Cancer Discov, 2015, 5(9): 944-959.
21. 朱克祥, 袁得峰, 張正聰, 等. RNAi結腸癌HOXB7基因表達對癌細胞增殖及凋亡的機制研究. 中國免疫學志, 2018, 34(3): 371-375.
22. 王藝, 張曉微, 房愛春. HOXB7基因對裸鼠結腸癌肺轉移模型的致癌機制研究. 海南醫學, 2018, 29(20): 2816-2819.
23. Liao WT, Jiang D, Yuan J, et al. HOXB7 as a prognostic factor and mediator of colorectal cancer progression. Clin Cancer Res, 2011, 17(11): 3569-3578.
24. Iman M, Mostafavi SS, Arab SS, et al. HOXB7 and Hsa-miR-222 as the potential therapeutic candidates for metastatic colorectal cancer. Recent Pat Anticancer Drug Discov, 2016, 11(4): 434-443.
25. 肖海娟, 楊林, 徐鵬飛, 等. 結直腸癌侵襲轉移過程中HOXB7介導Wnt/β-Catenin信號通路作用及機制研究. 中國臨床研究, 2016, 29(11): 1453-1457.
26. 李婷婷. HOXB7激活WnT/β-Catenin信號通路促進結直腸癌侵襲轉移的分子機制. 廣州: 南方醫科大學, 2013.
27. 陳翠敏. HOXB7激活Wnt/β-Catenin信號通路誘導結直腸癌轉移. 廣州: 南方醫科大學, 2012.
28. 郭貞, 焦鋒, 金子良, 等. 轉錄因子HOXB7在腫瘤及相關信號通路中的作用. 腫瘤防治研究, 2015, 42(2): 200-203.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of HOXB7 molecule in colorectal cancer tissues and its clinical significance

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