Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAO Huiqi , DONG Xiaohua , DONG Baolong , HE Yu , GAO Peng ,  YANG Xiaojun

Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, P. R. China;

Corresponding?author：

YANG Xiaojun, Email: yangxjmd@aliyun.com

Keywords：

small cell carcinoma; surgically radical surgery; MDT

DOI：

10.7507/1007-9424.201810074

Video：

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Objective To explore the application of MDT mode in the diagnosis and treatment of a large retroperitoneal small cell carcinoma.Methods A huge retroperitoneal tumor about 25 cm×18 cm was found by the preoperative abdominal MRI examination, which was considered as the malignant tumor. Considering the patient’s condition, MDT consultation of the specialists in radiology, oncology, vascular surgery, urinary surgery, and anesthesiology was conducted.Results By MDT discussion, the general condition of patient was good. At present, the diagnosis of the huge retroperitoneal tumor was confirmed. Although the tumor was surrounded with related organs closely, yet the radical operation was finished smoothly and the R0 resection was achieved through the collaboration of MDT. The operation lasted 365 minutes, and the intraoperative blood loss was about 200 mL. Postoperative pathology confirmed that the tumor margin was negative and no postoperative complication occurred. The total number of hospital stays was 23 days. The patient’s return to the hospital for review in 4 months after discharge revealed a tumor recurrence. Then, combined with radiotherapy and chemotherapy, the patient’s condition was stable during treatment.Conclusion For rare cases of retroperitoneal small cell carcinoma involving multiple disciplines, the treatment based on MDT is able to bring better clinical outcome to patients due to safer and more feasible.

Citation： ZHAO Huiqi, DONG Xiaohua, DONG Baolong, HE Yu, GAO Peng, YANG Xiaojun. Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(2): 207-211. doi: 10.7507/1007-9424.201810074 Copy

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3.	Grabowski P, Sch?nfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch, 2002, 441(3): 256-263.
4.	Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol, 1992, 20(2): 89-99.
5.	Duquid JB, Kennedy AM. Oat-cell tumors of mediasatinal glands. J Pathological Bacteriol, 1930, 33: 93-99.
6.	Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer, 1997, 79(9): 1729-1736.
7.	Brammer JE, Lulla P, Lynch GR. Retrospective review of extra-pulmonary small cell carcinoma and prognostic factors. Int J Clin Oncol, 2014, 19(5): 822-828.
8.	戴永美, 徐馴宇, 黃郴, 等. 肺外小細胞癌的臨床病理特征及綜合治療策略. 中外醫療, 2016, 35(31): 37-39.
9.	孫紅梅, 陳文彰, 燕麗香, 等. 肺外小細胞癌的診斷和治療. 中華老年多器官疾病雜志, 2011, 10(5): 474-477.
10.	Frazier SR, Kaplan PA, Loy TS. The pathology of extrapulmonary small cell carcinoma. Semin Oncol, 2007, 34(1): 30-38.
11.	李玲, 白志強, 李鵬, 等. 人巨細胞病毒感染對人神經干細胞定向星形膠質細胞分化過程中 Notch 相關信號分子表達的影響. 醫學研究生學報, 2010, 23(10): 1013-1019.
12.	Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med, 2002, 8(9): 979-986.

1. Hammar SP, Bolen JW. Undifferentiated retroperitoneal small cell carcinoma. Ultrastruct Pathol, 1985, 9(1-2): 71-76.
2. 李自強, 俞志剛. 腹膜后小細胞癌 1 例. 實用醫學雜志, 2010, 26(5): 731.
3. Grabowski P, Sch?nfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch, 2002, 441(3): 256-263.
4. Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol, 1992, 20(2): 89-99.
5. Duquid JB, Kennedy AM. Oat-cell tumors of mediasatinal glands. J Pathological Bacteriol, 1930, 33: 93-99.
6. Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer, 1997, 79(9): 1729-1736.
7. Brammer JE, Lulla P, Lynch GR. Retrospective review of extra-pulmonary small cell carcinoma and prognostic factors. Int J Clin Oncol, 2014, 19(5): 822-828.
8. 戴永美, 徐馴宇, 黃郴, 等. 肺外小細胞癌的臨床病理特征及綜合治療策略. 中外醫療, 2016, 35(31): 37-39.
9. 孫紅梅, 陳文彰, 燕麗香, 等. 肺外小細胞癌的診斷和治療. 中華老年多器官疾病雜志, 2011, 10(5): 474-477.
10. Frazier SR, Kaplan PA, Loy TS. The pathology of extrapulmonary small cell carcinoma. Semin Oncol, 2007, 34(1): 30-38.
11. 李玲, 白志強, 李鵬, 等. 人巨細胞病毒感染對人神經干細胞定向星形膠質細胞分化過程中 Notch 相關信號分子表達的影響. 醫學研究生學報, 2010, 23(10): 1013-1019.
12. Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med, 2002, 8(9): 979-986.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma

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