Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Yang ¹ ,  XIN Wenqiong ¹ , XIANG Bo ¹ , YANG Jiayin ² , JIN Shuguang ¹

1. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Center of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

XIN Wenqiong, Email: xiaoerwaikehs@163.com

Keywords：

living donor liver transplantation; children; quality of life

DOI：

10.7507/1007-9424.201801076

Video：

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Objective To investigate quality of life of pediatric living donor liver transplantation recipient (PLDLTR) and analyze it’s influencing factors. Methods The convenient sampling method was adopted. Fifty-three PLDLTRs from May 2012 to January 2017 in the West China Hospital of Sichuan University were selected. At the same time, 56 children who participated in the physical examination and had no abnormality results were selected as reference (control group), their age and gender matched with the PLDLTRs. A general data inventory and a self-assessment scale for children’s quality of life (Pediatric Quality of Life Inventory 4 Generic Core Scales, PedsQL4.0) were used to evaluate the quality of life of the 53 PLDLTRs. Results A total of 53 questionnaires were distributed to all the 2 groups, all of them were effectively recovered. The points of quality of life of the physiological function, emotional function, social function, and school performance for the PLDLTRs were significantly higher than those of the control group (P<0.050), which for the PLDLTRs with male and more than 3 years after the operation were significantly higher than those of the PLDLTRs with female and within 1 year after the operation (P<0.050). For the PLDLTRs with age >4 years old, the points of the emotional function, social function, and school performance were significantly higher than those of the PLDLTRs with age ≤4 years old. For the PLDLTRs without postoperative complications, the points of quality of life of the physiological function, emotional function, and school performance were significantly higher than those of the PLDLTRs with Ⅱ grade of postoperative complications (P<0.050). Conclusions Life quality of PLDLTR is poorer than that of normal children. Postoperative time, postoperative complications, age, and gender are certainly associated with quality of life for PLDLTR.

Citation： YANG Yang, XIN Wenqiong, XIANG Bo, YANG Jiayin, JIN Shuguang. Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(8): 912-916. doi: 10.7507/1007-9424.201801076 Copy

1.	Junge N, Migal K, Goldschmidt I, et al. Transition after pediatric liver transplantation—Perceptions of adults, adolescents and parents. World J Gastroenterol, 2017, 23(13): 2365-2375.
2.	Khorsandi SE, Giorgakis E, Vilca-Melendez H, et al. Developing a donation after cardiac death risk index for adult and pediatric liver transplantation. World J Transplant, 2017, 7(3): 203-212.
3.	Jin SJ, Kim SK, Choi SS, et al. Risk factors for intraoperative massive transfusion in pediatric liver transplantation: a multivariate analysis. Int J Med Sci, 2017, 14(2): 173-180.
4.	Rawal N, Yazigi N. Pediatric liver transplantation. Pediatr Clin North Am, 2017, 64(3): 677-684.
5.	饒建華, 王學浩. 活體肝移植在中國的發展與前景. 中國普外基礎與臨床雜志, 2017, 24(8): 913-915.
6.	萬平, 夏強. 小兒肝移植的進展與前沿. 實用器官移植電子雜志, 2017, 5(1): 7.
7.	Hardikar W, Smith AL, Angus P, et al. Paediatric liver transplantation [corrected] in Melbourne: the first 50 patients. Pediatr Surg Int, 2002, 18(5-6): 354-356.
8.	Heffron TG, Pillen T, Smallwood G, et al. Pediatric liver transplantation for acute liver failure at a single center: a 10-yr experience. Pediatr Transplant, 2010, 14(2): 228-232.
9.	Kerkar N, Danialifar T. Changing definitions of successful outcomes in pediatric liver transplantation. Curr Opin Organ Transplant, 2014, 19(5): 480-485.
10.	夏強, 何康. 兒童活體肝移植的發展概況. 中國普外基礎與臨床雜志, 2017, 24(8): 920-922.
11.	Anthony SJ, Annunziato RA, Fairey E, et al. Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care. Pediatr Transplant, 2014, 18(5): 423-434.
12.	盧奕云, 田琪, 郝元濤, 等. 兒童生存質量測定量表 PedsQL4.0 中文版的信度和效度分析. 中山大學學報(醫學科學版), 2008, 29(3): 328-331.
13.	Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care, 1999, 37(2): 126-139.
14.	Ng V, Nicholas D, Dhawan A, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients. J Pediatr, 2014, 165(3): 547-555.
15.	Alba A, Uribe M, Hunter B, et al. Health-related quality of life after pediatric liver transplant: single-center experience in Chile. Transplant Proc, 2013, 45(10): 3728-3730.
16.	Ng VL, Alonso EM, Bucuvalas JC, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr, 2012, 160(5): 820-826.
17.	宋東建, 岳麗芳, 楊林, 等. 小兒腫瘤治療中醫學人文精神的融入. 醫學與哲學, 2017, 38(16): 84-86.
18.	Fredericks EM. Family roles and routines after pediatric liver transplantation: implications for quality of life and beyond. Pediatr Transplant, 2012, 16(7): 688-691.
19.	Denny B, Beyerle K, Kienhuis M, et al. New insights into family functioning and quality of life after pediatric liver transplantation. Pediatr Transplant, 2012, 16(7): 711-715.
20.	李楊, 劉庚. 小兒活體肝移植術供體焦慮狀態調查. 護理研究, 2016, 30(8): 1002-1004.
21.	王新艷, 彭守華, 張翠萍, 等. 神經外科急重癥顱腦手術患者家屬的心理危機干預研究. 新疆醫科大學學報, 2016, 39(1): 111-113.
22.	張小強, 馬家馳, 李一平, 等. 術后炎癥性腸梗阻患者抑郁和焦慮情況調查. 中國普外基礎與臨床雜志, 2016, 23(9): 1084-1088.
23.	朱志軍, 張海明, 沈中陽, 等. 再次肝移植的原因與預后分析. 中國普外基礎與臨床雜志, 2013, 20(3): 235-240.
24.	潘學勤, 周慶云. 內鏡下逆行胰膽管造影治療肝移植術后膽管并發癥的圍術期護理. 安徽醫藥, 2017, 21(1): 173-175.
25.	朱志軍, 曾志貴. 兒童肝移植術后早期血管并發癥的診斷、治療及預防. 中國普外基礎與臨床雜志, 2015, (12): 1425-1427.
26.	Bucuvalas JC, Britto M, Krug S, et al. Health-related quality of life in pediatric liver transplant recipients: A single-center study. Liver Transpl, 2003, 9(1): 62-71.

1. Junge N, Migal K, Goldschmidt I, et al. Transition after pediatric liver transplantation—Perceptions of adults, adolescents and parents. World J Gastroenterol, 2017, 23(13): 2365-2375.
2. Khorsandi SE, Giorgakis E, Vilca-Melendez H, et al. Developing a donation after cardiac death risk index for adult and pediatric liver transplantation. World J Transplant, 2017, 7(3): 203-212.
3. Jin SJ, Kim SK, Choi SS, et al. Risk factors for intraoperative massive transfusion in pediatric liver transplantation: a multivariate analysis. Int J Med Sci, 2017, 14(2): 173-180.
4. Rawal N, Yazigi N. Pediatric liver transplantation. Pediatr Clin North Am, 2017, 64(3): 677-684.
5. 饒建華, 王學浩. 活體肝移植在中國的發展與前景. 中國普外基礎與臨床雜志, 2017, 24(8): 913-915.
6. 萬平, 夏強. 小兒肝移植的進展與前沿. 實用器官移植電子雜志, 2017, 5(1): 7.
7. Hardikar W, Smith AL, Angus P, et al. Paediatric liver transplantation [corrected] in Melbourne: the first 50 patients. Pediatr Surg Int, 2002, 18(5-6): 354-356.
8. Heffron TG, Pillen T, Smallwood G, et al. Pediatric liver transplantation for acute liver failure at a single center: a 10-yr experience. Pediatr Transplant, 2010, 14(2): 228-232.
9. Kerkar N, Danialifar T. Changing definitions of successful outcomes in pediatric liver transplantation. Curr Opin Organ Transplant, 2014, 19(5): 480-485.
10. 夏強, 何康. 兒童活體肝移植的發展概況. 中國普外基礎與臨床雜志, 2017, 24(8): 920-922.
11. Anthony SJ, Annunziato RA, Fairey E, et al. Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care. Pediatr Transplant, 2014, 18(5): 423-434.
12. 盧奕云, 田琪, 郝元濤, 等. 兒童生存質量測定量表 PedsQL4.0 中文版的信度和效度分析. 中山大學學報(醫學科學版), 2008, 29(3): 328-331.
13. Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care, 1999, 37(2): 126-139.
14. Ng V, Nicholas D, Dhawan A, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients. J Pediatr, 2014, 165(3): 547-555.
15. Alba A, Uribe M, Hunter B, et al. Health-related quality of life after pediatric liver transplant: single-center experience in Chile. Transplant Proc, 2013, 45(10): 3728-3730.
16. Ng VL, Alonso EM, Bucuvalas JC, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr, 2012, 160(5): 820-826.
17. 宋東建, 岳麗芳, 楊林, 等. 小兒腫瘤治療中醫學人文精神的融入. 醫學與哲學, 2017, 38(16): 84-86.
18. Fredericks EM. Family roles and routines after pediatric liver transplantation: implications for quality of life and beyond. Pediatr Transplant, 2012, 16(7): 688-691.
19. Denny B, Beyerle K, Kienhuis M, et al. New insights into family functioning and quality of life after pediatric liver transplantation. Pediatr Transplant, 2012, 16(7): 711-715.
20. 李楊, 劉庚. 小兒活體肝移植術供體焦慮狀態調查. 護理研究, 2016, 30(8): 1002-1004.
21. 王新艷, 彭守華, 張翠萍, 等. 神經外科急重癥顱腦手術患者家屬的心理危機干預研究. 新疆醫科大學學報, 2016, 39(1): 111-113.
22. 張小強, 馬家馳, 李一平, 等. 術后炎癥性腸梗阻患者抑郁和焦慮情況調查. 中國普外基礎與臨床雜志, 2016, 23(9): 1084-1088.
23. 朱志軍, 張海明, 沈中陽, 等. 再次肝移植的原因與預后分析. 中國普外基礎與臨床雜志, 2013, 20(3): 235-240.
24. 潘學勤, 周慶云. 內鏡下逆行胰膽管造影治療肝移植術后膽管并發癥的圍術期護理. 安徽醫藥, 2017, 21(1): 173-175.
25. 朱志軍, 曾志貴. 兒童肝移植術后早期血管并發癥的診斷、治療及預防. 中國普外基礎與臨床雜志, 2015, (12): 1425-1427.
26. Bucuvalas JC, Britto M, Krug S, et al. Health-related quality of life in pediatric liver transplant recipients: A single-center study. Liver Transpl, 2003, 9(1): 62-71.

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Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors

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