Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHU Min ¹ , WANG Huguo ¹ , ZHANG Ying ² , Wufuer·Yimaer ¹ , MIAO Yutang ¹ ,  Sailike·Magaoweiya ¹

1. Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, P. R. China;
2. Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, Urumqi 830054, P. R. China;

Corresponding?author：

Sailike·Magaoweiya, Email: sairike@126.com

Keywords：

thyroid neoplasm; chronic lymphocytic thyroiditis; clinicopathologic feature

DOI：

10.7507/1007-9424.201708060

Video：

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Objective To analyze clinical and pathological features of patients with papillary thyroid carcinoma (PTC) with coexistent chronic lymphocytic thyroiditis (CLT). Methods The clinicopathologic data of 756 cases of PTC were collected from January 2014 to January 2017 in the First Affiliated Hospital, Xinjiang Medical University were collected. The patients were designed to observational group (PTC with coexistent CLT, n=194) and control group (simple PTC, n=562) according to whether CLT was diagnosed by pathology, then the clinical data, ultrasonic features, thyroid function, and pathological features in these two groups were compared. Results The proportion of the female patients, the proportions of theserum thyroid stimulating hormone and thyroid autoimmune antibodies (thyroglobulin antibody and thyroid peroxidase antibody), and the proportion of multifocal carcinoma in the observational group were significantly higher than those in the control group (P<0.05). There were no significant differences in the preoperative ultrasound, tumor diameter, thyroid capsule invasion, central lymph node metastasis, and TNM stage in these two groups (P>0.05). The results of the multivariate analysis showed that the female, serum thyroid autoimmune antibodies, and the multifocal carcinoma were the independent predictive factors of PTC with CLT (P<0.05). Conclusions There might be a certain correlation between PTC and CLT, PTC with coexistent CLT is more common in female patient and with multifocal carcinoma. With coexistent CLT does not increase invasion of PTC. This may be associated with limit of CLT to development of PTC nodules. It is speculated that CLT may be a protective factor of PTC.

Citation： ZHU Min, WANG Huguo, ZHANG Ying, Wufuer·Yimaer, MIAO Yutang, Sailike·Magaoweiya. Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(3): 307-311. doi: 10.7507/1007-9424.201708060 Copy

1.	Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto's thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2.	Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
3.	劉捷. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床病理特征. 現代腫瘤醫學, 2016, 24(2): 222-225.
4.	陳誠, 余寧康, 龔進發, 等. 橋本甲狀腺炎合并甲狀腺乳頭狀癌的臨床特點及外科治療. 中華普通外科雜志, 2013, 28(7): 511-514.
5.	Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
6.	Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto's thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9):1045-1047.
7.	Kim SG, Seo HS, Lee HH, et al. Comparison of the differences in survival rates between the 7th and 8th editions of the AJCC TNM staging system for gastric adenocarcinoma: a single-institution study of 5 507 patients in Korea. J Gastric Cancer, 2017, 17(3): 212-219.
8.	Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9.	Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10.	朱敏, 賽力克?馬高維亞. 慢性淋巴細胞性甲狀腺炎與甲狀腺乳頭狀癌的相關性研究進展. 中國普外基礎與臨床雜志, 2017, 24(10): 1289-1294.
11.	Girardi FM, Barra MB, Zettler CG. Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease? Braz J Otorhinolaryngol, 2015, 81(3): 283-287.
12.	郝戰宇, 李波. 橋本甲狀腺炎合并甲狀腺乳頭狀癌的臨床及病理學特征. 山東大學學報(醫學版), 2016, 54(6): 73-77.
13.	黃偉欽, 薛恩生, 林禮務, 等. 橋本甲狀腺炎背景下甲狀腺癌的超聲表現探討. 中華醫學超聲雜志(電子版), 2009, 6(3): 61-64.
14.	劉友忠, 于洋, 趙翠, 等. 甲狀腺乳頭狀癌合并橋本甲狀腺炎的臨床生物學特性分析. 中華普通外科雜志, 2013, 28(4): 256-258.
15.	鄧江波. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床和病理特點. 深圳中西醫結合雜志, 2016, 26(13): 90-92.
16.	劉明明, 高瑩, 張楊, 等. 抗甲狀腺球蛋白抗體的親合力在 Graves 病與 Graves 病合并橋本甲狀腺炎鑒別診斷中的意義. 大連: 中華醫學會內分泌學分會, 中華醫學會第九次全國內分泌學學術會議, 2010.
17.	張德杰, 林國樑, 張銘, 等. 橋本氏甲狀腺炎合并甲狀腺癌的臨床及病理研究. 蘭州大學學報(醫學版), 2017, 43(1): 31-35.
18.	杜婧, 武心萍, 丁文波, 等. 橋本氏甲狀腺炎合并甲狀腺乳頭狀癌患者血清 Tg-Ab 和 TPO-Ab 濃度的變化. 江蘇醫藥, 2017, 43(5): 379-380.
19.	Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto's thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
20.	林琳, 鄭向前, 劉磊, 等. 多灶性甲狀腺乳頭狀癌的生物學特性及治療分析. 中華普通外科雜志, 2010, 25(8): 621-623.
21.	周曉倩, 金慧, 鄭淼, 等. 合并橋本甲狀腺炎的甲狀腺乳頭狀癌術式探討. 中華普通外科雜志, 2016, 31(3): 236-237.
22.	茅建婭, 王薇, 別克扎提, 等. 甲狀腺乳頭狀癌合并橋本甲狀腺炎的臨床病理研究. 中國普通外科雜志, 2016, 25(5): 665-669.
23.	Konturek A, Barczyński M, Wierzchowski W, et al. Coexistence of papillary thyroid cancer with Hashimoto thyroiditis. Langenbecks Arch Surg, 2013, 398(3): 389-394.
24.	徐冬冬, 論語, 劉勛, 等. Graves 病合并 PTC 與橋本甲狀腺炎合并 PTC 的臨床及病理特征比較. 中華醫學雜志, 2017, 97(32): 2491-2495.
25.	倫語, 吳小雨, 辛世杰, 等. 橋本甲狀腺炎與甲狀腺乳頭狀癌關系的臨床研究. 中國普通外科雜志, 2014, 23(5):484-590.

1. Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto's thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2. Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
3. 劉捷. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床病理特征. 現代腫瘤醫學, 2016, 24(2): 222-225.
4. 陳誠, 余寧康, 龔進發, 等. 橋本甲狀腺炎合并甲狀腺乳頭狀癌的臨床特點及外科治療. 中華普通外科雜志, 2013, 28(7): 511-514.
5. Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
6. Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto's thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9):1045-1047.
7. Kim SG, Seo HS, Lee HH, et al. Comparison of the differences in survival rates between the 7th and 8th editions of the AJCC TNM staging system for gastric adenocarcinoma: a single-institution study of 5 507 patients in Korea. J Gastric Cancer, 2017, 17(3): 212-219.
8. Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9. Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10. 朱敏, 賽力克?馬高維亞. 慢性淋巴細胞性甲狀腺炎與甲狀腺乳頭狀癌的相關性研究進展. 中國普外基礎與臨床雜志, 2017, 24(10): 1289-1294.
11. Girardi FM, Barra MB, Zettler CG. Papillary thyroid carcinoma: does the association with Hashimoto's thyroiditis affect the clinicopathological characteristics of the disease? Braz J Otorhinolaryngol, 2015, 81(3): 283-287.
12. 郝戰宇, 李波. 橋本甲狀腺炎合并甲狀腺乳頭狀癌的臨床及病理學特征. 山東大學學報(醫學版), 2016, 54(6): 73-77.
13. 黃偉欽, 薛恩生, 林禮務, 等. 橋本甲狀腺炎背景下甲狀腺癌的超聲表現探討. 中華醫學超聲雜志(電子版), 2009, 6(3): 61-64.
14. 劉友忠, 于洋, 趙翠, 等. 甲狀腺乳頭狀癌合并橋本甲狀腺炎的臨床生物學特性分析. 中華普通外科雜志, 2013, 28(4): 256-258.
15. 鄧江波. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床和病理特點. 深圳中西醫結合雜志, 2016, 26(13): 90-92.
16. 劉明明, 高瑩, 張楊, 等. 抗甲狀腺球蛋白抗體的親合力在 Graves 病與 Graves 病合并橋本甲狀腺炎鑒別診斷中的意義. 大連: 中華醫學會內分泌學分會, 中華醫學會第九次全國內分泌學學術會議, 2010.
17. 張德杰, 林國樑, 張銘, 等. 橋本氏甲狀腺炎合并甲狀腺癌的臨床及病理研究. 蘭州大學學報(醫學版), 2017, 43(1): 31-35.
18. 杜婧, 武心萍, 丁文波, 等. 橋本氏甲狀腺炎合并甲狀腺乳頭狀癌患者血清 Tg-Ab 和 TPO-Ab 濃度的變化. 江蘇醫藥, 2017, 43(5): 379-380.
19. Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto's thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
20. 林琳, 鄭向前, 劉磊, 等. 多灶性甲狀腺乳頭狀癌的生物學特性及治療分析. 中華普通外科雜志, 2010, 25(8): 621-623.
21. 周曉倩, 金慧, 鄭淼, 等. 合并橋本甲狀腺炎的甲狀腺乳頭狀癌術式探討. 中華普通外科雜志, 2016, 31(3): 236-237.
22. 茅建婭, 王薇, 別克扎提, 等. 甲狀腺乳頭狀癌合并橋本甲狀腺炎的臨床病理研究. 中國普通外科雜志, 2016, 25(5): 665-669.
23. Konturek A, Barczyński M, Wierzchowski W, et al. Coexistence of papillary thyroid cancer with Hashimoto thyroiditis. Langenbecks Arch Surg, 2013, 398(3): 389-394.
24. 徐冬冬, 論語, 劉勛, 等. Graves 病合并 PTC 與橋本甲狀腺炎合并 PTC 的臨床及病理特征比較. 中華醫學雜志, 2017, 97(32): 2491-2495.
25. 倫語, 吳小雨, 辛世杰, 等. 橋本甲狀腺炎與甲狀腺乳頭狀癌關系的臨床研究. 中國普通外科雜志, 2014, 23(5):484-590.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinicopathologic features of papillary thyroid carcinoma with coexistent chronic lymphocytic thyroiditis

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