Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHU Min ,  Sailike·Magaoweiya

Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, P. R. China;

Corresponding?author：

Sailike·Magaoweiya, Email: sairike@126.com

Keywords：

thyroid neoplasm; chronic lymphocytic thyroiditis; mechanism; treatment; prognosis

DOI：

10.7507/1007-9424.201612109

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize research status of correlation of chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC), in order to provide a basis for early diagnosis, prognosis, and prevention of PTC. Method The literatures about the recent studies of the correlation of the CLT and PTC were reviewed according to the results searched from PubMed database, SpringerLink database, Web of Science database, Wanfang database, CNKI database, and VIP database. Results The most of patients with CLT combined with PTC are young women, the characteristics are multifocal and occult, the prognosis is good. Its genesis might be related to the ionizing radiation, iodine intake, endocrine disorders, immune disorders, molecular biology, and other factors. But there are still different controversies about its specific pathogenesis and surgical treatment. Conclusions CLT is closely related to PTC. However, relationship between CLT combined with PTC and changing regularity of molecular biology, pathogenesis, or prognosis needs further to be studied and followed-up for a longer-term.

Citation： ZHU Min, Sailike·Magaoweiya. Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(10): 1289-1294. doi: 10.7507/1007-9424.201612109 Copy

1.	Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto’s thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2.	Kwak JY, Kim EK, Kim JK, et al. Dual priming oligonucleotide-based multiplex PCR analysis for detection of BRAF^V600E mutation in FNAB samples of thyroid nodules in BRAF^V600E mutation-prevalent area. Head Neck, 2010, 32(4): 490-498.
3.	Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg, 1955, 70(2): 291-297.
4.	Anand A, Singh KR, Kushwaha JK, et al. Papillary thyroid cancer and Hashimoto’s thyroiditis: an association less understood. Indian J Surg Oncol, 2014, 5(3): 199-204.
5.	Kwon JH, Nam ES, Shin HS, et al. P2X7 receptor expression in coexistence of papillary thyroid carcinoma with Hashimoto’s thyroiditis. Korean J Pathol, 2014, 48(1): 30-35.
6.	李康, 于健春, 康維明. 碘攝入與甲狀腺疾病. 中華地方病學雜志, 2016, 35(3): 166-169.0.
7.	Cheng V, Brainard J, Nasr C. Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto’s thyroiditis. Thyroid, 2012, 22(6): 647-650.
8.	Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9.	Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10.	Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
11.	劉捷. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床病理特征. 現代腫瘤醫學, 2016, 24(2): 222-225.0.
12.	Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto’s thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9): 1045-1047.
13.	Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto’s thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
14.	Fiore E, Rago T, Latrofa F, et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer, 2011, 18(4): 429-437.
15.	Singh B, Shaha AR, Trivedi H, et al. Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery, 1999, 126(6): 1070-1077.
16.	李惠. 橋本甲狀腺炎合并乳頭狀甲狀腺癌的臨床病理特征. 復旦大學, 2012.
17.	Giagourta I, Evangelopoulou C, Papaioannou G, et al. Autoimmune thyroiditis in benign and malignant thyroid nodules: 16-year results. Head Neck, 2014, 36(4): 531-535.
18.	Jeong JS, Kim HK, Lee CR, et al. Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. J Korean Med Sci, 2012, 27(8): 883-889.
19.	Kim EY, Kim WG, Kim WB, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf), 2009, 71(4): 581-586.
20.	Okayasu I, Fujiwara M, Hara Y, et al. Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer, 1995, 76(11): 2312-2318.
21.	Okayasu I. The relationship of lymphocytic thyroiditis to the development of thyroid carcinoma. Endocr Pathol, 1997, 8(3): 225-230.
22.	Okayasu I, Hatakeyama S, Tanaka Y, et al. Is focal chronic autoimmune thyroiditis an age-related disease? Differences in incidence and severity between Japanese and British. J Pathol, 1991, 163(3): 257-264.
23.	Okayasu I, Hara Y, Nakamura K, et al. Racial and age-related differences in incidence and severity of focal autoimmune thyroiditis. Am J Clin Pathol, 1994, 101(6): 698-702.
24.	Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab, 2013, 98(2): 474-482.
25.	Cunha LL, Ferreira RC, Marcello MA, et al. Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer. J Thyroid Res, 2011, 2011: 387062.
26.	Haymart MR, Glinberg SL, Liu J, et al. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf), 2009, 71(3): 434-439.
27.	Franco AT, Malaguarnera R, Refetoff S, et al. Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci USA, 2011, 108(4): 1615-1620.
28.	Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto’s thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
29.	張昶, 鄭立農, 徐金鑫. 甲狀腺局部自身免疫作用在橋本甲狀腺炎癌變中的作用. 中華內分泌雜志, 1999, 76(3): 160-163.0.
30.	趙遠杰, 羅定存, 張煜, 等. 橋本氏病合并甲狀腺乳頭狀癌機制的研究進展. 浙江醫學, 2016, 38(17): 1460-1464.0.
31.	卜文瑾, 房秀霞. 超聲在診斷甲狀腺結節性病變的研究進展. 臨床醫學工程, 2012, 19(12): 2296-2298.0.
32.	Baker SR, Bhatti WA. The thyroid cancer epidemic: is it the dark side of the CT revolution? Eur J Radiol, 2006, 60(1): 67-69.
33.	Hatch M, Furukawa K, Brenner A, et al. Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study. Radiat Res, 2010, 174(6): 763-772.
34.	歐陽鑫, 謝婉瑩, 秦春宏. 甲狀腺癌的流行病學特征及其危險因素. 實用醫藥雜志, 2015, 32(4): 312-315.0.
35.	Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol, 2007, 51(5): 701-712.
36.	Sohn SY, Choi JY, Jang HW, et al. Association between excessive urinary iodine excretion and failure of radioactive iodine thyroid ablation in patients with papillary thyroid cancer. Thyroid, 2013, 23(6): 741-747.
37.	Latrofa F, Fiore E, Rago T, et al. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin. J Clin Endocrinol Metab, 2013, 98(11): E1768-E1774.
38.	Kanno J, Onodera H, Furuta K, et al. Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid. Toxicol Pathol, 1992, 20(2): 226-235.
39.	劉衛懷, 李鵬飛, 張遠炎, 等. 高碘、鈉碘轉運體及甲狀腺腫瘤的關系. 中華內分泌外科雜志, 2014, 8(4): 293-295.0.
40.	馬曄, 沈美萍. 高碘對鈉碘轉運體表達調節的研究進展. 江蘇醫藥, 2011, 37(17): 2058-2060.0.
41.	王顏剛, 閻勝利, 趙世華, 等. 山東沿海居民橋本甲狀腺炎與尿碘水平的關系. 中華內分泌代謝雜志, 2004, 20(4): 337-338.0.
42.	Büyüka??k O, Hasdemir AO, Yal??n E, et al. The association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach? Endokrynol Pol, 2011, 62(4): 303-308.
43.	Kim KH, Suh KS, Kang DW, et al. Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto’s thyroiditis. Pathol Int, 2005, 55(9): 540-545.
44.	Givens DJ, Buchmann LO, Agarwal AM, et al. BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma. Laryngoscope, 2014, 124(9): E389-E393.
45.	Cordioli MI, Cury AN, Nascimento AO, et al. Study of the histological profile of papillary thyroid carcinomas associated with Hashimoto’s thyroiditis. Arq Bras Endocrinol Metabol, 2013, 57(6): 445-449.
46.	Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett, 2008, 267(2): 204-215.
47.	Ryder M, Ghossein RA, Ricarte-Filho JC, et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer, 2008, 15(4): 1069-1074.
48.	蘭霞斌, 張浩. 《2015美國甲狀腺學會成人甲狀腺結節與分化型甲狀腺癌診治指南》外科治療更新解讀. 中華外科雜志, 2016, 54(3): 172-176.0.
49.	Lucas SD, Karlsson-Parra A, Nilsson B, et al. Tumor-specific deposition of immunoglobulin G and complement in papillary thyroid carcinoma. Hum Pathol, 1996, 27(12): 1329-1335.
50.	Villagelin DG, Santos RB, Romaldini JH. Is diffuse and peritumoral lymphocyte infiltration in papillary thyroid cancer a marker of good prognosis? J Endocrinol Invest, 2011, 34(11): e403-e408.
51.	楊曉晨, 周沁, 孫麗, 等. 甲狀腺乳頭狀癌是否合并橋本甲狀腺炎的臨床病理學特征差異性分析. 中華臨床醫師雜志(電子版), 2016, 10(17): 2552-2555.0.
52.	俞建平, 陳潤浩, 桂律, 等. 橋本氏病合并甲狀腺乳頭狀腺癌. 中國癌癥雜志, 2005, 15(1): 16-18.0.
53.	Ye ZQ, Gu DN, Hu HY, et al. Hashimoto’s thyroiditis, microcalcification and raised thyrotropin levels within normal range are associated with thyroid cancer. World J Surg Oncol, 2013, 11: 56.

1. Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto’s thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2. Kwak JY, Kim EK, Kim JK, et al. Dual priming oligonucleotide-based multiplex PCR analysis for detection of BRAF^V600E mutation in FNAB samples of thyroid nodules in BRAF^V600E mutation-prevalent area. Head Neck, 2010, 32(4): 490-498.
3. Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg, 1955, 70(2): 291-297.
4. Anand A, Singh KR, Kushwaha JK, et al. Papillary thyroid cancer and Hashimoto’s thyroiditis: an association less understood. Indian J Surg Oncol, 2014, 5(3): 199-204.
5. Kwon JH, Nam ES, Shin HS, et al. P2X7 receptor expression in coexistence of papillary thyroid carcinoma with Hashimoto’s thyroiditis. Korean J Pathol, 2014, 48(1): 30-35.
6. 李康, 于健春, 康維明. 碘攝入與甲狀腺疾病. 中華地方病學雜志, 2016, 35(3): 166-169.0.
7. Cheng V, Brainard J, Nasr C. Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto’s thyroiditis. Thyroid, 2012, 22(6): 647-650.
8. Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9. Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10. Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
11. 劉捷. 甲狀腺乳頭狀癌合并橋本氏甲狀腺炎的臨床病理特征. 現代腫瘤醫學, 2016, 24(2): 222-225.0.
12. Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto’s thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9): 1045-1047.
13. Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto’s thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
14. Fiore E, Rago T, Latrofa F, et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer, 2011, 18(4): 429-437.
15. Singh B, Shaha AR, Trivedi H, et al. Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery, 1999, 126(6): 1070-1077.
16. 李惠. 橋本甲狀腺炎合并乳頭狀甲狀腺癌的臨床病理特征. 復旦大學, 2012.
17. Giagourta I, Evangelopoulou C, Papaioannou G, et al. Autoimmune thyroiditis in benign and malignant thyroid nodules: 16-year results. Head Neck, 2014, 36(4): 531-535.
18. Jeong JS, Kim HK, Lee CR, et al. Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. J Korean Med Sci, 2012, 27(8): 883-889.
19. Kim EY, Kim WG, Kim WB, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf), 2009, 71(4): 581-586.
20. Okayasu I, Fujiwara M, Hara Y, et al. Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer, 1995, 76(11): 2312-2318.
21. Okayasu I. The relationship of lymphocytic thyroiditis to the development of thyroid carcinoma. Endocr Pathol, 1997, 8(3): 225-230.
22. Okayasu I, Hatakeyama S, Tanaka Y, et al. Is focal chronic autoimmune thyroiditis an age-related disease? Differences in incidence and severity between Japanese and British. J Pathol, 1991, 163(3): 257-264.
23. Okayasu I, Hara Y, Nakamura K, et al. Racial and age-related differences in incidence and severity of focal autoimmune thyroiditis. Am J Clin Pathol, 1994, 101(6): 698-702.
24. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab, 2013, 98(2): 474-482.
25. Cunha LL, Ferreira RC, Marcello MA, et al. Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer. J Thyroid Res, 2011, 2011: 387062.
26. Haymart MR, Glinberg SL, Liu J, et al. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf), 2009, 71(3): 434-439.
27. Franco AT, Malaguarnera R, Refetoff S, et al. Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci USA, 2011, 108(4): 1615-1620.
28. Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto’s thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
29. 張昶, 鄭立農, 徐金鑫. 甲狀腺局部自身免疫作用在橋本甲狀腺炎癌變中的作用. 中華內分泌雜志, 1999, 76(3): 160-163.0.
30. 趙遠杰, 羅定存, 張煜, 等. 橋本氏病合并甲狀腺乳頭狀癌機制的研究進展. 浙江醫學, 2016, 38(17): 1460-1464.0.
31. 卜文瑾, 房秀霞. 超聲在診斷甲狀腺結節性病變的研究進展. 臨床醫學工程, 2012, 19(12): 2296-2298.0.
32. Baker SR, Bhatti WA. The thyroid cancer epidemic: is it the dark side of the CT revolution? Eur J Radiol, 2006, 60(1): 67-69.
33. Hatch M, Furukawa K, Brenner A, et al. Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study. Radiat Res, 2010, 174(6): 763-772.
34. 歐陽鑫, 謝婉瑩, 秦春宏. 甲狀腺癌的流行病學特征及其危險因素. 實用醫藥雜志, 2015, 32(4): 312-315.0.
35. Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol, 2007, 51(5): 701-712.
36. Sohn SY, Choi JY, Jang HW, et al. Association between excessive urinary iodine excretion and failure of radioactive iodine thyroid ablation in patients with papillary thyroid cancer. Thyroid, 2013, 23(6): 741-747.
37. Latrofa F, Fiore E, Rago T, et al. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin. J Clin Endocrinol Metab, 2013, 98(11): E1768-E1774.
38. Kanno J, Onodera H, Furuta K, et al. Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid. Toxicol Pathol, 1992, 20(2): 226-235.
39. 劉衛懷, 李鵬飛, 張遠炎, 等. 高碘、鈉碘轉運體及甲狀腺腫瘤的關系. 中華內分泌外科雜志, 2014, 8(4): 293-295.0.
40. 馬曄, 沈美萍. 高碘對鈉碘轉運體表達調節的研究進展. 江蘇醫藥, 2011, 37(17): 2058-2060.0.
41. 王顏剛, 閻勝利, 趙世華, 等. 山東沿海居民橋本甲狀腺炎與尿碘水平的關系. 中華內分泌代謝雜志, 2004, 20(4): 337-338.0.
42. Büyüka??k O, Hasdemir AO, Yal??n E, et al. The association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach? Endokrynol Pol, 2011, 62(4): 303-308.
43. Kim KH, Suh KS, Kang DW, et al. Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto’s thyroiditis. Pathol Int, 2005, 55(9): 540-545.
44. Givens DJ, Buchmann LO, Agarwal AM, et al. BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma. Laryngoscope, 2014, 124(9): E389-E393.
45. Cordioli MI, Cury AN, Nascimento AO, et al. Study of the histological profile of papillary thyroid carcinomas associated with Hashimoto’s thyroiditis. Arq Bras Endocrinol Metabol, 2013, 57(6): 445-449.
46. Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett, 2008, 267(2): 204-215.
47. Ryder M, Ghossein RA, Ricarte-Filho JC, et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer, 2008, 15(4): 1069-1074.
48. 蘭霞斌, 張浩. 《2015美國甲狀腺學會成人甲狀腺結節與分化型甲狀腺癌診治指南》外科治療更新解讀. 中華外科雜志, 2016, 54(3): 172-176.0.
49. Lucas SD, Karlsson-Parra A, Nilsson B, et al. Tumor-specific deposition of immunoglobulin G and complement in papillary thyroid carcinoma. Hum Pathol, 1996, 27(12): 1329-1335.
50. Villagelin DG, Santos RB, Romaldini JH. Is diffuse and peritumoral lymphocyte infiltration in papillary thyroid cancer a marker of good prognosis? J Endocrinol Invest, 2011, 34(11): e403-e408.
51. 楊曉晨, 周沁, 孫麗, 等. 甲狀腺乳頭狀癌是否合并橋本甲狀腺炎的臨床病理學特征差異性分析. 中華臨床醫師雜志(電子版), 2016, 10(17): 2552-2555.0.
52. 俞建平, 陳潤浩, 桂律, 等. 橋本氏病合并甲狀腺乳頭狀腺癌. 中國癌癥雜志, 2005, 15(1): 16-18.0.
53. Ye ZQ, Gu DN, Hu HY, et al. Hashimoto’s thyroiditis, microcalcification and raised thyrotropin levels within normal range are associated with thyroid cancer. World J Surg Oncol, 2013, 11: 56.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma

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