Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MAJingyou ^1,2 , CUIZhexu ^1,2 , LIHuagen ^1,2 , YANGFuqiang ^1,2 , WANGYan ^1,2 , SHENHao ¹ ,  LIUZhen ^1,2

1. Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region ?028000, P.R.China;
2. Department of General Surgery, The Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia autonomous Region 028000, P.R.China;

Corresponding?author：

LIUZhen, Email: liuzhen95@sohu.com

Keywords：

papillary thyroid carcinoma; metastatic lymph nodes; Notch-1 protein

DOI：

10.7507/1007-9424.201607012

Video：

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Objective To investigate the expression and clinical significance of Notch-1 protein in papillary thyroid carcinoma (PTC) tissues and cervical lymph node metastases. Methods Immunohistochemical method was used to detect the expression of Notch-1 protein in 69 cases of PTC tissues, along with tumor adjacent tissues and 34 cases of metastatic lymph node tissues, and to analyze its role in PTC and metastatic lymph node tissue. Results Compared with PTC tissues or cervical lymph node metastases and tumor adjacent tissues, the positive rates of expression of Notch-1 protein in PTC tissues or cervical lymph node metastases were significantly lower than that in cancer adjacent tissues (P＜0.05). The expression of Notch-1 protein was correlated with the tumor size and capsule invasion of patients with PTC. Conclusions Notch-1 protein expression is decreased in PTC tissues and metastatic lymph node tissues, suggesting that the Notch-1 protein may play an important role in the development, invasion and metastasis of PTC. There is no significant difference in the positive rates of Notch-1 protein expression in PTC tissues and metastatic lymph node tissues, it's suggested that the malignant degree of cancer cells in lymph node metastasis is not significantly increased, and the biological behavior remained relatively stable.

Citation： MAJingyou, CUIZhexu, LIHuagen, YANGFuqiang, WANGYan, SHENHao, LIUZhen. Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(1): 70-73. doi: 10.7507/1007-9424.201607012 Copy

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2.	任立軍, 楊延芳, 張成雷. 甲狀腺乳頭狀癌淋巴結轉移規律的臨床研究. 中國普外基礎與臨床雜志, 2011, 11(4): 419-422.
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18.	Besic N, Pilko G, Petric R,et al. Papillary thyroid microcarcinoma: prognostic factors and treatment. J Surg Oncol, 2008, 97(3): 221-225.
19.	Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther, 2014, 141(2): 140-149.
20.	陶久梅, 王艷, 朱姝, 等. 甲狀腺乳頭狀癌頸部淋巴結轉移規律及影響因素分析. 臨床耳鼻咽喉頭頸外科雜志, 2014, 28(12): 859-861, 864.
21.	Hou L, Ren S, Su B,et al. High concordance of ALK rearrangement between primary tumor and paired metastatic lymph node in patients with lung adenocarcinoma. J Thorac Dis, 2016, 8(6): 1103-1111.
22.	邊學. 甲狀腺乳頭狀癌與轉移淋巴結組織蛋白質組學差異表達分析. 中國耳鼻咽喉頭頸外科, 2011, 18(7): 363-366.
23.	曾令瑞, 韓玉貞, 馬英路, 等. 乳腺原發癌和相應淋巴結轉移癌干細胞Wnt、Notch信號通路相關分子的比較. 臨床與實驗病理學雜志, 2014, 30(9): 963-966.
24.	Krook KA, Fedewa SA, Amy Y,et al. Prognostic indicators in well-differentiated thyroid carcinoma when controlling for stage and treatment. Laryngoscope, 2015, 125(4): 1021-1027.
25.	叢慧, 梁軍, 李方, 等. 分化型甲狀腺癌治療后TgAb變化趨勢及其影響因素. 中國醫學科學院學報, 2015, 37(1): 61-65.

1. ?陳振宇, 吳毅. 雙側甲狀腺癌的臨床新特點. 中國實用外科雜志, 2012, 32(1): 77-79, 84.
2. 任立軍, 楊延芳, 張成雷. 甲狀腺乳頭狀癌淋巴結轉移規律的臨床研究. 中國普外基礎與臨床雜志, 2011, 11(4): 419-422.
3. Chung YS, Kim JY, Bae JS,et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid, 2009, 19(3): 241-246.
4. Yap LF, Lee D, Khairuddin A,et al. The opposing roles of NOTCH signaling in head and neck cancer: a mini review. Oral Dis, 2015, 21(7): 850-857.
5. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 2009, 137(2): 216-233.
6. Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histology Histopathol, 2012, 27(2): 151-156.
7. 金曉燕, 梁勇, 陳佳玉, 等. Notch-1在甲狀腺乳頭狀癌中的表達及意義. 中國衛生檢驗雜志, 2011, 21(1): 1-3.
8. 曹子龍, 張卓, 胡建立, 等. NKD1和APC在乳腺癌組織中的表達及意義. 中國普外基礎與臨床雜志, 2015, 23(10): 1226-1229.
9. Sato C, Zhao G, Ilagan MX. An overview of Notch signaling in adult tissue renewal and maintenance. Curr Alzheimer Res, 2012, 9(2): 227-240.
10. Dang TP. Notch, apoptosis and cancer. Adv Exp Med Biol, 2012, 727: 199-209.
11. Hu YY, Zheng MH, Zhang R,et al. Notch signaling pathway and cancer metastasis. Adv Exp Med Biol, 2012, 727: 186-198.
12. Fernandezmarcos PJ, Serrano M, Maraver A. Bladder cancer and the Notch pathway. Oncotarget, 2015, 6(3): 1346-1347.
13. Guo H, Lu Y, Wang J,et al. Targeting the Notch signaling pathway in cancer therapeutics. Thoracic Cancer, 2014, 5(6): 473-486.
14. 蓋大偉, 郭凌云, 劉濤, 等. Notch信號通路在消化系腫瘤中的研究進展. 中國普外基礎與臨床雜志, 2013, 20(10): 1188-1192.
15. Doshi WB, Thury PG, Chen R,et al. Synergistic interaction between AKT and Notch-1 signaling in cervical cancer: a critical role in tumor cell migration and invasion. Am J Biomed, 2014, 2(2): 200-211.
16. Park HS, Jung CK, Lee SH,et al. Notch-1 receptor as a marker of lymph node metastases in papillary thyroid cancer. Cancer Sci, 2012, 103(2): 305-309.
17. Fu H, Ma C, Guan W,et al. Expression of Notch 1 receptor associated with tumor aggressiveness in papillary thyroid carcinoma. Onco Targets Ther, 2016, 9: 1519-1523.
18. Besic N, Pilko G, Petric R,et al. Papillary thyroid microcarcinoma: prognostic factors and treatment. J Surg Oncol, 2008, 97(3): 221-225.
19. Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther, 2014, 141(2): 140-149.
20. 陶久梅, 王艷, 朱姝, 等. 甲狀腺乳頭狀癌頸部淋巴結轉移規律及影響因素分析. 臨床耳鼻咽喉頭頸外科雜志, 2014, 28(12): 859-861, 864.
21. Hou L, Ren S, Su B,et al. High concordance of ALK rearrangement between primary tumor and paired metastatic lymph node in patients with lung adenocarcinoma. J Thorac Dis, 2016, 8(6): 1103-1111.
22. 邊學. 甲狀腺乳頭狀癌與轉移淋巴結組織蛋白質組學差異表達分析. 中國耳鼻咽喉頭頸外科, 2011, 18(7): 363-366.
23. 曾令瑞, 韓玉貞, 馬英路, 等. 乳腺原發癌和相應淋巴結轉移癌干細胞Wnt、Notch信號通路相關分子的比較. 臨床與實驗病理學雜志, 2014, 30(9): 963-966.
24. Krook KA, Fedewa SA, Amy Y,et al. Prognostic indicators in well-differentiated thyroid carcinoma when controlling for stage and treatment. Laryngoscope, 2015, 125(4): 1021-1027.
25. 叢慧, 梁軍, 李方, 等. 分化型甲狀腺癌治療后TgAb變化趨勢及其影響因素. 中國醫學科學院學報, 2015, 37(1): 61-65.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and clinical significance of notch-1 protein in papillary thyroid carcinoma tissues and cervical lymph node metastases

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