Current Status and Progress of Vagus Nerve-Preserving Radical Gastrectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUChun-yang ,  HAOYing-xue

Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, The First Affiliated Hospital, The Third Military Medical University, Chongqing 400038, China;

Corresponding?author：

HAOYing-xue, Email: haoyingxue@hotmail.com

Keywords：

Vagus nerve; Gastric cancer; Acute inflammation reaction; Gastrointestinal hormone; Quality of life

DOI：

10.7507/1007-9424.20160360

Video：

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Objective To comprehensively analyze current status and progress of vagus nerve-preserving radical gastrectomy for gastric cancer at domestic and foreign. Method Relevant literatures about vagus nerve-preserving radical gastrectomy at domestic and foreign since 1996 were collected and reviewed. Results Vagus nerve-preserving radical gastrectomy for gastric cancer had been recognized by many scholars both at home and abroad, which had a higher operation safety and feasibility, could obviously reduce the occurrence of postoperative acute inflammation, maintain the stability of gastrointestinal function to the greatest extent, significantly reduce the incidence of postoperative complications such as gallbladder stone and diarrhea, improve the postoperative quality of life. Conclusion Under premise of strictly controlling operation indications and ensuring curative effect, vagus nerve-preserving radical gastrectomy is of great significance to improve prognosis of patient with gastric cancer.

Citation： LIUChun-yang, HAOYing-xue. Current Status and Progress of Vagus Nerve-Preserving Radical Gastrectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(11): 1407-1412. doi: 10.7507/1007-9424.20160360 Copy

1.	郭大川, 王舒寶. 保留迷走神經的胃癌根治術解剖學研究. 中國實用外科雜志, 1999, 19(3):160-162.
2.	Ando S, Tsuji H. Surgical technique of vagus nerve-preserving gastrectomy with D2 lymphadenectomy for gastric cancer. ANZ J Surg, 2008, 78(3):172-176.
3.	幕內雅敏(日)監修. 技巧與誤區:胃外科要點與盲點. 段志泉總主譯. 沈陽:遼寧科學技術出版社, 2009:212.
4.	翟同善. T3期胃下部癌D2術式選擇性自主神經保留可行性探討. 中國醫科大學學報, 2010, 39(9):773-774.
5.	Miwa K, Kinami S, Sato T, et al. Vagus-saving D2 procedure for early gastric carcinoma. Nihon Geka Gakkai Zasshi, 1996, 97(4):286-290.
6.	Sasada S, Ninomiya M, Nishizaki M, et al. Survival of patients treated by an autonomic nerve-preserving gastrectomy for early gastric cancer. Surg Today, 2010, 40(5):444-450.
7.	Wang L, Zhang W, Quan C, et al. Quality of life and prognosis after celiac branch of vagus preserving distal radical gastrectomy. Eur Surg ACA, 2015, 47 Suppl 1:S11.
8.	Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted Billroth Ⅰ gastrectomy. Surg Laparosc Endosc, 1994, 4(2):146-148.
9.	Takiguchi S, Hiura Y, Takahashi T, et al. Preservation of the celiac branch of the vagus nerve during laparoscopy-assisted distal gastrec-tomy:impact on postprandial changes in ghrelin secretion. World J Surg, 2013, 37(9):2172-2179.
10.	Kim SM, Cho J, Kang D, et al. A randomized controlled trial of vagus nerve-preserving distal gastrectomy versus conventional distal gastrectomy for postoperative quality of life in early stage gastric cancer patients. Ann Surg, 2016, 263(6):1079-1084.
11.	房學東, 王旭東, 劉卓. 保留迷走神經的遠端胃癌根治術的臨床研究. 消化腫瘤雜志:電子版, 2009, 1(1):24-28.
12.	謝小平, 朱國民, 吳厚斌, 等. 保留迷走神經的遠端胃癌根治術對早期胃癌的療效觀察. 江西醫藥, 2015, 50(7):620-623.
13.	Kojima K, Yamada H, Inokuchi M, et al. Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. Surg Endosc, 2008, 22(9):2003-2008.
14.	Pavlov VA, Wang H, Czura CJ, et al. The cholinergic anti-inflamma-tory pathway:a missing link in neuroimmunomodulation. Mol Med, 2003, 9(5-8):125-134.
15.	van Westerloo DJ, Giebelen IA, Florquin S, et al. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis, 2005, 191(12):2138-2148.
16.	Kessler W, Traeger T, Westerholt A, et al. The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis. Langenbecks Arch Surg, 2006, 391(2):83-87.
17.	Fujita T, Yanaga K. Clinical influence of vagotomy on postoperative acute phase response. Langenbecks Arch Surg, 2007, 392(2):127-130.
18.	繩繼健, 孫國瑞, 何慶泗, 等. 胃癌根治術保留迷走神經對術后急性炎癥反應的影響研究. 中國現代普通外科進展, 2012, 15(9):703-706.
19.	Goverse G, Stakenborg M, Matteoli G. The intestinal cholinergic anti-inflammatory pathway. J Physiol, 2016 Mar 9.
20.	Kim HH, Park MI, Lee SH, et al. Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy. World J Gastroenterol, 2012, 18(30):4044-4050.
21.	Zhang T, Uchida T, Gomez G, et al. Neural regulation of peptide YY secretion. Regul Pept, 1993, 48(3):321-328.
22.	Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 2002, 418(6898):650-654.
23.	Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med, 2003, 349(10):941-948.
24.	胡英斌, 江勃年, 唐自元, 等. 保留迷走神經腹腔支胃癌根治術的臨床研究. 中國現代手術學雜志, 2011, 15(2):98-100.
25.	吳厚賓, 謝小平, 朱國民, 等. 保留迷走神經遠端胃癌根治術患者的營養及預后. 廣東醫學, 2014, 35(12):1923-1925.
26.	Aly A, Shulkes A, Baldwin GS. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta, 2004, 1704(1):1-10.
27.	Cowey SL, Quast M, Belalcazar LM, et al. Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression. Cancer, 2005, 103(12):2643-2653.
28.	Gaddipati KV, Simonian HP, Kresge KM, et al. Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci, 2006, 51(8):1339-1346.
29.	Taylor IL, Impicciatore M, Carter DC, et al. Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. Am J Physiol, 1978, 235(4):E443-E447.
30.	Ihasz M, Griffith CA. Gallstones after vagotomy. Am J Surg, 1981, 141(1):48-50.
31.	Tsuji H, Andoh S, Sakakibara K, et al. The clinical evaluation of vagus nerve preserving gastric operation with d2 lymph node dissec-tion for early and advanced gastric cancer. Nippon Shokaki Geka Gakkai Zasshi, 2003, 36(2):78-84.
32.	Tomita R, Fujisaki S, Koshinaga T, et al. Clinical assessments in pati-ents ten years after pylorus-preserving gastrectomy with or without preserving both pyloric and hepatic branches of the vagal nerve for early gastric cancer. Hepatogastroenterology, 2010, 57(11):984-988.
33.	Chen XJ, Li N, Huang YD, et al. Factors for postoperative gallstone occurrence in patients with gastric cancer:a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(2):877-881.
34.	呂云福, 董永紅, 黃海, 等. 賁門周圍血管離斷術后胃動力障礙的病因分析與預防措施. 中華普通外科雜志, 2003, 18(9):553-555.
35.	Murakami H, Matsumoto H, Kubota H, et al. Evaluation of electrical activity after vagus nerve-preserving distal gastrectomy using multi-channel electrogastrography. J Smooth Muscle Res, 2013, 49:1-14.
36.	桑溫昌, 李兆德, 宮東堯, 等. 保留迷走神經的全胃切除術療效分析. 中華臨床醫師雜志:電子版, 2011, 5(8):2232-2235.
37.	Hiki N, Nunobe S, Kubota T, et al. Function-preserving gastrectomy for early gastric cancer. Ann Surg Oncol, 2013, 20(8):2683-2692.
38.	Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery:morbi-dity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy-Japan Clinical Oncology Group study 9501. J Clin Oncol, 2004, 22(14):2767-2773.

1. 郭大川, 王舒寶. 保留迷走神經的胃癌根治術解剖學研究. 中國實用外科雜志, 1999, 19(3):160-162.
2. Ando S, Tsuji H. Surgical technique of vagus nerve-preserving gastrectomy with D2 lymphadenectomy for gastric cancer. ANZ J Surg, 2008, 78(3):172-176.
3. 幕內雅敏(日)監修. 技巧與誤區:胃外科要點與盲點. 段志泉總主譯. 沈陽:遼寧科學技術出版社, 2009:212.
4. 翟同善. T3期胃下部癌D2術式選擇性自主神經保留可行性探討. 中國醫科大學學報, 2010, 39(9):773-774.
5. Miwa K, Kinami S, Sato T, et al. Vagus-saving D2 procedure for early gastric carcinoma. Nihon Geka Gakkai Zasshi, 1996, 97(4):286-290.
6. Sasada S, Ninomiya M, Nishizaki M, et al. Survival of patients treated by an autonomic nerve-preserving gastrectomy for early gastric cancer. Surg Today, 2010, 40(5):444-450.
7. Wang L, Zhang W, Quan C, et al. Quality of life and prognosis after celiac branch of vagus preserving distal radical gastrectomy. Eur Surg ACA, 2015, 47 Suppl 1:S11.
8. Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted Billroth Ⅰ gastrectomy. Surg Laparosc Endosc, 1994, 4(2):146-148.
9. Takiguchi S, Hiura Y, Takahashi T, et al. Preservation of the celiac branch of the vagus nerve during laparoscopy-assisted distal gastrec-tomy:impact on postprandial changes in ghrelin secretion. World J Surg, 2013, 37(9):2172-2179.
10. Kim SM, Cho J, Kang D, et al. A randomized controlled trial of vagus nerve-preserving distal gastrectomy versus conventional distal gastrectomy for postoperative quality of life in early stage gastric cancer patients. Ann Surg, 2016, 263(6):1079-1084.
11. 房學東, 王旭東, 劉卓. 保留迷走神經的遠端胃癌根治術的臨床研究. 消化腫瘤雜志:電子版, 2009, 1(1):24-28.
12. 謝小平, 朱國民, 吳厚斌, 等. 保留迷走神經的遠端胃癌根治術對早期胃癌的療效觀察. 江西醫藥, 2015, 50(7):620-623.
13. Kojima K, Yamada H, Inokuchi M, et al. Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. Surg Endosc, 2008, 22(9):2003-2008.
14. Pavlov VA, Wang H, Czura CJ, et al. The cholinergic anti-inflamma-tory pathway:a missing link in neuroimmunomodulation. Mol Med, 2003, 9(5-8):125-134.
15. van Westerloo DJ, Giebelen IA, Florquin S, et al. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis, 2005, 191(12):2138-2148.
16. Kessler W, Traeger T, Westerholt A, et al. The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis. Langenbecks Arch Surg, 2006, 391(2):83-87.
17. Fujita T, Yanaga K. Clinical influence of vagotomy on postoperative acute phase response. Langenbecks Arch Surg, 2007, 392(2):127-130.
18. 繩繼健, 孫國瑞, 何慶泗, 等. 胃癌根治術保留迷走神經對術后急性炎癥反應的影響研究. 中國現代普通外科進展, 2012, 15(9):703-706.
19. Goverse G, Stakenborg M, Matteoli G. The intestinal cholinergic anti-inflammatory pathway. J Physiol, 2016 Mar 9.
20. Kim HH, Park MI, Lee SH, et al. Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy. World J Gastroenterol, 2012, 18(30):4044-4050.
21. Zhang T, Uchida T, Gomez G, et al. Neural regulation of peptide YY secretion. Regul Pept, 1993, 48(3):321-328.
22. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 2002, 418(6898):650-654.
23. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med, 2003, 349(10):941-948.
24. 胡英斌, 江勃年, 唐自元, 等. 保留迷走神經腹腔支胃癌根治術的臨床研究. 中國現代手術學雜志, 2011, 15(2):98-100.
25. 吳厚賓, 謝小平, 朱國民, 等. 保留迷走神經遠端胃癌根治術患者的營養及預后. 廣東醫學, 2014, 35(12):1923-1925.
26. Aly A, Shulkes A, Baldwin GS. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta, 2004, 1704(1):1-10.
27. Cowey SL, Quast M, Belalcazar LM, et al. Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression. Cancer, 2005, 103(12):2643-2653.
28. Gaddipati KV, Simonian HP, Kresge KM, et al. Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci, 2006, 51(8):1339-1346.
29. Taylor IL, Impicciatore M, Carter DC, et al. Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. Am J Physiol, 1978, 235(4):E443-E447.
30. Ihasz M, Griffith CA. Gallstones after vagotomy. Am J Surg, 1981, 141(1):48-50.
31. Tsuji H, Andoh S, Sakakibara K, et al. The clinical evaluation of vagus nerve preserving gastric operation with d2 lymph node dissec-tion for early and advanced gastric cancer. Nippon Shokaki Geka Gakkai Zasshi, 2003, 36(2):78-84.
32. Tomita R, Fujisaki S, Koshinaga T, et al. Clinical assessments in pati-ents ten years after pylorus-preserving gastrectomy with or without preserving both pyloric and hepatic branches of the vagal nerve for early gastric cancer. Hepatogastroenterology, 2010, 57(11):984-988.
33. Chen XJ, Li N, Huang YD, et al. Factors for postoperative gallstone occurrence in patients with gastric cancer:a meta-analysis. Asian Pac J Cancer Prev, 2014, 15(2):877-881.
34. 呂云福, 董永紅, 黃海, 等. 賁門周圍血管離斷術后胃動力障礙的病因分析與預防措施. 中華普通外科雜志, 2003, 18(9):553-555.
35. Murakami H, Matsumoto H, Kubota H, et al. Evaluation of electrical activity after vagus nerve-preserving distal gastrectomy using multi-channel electrogastrography. J Smooth Muscle Res, 2013, 49:1-14.
36. 桑溫昌, 李兆德, 宮東堯, 等. 保留迷走神經的全胃切除術療效分析. 中華臨床醫師雜志:電子版, 2011, 5(8):2232-2235.
37. Hiki N, Nunobe S, Kubota T, et al. Function-preserving gastrectomy for early gastric cancer. Ann Surg Oncol, 2013, 20(8):2683-2692.
38. Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery:morbi-dity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy-Japan Clinical Oncology Group study 9501. J Clin Oncol, 2004, 22(14):2767-2773.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Current Status and Progress of Vagus Nerve-Preserving Radical Gastrectomy

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