Clinical Efficacy of Percutaneous Nephroscope in Treatment of Patients with Severe Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGGuo-chun , CHENHong-gang , LIUQi-fei , JIAHong-gang , LIUHong-yan

Department of Emergency Surgery, Affiliated Hospital of Shandong Academy of Medical Sciences, Ji'nan 250031, Shandong Province, China;

Corresponding?author：

YANGGuo-chun, Email: yangguochun25@yeah.net

Keywords：

Percutaneous nephroscope; Severe acute pancreatitis; Inflammatory reaction; Complications

DOI：

10.7507/1007-9424.20160349

Video：

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Objective To investigate clinical efficacy of percutaneous nephroscope in treatment of patients with severe acute pancreatitis (SAP). Methods Eighty-six patients with SAP in this hospital from August 2012 to November 2015 were selected, which were divided into percutaneous nephroscope treatment group (43 cases) and laparotomy treat-ment group (43 cases) according to the difference of therapy modality. The conventional drug therapy was performed for all of them. The postoperative recovery, content of serum C reactive protein (CRP) on day 14 after operation, and post-operative complications were observed in these two groups. Results ① The abdominal pain relief time, postoperative bowel sounds recovery time, normal body temperature recovery time, and postoperative hospitalization time in the percu-taneous nephroscope treatment group were significantly shorter than those in the laparotomy treatment group (P<0.05). ② The contents of serum CRP in the percutaneous nephroscope treatment group and in the laparotomy treatment group on day 14 after operation were significantly lower than those on day 1 before operation[(8.35±2.13) mg/L versus (31.44±3.45) mg/L, P<0.05; (16.42±2.44) mg/L versus (32.09±2.98) mg/L, P<0.05]. On day 14 after operation, the content of serum CRP in the percutaneous nephroscope treatment group was significantly lower than that in the laparotomy treat-ment group[(8.35±2.13) mg/L versus (16.42±2.44) mg/L, P<0.05]. ③ The incidence rate of postoperative complications in the percutaneous nephroscope treatment group was significantly lower than that in the laparotomy treatment group[14.0% (6/43) versus 32.6% (14/43), P<0.05]. Conclusion Percutaneous nephroscope in treatment of patients with SAP is effect, it has advantages of shorter hospital stay and early recovery, which could reduce incidence of postoperative complications, and it's mechanism might be related to systemic inflammatory response.

Citation： YANGGuo-chun, CHENHong-gang, LIUQi-fei, JIAHong-gang, LIUHong-yan. Clinical Efficacy of Percutaneous Nephroscope in Treatment of Patients with Severe Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(11): 1366-1369. doi: 10.7507/1007-9424.20160349 Copy

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2.	Li Z, Xia C, Zhang L, et al. Peritoneal lavage for severe acute pancrea-titis:a meta-analysis and systematic review. Pancreas, 2016, 45(6):806-813.
3.	姚蘭杰. 重癥急性胰腺炎的臨床治療方法與效果觀察. 中國實用醫刊, 2015, 42(3):29-30.
4.	Wang G, Zhang J, Xu C, et al. Inhibition of SOCs attenuates acute lung injury induced by severe acute pancreatitis in rats and PMVECs injury induced by lipopolysaccharide. Inflammation, 2016, 39(3):1049-1058.
5.	Shavakhi A, Khodadustan M, Tamizifar B. The effect of prophylactic peripapillary administration of methylprednisolone in reducing the risk and severity of postendoscopic retrograde cholangiopancreatog-raphy pancreatitis:A double blind clinical trial. J Res Med Sci, 2015, 20(9):850-854.
6.	邱慶文. 重癥急性胰腺炎患者腹腔鏡手術圍術期胃腸激素及機體應激狀態變化觀察. 中南醫學科學雜志, 2015, 17(6):675-678.
7.	文毅, 許芳怡, 康娟. 容積敏感性氯通道在急性胰腺炎早期的應用研究. 浙江臨床醫學, 2015, 22(4):516-517.
8.	王瑞江. 重癥胰腺炎合并腸梗阻的治療體會. 醫學臨床研究, 2013, 30(1):56-57.
9.	Tan CL, Zhang H, Li KZ. Single center experience in selecting the laparoscopic Frey procedure for chronic pancreatitis. World J Gastroenterol, 2015, 21(44):12644-12652.
10.	張曉東. 復發性膽源性胰腺炎應用十二指腸鏡聯合腹腔鏡的療效分析. 中國現代醫生, 2015, 53(23):82-84.
11.	Banday IA, Gattoo I, Khan AM, et al. Modified computed tomogra-phy severity index for evaluation of acute pancreatitis and its correla-tion with clinical outcome:A Tertiary Care Hospital Based Observa-tional Study. J Clin Diagn Res, 2015, 9(8):TC01-TC05.
12.	辛憲磊, 蔡守旺, 劉志偉, 等. 經皮腎鏡治療重癥急性胰腺炎術后殘余感染的體會. 中華外科雜志, 2015, 53(9):676-679.
13.	練繼文, 肖志偉. 經皮腎鏡治療胰腺周圍膿腫體會(附12例報告). 中國現代藥物應用, 2015, 9(18):23-24.
14.	Gormezano NW, Otsuzi CI, Barros DL, et al. Macrophage activation syndrome:A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1 830 adult-onset systemic lupus erythematosus patients. Semin Arthritis Rheum, 2016, 45(6):706-710.
15.	楊涓, 鄭盛, 張帆, 等. 不同評分系統早期預測急性胰腺炎病情嚴重程度的比較研究. 中國醫藥導報, 2016, 13(2):133-137.
16.	徐濤. 手術與非手術治療重癥急性胰腺炎療效比較. 中外醫學研究, 2015, 13(12):142-142, 143.
17.	石云, 趙玉芳. 經皮腎鏡治療急性壞死性胰腺炎后的護理. 實用醫技雜志, 2015, 22(1):106-109.
18.	劉路培, 劉明祥, 羅毅. 重癥胰腺炎患者感染的臨床分析. 中華醫院感染學雜志, 2015, 25(17):4000-4002.
19.	Wei AL, Guo Q, Wang MJ, et al. Early complications after interven-tions in patients with acute pancreatitis. World J Gastroenterol, 2016, 22(9):2828-2836.
20.	Cavicchioli L, Zappulli V, Beffagna G, et al. Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally infected turkeys showing evidence of pancreatic regeneration. Avian Pathol, 2015, 44(6):498-508.
21.	徐笑群. 重癥急性胰腺炎合并感染患者降鈣素原檢測的臨床意義. 中國實用醫刊, 2015, 42(8):46-47.
22.	周波, 戴飛躍, 翁國虎. 急性胰腺炎的診療進展. 現代中西醫結合雜志, 2015, 17(5):565-567.

1. 杜奕奇, 李兆申. 2015版中國急性胰腺炎MDT共識意見解讀. 中華胰腺病雜志, 2015, 15(5):289-291.
2. Li Z, Xia C, Zhang L, et al. Peritoneal lavage for severe acute pancrea-titis:a meta-analysis and systematic review. Pancreas, 2016, 45(6):806-813.
3. 姚蘭杰. 重癥急性胰腺炎的臨床治療方法與效果觀察. 中國實用醫刊, 2015, 42(3):29-30.
4. Wang G, Zhang J, Xu C, et al. Inhibition of SOCs attenuates acute lung injury induced by severe acute pancreatitis in rats and PMVECs injury induced by lipopolysaccharide. Inflammation, 2016, 39(3):1049-1058.
5. Shavakhi A, Khodadustan M, Tamizifar B. The effect of prophylactic peripapillary administration of methylprednisolone in reducing the risk and severity of postendoscopic retrograde cholangiopancreatog-raphy pancreatitis:A double blind clinical trial. J Res Med Sci, 2015, 20(9):850-854.
6. 邱慶文. 重癥急性胰腺炎患者腹腔鏡手術圍術期胃腸激素及機體應激狀態變化觀察. 中南醫學科學雜志, 2015, 17(6):675-678.
7. 文毅, 許芳怡, 康娟. 容積敏感性氯通道在急性胰腺炎早期的應用研究. 浙江臨床醫學, 2015, 22(4):516-517.
8. 王瑞江. 重癥胰腺炎合并腸梗阻的治療體會. 醫學臨床研究, 2013, 30(1):56-57.
9. Tan CL, Zhang H, Li KZ. Single center experience in selecting the laparoscopic Frey procedure for chronic pancreatitis. World J Gastroenterol, 2015, 21(44):12644-12652.
10. 張曉東. 復發性膽源性胰腺炎應用十二指腸鏡聯合腹腔鏡的療效分析. 中國現代醫生, 2015, 53(23):82-84.
11. Banday IA, Gattoo I, Khan AM, et al. Modified computed tomogra-phy severity index for evaluation of acute pancreatitis and its correla-tion with clinical outcome:A Tertiary Care Hospital Based Observa-tional Study. J Clin Diagn Res, 2015, 9(8):TC01-TC05.
12. 辛憲磊, 蔡守旺, 劉志偉, 等. 經皮腎鏡治療重癥急性胰腺炎術后殘余感染的體會. 中華外科雜志, 2015, 53(9):676-679.
13. 練繼文, 肖志偉. 經皮腎鏡治療胰腺周圍膿腫體會(附12例報告). 中國現代藥物應用, 2015, 9(18):23-24.
14. Gormezano NW, Otsuzi CI, Barros DL, et al. Macrophage activation syndrome:A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1 830 adult-onset systemic lupus erythematosus patients. Semin Arthritis Rheum, 2016, 45(6):706-710.
15. 楊涓, 鄭盛, 張帆, 等. 不同評分系統早期預測急性胰腺炎病情嚴重程度的比較研究. 中國醫藥導報, 2016, 13(2):133-137.
16. 徐濤. 手術與非手術治療重癥急性胰腺炎療效比較. 中外醫學研究, 2015, 13(12):142-142, 143.
17. 石云, 趙玉芳. 經皮腎鏡治療急性壞死性胰腺炎后的護理. 實用醫技雜志, 2015, 22(1):106-109.
18. 劉路培, 劉明祥, 羅毅. 重癥胰腺炎患者感染的臨床分析. 中華醫院感染學雜志, 2015, 25(17):4000-4002.
19. Wei AL, Guo Q, Wang MJ, et al. Early complications after interven-tions in patients with acute pancreatitis. World J Gastroenterol, 2016, 22(9):2828-2836.
20. Cavicchioli L, Zappulli V, Beffagna G, et al. Histopathological and immunohistochemical study of exocrine and endocrine pancreatic lesions in avian influenza A experimentally infected turkeys showing evidence of pancreatic regeneration. Avian Pathol, 2015, 44(6):498-508.
21. 徐笑群. 重癥急性胰腺炎合并感染患者降鈣素原檢測的臨床意義. 中國實用醫刊, 2015, 42(8):46-47.
22. 周波, 戴飛躍, 翁國虎. 急性胰腺炎的診療進展. 現代中西醫結合雜志, 2015, 17(5):565-567.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Efficacy of Percutaneous Nephroscope in Treatment of Patients with Severe Acute Pancreatitis

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