The Complications and Safety of Supraclavicular Lymph Node Dissection for Invasive Breast Cancer with Ipsilateral Supraclavicular Lymph Node Metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUXue-juan ,  WANGJing , LIWen

Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

WANGJing, Email: wangj889@163.com

Keywords：

Supraclavicular lymph node dissection; Breast cancer of Ⅲc stage; Ipsilateral supraclavicular lymph node metastasis

DOI：

10.7507/1007-9424.20160270

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Objective To summarize the complications after supraclavicular lymph node dissection for invasive breast cancer patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis, and to analyze its safty. Methods A retrospectively clinical analysis of the complications of 98 invasive breast cancer patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis, who underwent supraclavicular lymph node dissection in our hospital from Jan. 2014 to Dec. 2015 was performed. Results There were 20 cases of lymphedema (20.4%, 20/98), 4 cases of hypaesthesia (4.1%, 4/98), and 4 cases of abduction restriction of shoulder joint (4.1%, 4/98). No other serious complications occurred. There was no shape change of shoulder and upper arm abduction, facial edema, head and neck disorders, pleural effusion or chylothorax happened. The extubation time of drainage tube at axillary and chest wall in 78 cases was in 1 month after the operation, 18 cases was in 1-2 months, and 2 cases was in 2-3 months. There were 14 cases (14.3%) suffered from the ipsilateral axillary or pleural effusion after extubation. The extubation time of supraclavicular drainage tube in 98 cases was 3-7 days after the surgery, with the median of 4.5 days, including 3 cases (3.1%) of chyle leakage. Conclusion The supraclavicular lymph node dissection has no serious postoperative complications, and is safe to patients with ipsilateral supraclavicular lymph node metastasis but without distant metastasis.

Citation： LIU Xue-juan, WANG Jing, LI Wen. The Complications and Safety of Supraclavicular Lymph Node Dissection for Invasive Breast Cancer with Ipsilateral Supraclavicular Lymph Node Metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(9): 1040-1043. doi: 10.7507/1007-9424.20160270 Copy

1.	Chen SC, Chen MF, Hwang TL, et al. Prediction of supraclavicular lymph node metastasis in breast carcinoma. Int J Radiat Oncol Biol Phys, 2002, 52(3):614-619.
2.	Kiricuta IC, Willner J, K?lbl O, et al. The prognostic significance of the supraclavicular lymph node metastases in breast cancer patients. Int J Radiat Oncol Biol Phys, 1994, 28(2):387-393.
3.	Willner J, Kiricuta IC, K?lbl O. Locoregional recurrence of breast cancer following mastectomy:always a fatal event? Results of univariate and multivariate analysis. Int J Radiat Oncol Biol Phys, 1997, 37(4):853-863.
4.	Halverson KJ, Perez CA, Kuske RR, et al. Survival following locoregional recurrence of breast cancer:univariate and multivariate analysis. Int J Radiat Oncol Biol Phys, 1992, 23(2):285-291.
5.	Fan Y, Xu B, Liao Y, et al. A retrospective study of metachronous and synchronous ipsilateral supraclavicular lymph node metastases in breast cancer patients. Breast, 2010, 19(5):365-369.
6.	Dellapasqua S, Bagnardi V, Balduzzi AA, et al. Outcomes of patients with breast cancer who present with ipsilateral supraclavicular or internal mammary lymph node metastases. Clin Breast Cancer, 2014, 14(1):53-60.
7.	Pergolizzi S, Settineri N, Russi EG, et al. Supraclavicular lymph node metastases (SLM) from breast cancer as only site of distant disease:has radiotherapy any role. Anticancer Res, 1997, 17(3C):2303-2308.
8.	Wang CW, Kuo WH, Chang KJ, et al. Should adjuvant radiotherapy to the supraclavicular fossa be routinely given in patients with breast conservative treatment. J Surg Oncol, 2007, 96(2):144-150.
9.	Pergolizzi S, Settineri N, Santacaterina A, et al. Ipsilateral supraclavicular lymph nodes metastases from breast cancer as only site of disseminated disease. Chemotherapy alone vs. induction chemotherapy to radical radiation therapy. Ann Oncol, 2001, 12(8):1091-1095.
10.	Wu SG, Sun JY, Zhou J, et al. The value of radiotherapy in breast cancer patients with isolated ipsilateral supraclavicular lymph node metastasis without distant metastases at diagnosis:a retrospective analysis of Chinese patients. Oncl Targets Ther, 2014, 7(1):281-288.
11.	Huang EH, Strom EA, Valero V, et al. Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis. Int J Radiat Oncol Biol Phys, 2007, 67(2):490-496.
12.	Olivotto IA, Chua B, Allan SJ, et al. Long-term survival of patients with supraclavicular metastases at diagnosis of breast cancer. J Clin Oncol, 2003, 21(5):851-854.
13.	Brito RA, Valero V, Buzdar AU, et al. Long-term results of combinedmodality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases:The University of Texas M.D. Anderson Cancer Center experience. J Clin Oncol, 2001, 19(3):628-633.
14.	Ogino T, Komoike Y, Ishitobi M, et al. Breast cancer with ipsilateral supraclavicular metastases. Breast J, 2011, 17(5):555-557.
15.	Lundstedt D, Gustafsson M, Steineck G, et al. Long-term symptoms after radiotherapy of supraclavicular lymph nodes in breast cancer patients. Radiother Oncol, 2012, 103(2):155-160.
16.	Chen SC, Chang HK, Lin YC, et al. Prognosis of breast cancer after supraclavicular lymph node metastasis:not a distant metastasis. Ann Surg Oncol, 2006, 13(11):1457-1465.
17.	任書偉, 張鋒, 楊富斌.乳腺癌鎖骨上淋巴結轉移的綜合治療.陜西腫瘤醫學, 2002, 10(1):23-24.
18.	姚廷敬, 李文菁, 彭德峰, 等.乳腺癌伴鎖骨上淋巴結轉移的臨床綜合治療分析.中華全科醫學, 2008, 6(7):673-674.
19.	董津生.乳腺癌鎖骨上淋巴結轉移的外科治療探討.職業與健康, 2005, 21(3):446-447.
20.	劉俊田, 高明, 齊立強, 等.頸胸聯合根治術在伴有鎖骨上淋巴結轉移的乳腺癌患者中的應用.腫瘤防治雜志, 2005, 12(17):1317-1318.
21.	李會齊, 郝福軍, 王向東, 等.頸胸聯合根治術治療N3期乳腺癌17例.腫瘤研究與臨床, 2011, 23(10):714, 720.
22.	Liu XH, Zhang L, Chen B. A meta-analysis of the prognosis in patients with breast cancer with ipsilateral supraclavicular lymph node metastasis versus patients with stage Ⅲb/c or Ⅳ breast cancer. Chron Dis Transl Med, 2016, 1(4):236-242.
23.	Chang XZ, Yin J, Sun J, et al. A retrospective study of different local treatments in breast cancer patients with synchronous ipsilateral supraclavicular lymph node metastasis. J Cancer Res Ther, 2013, 9(Suppl):S158-S161.
24.	Deo SV, Purkayastha J, Shukla NK, et al. Intent of therapy in metastatic breast cancer with isolated ipsilateral supraclavicular lymph node spread-a therapeutic dilemma. J Assoc Physicians India, 2003, 51:272-275.
25.	高潮光.手術治療乳腺癌伴鎖骨上淋巴轉移30例療效分析.現代醫藥衛生, 2005, 21(23):3249.

1. Chen SC, Chen MF, Hwang TL, et al. Prediction of supraclavicular lymph node metastasis in breast carcinoma. Int J Radiat Oncol Biol Phys, 2002, 52(3):614-619.
2. Kiricuta IC, Willner J, K?lbl O, et al. The prognostic significance of the supraclavicular lymph node metastases in breast cancer patients. Int J Radiat Oncol Biol Phys, 1994, 28(2):387-393.
3. Willner J, Kiricuta IC, K?lbl O. Locoregional recurrence of breast cancer following mastectomy:always a fatal event? Results of univariate and multivariate analysis. Int J Radiat Oncol Biol Phys, 1997, 37(4):853-863.
4. Halverson KJ, Perez CA, Kuske RR, et al. Survival following locoregional recurrence of breast cancer:univariate and multivariate analysis. Int J Radiat Oncol Biol Phys, 1992, 23(2):285-291.
5. Fan Y, Xu B, Liao Y, et al. A retrospective study of metachronous and synchronous ipsilateral supraclavicular lymph node metastases in breast cancer patients. Breast, 2010, 19(5):365-369.
6. Dellapasqua S, Bagnardi V, Balduzzi AA, et al. Outcomes of patients with breast cancer who present with ipsilateral supraclavicular or internal mammary lymph node metastases. Clin Breast Cancer, 2014, 14(1):53-60.
7. Pergolizzi S, Settineri N, Russi EG, et al. Supraclavicular lymph node metastases (SLM) from breast cancer as only site of distant disease:has radiotherapy any role. Anticancer Res, 1997, 17(3C):2303-2308.
8. Wang CW, Kuo WH, Chang KJ, et al. Should adjuvant radiotherapy to the supraclavicular fossa be routinely given in patients with breast conservative treatment. J Surg Oncol, 2007, 96(2):144-150.
9. Pergolizzi S, Settineri N, Santacaterina A, et al. Ipsilateral supraclavicular lymph nodes metastases from breast cancer as only site of disseminated disease. Chemotherapy alone vs. induction chemotherapy to radical radiation therapy. Ann Oncol, 2001, 12(8):1091-1095.
10. Wu SG, Sun JY, Zhou J, et al. The value of radiotherapy in breast cancer patients with isolated ipsilateral supraclavicular lymph node metastasis without distant metastases at diagnosis:a retrospective analysis of Chinese patients. Oncl Targets Ther, 2014, 7(1):281-288.
11. Huang EH, Strom EA, Valero V, et al. Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis. Int J Radiat Oncol Biol Phys, 2007, 67(2):490-496.
12. Olivotto IA, Chua B, Allan SJ, et al. Long-term survival of patients with supraclavicular metastases at diagnosis of breast cancer. J Clin Oncol, 2003, 21(5):851-854.
13. Brito RA, Valero V, Buzdar AU, et al. Long-term results of combinedmodality therapy for locally advanced breast cancer with ipsilateral supraclavicular metastases:The University of Texas M.D. Anderson Cancer Center experience. J Clin Oncol, 2001, 19(3):628-633.
14. Ogino T, Komoike Y, Ishitobi M, et al. Breast cancer with ipsilateral supraclavicular metastases. Breast J, 2011, 17(5):555-557.
15. Lundstedt D, Gustafsson M, Steineck G, et al. Long-term symptoms after radiotherapy of supraclavicular lymph nodes in breast cancer patients. Radiother Oncol, 2012, 103(2):155-160.
16. Chen SC, Chang HK, Lin YC, et al. Prognosis of breast cancer after supraclavicular lymph node metastasis:not a distant metastasis. Ann Surg Oncol, 2006, 13(11):1457-1465.
17. 任書偉, 張鋒, 楊富斌.乳腺癌鎖骨上淋巴結轉移的綜合治療.陜西腫瘤醫學, 2002, 10(1):23-24.
18. 姚廷敬, 李文菁, 彭德峰, 等.乳腺癌伴鎖骨上淋巴結轉移的臨床綜合治療分析.中華全科醫學, 2008, 6(7):673-674.
19. 董津生.乳腺癌鎖骨上淋巴結轉移的外科治療探討.職業與健康, 2005, 21(3):446-447.
20. 劉俊田, 高明, 齊立強, 等.頸胸聯合根治術在伴有鎖骨上淋巴結轉移的乳腺癌患者中的應用.腫瘤防治雜志, 2005, 12(17):1317-1318.
21. 李會齊, 郝福軍, 王向東, 等.頸胸聯合根治術治療N3期乳腺癌17例.腫瘤研究與臨床, 2011, 23(10):714, 720.
22. Liu XH, Zhang L, Chen B. A meta-analysis of the prognosis in patients with breast cancer with ipsilateral supraclavicular lymph node metastasis versus patients with stage Ⅲb/c or Ⅳ breast cancer. Chron Dis Transl Med, 2016, 1(4):236-242.
23. Chang XZ, Yin J, Sun J, et al. A retrospective study of different local treatments in breast cancer patients with synchronous ipsilateral supraclavicular lymph node metastasis. J Cancer Res Ther, 2013, 9(Suppl):S158-S161.
24. Deo SV, Purkayastha J, Shukla NK, et al. Intent of therapy in metastatic breast cancer with isolated ipsilateral supraclavicular lymph node spread-a therapeutic dilemma. J Assoc Physicians India, 2003, 51:272-275.
25. 高潮光.手術治療乳腺癌伴鎖骨上淋巴轉移30例療效分析.現代醫藥衛生, 2005, 21(23):3249.

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The Complications and Safety of Supraclavicular Lymph Node Dissection for Invasive Breast Cancer with Ipsilateral Supraclavicular Lymph Node Metastasis

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