Influencing Factors Analysis of Long-Term Survival of Primary Colorectal Signet-Ring Cell Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHENXi ^1,2 ,  YANDeng-guo ¹ , LIANGZheng-zi ¹ , LIGuo-sheng ¹ , CHENGhai-Yu ¹

1. Department of Colorectal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, China;
2. Guizhou Medical University, Guiyang 550004, Guizhou Province, China;

Corresponding?author：

YANDeng-guo, Email: dengguoy@163.com

Keywords：

Colorectal cancer; Signet-ring cell carcinoma; Long-term survival; Clinicopathologic feature

DOI：

10.7507/1007-9424.20160257

Video：

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Objective To investigate influence factor of long-term survival of primary colorectal signet-ring cell carcinoma. Method The clinical data of 37 patients with primary colorectal signet-ring cell carcinoma from January 1990 to November 2010 in this hospital were analyzed retrospectively. Results The cumulative survival rates of 1-, 2-, 3and 5-year after the initial surgery were 70.3%, 51.4%, 27.0%, and 10.8% respectively. The survival time of 37 patients was 26 months. The results of univariate analysis showed that the TNM stage, T stage, preoperative intestinal obstruction or not, operation mode, and postoperative chemotherapy or not were associated with the survival time of primary colorectal signet-ring cell carcinoma (P < 0.05). The results of multivariable analysis showed that TNM stage, T stage, and preoperative intestinal obstruction or not were the independent factors for the prognosis of patients with primary colorectal signetring cell carcinoma. Conclusions The survival rate of patients with primary colorectal signet-ring cell carcinoma is lower. TNM stage, T stage, and preoperative intestinal obstruction or not are independent factors of it. Chemotherapy after operation could prolong survival time of patients with primary colorectal signet-ring cell carcinoma.

Citation： CHENXi, YANDeng-guo, LIANGZheng-zi, LIGuo-sheng, CHENGhai-Yu. Influencing Factors Analysis of Long-Term Survival of Primary Colorectal Signet-Ring Cell Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 987-991. doi: 10.7507/1007-9424.20160257 Copy

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2.	Chew MH, Yeo SA, Ng ZP, et al. Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2 764 sporadic colorectal cancers. Int J Colorectal Dis, 2010, 25(10):1221-1229.
3.	Ishihara S, Watanabe T, Akahane T, et al. Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon. Int J Colorectal Dis, 2012, 27(3):371-379.
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5.	America Joint Committee on Cancer. AJCC Cancer staging Manual. 7th ed. New York:Springer, 2010.
6.	Manfredi S, Lepage C, Hatem C, et al. Epidemiology and management of liver metastasis from colorectal cancer. Ann Surg, 2010, 32(1):67-70.
7.	Hyngstrom JR, Hu CY, Xing Y, et al. Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma:analysis from the National Cancer Data Base. Ann Surg Oncol, 2012, 19(9):2814-2821.
8.	Kitajima K, Fujimori T, Fujii S, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma:a Japanese collaborative study. J Gastroenterol, 2004, 39(6):534-543.
9.	Darwanto A, Kitazawa R, Maeda S, et al. MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma. Cancer Sci, 2003, 94(5):442-447.
10.	李宏偉, 張海, 許若飛, 等.結直腸腺癌中galectin-3, fascin-1和β-catenin蛋白表達與其臨床病理特征的關系.中國普外基礎與臨床雜志, 2012, 19(4):410-415.
11.	Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer:a multi-institutional study. J Clin Oncol, 2004, 22(16):3284-3292.
12.	Knorr C, Reingruber B, Meyer T, et al. Peritoneal carcinomatosis of colorectal cancer:incidence, prognosis, and treatment modalities. Int J Colorectal Dis, 2004, 19(3):181-187.
13.	Esquivel J, Chua TC, Stojadinovic A, et al. Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis:a multi-institutional study. J Surg Oncol, 2010, 102(6):565-570.
14.	Kecmanovic DM, Pavlov MJ, Ceranic MS, et al. Treatment of peritoneal carcinomatosis from colorectal cancer by cytoreductive surgery and hyperthermic perioperative intraperitoneal chemotherapy. Eur J Surg Oncol, 2005, 31(2):147-152.
15.	Levine EA, Stewart JH 4th, Russell GB, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy:experience with 501 procedures. J Am Coll Surg, 2007, 204(5):943-955.
16.	Pilati P, Mocellin S, Rossi CR, et al. Cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy for peritoneal carcinomatosis arising from colon adenocarcinoma. Ann Surg Oncol, 2003, 10(5):508-513.
17.	Shen P, Hawksworth J, Lovato J, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis from nonappendiceal colorectal carcinoma. Ann Surg Oncol, 2004, 11(2):178-186.
18.	Sobin LH, Gospodarowice MK, Wittekind CH. TNM Classification of Malignent tumors. UICC international Union Against Cancer. 7th ed. New York:Wiley, 2009:100-105.
19.	Dauphine CE, Tan P, Beart RW Jr, et al. Placement of self-expanding metal stents for acute malignant large-bowel obstruction:a collective review. Ann Surg Oncol, 2002, 9(6):574-579.
20.	Ohman U. Prognosis in patients with obstructing colorectal carcinoma. Am J Surg, 1982, 143(6):742-747.
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23.	Tekkis PP, Kinsman R, Thompson MR, et al. The association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg, 2004, 240(1):76-81.
24.	陳健, 張宏, 顏登國.結直腸癌患者圍手術期死亡風險評估.中華普通外科雜志, 2014, 29(9):707-710.
25.	Nakahara H, Ishikawa T, Itabashi M, et al. Diffusely infiltrating primary colorectal carcinoma of linitis plastica and lymphangiosis types. Cancer, 1992, 69(4):901-906.
26.	Shirouzu K, Isomoto H, Morodomi T, et al. Primary linitis plastica carcinoma of the colon and rectum. Cancer, 1994, 74(7):1863-1868.
27.	Nadel L, Mori K, Shinya H. Primary linitis plastica of the colon and rectum. Report of two cases. Dis Colon Rectum, 1983, 26(11):736-740.
28.	王紅巖, 董齊, 柳青峰, 等.腸梗阻導管在結直腸癌性腸梗阻治療中的應用研究.中國普外基礎與臨床雜志, 2009, 16(9):698-701.
29.	André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med, 2004, 350(23):2343-2351.
30.	顏登國, 張汝一, 甄運寰, 等.結直腸癌肝轉移的治療.中華普通外科雜志, 2010, 25(2):170-171.
31.	Ozawa H, Kotake K, Kobayashi H, et al. Prognostic factors for peritoneal carcinomatosis originating from colorectal cancer:an analysis of 921 patients from a multi-institutional database. Surg Today, 2014, 44(9):1643-1650.
32.	Sadahiro S, Suzuki T, Maeda Y, et al. Prognostic factors in patients with synchronous peritoneal carcinomatosis (PC) caused by a primary cancer of the colon. J Gastrointest Surg, 2009, 13(9):1593-1598.
33.	Franko J, Ibrahim Z, Gusani NJ, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis. Cancer, 2010, 116(16):3756-3762.

1. Mizushima T, Nomura M, Fujii M, et al. Primary colorectal signet-ring cell carcinoma:clinicopathological features and postoperative survival. Surg Today, 2010, 40(3):234-238.
2. Chew MH, Yeo SA, Ng ZP, et al. Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2 764 sporadic colorectal cancers. Int J Colorectal Dis, 2010, 25(10):1221-1229.
3. Ishihara S, Watanabe T, Akahane T, et al. Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon. Int J Colorectal Dis, 2012, 27(3):371-379.
4. Kang H, O'Connell JB, Maggard MA, et al. A 10-years outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum, 2005, 48(6):1161-1168.
5. America Joint Committee on Cancer. AJCC Cancer staging Manual. 7th ed. New York:Springer, 2010.
6. Manfredi S, Lepage C, Hatem C, et al. Epidemiology and management of liver metastasis from colorectal cancer. Ann Surg, 2010, 32(1):67-70.
7. Hyngstrom JR, Hu CY, Xing Y, et al. Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma:analysis from the National Cancer Data Base. Ann Surg Oncol, 2012, 19(9):2814-2821.
8. Kitajima K, Fujimori T, Fujii S, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma:a Japanese collaborative study. J Gastroenterol, 2004, 39(6):534-543.
9. Darwanto A, Kitazawa R, Maeda S, et al. MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma. Cancer Sci, 2003, 94(5):442-447.
10. 李宏偉, 張海, 許若飛, 等.結直腸腺癌中galectin-3, fascin-1和β-catenin蛋白表達與其臨床病理特征的關系.中國普外基礎與臨床雜志, 2012, 19(4):410-415.
11. Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer:a multi-institutional study. J Clin Oncol, 2004, 22(16):3284-3292.
12. Knorr C, Reingruber B, Meyer T, et al. Peritoneal carcinomatosis of colorectal cancer:incidence, prognosis, and treatment modalities. Int J Colorectal Dis, 2004, 19(3):181-187.
13. Esquivel J, Chua TC, Stojadinovic A, et al. Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis:a multi-institutional study. J Surg Oncol, 2010, 102(6):565-570.
14. Kecmanovic DM, Pavlov MJ, Ceranic MS, et al. Treatment of peritoneal carcinomatosis from colorectal cancer by cytoreductive surgery and hyperthermic perioperative intraperitoneal chemotherapy. Eur J Surg Oncol, 2005, 31(2):147-152.
15. Levine EA, Stewart JH 4th, Russell GB, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy:experience with 501 procedures. J Am Coll Surg, 2007, 204(5):943-955.
16. Pilati P, Mocellin S, Rossi CR, et al. Cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy for peritoneal carcinomatosis arising from colon adenocarcinoma. Ann Surg Oncol, 2003, 10(5):508-513.
17. Shen P, Hawksworth J, Lovato J, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis from nonappendiceal colorectal carcinoma. Ann Surg Oncol, 2004, 11(2):178-186.
18. Sobin LH, Gospodarowice MK, Wittekind CH. TNM Classification of Malignent tumors. UICC international Union Against Cancer. 7th ed. New York:Wiley, 2009:100-105.
19. Dauphine CE, Tan P, Beart RW Jr, et al. Placement of self-expanding metal stents for acute malignant large-bowel obstruction:a collective review. Ann Surg Oncol, 2002, 9(6):574-579.
20. Ohman U. Prognosis in patients with obstructing colorectal carcinoma. Am J Surg, 1982, 143(6):742-747.
21. Wang HS, Lin JK, Mou CY, et al. Long-term prognosis of patients with obstructing carcinoma of the right colon. Am J Surg, 2004, 187(4):497-500.
22. 裴煒, 梁建偉, 周志祥, 等.高齡梗阻性結直腸癌的外科治療.中國腫瘤臨床, 2010, 37(5):254-256.
23. Tekkis PP, Kinsman R, Thompson MR, et al. The association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg, 2004, 240(1):76-81.
24. 陳健, 張宏, 顏登國.結直腸癌患者圍手術期死亡風險評估.中華普通外科雜志, 2014, 29(9):707-710.
25. Nakahara H, Ishikawa T, Itabashi M, et al. Diffusely infiltrating primary colorectal carcinoma of linitis plastica and lymphangiosis types. Cancer, 1992, 69(4):901-906.
26. Shirouzu K, Isomoto H, Morodomi T, et al. Primary linitis plastica carcinoma of the colon and rectum. Cancer, 1994, 74(7):1863-1868.
27. Nadel L, Mori K, Shinya H. Primary linitis plastica of the colon and rectum. Report of two cases. Dis Colon Rectum, 1983, 26(11):736-740.
28. 王紅巖, 董齊, 柳青峰, 等.腸梗阻導管在結直腸癌性腸梗阻治療中的應用研究.中國普外基礎與臨床雜志, 2009, 16(9):698-701.
29. André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med, 2004, 350(23):2343-2351.
30. 顏登國, 張汝一, 甄運寰, 等.結直腸癌肝轉移的治療.中華普通外科雜志, 2010, 25(2):170-171.
31. Ozawa H, Kotake K, Kobayashi H, et al. Prognostic factors for peritoneal carcinomatosis originating from colorectal cancer:an analysis of 921 patients from a multi-institutional database. Surg Today, 2014, 44(9):1643-1650.
32. Sadahiro S, Suzuki T, Maeda Y, et al. Prognostic factors in patients with synchronous peritoneal carcinomatosis (PC) caused by a primary cancer of the colon. J Gastrointest Surg, 2009, 13(9):1593-1598.
33. Franko J, Ibrahim Z, Gusani NJ, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis. Cancer, 2010, 116(16):3756-3762.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Influencing Factors Analysis of Long-Term Survival of Primary Colorectal Signet-Ring Cell Carcinoma

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