高強度超聲聚焦刀序貫同步放化療治療結腸癌肝轉移的臨床療效觀察_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 舒暢 ,  龔軍

鄂東醫療集團黃石市中心醫院普愛院區腹盆腫瘤內科, 湖北黃石 435002;

Corresponding?author：

龔軍, Email: gongjun32@163.com

Keywords：

高強度超聲聚焦刀; 同步放化療; 結腸癌; 肝轉移

DOI：

10.7507/1007-9424.20160207

Video：

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目的觀察高強度超聲聚焦刀序貫同步放化療治療結腸癌肝轉移的臨床療效方法選取筆者所在醫院2011年9月至2014年12月期間收治的結腸癌肝轉移患者120例，根據治療方法的不同分為觀察組與對照組，各60例，對照組給予同步放化療治療，觀察組在對照組治療的基礎上給予高強度超聲聚焦刀序貫治療，2組均治療觀察3個月。結果治療后觀察組與對照組的近期有效率分別為70.0%和40.0%，觀察組的有效率明顯高于對照組（P＜0.05）。觀察組治療期間的肝腎毒性、消化道出血、骨髓抑制、感染等毒性反應情況與對照組比較差異無統計學意義（P＞0.05）。所有患者隨訪（30.25±8.24）個月（12～48個月），觀察組1年生存率與中位生存時間分別為50.0%和（12.42±2.45）個月，高于或長于對照組的33.3%和（8.98±2.87）個月，其差異有統計學意義（P＜0.05）。結論高強度超聲聚焦刀序貫同步放化療治療結腸癌肝轉移能提高近期療效，延長生存時間，有很好的應用安全性，值得推廣應用。

Citation： 舒暢, 龔軍. 高強度超聲聚焦刀序貫同步放化療治療結腸癌肝轉移的臨床療效觀察. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(7): 787-789. doi: 10.7507/1007-9424.20160207 Copy

1.	楊武威, 尉承澤.肝細胞肝癌的微創消融治療.中華肝臟外科手術學電子雜志, 2012, 1(2): 132-137.
2.	嚴冬, 戴紅.恩度聯合XELOX方案一線治療老年晚期結直腸癌的臨床觀察.中華腫瘤防治雜志, 2011, 18(12): 961-964.
3.	Mearini L. High intensity focused ultrasound, liver disease and bridging therapy. World J Gastroenterol, 2013, 19(43): 7494-7499.
4.	杜海峰, 魏長宏, 王作志, 等.體部伽瑪刀聯合高強度聚焦超聲治療中晚期原發性肝癌的療效觀察.醫學綜述, 2015, 3(21): 572-573.
5.	于龍, 張絹絹, 陳英紅, 等.高強度聚焦超聲刀治療原發性肝癌合并門靜脈癌栓50例分析.中國實用醫藥, 2013, 8(30): 110-112.
6.	De Divitiis C, Cassata A, Nasti G, et al. Late complete response after long remission from treatment with FOLFIRI-aflibercept for metas-tatic colorectal cancer after progression to FOLFOX-bevacizumab. Recenti Prog Med, 2015, 106(8): 407-413.
7.	洪立立, 郭志, 于海鵬, 等.低功率高強度聚焦超聲聯合SOX方案治療結直腸癌伴盆腔轉移.中華醫學雜志, 2014, 25(13): 1929-1932.
8.	Imperatori A, Rotolo N, Dominioni L, et al. Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses. BMC Cancer, 2015, 15(1): 567-568.
9.	袁選舉, 陳萍, 曹風軍, 等.高強度超聲聚焦刀聯合鴉膽子油乳介入治療中晚期肝癌35例臨床觀察.臨床和實驗醫學雜志, 2013, 12(21): 1765-1767.
10.	Dupré A, Melodelima D, Pérol D, et al. First clinical experience of intra-operative high intensity focused ultrasound in patients with colorectal liver metastases: a phase I-IIa study. PLoS One, 2015, 10(2): 212-213.
11.	Lei J, Yan L. Outcome comparisons among the Hangzhou, Chengdu, and UCSF criteria for hepatocellular carcinoma liver transplantation after successful downstaging therapies. J Gastrointest Surg, 2013, 17(6): 1116-1122.
12.	張秀峰, 楊關根, 張瑩, 等.血管內皮抑素微泡聯合聚焦超聲抗結腸癌腫瘤血管生成的實驗研究.中華胃腸外科雜志, 2013, 16(12): 1208-1214.
13.	Mainenti PP, Romano F, Pizzuti L, et al. Non-invasive diagnostic imaging of colorectal liver metastases. World J Radiol, 2015, 7(7): 157-169.
14.	王宏偉, 王崑, 包全, 等.結直腸癌肝轉移切除術后并發癥對生存影響.中華普通外科雜志, 2015, 30(1): 42-45.
15.	Ramírez-Plaza CP, Moreno-Ruiz FJ, Pérez-Daga JA. A multidisci-plinary approach for peritoneal carcinomatosis and bilobar liver metastases from colorectal cancer: case report and review of the literature. World J Surg Oncol, 2015, 13(1): 233-235.
16.	劉文稚, 李孟考, 陳祥明.雷替曲塞聯合奧沙利鉑治療結直腸癌肝轉移的臨床研究.中華臨床醫師雜志:電子版, 2015, 1(22): 146-148.
17.	Fan Z, Luo W, Song Z, et al. Effect of healthy tissue ablation surroun-ding VX2 rabbit liver tumors by high-intensity focused ultrasound combined with an ultrasound contrast agent. J Ultrasound Med, 2012, 31(6): 863-871.
18.	鐘華, 李銳, 郭燕麗, 等.高機械指數超聲輻照微泡對結腸癌細胞骨架的影響.中華超聲影像學雜志, 2011, 20(11): 996-999.

1. 楊武威, 尉承澤.肝細胞肝癌的微創消融治療.中華肝臟外科手術學電子雜志, 2012, 1(2): 132-137.
2. 嚴冬, 戴紅.恩度聯合XELOX方案一線治療老年晚期結直腸癌的臨床觀察.中華腫瘤防治雜志, 2011, 18(12): 961-964.
3. Mearini L. High intensity focused ultrasound, liver disease and bridging therapy. World J Gastroenterol, 2013, 19(43): 7494-7499.
4. 杜海峰, 魏長宏, 王作志, 等.體部伽瑪刀聯合高強度聚焦超聲治療中晚期原發性肝癌的療效觀察.醫學綜述, 2015, 3(21): 572-573.
5. 于龍, 張絹絹, 陳英紅, 等.高強度聚焦超聲刀治療原發性肝癌合并門靜脈癌栓50例分析.中國實用醫藥, 2013, 8(30): 110-112.
6. De Divitiis C, Cassata A, Nasti G, et al. Late complete response after long remission from treatment with FOLFIRI-aflibercept for metas-tatic colorectal cancer after progression to FOLFOX-bevacizumab. Recenti Prog Med, 2015, 106(8): 407-413.
7. 洪立立, 郭志, 于海鵬, 等.低功率高強度聚焦超聲聯合SOX方案治療結直腸癌伴盆腔轉移.中華醫學雜志, 2014, 25(13): 1929-1932.
8. Imperatori A, Rotolo N, Dominioni L, et al. Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses. BMC Cancer, 2015, 15(1): 567-568.
9. 袁選舉, 陳萍, 曹風軍, 等.高強度超聲聚焦刀聯合鴉膽子油乳介入治療中晚期肝癌35例臨床觀察.臨床和實驗醫學雜志, 2013, 12(21): 1765-1767.
10. Dupré A, Melodelima D, Pérol D, et al. First clinical experience of intra-operative high intensity focused ultrasound in patients with colorectal liver metastases: a phase I-IIa study. PLoS One, 2015, 10(2): 212-213.
11. Lei J, Yan L. Outcome comparisons among the Hangzhou, Chengdu, and UCSF criteria for hepatocellular carcinoma liver transplantation after successful downstaging therapies. J Gastrointest Surg, 2013, 17(6): 1116-1122.
12. 張秀峰, 楊關根, 張瑩, 等.血管內皮抑素微泡聯合聚焦超聲抗結腸癌腫瘤血管生成的實驗研究.中華胃腸外科雜志, 2013, 16(12): 1208-1214.
13. Mainenti PP, Romano F, Pizzuti L, et al. Non-invasive diagnostic imaging of colorectal liver metastases. World J Radiol, 2015, 7(7): 157-169.
14. 王宏偉, 王崑, 包全, 等.結直腸癌肝轉移切除術后并發癥對生存影響.中華普通外科雜志, 2015, 30(1): 42-45.
15. Ramírez-Plaza CP, Moreno-Ruiz FJ, Pérez-Daga JA. A multidisci-plinary approach for peritoneal carcinomatosis and bilobar liver metastases from colorectal cancer: case report and review of the literature. World J Surg Oncol, 2015, 13(1): 233-235.
16. 劉文稚, 李孟考, 陳祥明.雷替曲塞聯合奧沙利鉑治療結直腸癌肝轉移的臨床研究.中華臨床醫師雜志:電子版, 2015, 1(22): 146-148.
17. Fan Z, Luo W, Song Z, et al. Effect of healthy tissue ablation surroun-ding VX2 rabbit liver tumors by high-intensity focused ultrasound combined with an ultrasound contrast agent. J Ultrasound Med, 2012, 31(6): 863-871.
18. 鐘華, 李銳, 郭燕麗, 等.高機械指數超聲輻照微泡對結腸癌細胞骨架的影響.中華超聲影像學雜志, 2011, 20(11): 996-999.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

高強度超聲聚焦刀序貫同步放化療治療結腸癌肝轉移的臨床療效觀察

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