Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 GOUWen-xiao ^1,2 ,  YINLong-lin ¹ , CHENXiao-yu ² , XIEHuan ^1,2 , WANGFu-min ²

1. Department of Medical Imaging, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
2. Department of Radiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China;

Corresponding?author：

YINLong-lin, Email: yinlonglin@163.com

Keywords：

Xanthogranulomatous cholecystitis; Gallbladder cancer; Magnetic resonance imaging

DOI：

10.7507/1007-9424.20160167

Video：

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Objective To investigate clinical value of magnetic resonance imaging (MRI) in differentiating xanthogranulomatous cholecystitis (XGC) with gallbladder cancer (GBC). Methods MRI data of 7 patients with XGC and 13 patients with GBC proved by surgery and pathology were analyzed retrospectively. The main contents of the observation included:①Maximum thickness of gallbladder wall; ②Diffuse thickening or localized thickening of gallbladder wall; ③Enhancement pattern (uniform or nonuniform) of gallbladder wall; ④Gallbladder wall sandwiches enhancement; ⑤Gallbladder wall nodules; ⑥Completeness of gallbladder mucosa lines; ⑦Obstruction of biliary tract; ⑧Calculus in gallbladder or bile duct; ⑨Involvement of adjacent liver; ⑩Definition of surrounding fat layer; Lymphadenopathy. Results In above 11 MRI comparing features, these features such as the gallbladder wall sandwiches enhancement, the gallbladder wall nodules, the completeness of gallbladder mucosa lines, the biliary obstruction, and the lymphadenopathy were statistically significant between the XGC and the GBC (P < 0.05), while the rest features such as the maximum thickness of gallbladder wall, the type of gallbladder wall thickening, the gallbladder wall enhancement pattern, the calculus in gallbladder or bile duct, the involvement of adjacent liver, and the definition of surrounding fat layer were not statistically significant between the XGC and the GBC (P > 0.05). Conclusion MRI has important values in differentiating XGC with GBC.

Citation： GOUWen-xiao, YINLong-lin, CHENXiao-yu, XIEHuan, WANGFu-min. Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 615-619. doi: 10.7507/1007-9424.20160167 Copy

1.	Guzmán-Valdivia G. Xanthogranulomatous cholecystitis: 15 years' experience. World J Surg, 2004, 28(3): 254-257.
2.	McCoy JJ, Vila R, Petrossian G, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc, 1976, 72(3): 78-79.
3.	馬光慧, 嵇鳴, 葉春濤, 等.黃色肉芽腫性膽囊炎的MRI特征.磁共振成像, 2014, 5(4): 283-286.
4.	Parra JA, Acinas O, Bueno J, et al. Xanthogranulomatous cholecystitis: clinical, sonographic, andCTfindings in 26 patients. AJR Am J Roentgenol, 2000, 174(4): 979-983.
5.	Goshima S, Chang S, Wang JH, et al. Xanthogranulomatous cholecystitis: diagnostic performance ofCTto differentiate from gallbladder cancer. Eur J Radiol, 2010, 74(3): e79-e83.
6.	龔海燕, 戈偉, 蔣松松, 等. 48例黃色肉芽腫性膽囊炎的診治分析.中國普外基礎與臨床雜志, 2014, 21(8): 1009-1012.
7.	Takahashi K, Oka K, Hakozaki H, et al. Ceroid-like histiocytic granuloma of gallbladder-a previously undescribed lesion. Acta Pathol Jpn, 1976, 26(1): 25-46.
8.	Singal R, Gupta S, Pande P, et al. Xanthogranulomatouscholecystitis: case series in a rural area, clinicopathologicalstudy and review of literature. Acta Gastroenterol Latinoam, 2011, 41(4): 331-334.
9.	王蔚藍, 孫海明.黃色肉芽腫性膽囊炎45例診治分析.肝膽胰外科雜志, 2015, 27(1): 74-75.
10.	蔣兆彥, 韓天權, 張圣道.對膽囊結石導致膽囊癌發病的認識.中國實用外科雜志, 2011, 31(3): 202-204.
11.	Agrawal V, Goel A, Krishnani N, et al. p53, carcinoembryonic antigen and carbohydrate antigen 19.9 expression in gall bladder cancer, precursor epithelial lesions and xanthogranulomatous cholecystitis. J Postgrad Med, 2010, 56(4): 262-266.
12.	Han SH, Chen YL. Diagnosis and treatment of xanthogranulomatous cholecystitis: a report of 39 cases. Cell Biochem Biophys, 2012, 64(2): 131-135.
13.	13吳森炎, 蔡軍.膽囊癌診療現狀.實用臨床醫學, 2016, 17(2): 102-107.
14.	14戚成, 閆長春.血清CEA、CA199、CA125、CA50單獨及聯合檢測診斷膽囊癌的價值.山東醫藥, 2013, 53(14): 38-39.
15.	Lee ES, Kim JH, Joo I, et al. Xanthogranulomatous cholecystitis: diagnostic performance of US, CT, and MRI for differentiation from gallbladder carcinoma. Abdom Imaging, 2015, 40(7): 2281-2292.
16.	Shuto R, Kiyosue H, Komatsu E, et al.CTand MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol, 2004, 14(3): 440-446.
17.	趙黎明, 宋彬.急性膽囊炎的CT和MRI診斷價值.中國普外基礎與臨床雜志, 2008, 15(9): 699-703.
18.	梁廷波, 白雪莉.膽囊癌分期臨床意義及評價.中國實用外科雜志, 2011, 31(3): 194-197.
19.	Chang BJ, Kim SH, Park HY, et al. Distinguishing xanthogranulomatous cholecystitis fromthe wall-thickening type of early-stage gallbladder cancer. Gut Liver, 2010, 4(4): 518-523.
20.	Zhao F, Lu PX, Yan SX.CTand MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol, 2013, 89(9): 1391-1397.
21.	李代欣, 朱西琪, 田玉亭, 等. CT及MRI在黃色肉芽腫性膽囊炎診斷中的應用.生物醫學工程與臨床, 2015, 19(2): 164-168.
22.	王建良, 朱玉春.黃色肉芽腫性膽囊炎與厚壁型膽囊癌的螺旋CT鑒別診斷.腹部放射學, 2015, 34(1): 74-78.
23.	Yoshimitsu K, Irie H, Aibe H, et al. Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol, 2005, 15(2): 229-233.
24.	Chun KA, Ha HK, Yu ES, et al. Xanthogranulomatous cholecystitis:CTfeatures with emphasis on differentiation from gallbladder carcinoma. Radiology, 1997, 203(1): 93-97.
25.	Guermazi A. Are there other imaging features to differentiate xanthogranulomatous cholecystitis from gallbladder carcinoma. Eur Radiol, 2005, 15(6): 1271-1272.

1. Guzmán-Valdivia G. Xanthogranulomatous cholecystitis: 15 years' experience. World J Surg, 2004, 28(3): 254-257.
2. McCoy JJ, Vila R, Petrossian G, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc, 1976, 72(3): 78-79.
3. 馬光慧, 嵇鳴, 葉春濤, 等.黃色肉芽腫性膽囊炎的MRI特征.磁共振成像, 2014, 5(4): 283-286.
4. Parra JA, Acinas O, Bueno J, et al. Xanthogranulomatous cholecystitis: clinical, sonographic, andCTfindings in 26 patients. AJR Am J Roentgenol, 2000, 174(4): 979-983.
5. Goshima S, Chang S, Wang JH, et al. Xanthogranulomatous cholecystitis: diagnostic performance ofCTto differentiate from gallbladder cancer. Eur J Radiol, 2010, 74(3): e79-e83.
6. 龔海燕, 戈偉, 蔣松松, 等. 48例黃色肉芽腫性膽囊炎的診治分析.中國普外基礎與臨床雜志, 2014, 21(8): 1009-1012.
7. Takahashi K, Oka K, Hakozaki H, et al. Ceroid-like histiocytic granuloma of gallbladder-a previously undescribed lesion. Acta Pathol Jpn, 1976, 26(1): 25-46.
8. Singal R, Gupta S, Pande P, et al. Xanthogranulomatouscholecystitis: case series in a rural area, clinicopathologicalstudy and review of literature. Acta Gastroenterol Latinoam, 2011, 41(4): 331-334.
9. 王蔚藍, 孫海明.黃色肉芽腫性膽囊炎45例診治分析.肝膽胰外科雜志, 2015, 27(1): 74-75.
10. 蔣兆彥, 韓天權, 張圣道.對膽囊結石導致膽囊癌發病的認識.中國實用外科雜志, 2011, 31(3): 202-204.
11. Agrawal V, Goel A, Krishnani N, et al. p53, carcinoembryonic antigen and carbohydrate antigen 19.9 expression in gall bladder cancer, precursor epithelial lesions and xanthogranulomatous cholecystitis. J Postgrad Med, 2010, 56(4): 262-266.
12. Han SH, Chen YL. Diagnosis and treatment of xanthogranulomatous cholecystitis: a report of 39 cases. Cell Biochem Biophys, 2012, 64(2): 131-135.
13. 13吳森炎, 蔡軍.膽囊癌診療現狀.實用臨床醫學, 2016, 17(2): 102-107.
14. 14戚成, 閆長春.血清CEA、CA199、CA125、CA50單獨及聯合檢測診斷膽囊癌的價值.山東醫藥, 2013, 53(14): 38-39.
15. Lee ES, Kim JH, Joo I, et al. Xanthogranulomatous cholecystitis: diagnostic performance of US, CT, and MRI for differentiation from gallbladder carcinoma. Abdom Imaging, 2015, 40(7): 2281-2292.
16. Shuto R, Kiyosue H, Komatsu E, et al.CTand MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol, 2004, 14(3): 440-446.
17. 趙黎明, 宋彬.急性膽囊炎的CT和MRI診斷價值.中國普外基礎與臨床雜志, 2008, 15(9): 699-703.
18. 梁廷波, 白雪莉.膽囊癌分期臨床意義及評價.中國實用外科雜志, 2011, 31(3): 194-197.
19. Chang BJ, Kim SH, Park HY, et al. Distinguishing xanthogranulomatous cholecystitis fromthe wall-thickening type of early-stage gallbladder cancer. Gut Liver, 2010, 4(4): 518-523.
20. Zhao F, Lu PX, Yan SX.CTand MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol, 2013, 89(9): 1391-1397.
21. 李代欣, 朱西琪, 田玉亭, 等. CT及MRI在黃色肉芽腫性膽囊炎診斷中的應用.生物醫學工程與臨床, 2015, 19(2): 164-168.
22. 王建良, 朱玉春.黃色肉芽腫性膽囊炎與厚壁型膽囊癌的螺旋CT鑒別診斷.腹部放射學, 2015, 34(1): 74-78.
23. Yoshimitsu K, Irie H, Aibe H, et al. Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol, 2005, 15(2): 229-233.
24. Chun KA, Ha HK, Yu ES, et al. Xanthogranulomatous cholecystitis:CTfeatures with emphasis on differentiation from gallbladder carcinoma. Radiology, 1997, 203(1): 93-97.
25. Guermazi A. Are there other imaging features to differentiate xanthogranulomatous cholecystitis from gallbladder carcinoma. Eur Radiol, 2005, 15(6): 1271-1272.

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Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer

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