Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 NIULu-wei ^1,2 ,  ZHANGJia-xin ¹

1. The second Department of Thyroid and Breast surgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China;
2. Graduate school of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China;

Corresponding?author：

ZHANGJia-xin, Email: xyfyzjx@163.com

Keywords：

Primary thyroid lymphoma; Hashimoto thyroiditis

DOI：

10.7507/1007-9424.20160159

Video：

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Objective To analyze clinical manifestation, diagnosis, therapy, and prognosis of primary thyroid lymphoma. Method From April 2012 to September 2015, the clinical data of 9 patients with primary thyroid lymphoma admitted to The Affiliated Hospital of Xuzhou Medical College, including clinical manifestation, diagnosis procedure, treatment project, and prognosis, were reviewed retrospectively. Results The thyroids or nodules of 4 patients increased rapidly in 1-3 months, with the surrounding tissues and organs oppression symptoms. The preoperative examination revealed that there were 5 patients with swollen lymph nodes. Eight patients were received preoperative thyroid function examination, there were 4 patients with subclinical hypothyroidism, 4 patients with rose TSH, 6 patients with rose thyroglobulin antibody. There were 5 cases of primary thyroid lymphoma associated with Hashimoto thyroiditis. Eight patients were underwent surgical treatment in our hospital, 1 patient was underwent surgery in the other hospital. The results of pathological histology showed that 5 patients with mucosa associated lymphadenoma were stageⅠE, 3 patients with diffuse large B cell lymphoma were stageⅠE, 1 patient with diffuse large B cell lymphoma was stageⅡE. Two patients with diffuse large B cell lymphoma were received chemotherapy, the scheme was CHOP and COP respectively. Seven patients were received follow-up, the follow-up time was 2-42 months, the median follow-up time was 20 months, all of them were survived. Conclusions Primary thyroid lymphoma should be considered for patients with rapid growth of thyroid mass in a short term, which relies on the histopathologic and immunohistochemical diagnosis finally. The individualized treatment should be performed for primary thyroid lymphoma according to pathological classification.

Citation： NIULu-wei, ZHANGJia-xin. Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 594-597. doi: 10.7507/1007-9424.20160159 Copy

1.	Kharrat S, Sethom A, Chelly I, et al. Primary thyroid lymphoma. Tunis Med, 2011, 89(7):648-649.
2.	Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland:a clinicopathologic study of 108 cases. Am J surg Pathol, 2000, 24(5):623-639.
3.	Orita Y, Sato Y, Kimura N, et al. Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland. Acta Otolaryngol, 2014, 134(1):93-99.
4.	Watanabe N, Noh JY, Narimatsu H, et al. Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease. Br J Haematol, 2011, 153(2):236-243.
5.	Takakuwa T, Miyauchi A, Aozasa K. Aberrant somatic hypermutations in thyroid lymphomas. Leuk Res, 2009, 33(5):649-654.
6.	Stein SA, Wartofsky L. Primary thyroid lymphoma:a clinical review. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
7.	Ruggiero FP, Frauenhoffer E, Stack BC Jr. Thyroid lymphoma:a single institution's experience. Otolaryngol Head Neck surg, 2005, 133(6):888-896.
8.	張平, 王志宏, 賀亮, 等.原發性甲狀腺惡性淋巴瘤的診斷與治療:附23例報告.中國普通外科雜志, 2012, 21(11):1369-1372.
9.	朱精強, 李纓來, 陳國經, 等.橋本病合并甲狀腺惡性腫瘤的診治(附8例報告).中國普外基礎與臨床雜志, 2000, 7(4):252-254.
10.	孫治君, 姚榛祥, 管小琴.甲狀腺原發性惡性淋巴瘤的診斷與治療(附7例報告).中國普外基礎與臨床雜志, 2003, 10(4):393-394.
11.	Katna R, Shet T, Sengar M, et al. Clinicopathologic study and outcome analysis of thyroid lymphomas:experience from a tertiary cancer center. Head Neck, 2013, 35(2):165-171.
12.	夏青萍, 衛駱云.原發性甲狀腺惡性淋巴瘤合并橋本氏甲狀腺炎11例診治分析.浙江實用醫學, 2015, 20(5):335-337.
13.	駱驚濤, 魏璽, 張侖.原發性甲狀腺淋巴瘤的超聲表現病理及其他影像學特征分析.中國腫瘤臨床, 2014, 41(2):123-126.
14.	孔德軍, 王平, 劉家開.原發性甲狀腺淋巴瘤的超聲表現及病理學特征分析.實用臨床醫藥雜志, 2015, 19(z1):145-147.
15.	楊盼, 孫映荷, 馬步云, 等.原發性甲狀腺非霍奇金淋巴瘤的超聲征象分析.中國普外基礎與臨床雜志, 2014, 21(9):1092-1096.
16.	Takashima S, Tomiyama N, Morimoto S, et al. Nonpalpable primary thyroid lymphoma diagnosed by ultrasound-guided fine needle biopsy. J Clin Ultrasound, 1992, 20(2):142-145.
17.	宋揚, 劉華, 盧滿存.13例原發性甲狀腺淋巴瘤的臨床分析.重慶醫學, 2012, 41(36):3844-3846.
18.	李建華, 李利文, 付利軍, 等.外科手術在原發性甲狀腺淋巴瘤綜合診治中的作用.腫瘤基礎與臨床, 2015, 28(3):213-217.
19.	Takano T, Asahi S, Matsuzuka F, et al. Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR:experience of eight cases. Leuk Res, 2008, 32(1):151-4.
20.	Motta G, Cea M, Carbone F, et al. Current standards and future strategies in immunochemotherapy of non-Hodgkin's lymphoma. J BUON, 2011, 16(1):9-15.
21.	Sakorafas GH. What's the role of surgery in the management of primary thyroid lymphoma? Acta Oncol, 2011, 50(2):319-320.
22.	徐曉帆, 顧軍, 張新華, 等.甲狀腺黏膜相關淋巴組織淋巴瘤的診斷及治療.江蘇醫藥, 2014, 40(20):2485-2487.
23.	謝婧, 鄧先兆, 樊友本, 等.原發性甲狀腺淋巴瘤療效分析(附20例報道).中國普外基礎與臨床雜志, 2014, 21(9):1097-1102.
24.	張秉棟, 薛勇敢, 劉洪一, 等.20例原發性甲狀腺淋巴瘤的臨床分析.解放軍醫學院學報, 2015, 36(5):419-424.
25.	楊棟, 王磊, 汪穎厚, 等.原發性甲狀腺惡性淋巴瘤22例臨床分析.臨床外科雜志, 2014, 22(12):903-905, 906.

1. Kharrat S, Sethom A, Chelly I, et al. Primary thyroid lymphoma. Tunis Med, 2011, 89(7):648-649.
2. Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland:a clinicopathologic study of 108 cases. Am J surg Pathol, 2000, 24(5):623-639.
3. Orita Y, Sato Y, Kimura N, et al. Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland. Acta Otolaryngol, 2014, 134(1):93-99.
4. Watanabe N, Noh JY, Narimatsu H, et al. Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease. Br J Haematol, 2011, 153(2):236-243.
5. Takakuwa T, Miyauchi A, Aozasa K. Aberrant somatic hypermutations in thyroid lymphomas. Leuk Res, 2009, 33(5):649-654.
6. Stein SA, Wartofsky L. Primary thyroid lymphoma:a clinical review. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
7. Ruggiero FP, Frauenhoffer E, Stack BC Jr. Thyroid lymphoma:a single institution's experience. Otolaryngol Head Neck surg, 2005, 133(6):888-896.
8. 張平, 王志宏, 賀亮, 等.原發性甲狀腺惡性淋巴瘤的診斷與治療:附23例報告.中國普通外科雜志, 2012, 21(11):1369-1372.
9. 朱精強, 李纓來, 陳國經, 等.橋本病合并甲狀腺惡性腫瘤的診治(附8例報告).中國普外基礎與臨床雜志, 2000, 7(4):252-254.
10. 孫治君, 姚榛祥, 管小琴.甲狀腺原發性惡性淋巴瘤的診斷與治療(附7例報告).中國普外基礎與臨床雜志, 2003, 10(4):393-394.
11. Katna R, Shet T, Sengar M, et al. Clinicopathologic study and outcome analysis of thyroid lymphomas:experience from a tertiary cancer center. Head Neck, 2013, 35(2):165-171.
12. 夏青萍, 衛駱云.原發性甲狀腺惡性淋巴瘤合并橋本氏甲狀腺炎11例診治分析.浙江實用醫學, 2015, 20(5):335-337.
13. 駱驚濤, 魏璽, 張侖.原發性甲狀腺淋巴瘤的超聲表現病理及其他影像學特征分析.中國腫瘤臨床, 2014, 41(2):123-126.
14. 孔德軍, 王平, 劉家開.原發性甲狀腺淋巴瘤的超聲表現及病理學特征分析.實用臨床醫藥雜志, 2015, 19(z1):145-147.
15. 楊盼, 孫映荷, 馬步云, 等.原發性甲狀腺非霍奇金淋巴瘤的超聲征象分析.中國普外基礎與臨床雜志, 2014, 21(9):1092-1096.
16. Takashima S, Tomiyama N, Morimoto S, et al. Nonpalpable primary thyroid lymphoma diagnosed by ultrasound-guided fine needle biopsy. J Clin Ultrasound, 1992, 20(2):142-145.
17. 宋揚, 劉華, 盧滿存.13例原發性甲狀腺淋巴瘤的臨床分析.重慶醫學, 2012, 41(36):3844-3846.
18. 李建華, 李利文, 付利軍, 等.外科手術在原發性甲狀腺淋巴瘤綜合診治中的作用.腫瘤基礎與臨床, 2015, 28(3):213-217.
19. Takano T, Asahi S, Matsuzuka F, et al. Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR:experience of eight cases. Leuk Res, 2008, 32(1):151-4.
20. Motta G, Cea M, Carbone F, et al. Current standards and future strategies in immunochemotherapy of non-Hodgkin's lymphoma. J BUON, 2011, 16(1):9-15.
21. Sakorafas GH. What's the role of surgery in the management of primary thyroid lymphoma? Acta Oncol, 2011, 50(2):319-320.
22. 徐曉帆, 顧軍, 張新華, 等.甲狀腺黏膜相關淋巴組織淋巴瘤的診斷及治療.江蘇醫藥, 2014, 40(20):2485-2487.
23. 謝婧, 鄧先兆, 樊友本, 等.原發性甲狀腺淋巴瘤療效分析(附20例報道).中國普外基礎與臨床雜志, 2014, 21(9):1097-1102.
24. 張秉棟, 薛勇敢, 劉洪一, 等.20例原發性甲狀腺淋巴瘤的臨床分析.解放軍醫學院學報, 2015, 36(5):419-424.
25. 楊棟, 王磊, 汪穎厚, 等.原發性甲狀腺惡性淋巴瘤22例臨床分析.臨床外科雜志, 2014, 22(12):903-905, 906.

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Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma

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