Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 XUJian , ZOUZhen-yu , XINGXiao-wei , MAYue , WANGLing-di , ZOUGui-jun , HUShi-dong ,  DUXiao-hui

Department of General Surgery, PLA General Hospital, Beijing 100853, China;

Corresponding?author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Perioperative period; Rectal cancer; Thymopentin; Immune function

DOI：

10.7507/1007-9424.20160151

Video：

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Objective To investigate effect of application of thymopentin during perioperative period on immune function of patients undergoing laparoscopic assisted radical resection for rectal carcinoma. Methods Forty-two patients undergoing laparoscopic assisted radical resection for rectal carcinoma from January 2015 to April 2015 in this hospital were collected. These patients were divided into study group and control group. The patients were received routine treatment in the control group. In addition to routine treatment same as the control group, the patients were received 2 mg thymopentin every day for a week in the study group. The changes of lymphocyte count, T lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺), and immunoglobulin (IgG, IgA, and IgM) were compared on the 1st day before surgery and on the 1st day and 5th day after surgery. Results The lymphocyte count, T lymphocyte subsets, and immunoglobulin on the first day after surgery were significantly lower than those on the 1st day before surgery in these two groups (P < 0.05). The lymphocyte count, T lymphocyte subsets (except for CD4⁺/CD8⁺), and immunoglobulin (except for IgA) in the study group were significantly higher than those in the control group on the 5th day after surgery (P < 0.05). The changes of lymphocyte count, T lymphocyte subsets, and immunoglobulin in the study group had no significant differences between on the 5th day after surgery and on the 1st day before surgery (P > 0.05), but which on the 5th day afer surgery were significantly lower than those on the 1st day before surgery (P < 0.05) in the control group. Conclusion Application of thymopentin during perioperative period could accelerate recovery of immune function after operation in patients undergoing laparoscopic assisted radical resection for rectal carcinoma.

Citation： XUJian, ZOUZhen-yu, XINGXiao-wei, MAYue, WANGLing-di, ZOUGui-jun, HUShi-dong, DUXiao-hui. Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 561-564. doi: 10.7507/1007-9424.20160151 Copy

1.	王旻, 陳學博, 王歡, 等. 直腸癌擴大根治術對患者外周血中細胞免疫功能的影響. 中國實驗診斷學, 2011, 15(3):521-523.
2.	葉平江, 郭貴龍, 應曉江. 腹腔鏡與開腹結直腸癌根治術對機體免疫系統影響的比較研究.中國內鏡雜志, 2011, 17(5):478-480.
3.	郭寧寧, 王輝, 肖蘭鳳, 等. T細胞過繼免疫治療法在腫瘤疾病治療中的應用進展. 廣東藥學院學報, 2011, 27(4):441-445.
4.	李媛. 胸腺五肽治療支原體肺炎的療效分析. 中國醫學工程, 2014, 22(5):67.
5.	葉銳良. 胸腺五肽治療初治肺結核的臨床研究. 臨床肺科雜志, 2015, 20(8):1493-1496.
6.	賈果珍. 中晚期肺癌化療聯合使用胸腺五肽臨床觀察. 中國藥物與臨床, 2014, 14(8):1103-1104.
7.	何文杰, 涂長玲, 江波. 胸腺五肽對老年晚期非小細胞肺癌患者免疫功能的影響研究. 實用心腦肺血管病雜志, 2015, 23(7):72-74.
8.	Bordón E, Henríquez-Hernández LA, Lara PC, et al. Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and natural killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients. Int J Radiat Biol, 2011, 87(4):424-431.
9.	王國俊, 高春芳. 腹腔鏡直腸癌全直腸系膜切除術. 中國普外基礎與臨床雜志, 2011, 18(1):92-94.
10.	汪利群, 吳勇. 腹腔鏡和開腹手術治療卵巢良性腫瘤的療效及對免疫功能的影響. 中國腫瘤臨床與康復, 2012, 19(6):515-517.
11.	劉江文, 孫琳, 仝德峰, 等. 進展期胃癌腹腔鏡輔助與開腹胃癌根治術對患者圍手術期免疫功能影響的對比研究. 中國普外基礎與臨床雜志, 2014, 21(10):1232-1235.
12.	任宏偉. 腹腔鏡手術治療對直腸癌患者免疫功能的影響分析. 中華醫藥科學, 2015, 5(8):11-13.
13.	姜洪偉, 何玉寶, 王舉. 直腸癌開腹手術與腹腔鏡手術術后免疫功能的研究. 中國現代普通外科進展, 2012, 15(9):699-702.
14.	王勇, 黃鑫, 唐恬. 腹腔鏡與開腹手術對直腸癌的治療分析. 中國醫學創新, 2013, 10(34):114-116.
15.	Wieder T, Braumuller H, Kneilling M, et al. T cell-mediated-help against tumors. Cell Cycle, 2008, 7(19):2974-2977.
16.	高揚. 創傷對老年機體免疫功能的影響. 醫學綜述, 2013, 19(19): 3500-3503.
17.	蘭志偉, 趙浩亮, 賀杰峰, 等. 胸腺五肽對大鼠肝癌免疫微環境中T細胞及其亞群的影響. 中華臨床醫師雜志:電子版, 2014, 8(6):1086-1090.
18.	黃文華. 胸腺五肽注射液調節老年慢性病患者免疫功能的安全性和療效. 求醫問藥, 2012, 10(4):429-430.
19.	謝婧, 張長平, 王詠梅, 等. 胸腺五肽輔助用藥的臨床有效性循證評價. 中國新藥雜志, 2015, 24(22):2599-2605.
20.	王娟. 替比夫定聯合胸腺五肽治療慢性乙型肝炎的療效觀察. 醫學信息, 2015, 28(5):308.
21.	鄭小清, 黃錦葵, 蘇偉強, 等. 霧化吸入痰熱清注射液聯合胸腺五肽治療上呼吸道感染的療效觀察. 中國醫藥科學, 2014, 4(13): 81-83.
22.	歐陽俐穎, 廖偉, 陳映波, 等. 胸腺五肽輔助治療食管癌術后重癥肺炎的效果. 廣東醫學, 2014(17):2756-2758.
23.	宋法云, 邢志紅. 胸腺五肽聯合化療對大腸癌患者細胞免疫功能和生存期的影響研究. 中國全科醫學, 2013, 16(21):2501-2503.
24.	趙春玲. 胸腺五肽配合化療治療中晚期惡性腫瘤療效觀察. 中國營養保健, 2013, 23(4):612.
25.	柴寶, 郭亞榮. 胸腺五肽聯合化療對大腸癌患者免疫功能的影響. 山西醫藥雜志, 2012, 41(23):1229-1230.
26.	劉洪, 吳格怡, 彭文劍. 胸腺五肽在肺癌化療后緩解期的免疫調節作用. 中國現代醫藥雜志, 2012, 14(9):83-84.
27.	周瑛, 李洪永. 胸腺五肽對晚期大腸癌患者化療毒副反應的影響. 中國普通外科雜志, 2015, 24(4):597-599.

1. 王旻, 陳學博, 王歡, 等. 直腸癌擴大根治術對患者外周血中細胞免疫功能的影響. 中國實驗診斷學, 2011, 15(3):521-523.
2. 葉平江, 郭貴龍, 應曉江. 腹腔鏡與開腹結直腸癌根治術對機體免疫系統影響的比較研究.中國內鏡雜志, 2011, 17(5):478-480.
3. 郭寧寧, 王輝, 肖蘭鳳, 等. T細胞過繼免疫治療法在腫瘤疾病治療中的應用進展. 廣東藥學院學報, 2011, 27(4):441-445.
4. 李媛. 胸腺五肽治療支原體肺炎的療效分析. 中國醫學工程, 2014, 22(5):67.
5. 葉銳良. 胸腺五肽治療初治肺結核的臨床研究. 臨床肺科雜志, 2015, 20(8):1493-1496.
6. 賈果珍. 中晚期肺癌化療聯合使用胸腺五肽臨床觀察. 中國藥物與臨床, 2014, 14(8):1103-1104.
7. 何文杰, 涂長玲, 江波. 胸腺五肽對老年晚期非小細胞肺癌患者免疫功能的影響研究. 實用心腦肺血管病雜志, 2015, 23(7):72-74.
8. Bordón E, Henríquez-Hernández LA, Lara PC, et al. Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and natural killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients. Int J Radiat Biol, 2011, 87(4):424-431.
9. 王國俊, 高春芳. 腹腔鏡直腸癌全直腸系膜切除術. 中國普外基礎與臨床雜志, 2011, 18(1):92-94.
10. 汪利群, 吳勇. 腹腔鏡和開腹手術治療卵巢良性腫瘤的療效及對免疫功能的影響. 中國腫瘤臨床與康復, 2012, 19(6):515-517.
11. 劉江文, 孫琳, 仝德峰, 等. 進展期胃癌腹腔鏡輔助與開腹胃癌根治術對患者圍手術期免疫功能影響的對比研究. 中國普外基礎與臨床雜志, 2014, 21(10):1232-1235.
12. 任宏偉. 腹腔鏡手術治療對直腸癌患者免疫功能的影響分析. 中華醫藥科學, 2015, 5(8):11-13.
13. 姜洪偉, 何玉寶, 王舉. 直腸癌開腹手術與腹腔鏡手術術后免疫功能的研究. 中國現代普通外科進展, 2012, 15(9):699-702.
14. 王勇, 黃鑫, 唐恬. 腹腔鏡與開腹手術對直腸癌的治療分析. 中國醫學創新, 2013, 10(34):114-116.
15. Wieder T, Braumuller H, Kneilling M, et al. T cell-mediated-help against tumors. Cell Cycle, 2008, 7(19):2974-2977.
16. 高揚. 創傷對老年機體免疫功能的影響. 醫學綜述, 2013, 19(19): 3500-3503.
17. 蘭志偉, 趙浩亮, 賀杰峰, 等. 胸腺五肽對大鼠肝癌免疫微環境中T細胞及其亞群的影響. 中華臨床醫師雜志:電子版, 2014, 8(6):1086-1090.
18. 黃文華. 胸腺五肽注射液調節老年慢性病患者免疫功能的安全性和療效. 求醫問藥, 2012, 10(4):429-430.
19. 謝婧, 張長平, 王詠梅, 等. 胸腺五肽輔助用藥的臨床有效性循證評價. 中國新藥雜志, 2015, 24(22):2599-2605.
20. 王娟. 替比夫定聯合胸腺五肽治療慢性乙型肝炎的療效觀察. 醫學信息, 2015, 28(5):308.
21. 鄭小清, 黃錦葵, 蘇偉強, 等. 霧化吸入痰熱清注射液聯合胸腺五肽治療上呼吸道感染的療效觀察. 中國醫藥科學, 2014, 4(13): 81-83.
22. 歐陽俐穎, 廖偉, 陳映波, 等. 胸腺五肽輔助治療食管癌術后重癥肺炎的效果. 廣東醫學, 2014(17):2756-2758.
23. 宋法云, 邢志紅. 胸腺五肽聯合化療對大腸癌患者細胞免疫功能和生存期的影響研究. 中國全科醫學, 2013, 16(21):2501-2503.
24. 趙春玲. 胸腺五肽配合化療治療中晚期惡性腫瘤療效觀察. 中國營養保健, 2013, 23(4):612.
25. 柴寶, 郭亞榮. 胸腺五肽聯合化療對大腸癌患者免疫功能的影響. 山西醫藥雜志, 2012, 41(23):1229-1230.
26. 劉洪, 吳格怡, 彭文劍. 胸腺五肽在肺癌化療后緩解期的免疫調節作用. 中國現代醫藥雜志, 2012, 14(9):83-84.
27. 周瑛, 李洪永. 胸腺五肽對晚期大腸癌患者化療毒副反應的影響. 中國普通外科雜志, 2015, 24(4):597-599.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma

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