Progress of Clinical Treatment of Hepatic Alveolar Echinococcosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LUYue-qing ¹ , DENGYong ^2,3 , ZHANGLing-qiang ^2,3 , ZHOUYing ^2,3 , RENLi ^2,3 , YANGDANCairang ^2,3 , HOULizhao ^2,3 , WENHao ⁴ , WANGHai-jiu ^2,3 ,  FANHai-ning ^2,3

1. Medical College of Qinghai University, Xining 810001, Qinghai Province, China;
2. Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China;
3. Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, Qinghai Province, China;
4. The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China;

Corresponding?author：

FANHai-ning, Email: fanhaining@medmail.com.cn

Keywords：

Hepatic alveolar echinococcosis; surgical treatment; Liver transplantation; Chemical treatment

DOI：

10.7507/1007-9424.20160147

Video：

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Objective To summarize clinical treatments of hepatic alveolar echinococcosis in recent years and provide a new basis for guiding clinical practice. Methods The relevant literatures about treating hepatic alveolar echinococcosis at home and abroad were reviewed. The clinical curative effect and advantages or disadvantages among various treatments were analyzed. Results The radical surgery was still the primary treatment of hepatic alveolar echinococcosis, liver transplantation was more used in the treatment of the late hepatic alveolar echinococcosis. surgery combined with chemical therapy had an obvously clinical curative effect. Conclusions With a high incidence and poor prognosis of hepatic alveolar echinococcosis, it is difficult to cure. Radical surgery, liver transplantation, chemotherapy and radiation therapy have been used in clinical treatment of hepatic alveolar echinococcosis. It is essential to fully acknowledge indications of various treatments. At the same time, if occurrence and development of this disease could be further researched, it might bring us a new hope of curing hepatic alveolar echinococcosis.

Citation： LUYue-qing, DENGYong, ZHANGLing-qiang, ZHOUYing, RENLi, YANGDANCairang, HOULizhao, WENHao, WANGHai-jiu, FANHai-ning. Progress of Clinical Treatment of Hepatic Alveolar Echinococcosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 547-551. doi: 10.7507/1007-9424.20160147 Copy

1.	?邵英梅, 蔣鐵民, 吐爾干艾力·阿吉, 等. 根治性及準根治性手術治療終末期肝泡型包蟲病. 中華消化外科雜志, 2011, 10(4):296-298.
2.	McManus DP, Zhang W, Li J, et al. Echinococcosis. Lancet, 2003, 362(9392):1295-1304.
3.	Buttenschoen K, Carli Buttenschoen D, Gruener B, et al. Long-term experience on surgical treatment of alveolar echinococcosis. Langenbecks Arch Surg, 2009, 394(4):689-698.
4.	溫浩. 兩型肝包蟲病手術療效547例臨床分析. 中華消化外科雜志, 2007, 6(1):13-18.
5.	阿依甫汗·阿汗, 吐爾干艾力, 邵英梅, 等. 肝包蟲病的外科治療現狀. 肝膽外科雜志, 2009, 17(1):13-14.
6.	溫浩, 劉文亞, 邵英梅, 等. 包蟲病影像診斷技術和手術治療進展. 國際醫學寄生蟲病學雜志, 2009, 36(5):299-306.
7.	Alonso Casado O, Moreno González E, Loinaz segurola C, et al. Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepatogastroenterology, 2001, 48(37):235-243.
8.	姚秉禮. 肝泡脹狀棘球蚴的診斷和治療. 中華外科雜志, 1965, 13(6):461.
9.	邵英梅, 蔣鐵民, 吐爾干·艾力, 等. 根治性及準根治性手術治療終末期肝泡型包蟲病. 中華消化外科雜志, 2011, 10(4):296-298.
10.	張瑞青, 邵英梅. 肝泡型包蟲病不同手術方式的臨床療效分析. 新疆醫科大學, 2013:3.
11.	Aydin U, Yazici P, Onen Z, et al. The optimal treatment of hydatid cyst of the liver:radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol, 2008, 19(1):33-39.
12.	Tagliacozzo s, Miccini M, Amore Bonapasta s, et al. surgical treatment of hydatid disease of the liver:25 years of experience. Am J Surg, 2011, 201(6):797-804.
13.	Kadry Z, Renner EC, Bachmann LM, et al. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg, 2005, 92(9):1110-1116.
14.	羅蘭云, 姚豫桐, 鄒海波, 等."掏核式肝切除法"治療晚期巨大肝泡型包蟲病9例臨床分析. 實用醫院臨床雜志, 2015, 12(2):56-58.
15.	李作安, 吐爾干艾力·阿吉, 冉博, 等."減體積式病灶肝切除" 治療晚期肝巨大泡型包蟲病的臨床應用. 中國普通外科雜志, 2012, 21(7):864-868.
16.	Katkhouda N, Fabiani P, Benizri E, et al. Laser resection of a liver hydatid cyst under video laparoscopy. Br J Surg, 1992, 79(6):560-561.
17.	Nari GA, Palacios Rodriguez ó, Russo N, et al. Laparoscopic approach to liver hydatidosis:initial experience. Cir Esp, 2015, 93(4):248-251.
18.	Gillet M, Miguet JP, Mantion G, et al. Orthotopic liver transplantation in alveolar echinococcosis of the liver:analysis of a series of six patients. Transplant Proc, 1988, 20(1 suppl 1):573-576.
19.	溫浩, 欒梅香, 王喜燕, 等. 國內首例肝移植治療肝泡型包蟲病報告. 地方病通報, 2001, 16(3):100.
20.	Bresson-Hadni s, Koch s, Miguet JP, et al. Indications and results of liver transplantation for Echinococcus alveolar infection:an overview. Langenbecks Arch Surg, 2003, 388(4):231-238.
21.	溫浩. 肝包蟲病診斷和手術技術治療新進展. 中華消化外科雜志, 2011, 10(4):290-292.
22.	溫浩, 董家鴻, 張金輝, 等. 體外肝切除聯合自體肝移植治療肝泡型包蟲病. 中華消化外科雜志, 2011, 10(2):148-149.
23.	王海, 景鴻恩, 徐小青, 等. 自體肝臟移植治療晚期泡型肝包蟲病. 腹部外科, 2011, 24(2):99-100.
24.	WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ, 1996, 74(3):231-242.
25.	Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop, 2010, 114(1):1-16.
26.	Wen H, New RR, Muhmut M, et al. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology, 1996, 113(Pt 2):111-121.
27.	Cobo F, Yarnoz C, sesma B, et al. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intraabdominal hydatisosis caused by echinococcus granulosus. Trop Med Int Health, 1998, 3(6):462-466.
28.	Kern P, Abboud P, Kern WV, stich A, et al. Critical appraisal of nitazoxanide for the treatment of alveolar echinococcosis. Am J Trop Med Hyg, 2008, 79(1):119.
29.	Tappe D, Müller A, Frosch M, et al. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol, 2009, 103(2):177-181.
30.	宋書邦. 人體包蟲病的超聲引導穿刺硬化治療. 中國超聲醫學雜志, 1996, 12(增刊):60-62.
31.	Karaman B, Battal B, Ustunsoz B, et al. Percutaneous treatment of a primary pancreatic hydatid cyst using a catheterization technique. Korean J Radiol, 2012, 13(2):232-236.
32.	Brunetti E, Filice C. Radiofrequency thermal ablation of echinococcal liver cysts. Lancet, 2001, 358(9291):1464.
33.	Bastid C, Ayela P, sahel J. Percutaneous treatment of a complex hydatid cyst of the liver under sonographic control. Report of the first case. Gastroenterol Clin Biol, 2005, 29(2):191-192.
34.	Du XL, Ma QJ, Wu T, et al. Treatment of hepatic cysts by B-ultrasoundguided radiofrequency ablation. Hepatobiliary Pancreat Dis Int, 2007, 6(3):330-332.
35.	Papaconstantinou I, Kontos M, Prassas E, et al. Radio frequency ablation (RFA)-assisted pericystectomy for hepatic echinococcosis:an alternative technique. Surg Laparosc Endosc Percutan Tech, 2006, 16(5):338-341.
36.	Zacharoulis D, Poultsidis A, Roundas C, et al. Liver hydatid disease:radiofrequency-assisted pericystectomy. Ann R Coll Surg Engl, 2006, 88(5):499-500.
37.	Vuitton DA, Millon L, Gottstein B, et al. Proceedings of the International symposium-Innovation for the management of echinococcosis. Besan?on, March 27-29, 2014. Parasite, 2014, 21:28.
38.	張永國, 張成武, 竇拉加. 高強度聚焦超聲治療巨大肝泡球蚴病一例. 中國寄生蟲學與寄生蟲病雜志, 2005, 23(4):256.
39.	葉華, 王煒, 景濤, 等. 復頻高能聚焦超聲治療小鼠泡球蚴病的實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(5):353-357.
40.	陳亮. 包蟲病放射治療的研究進展. 新疆醫科大學學報, 2013, 36(4):557-559.
41.	Ulger s, Barut H, Tunc M, et al. Radiation therapy for resistant sternal hydatid disease. Strahlenther Onkol, 2013, 189(6):508-509.
42.	包永星, 張月芬, 倪雅瓊, 等. 電子線治療大鼠繼發性泡球蚴病的實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(2):127-129.
43.	包永星, 毛睿, 齊洪志, 等. X線照射泡球蚴原頭節的體外實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(3):208-211.
44.	包永星, 毛睿, 謝增如, 等. 放射治療骨棘球蚴病一例. 中國寄生蟲學與寄生蟲病雜志, 2010, 28(4):F0003.
45.	王欣, 王小虎, 包根書, 等. 放射線治療包蟲病的實驗研究. 中國人獸共患病學報, 2009, 25(7):653-656.
46.	schmid M, Pendl G, samonigg H, et al. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis, 1998, 26(6):1379-1382.
47.	Zhang YF, Xie ZR, Ni YQ, et al. Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats. Chin Med J (Engl), 2011, 124(18):2845-2848.
48.	Gschwantler M, Brownstone E, Erben WD, et al. Combined endoscopic and pharmaceutical treatment of alveolar echinococcosis with rupture into the biliary tree. Gastrointest Endosc, 1994, 40(2 Pt 1):238-241.
49.	Adas G, Arikan s, Gurbuz E, et al. Comparison of endoscopic therapeutic modalities for postoperative biliary fistula of liver hydatid cyst:a retrospective multicentric study. Surg Laparosc Endosc Percutan Tech, 2010, 20(4):223-227.
50.	Akbulut s, senol A, sezgin A, et al. Radical vs conservative surgery for hydatid liver cysts:experience from single center. World J Gastroenterol, 2010, 16(8):953-959.
51.	Krasniqi A, Bicaj B, Limani D, et al. The role of perioperative endoscopic retrograde cholangiopancreatography and biliary drainage in large liver hydatid cysts. Sci World J, 2014, 2014:301891.
52.	王科燕, 杜新遠, 張永軍, 等. 中草藥治療棘球蚴病的研究概況. 西北藥學雜志, 2009, 24(3):240-242.

1. ?邵英梅, 蔣鐵民, 吐爾干艾力·阿吉, 等. 根治性及準根治性手術治療終末期肝泡型包蟲病. 中華消化外科雜志, 2011, 10(4):296-298.
2. McManus DP, Zhang W, Li J, et al. Echinococcosis. Lancet, 2003, 362(9392):1295-1304.
3. Buttenschoen K, Carli Buttenschoen D, Gruener B, et al. Long-term experience on surgical treatment of alveolar echinococcosis. Langenbecks Arch Surg, 2009, 394(4):689-698.
4. 溫浩. 兩型肝包蟲病手術療效547例臨床分析. 中華消化外科雜志, 2007, 6(1):13-18.
5. 阿依甫汗·阿汗, 吐爾干艾力, 邵英梅, 等. 肝包蟲病的外科治療現狀. 肝膽外科雜志, 2009, 17(1):13-14.
6. 溫浩, 劉文亞, 邵英梅, 等. 包蟲病影像診斷技術和手術治療進展. 國際醫學寄生蟲病學雜志, 2009, 36(5):299-306.
7. Alonso Casado O, Moreno González E, Loinaz segurola C, et al. Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepatogastroenterology, 2001, 48(37):235-243.
8. 姚秉禮. 肝泡脹狀棘球蚴的診斷和治療. 中華外科雜志, 1965, 13(6):461.
9. 邵英梅, 蔣鐵民, 吐爾干·艾力, 等. 根治性及準根治性手術治療終末期肝泡型包蟲病. 中華消化外科雜志, 2011, 10(4):296-298.
10. 張瑞青, 邵英梅. 肝泡型包蟲病不同手術方式的臨床療效分析. 新疆醫科大學, 2013:3.
11. Aydin U, Yazici P, Onen Z, et al. The optimal treatment of hydatid cyst of the liver:radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol, 2008, 19(1):33-39.
12. Tagliacozzo s, Miccini M, Amore Bonapasta s, et al. surgical treatment of hydatid disease of the liver:25 years of experience. Am J Surg, 2011, 201(6):797-804.
13. Kadry Z, Renner EC, Bachmann LM, et al. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg, 2005, 92(9):1110-1116.
14. 羅蘭云, 姚豫桐, 鄒海波, 等."掏核式肝切除法"治療晚期巨大肝泡型包蟲病9例臨床分析. 實用醫院臨床雜志, 2015, 12(2):56-58.
15. 李作安, 吐爾干艾力·阿吉, 冉博, 等."減體積式病灶肝切除" 治療晚期肝巨大泡型包蟲病的臨床應用. 中國普通外科雜志, 2012, 21(7):864-868.
16. Katkhouda N, Fabiani P, Benizri E, et al. Laser resection of a liver hydatid cyst under video laparoscopy. Br J Surg, 1992, 79(6):560-561.
17. Nari GA, Palacios Rodriguez ó, Russo N, et al. Laparoscopic approach to liver hydatidosis:initial experience. Cir Esp, 2015, 93(4):248-251.
18. Gillet M, Miguet JP, Mantion G, et al. Orthotopic liver transplantation in alveolar echinococcosis of the liver:analysis of a series of six patients. Transplant Proc, 1988, 20(1 suppl 1):573-576.
19. 溫浩, 欒梅香, 王喜燕, 等. 國內首例肝移植治療肝泡型包蟲病報告. 地方病通報, 2001, 16(3):100.
20. Bresson-Hadni s, Koch s, Miguet JP, et al. Indications and results of liver transplantation for Echinococcus alveolar infection:an overview. Langenbecks Arch Surg, 2003, 388(4):231-238.
21. 溫浩. 肝包蟲病診斷和手術技術治療新進展. 中華消化外科雜志, 2011, 10(4):290-292.
22. 溫浩, 董家鴻, 張金輝, 等. 體外肝切除聯合自體肝移植治療肝泡型包蟲病. 中華消化外科雜志, 2011, 10(2):148-149.
23. 王海, 景鴻恩, 徐小青, 等. 自體肝臟移植治療晚期泡型肝包蟲病. 腹部外科, 2011, 24(2):99-100.
24. WHO Informal Working Group on Echinococcosis. Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull World Health Organ, 1996, 74(3):231-242.
25. Brunetti E, Kern P, Vuitton DA; Writing Panel for the WHO-IWGE. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop, 2010, 114(1):1-16.
26. Wen H, New RR, Muhmut M, et al. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology, 1996, 113(Pt 2):111-121.
27. Cobo F, Yarnoz C, sesma B, et al. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intraabdominal hydatisosis caused by echinococcus granulosus. Trop Med Int Health, 1998, 3(6):462-466.
28. Kern P, Abboud P, Kern WV, stich A, et al. Critical appraisal of nitazoxanide for the treatment of alveolar echinococcosis. Am J Trop Med Hyg, 2008, 79(1):119.
29. Tappe D, Müller A, Frosch M, et al. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol, 2009, 103(2):177-181.
30. 宋書邦. 人體包蟲病的超聲引導穿刺硬化治療. 中國超聲醫學雜志, 1996, 12(增刊):60-62.
31. Karaman B, Battal B, Ustunsoz B, et al. Percutaneous treatment of a primary pancreatic hydatid cyst using a catheterization technique. Korean J Radiol, 2012, 13(2):232-236.
32. Brunetti E, Filice C. Radiofrequency thermal ablation of echinococcal liver cysts. Lancet, 2001, 358(9291):1464.
33. Bastid C, Ayela P, sahel J. Percutaneous treatment of a complex hydatid cyst of the liver under sonographic control. Report of the first case. Gastroenterol Clin Biol, 2005, 29(2):191-192.
34. Du XL, Ma QJ, Wu T, et al. Treatment of hepatic cysts by B-ultrasoundguided radiofrequency ablation. Hepatobiliary Pancreat Dis Int, 2007, 6(3):330-332.
35. Papaconstantinou I, Kontos M, Prassas E, et al. Radio frequency ablation (RFA)-assisted pericystectomy for hepatic echinococcosis:an alternative technique. Surg Laparosc Endosc Percutan Tech, 2006, 16(5):338-341.
36. Zacharoulis D, Poultsidis A, Roundas C, et al. Liver hydatid disease:radiofrequency-assisted pericystectomy. Ann R Coll Surg Engl, 2006, 88(5):499-500.
37. Vuitton DA, Millon L, Gottstein B, et al. Proceedings of the International symposium-Innovation for the management of echinococcosis. Besan?on, March 27-29, 2014. Parasite, 2014, 21:28.
38. 張永國, 張成武, 竇拉加. 高強度聚焦超聲治療巨大肝泡球蚴病一例. 中國寄生蟲學與寄生蟲病雜志, 2005, 23(4):256.
39. 葉華, 王煒, 景濤, 等. 復頻高能聚焦超聲治療小鼠泡球蚴病的實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(5):353-357.
40. 陳亮. 包蟲病放射治療的研究進展. 新疆醫科大學學報, 2013, 36(4):557-559.
41. Ulger s, Barut H, Tunc M, et al. Radiation therapy for resistant sternal hydatid disease. Strahlenther Onkol, 2013, 189(6):508-509.
42. 包永星, 張月芬, 倪雅瓊, 等. 電子線治療大鼠繼發性泡球蚴病的實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(2):127-129.
43. 包永星, 毛睿, 齊洪志, 等. X線照射泡球蚴原頭節的體外實驗研究. 中國寄生蟲學與寄生蟲病雜志, 2011, 29(3):208-211.
44. 包永星, 毛睿, 謝增如, 等. 放射治療骨棘球蚴病一例. 中國寄生蟲學與寄生蟲病雜志, 2010, 28(4):F0003.
45. 王欣, 王小虎, 包根書, 等. 放射線治療包蟲病的實驗研究. 中國人獸共患病學報, 2009, 25(7):653-656.
46. schmid M, Pendl G, samonigg H, et al. Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis, 1998, 26(6):1379-1382.
47. Zhang YF, Xie ZR, Ni YQ, et al. Curative effect of radiotherapy at various doses on subcutaneous alveolar echinococcosis in rats. Chin Med J (Engl), 2011, 124(18):2845-2848.
48. Gschwantler M, Brownstone E, Erben WD, et al. Combined endoscopic and pharmaceutical treatment of alveolar echinococcosis with rupture into the biliary tree. Gastrointest Endosc, 1994, 40(2 Pt 1):238-241.
49. Adas G, Arikan s, Gurbuz E, et al. Comparison of endoscopic therapeutic modalities for postoperative biliary fistula of liver hydatid cyst:a retrospective multicentric study. Surg Laparosc Endosc Percutan Tech, 2010, 20(4):223-227.
50. Akbulut s, senol A, sezgin A, et al. Radical vs conservative surgery for hydatid liver cysts:experience from single center. World J Gastroenterol, 2010, 16(8):953-959.
51. Krasniqi A, Bicaj B, Limani D, et al. The role of perioperative endoscopic retrograde cholangiopancreatography and biliary drainage in large liver hydatid cysts. Sci World J, 2014, 2014:301891.
52. 王科燕, 杜新遠, 張永軍, 等. 中草藥治療棘球蚴病的研究概況. 西北藥學雜志, 2009, 24(3):240-242.

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Progress of Clinical Treatment of Hepatic Alveolar Echinococcosis

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