The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 NIULu-wei ¹ , LIUHao ² , WANGKai ² , FUHai-xiao ² ,  FUWei ²

1. The Graduate School of Xuzhou Medical College, Xuzhou, 221000, Jiangsu Province, China;
2. Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221000, Jiangsu Province, China;

Corresponding?author：

FUWei, Email: master-fuwei@163.com

Keywords：

Neuroendocrine neoplasm; Gastrointestinal; Surgery

DOI：

10.7507/1007-9424.20160124

Video：

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Objective To investigate the clinical characteristic and treatment of gastrointestinal neuroendocrine neoplasm. Methods From January 2011 to July 2015, the clinical characteristic and treatment of 74 patients with gastrointestinal neuroendocrine neoplasm in The Affiliated Hospital of Xuzhou Medical College were retrospectively analyzed. Results Cases of gastrointestinal neuroendocrine neoplasm were increasing year by year. This study includes statistics of 74 patients. The number of male and female were 47 and 27, the rate was 1.74:1, the median age was 57.5 years old ranging from 24 up to 82 years. Of all the 74 cases, there were 38 cases (51.4%) in the stomach, 23 cases (31.1%) in rectum, 12 cases (16.2%) in colon, 1 case in duodenum. Of all the 74 cases with clinical symptom information, non-functional symptom accounts for 95.9% (71/74), while functional symptom accounts only for 4.1% (3/74). There were treatment data of 74 cases, including 34 cases in radical surgery, 23 cases in endoscopic excision, 8 cases in local resection, 4 cases in palliative resection, and 5cases in conservative treatment. The lymphatic metastasis was associated with gender, tumor size, tumor depth of invasion and tumor differentiation (P < 0.05). There was no statistically significant between the lymphatic metastasis and tumor location (P > 0.05). Preoperative distant metastasis was associated with tumor size and tumor depth of invasion (P < 0.05). Syn had a higher positive rate than CgA (P < 0.01). The positive rate of Syn and CgA was respectively 96.1% (49/51) and 72.9% (35/48). Conciusions Cases of gastrointestinal neuroendocrine neoplasm are increasing year by year, of which men has a higher morbidity than women. Radical surgery and endoscopic resection are the main treatment methods. The Syn and CgA test are helpful to the diagnosis of gastrointestinal neuroendocrine neoplasm.

Citation： NIULu-wei, LIUHao, WANGKai, FUHai-xiao, FUWei. The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 467-471. doi: 10.7507/1007-9424.20160124 Copy

1.	Massironi S, Sciola V, Peracchi M, et al. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol, 2008, 14(35):5377-5384.
2.	Niederle MB, Hackl M, Kaserer K, et al. Gastroenteropancreatic neumendocrine tumours:the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification:an analysis based on prospectively collected parameters. Endocr Relat Cancer, 2010, 17(4):909-918.
3.	朱雄增.胃腸胰神經內分泌腫瘤新分類的臨床意義.中華胃腸外科雜志, 2013, 16(1):12-14.
4.	Lawrence B, Gustafsson BI, Chan A, et al. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am, 2011, 40(1):1-18.
5.	Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid":epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States. J Clin Oncol, 2008, 26(18):3063-3072.
6.	葉郁紅, 張聲, 王行富, 等. 90例胃腸道神經內分泌腫瘤病理學重新診斷評估.華中科技大學學報:醫學版, 2012, 41(4):440-444.
7.	依荷芭麗·遲, 姜文昌, 杜豐, 等.神經內分泌瘤252例臨床分析.中華腫瘤雜志, 2013, 35(1):67-70.
8.	張輝亮. 113例胃腸道神經內分泌腫瘤臨床病理及預后分析.山東大學, 2014.
9.	王霄, 宋爭放, 姚文秀, 等.胃腸胰神經內分泌瘤的臨床病理特點及預后的多因素分析.中華醫學雜志, 2013, 93(18):1411-1414.
10.	郭林杰, 唐承薇.中國胃腸胰神經內分泌腫瘤臨床研究現狀分析.胃腸病學, 2012, 17(5):276-278.
11.	劉忠, 李俊強, 田大宇, 等.消化系統神經內分泌腫瘤29例臨床分析.中華胃腸外科雜志, 2013, 16(11):1084-1087.
12.	龔海燕, 戈偉, 蔣松松, 等. 70例胃腸胰神經內分泌腫瘤的診治分析.中國普外基礎與臨床雜志, 2014, 21(9):1145-1148.
13.	高巍, 劉尚梅, 魯海珍, 等.腸道神經內分泌腫瘤的臨床病理特點及預后分析.中華腫瘤雜志, 2012, 34(6):450-456.
14.	王鈺虹, 林原, 薛玲, 等. 87例胃腸胰神經內分泌腫瘤的診治分析.中華消化雜志, 2011, 31(8):531-535.
15.	潘定宇, 孫來寶, 陳紀偉, 等.胃腸道神經內分泌癌診治分析.武漢大學學報:醫學版, 2002, 23(3):238-240.
16.	Sarmiento JM, Heywood G, Rubin J, et al. Surgical treatment of neuroendocrine metastases to the liver:a plea for resection to increase survival. J Am Coll Surg, 2003, 197(1):29-37.
17.	陳偉偉, 谷云飛, 陳邑岐.直腸神經內分泌腫瘤16例臨床分析.中國普外基礎與臨床雜志, 2014, 21(12):1576-1578.
18.	馮金燕, 伍曉汀.胃腸道神經內分泌腫瘤的診療進展.中國普外基礎與臨床雜志, 2013, 20(3):334-339.
19.	王輝, 宋軍, 徐為, 等. 15例胃腸道類癌的診治分析.徐州醫學院學報, 2012, 32(4):254-255.
20.	高茹, 高峰, 張杰, 等.消化道類癌38例的臨床分析.中華臨床醫師雜志:電子版, 2012, 6(14):4096-4098.
21.	王化冰, 王連鵬.直腸神經內分泌腫瘤的臨床病理特點分析.中華醫學雜志, 2010, 90(24):1686-1689.
22.	朱軍, 丁健華, 趙克, 等.直腸類癌預后影響因素分析.中國普外基礎與臨床雜志, 2012, 19(4):387-390.
23.	Soga J. Early-stage carcinoids of the gastrointestinal tract:an analysis of 1 914 reported cases. Cancer, 2005, 103(8):1587-1595.
24.	Hodul PJ, Strosberg JR, Kvols LK. Aggressive surgical resection in the management of pancreatic neuroendocrine tumors:when is it indicated. Cancer Control, 2008, 15(4):314-321.
25.	Rindi G, D'Adda T, Froio E, et al.Prognostic factors in gastrointestinal endocrine tumors. Endocr Pathol, 2007, 18(3):145-149.

1. Massironi S, Sciola V, Peracchi M, et al. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol, 2008, 14(35):5377-5384.
2. Niederle MB, Hackl M, Kaserer K, et al. Gastroenteropancreatic neumendocrine tumours:the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification:an analysis based on prospectively collected parameters. Endocr Relat Cancer, 2010, 17(4):909-918.
3. 朱雄增.胃腸胰神經內分泌腫瘤新分類的臨床意義.中華胃腸外科雜志, 2013, 16(1):12-14.
4. Lawrence B, Gustafsson BI, Chan A, et al. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am, 2011, 40(1):1-18.
5. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid":epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States. J Clin Oncol, 2008, 26(18):3063-3072.
6. 葉郁紅, 張聲, 王行富, 等. 90例胃腸道神經內分泌腫瘤病理學重新診斷評估.華中科技大學學報:醫學版, 2012, 41(4):440-444.
7. 依荷芭麗·遲, 姜文昌, 杜豐, 等.神經內分泌瘤252例臨床分析.中華腫瘤雜志, 2013, 35(1):67-70.
8. 張輝亮. 113例胃腸道神經內分泌腫瘤臨床病理及預后分析.山東大學, 2014.
9. 王霄, 宋爭放, 姚文秀, 等.胃腸胰神經內分泌瘤的臨床病理特點及預后的多因素分析.中華醫學雜志, 2013, 93(18):1411-1414.
10. 郭林杰, 唐承薇.中國胃腸胰神經內分泌腫瘤臨床研究現狀分析.胃腸病學, 2012, 17(5):276-278.
11. 劉忠, 李俊強, 田大宇, 等.消化系統神經內分泌腫瘤29例臨床分析.中華胃腸外科雜志, 2013, 16(11):1084-1087.
12. 龔海燕, 戈偉, 蔣松松, 等. 70例胃腸胰神經內分泌腫瘤的診治分析.中國普外基礎與臨床雜志, 2014, 21(9):1145-1148.
13. 高巍, 劉尚梅, 魯海珍, 等.腸道神經內分泌腫瘤的臨床病理特點及預后分析.中華腫瘤雜志, 2012, 34(6):450-456.
14. 王鈺虹, 林原, 薛玲, 等. 87例胃腸胰神經內分泌腫瘤的診治分析.中華消化雜志, 2011, 31(8):531-535.
15. 潘定宇, 孫來寶, 陳紀偉, 等.胃腸道神經內分泌癌診治分析.武漢大學學報:醫學版, 2002, 23(3):238-240.
16. Sarmiento JM, Heywood G, Rubin J, et al. Surgical treatment of neuroendocrine metastases to the liver:a plea for resection to increase survival. J Am Coll Surg, 2003, 197(1):29-37.
17. 陳偉偉, 谷云飛, 陳邑岐.直腸神經內分泌腫瘤16例臨床分析.中國普外基礎與臨床雜志, 2014, 21(12):1576-1578.
18. 馮金燕, 伍曉汀.胃腸道神經內分泌腫瘤的診療進展.中國普外基礎與臨床雜志, 2013, 20(3):334-339.
19. 王輝, 宋軍, 徐為, 等. 15例胃腸道類癌的診治分析.徐州醫學院學報, 2012, 32(4):254-255.
20. 高茹, 高峰, 張杰, 等.消化道類癌38例的臨床分析.中華臨床醫師雜志:電子版, 2012, 6(14):4096-4098.
21. 王化冰, 王連鵬.直腸神經內分泌腫瘤的臨床病理特點分析.中華醫學雜志, 2010, 90(24):1686-1689.
22. 朱軍, 丁健華, 趙克, 等.直腸類癌預后影響因素分析.中國普外基礎與臨床雜志, 2012, 19(4):387-390.
23. Soga J. Early-stage carcinoids of the gastrointestinal tract:an analysis of 1 914 reported cases. Cancer, 2005, 103(8):1587-1595.
24. Hodul PJ, Strosberg JR, Kvols LK. Aggressive surgical resection in the management of pancreatic neuroendocrine tumors:when is it indicated. Cancer Control, 2008, 15(4):314-321.
25. Rindi G, D'Adda T, Froio E, et al.Prognostic factors in gastrointestinal endocrine tumors. Endocr Pathol, 2007, 18(3):145-149.

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The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm

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