The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHOULin , WANGHuan ,  LIANGDao-ming , WANBao-sheng , WANGHua , SUNFeng

Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China;

Corresponding?author：

LIANGDao-ming, Email: daoming-liang@sina.cn

Keywords：

Gastric Cancer; Tumor marker; Preoperative staging

DOI：

10.7507/1007-9424.20160113

Video：

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Objective To study the preoperative evaluation value of serum tumor markers (CA72-4, CEA, CA199 and CA125) in patients with gastric cancer. Methods Serum levels of tumor markers (CA72-4, CEA, CA199 and CA125) and clinical pathological data of 70 patients with gastric cancer before operation who underwent surgical treatment in the Gastrointestinal Surgery Department of Second Affiliated Hospital of Kunming Medical University in June 2013 to 2014 June were retrospectively analyzed. Results There were some connection between the concentration of the serum CA72-4 and the tumor diameter, TNM staging, invasion depth, and the number of lymph node metastasis (P < 0.05), between CA199 and tumor size, TNM staging, and invasion depth (P < 0.05), between CEA, CA125 and tumor diameter, TNM staging and distant metastasis (P < 0.05), but the CA72-4, CA72-4, CEA and CA125 had nothing to do with patient' age and gender. Conclusion The serum tumor markers of CA724, CEA, CA199, and CA125 have clinical application value in preoperative evaluation of gastric cancer.

Citation： ZHOULin, WANGHuan, LIANGDao-ming, WANBao-sheng, WANGHua, SUNFeng. The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 425-428. doi: 10.7507/1007-9424.20160113 Copy

1.	Choi SR, Jang JS, Lee JH, et al. Role of serum tumor markers in moni toring for recurrence of gastric cancer following radical gastrectomy. Dig Dis Sci, 2006, 51(11): 2081-2086.
2.	劉英強, 姬社青, 龔建平, 等.多層螺旋CT在胃癌術前分期及評估中的應用價值.中華實用診斷與治療雜志, 2010, 24(4): 364-367.
3.	楊小波, 鄒亮, 章園.腫瘤標志物在胃癌治療及預后判斷應用中的研究進展.中國普通外科雜志, 2013, 22(10): 1334-1337.
4.	王洋, 王歡, 莫佳美, 等.血清腫瘤標志物在胃癌診斷中的價值.現代腫瘤醫學, 2014, 22(4): 883-885.
5.	張金鋒.血清胃蛋白酶原、CEA、CA199及CA72-4檢測對胃癌的診斷價值探討.檢驗醫學, 2014, (8): 831-834．.
6.	張軍華, 李中.聯合檢測血清CEA、CA199、CA50、CA72-4水平對胃癌的臨床診斷價值.實用臨床醫藥雜志, 2014, 18(5): 1-3．.
7.	金秀穎, 孫紅花, 金永民, 等.聯合檢測CEA、CA199在D2胃癌術后隨訪中的價值.現代腫瘤醫學, 2014, 22(6): 1360-1362．.
8.	Fernandes LL, Martins LC, Nagashime CA, et al. CA72-4 antigen levels in serum and peritoneal washing in gastric cancer:Correla tion with morphological aspects of neoplasia. Arq Gastroenterol, 2007, 44(3): 235-239．.
9.	Zou L, Qian J. Decline of serum CA72-4 as aprobable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma. Chin J Cancer Res, 2014, 26(4): 404-409.
10.	盛衛忠, 張延偉, 張軼斌.血清CA72-4、CA19-9及CEA免疫放射量度分析在胃癌診治中的意義.上海醫科大學學報, 2000, 27(2): 94-97.
11.	郭花, 朱金水, 朱勵, 等.腫瘤標志物對胃癌診斷應用價值的比較.中國臨床醫學, 2009, 16(3): 369-371.
12.	Ubukata H, Katano M, Motohashi G, et al. Evaluation of CA72-4 as a tumor marker in patients with gastric cancer. Gan To Kagaku Ryoho, 2003, 30(11): 1821-1824．.
13.	Mattar R, Andrade CR, Difavero GM, et al. Preoperative serum levels of CA 72-4, CEA, CA 19-9 and alpha-fetoprotein in patients with gastric cancer. Rev Hosp Clin Fac Med Sao Paulo, 2002, 57(3): 89-92.
14.	Ikeguchi M, Katano K, Saitou H, et al. Pre-operative serum levels of CA72-4 in patientswith gastric adenocarcinoma. Hepatogastroen terology, 1997, 44(15): 866-871.
15.	Kanellos I, Zacharakis E, Kanellos D, et al. Prognositic significance of CEA levels and detection of CEAmRNA in draining venous blood in patients with colorectal cancer. Surg Oncol, 2006, 94(1): 3-8.
16.	Miyazono F, Natsugoe S, Takao S, et al. Surgical maneuvers enhance molecular detection of circulating tumor cells during gastric cancer surgery. Ann Surg, 2001, 233(2): 189-194.
17.	Ikeda Y, Mori M, Kajiyama K, et al. Indicative value of carcinoem bryonic antigen (CEA) for liver recurrence following curative resec tion of stageⅡandⅢgastric cancer. Hepatogastroenterology, 1996, 43(11): 1281-1287.
18.	張永樂, 薛英威, 藍秀文, 等.腫瘤標記物CAl99、CEA對胃癌轉移和預后預測價值的分析.哈爾濱醫科大學學報, 2010, 44(2):181-184．.
19.	Pectasides D, Myloanlakis A, Kostopouiou M, et al. CEA, CA19-9 and CA-50 in monitoring gastric carcinoma. Am J Clin Oncol, 1997, 20(4): 348-353.
20.	Kochi M, Fuji M, Kanamor N, et al. Evalution of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. GastricCancer, 2003, 3(4): 177-186.
21.	李巖.血清胃癌腫瘤標志物的臨床價值.繼續醫學教育, 2006, 20(3): 58-63.
22.	Yang SH. Risk factors for peritoneal dissemination of colorectal cancer. Surg Oncol, 2004, 87(4):167-173.
23.	Takahashi Y. Gastrointestinal cancer. Gan To Kagaku Ryoho, 2004, 31(8): 1275-1279．.
24.	張燕華, 李雁, 陳創, 等.多種腫瘤標志物與胃癌進展及預后的關系.武漢大學學報:醫學版, 2009, 30(4): 455-462．.
25.	Lai IR, Lee WJ, Huang MT, et al. Comparison of serumCA72-4, CEA, TPA, CAl9-9 and CAl25 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology, 2002, 49(46): 1157-1160．.
26.	余志金, 陳惠新, 彭曉峰, 等.多種腫瘤標志物聯合監測胃癌術后復發.現代臨床醫學, 2013, 39(5): 354-356.
27.	周鵬, 曲輝, 史惠文, 等.血清糖類抗原125對胃癌腹膜轉移及其預后的預測價值.中華胃腸外科雜志, 2014, 17(10): 1027-1030.

1. Choi SR, Jang JS, Lee JH, et al. Role of serum tumor markers in moni toring for recurrence of gastric cancer following radical gastrectomy. Dig Dis Sci, 2006, 51(11): 2081-2086.
2. 劉英強, 姬社青, 龔建平, 等.多層螺旋CT在胃癌術前分期及評估中的應用價值.中華實用診斷與治療雜志, 2010, 24(4): 364-367.
3. 楊小波, 鄒亮, 章園.腫瘤標志物在胃癌治療及預后判斷應用中的研究進展.中國普通外科雜志, 2013, 22(10): 1334-1337.
4. 王洋, 王歡, 莫佳美, 等.血清腫瘤標志物在胃癌診斷中的價值.現代腫瘤醫學, 2014, 22(4): 883-885.
5. 張金鋒.血清胃蛋白酶原、CEA、CA199及CA72-4檢測對胃癌的診斷價值探討.檢驗醫學, 2014, (8): 831-834．.
6. 張軍華, 李中.聯合檢測血清CEA、CA199、CA50、CA72-4水平對胃癌的臨床診斷價值.實用臨床醫藥雜志, 2014, 18(5): 1-3．.
7. 金秀穎, 孫紅花, 金永民, 等.聯合檢測CEA、CA199在D2胃癌術后隨訪中的價值.現代腫瘤醫學, 2014, 22(6): 1360-1362．.
8. Fernandes LL, Martins LC, Nagashime CA, et al. CA72-4 antigen levels in serum and peritoneal washing in gastric cancer:Correla tion with morphological aspects of neoplasia. Arq Gastroenterol, 2007, 44(3): 235-239．.
9. Zou L, Qian J. Decline of serum CA72-4 as aprobable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma. Chin J Cancer Res, 2014, 26(4): 404-409.
10. 盛衛忠, 張延偉, 張軼斌.血清CA72-4、CA19-9及CEA免疫放射量度分析在胃癌診治中的意義.上海醫科大學學報, 2000, 27(2): 94-97.
11. 郭花, 朱金水, 朱勵, 等.腫瘤標志物對胃癌診斷應用價值的比較.中國臨床醫學, 2009, 16(3): 369-371.
12. Ubukata H, Katano M, Motohashi G, et al. Evaluation of CA72-4 as a tumor marker in patients with gastric cancer. Gan To Kagaku Ryoho, 2003, 30(11): 1821-1824．.
13. Mattar R, Andrade CR, Difavero GM, et al. Preoperative serum levels of CA 72-4, CEA, CA 19-9 and alpha-fetoprotein in patients with gastric cancer. Rev Hosp Clin Fac Med Sao Paulo, 2002, 57(3): 89-92.
14. Ikeguchi M, Katano K, Saitou H, et al. Pre-operative serum levels of CA72-4 in patientswith gastric adenocarcinoma. Hepatogastroen terology, 1997, 44(15): 866-871.
15. Kanellos I, Zacharakis E, Kanellos D, et al. Prognositic significance of CEA levels and detection of CEAmRNA in draining venous blood in patients with colorectal cancer. Surg Oncol, 2006, 94(1): 3-8.
16. Miyazono F, Natsugoe S, Takao S, et al. Surgical maneuvers enhance molecular detection of circulating tumor cells during gastric cancer surgery. Ann Surg, 2001, 233(2): 189-194.
17. Ikeda Y, Mori M, Kajiyama K, et al. Indicative value of carcinoem bryonic antigen (CEA) for liver recurrence following curative resec tion of stageⅡandⅢgastric cancer. Hepatogastroenterology, 1996, 43(11): 1281-1287.
18. 張永樂, 薛英威, 藍秀文, 等.腫瘤標記物CAl99、CEA對胃癌轉移和預后預測價值的分析.哈爾濱醫科大學學報, 2010, 44(2):181-184．.
19. Pectasides D, Myloanlakis A, Kostopouiou M, et al. CEA, CA19-9 and CA-50 in monitoring gastric carcinoma. Am J Clin Oncol, 1997, 20(4): 348-353.
20. Kochi M, Fuji M, Kanamor N, et al. Evalution of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. GastricCancer, 2003, 3(4): 177-186.
21. 李巖.血清胃癌腫瘤標志物的臨床價值.繼續醫學教育, 2006, 20(3): 58-63.
22. Yang SH. Risk factors for peritoneal dissemination of colorectal cancer. Surg Oncol, 2004, 87(4):167-173.
23. Takahashi Y. Gastrointestinal cancer. Gan To Kagaku Ryoho, 2004, 31(8): 1275-1279．.
24. 張燕華, 李雁, 陳創, 等.多種腫瘤標志物與胃癌進展及預后的關系.武漢大學學報:醫學版, 2009, 30(4): 455-462．.
25. Lai IR, Lee WJ, Huang MT, et al. Comparison of serumCA72-4, CEA, TPA, CAl9-9 and CAl25 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology, 2002, 49(46): 1157-1160．.
26. 余志金, 陳惠新, 彭曉峰, 等.多種腫瘤標志物聯合監測胃癌術后復發.現代臨床醫學, 2013, 39(5): 354-356.
27. 周鵬, 曲輝, 史惠文, 等.血清糖類抗原125對胃癌腹膜轉移及其預后的預測價值.中華胃腸外科雜志, 2014, 17(10): 1027-1030.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer

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