Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 WANGQi-yan , HUANGZi-xing , WUMing-peng , ZHENGXing-ju , QUYa-li ,  SONGBin

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

SONGBin, Email: cjr.songbin@vip.163.com

Keywords：

Pancreatic neuroendocrine neoplasm; Pathological grading; MSCT

DOI：

10.7507/1007-9424.20160067

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate value of MSCT imaging on differentiating low grade pancreatic neuroendo-crine neoplasms (pNENs) from non-low grade pNENs. Method The clinical and CT data of 32 patients with pNENs,who were confirmed by pathological diagnosis from January 2014 to August 2015,were collected and analyzed retrospec-tively. Results There were 15 patients with grade 1 in the low grade pNENs group,there were 11 patients with grade 2 and 6 patients with grade 3 in the non-low grade pNENs group.Compared with the low grade pNENs,the non-low grade pNENs had the larger diameter of the tumor (P=0.007),irregular tumor shape (P=0.006),obscure tumor margin (P=0.003),peripancreatic tissue or vascular invasion (P=0.036),lymphadenopathy (P=0.003),distant metastasis (P=0.019),lower absolute enhancement of tumor at the arterial (P=0.003) and the relative enhancement of tumor at the arterial (P=0.013). Conclusion The analysis of MSCT features might help for differentiating low grade pNENs from non-low grade pNENs,so that more timely selection of appropriate treatment strategies would be made.

Citation： WANGQi-yan, HUANGZi-xing, WUMing-peng, ZHENGXing-ju, QUYa-li, SONGBin. Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 243-247. doi: 10.7507/1007-9424.20160067 Copy

1.	?CSCO神經內分泌腫瘤專家委員會.中國胃腸胰神經內分泌腫瘤專家共識. 臨床腫瘤學雜志, 2013, 18(9):815-832.
2.	章婷婷, 余永強, 錢銀鋒, 等. 胰腺神經內分泌腫瘤MSCT表現及良惡性鑒別. 臨床放射學雜志, 2014, 33(5):722-726.
3.	Pelosi G, Bresaola E, Bogina G, et al. Endocrine tumors of the pancreas:Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy:a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol, 1996, 27(11):1124-1134.
4.	Gallotti A, Johnston RP, Bonaffini PA, et al. Incidental neuroendo-crine tumors of the pancreas:MDCT findings and features of malignancy. AJR Am J Roentgenol, 2013, 200(2):355-362.
5.	Rodallec M, Vilgrain V, Couvelard A, et al. Endocrine pancreatic tumours and helical CT:contrast enhancement is correlated with microvascular density, histoprognostic factors and survival. Pancreatology, 2006, 6(1-2):77-85.
6.	D'Assignies G, Couvelard A, Bahrami SA, et al. Pancreatic endocrine tumors:tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors. Radiology, 2009, 250(2):407-416.
7.	Tatsumoto S, Kodama Y, Sakurai Y, et al. Pancreatic neuroendocrine neoplasm:correlation between computed tomography enhancement patterns and prognostic factors of surgical and endoscopic ultra-sound-guided fine-needle aspiration biopsy specimens. Abdom Imaging, 2013, 38(2):358-366.
8.	Rindi G, Arnold R, Bosman F, et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system//Bosman F, Carneiro F, Hruban R, et al (eds). WHO classification of tumors of the digestive system. Lyon:IARC Press, 2010:13-14.
9.	Rappeport ED, Hansen CP, Kjaer A, et al. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol, 2006, 47(3):248-256.
10.	Bettini R, Boninsegna L, Mantovaniwet A. Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol, 2008, 19(5):903-908.
11.	Foti G, Boninsegna L, Falconi M, et al. Preoperative assessment of nonfunctioning pancreatic endocrine tumours:role of MDCT and MRI. Radiol Med, 2013, 118(7):1082-1101.
12.	徐學勤, 繆飛, 林曉珠, 等. 胰腺神經內分泌腫瘤影像學特征與病理分級的關系. 診斷學理論與實踐, 2014, 13(5):481-486.
13.	Luo Y, Dong Z, Chen J, et al. Pancreatic neuroendocrine tumours:correlation between MSCT features and pathological classification. Eur Radiol, 2014, 24(11):2945-2952.
14.	Poultsides GA, Huang LC, Chen Y, et al. Pancreatic neuroendocrine tumors:radiographic calcifications correlate with grade and metastasis. Ann Surg Oncol, 2012,19(7):2295-2303.
15.	Horton KM, Hruban RH, Yeo C, et al. Multi-detector row CT of pancreatic islet cell tumors. Radiographics, 2006, 26(2):453-464.
16.	Rha SE, Jung SE, Lee KH, et al. CT and MR imaging findings of endocrine tumor of the pancreas according to WHO classification. Eur J Radiol, 2007, 62(3):371-377.
17.	Bettini R, Partelli S, Boninsegna L, et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor. Surgery, 2011, 150(1):75-82.
18.	Osawa A, Sumiyama Y, Watanabe M, et al. Single case of renalcell carcinoma and endocrine pancreation head cancer occurring with von Hippel-Lindau disease. J Hepatobiliary Pancreat Surg, 2006, 13(2):174-180.
19.	Gr?zinger G, Gr?zingger A, Horger M. The role of volume perfusion CT in the diagnosis of pathologies of the pancreas. Rofo, 2014, 186(12):1082-1093.
20.	Worhunsky DJ, Krampitz GW, Poullos PD, et al. Pancreatic neuroen-docrine tumours:hypoenhancement on arterial phase computed tomography predicts biological aggressiveness. HPB (Oxford), 2014, 16(4):304-311.

1. ?CSCO神經內分泌腫瘤專家委員會.中國胃腸胰神經內分泌腫瘤專家共識. 臨床腫瘤學雜志, 2013, 18(9):815-832.
2. 章婷婷, 余永強, 錢銀鋒, 等. 胰腺神經內分泌腫瘤MSCT表現及良惡性鑒別. 臨床放射學雜志, 2014, 33(5):722-726.
3. Pelosi G, Bresaola E, Bogina G, et al. Endocrine tumors of the pancreas:Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy:a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol, 1996, 27(11):1124-1134.
4. Gallotti A, Johnston RP, Bonaffini PA, et al. Incidental neuroendo-crine tumors of the pancreas:MDCT findings and features of malignancy. AJR Am J Roentgenol, 2013, 200(2):355-362.
5. Rodallec M, Vilgrain V, Couvelard A, et al. Endocrine pancreatic tumours and helical CT:contrast enhancement is correlated with microvascular density, histoprognostic factors and survival. Pancreatology, 2006, 6(1-2):77-85.
6. D'Assignies G, Couvelard A, Bahrami SA, et al. Pancreatic endocrine tumors:tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors. Radiology, 2009, 250(2):407-416.
7. Tatsumoto S, Kodama Y, Sakurai Y, et al. Pancreatic neuroendocrine neoplasm:correlation between computed tomography enhancement patterns and prognostic factors of surgical and endoscopic ultra-sound-guided fine-needle aspiration biopsy specimens. Abdom Imaging, 2013, 38(2):358-366.
8. Rindi G, Arnold R, Bosman F, et al. Nomenclature and classification of neuroendocrine neoplasms of the digestive system//Bosman F, Carneiro F, Hruban R, et al (eds). WHO classification of tumors of the digestive system. Lyon:IARC Press, 2010:13-14.
9. Rappeport ED, Hansen CP, Kjaer A, et al. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol, 2006, 47(3):248-256.
10. Bettini R, Boninsegna L, Mantovaniwet A. Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol, 2008, 19(5):903-908.
11. Foti G, Boninsegna L, Falconi M, et al. Preoperative assessment of nonfunctioning pancreatic endocrine tumours:role of MDCT and MRI. Radiol Med, 2013, 118(7):1082-1101.
12. 徐學勤, 繆飛, 林曉珠, 等. 胰腺神經內分泌腫瘤影像學特征與病理分級的關系. 診斷學理論與實踐, 2014, 13(5):481-486.
13. Luo Y, Dong Z, Chen J, et al. Pancreatic neuroendocrine tumours:correlation between MSCT features and pathological classification. Eur Radiol, 2014, 24(11):2945-2952.
14. Poultsides GA, Huang LC, Chen Y, et al. Pancreatic neuroendocrine tumors:radiographic calcifications correlate with grade and metastasis. Ann Surg Oncol, 2012,19(7):2295-2303.
15. Horton KM, Hruban RH, Yeo C, et al. Multi-detector row CT of pancreatic islet cell tumors. Radiographics, 2006, 26(2):453-464.
16. Rha SE, Jung SE, Lee KH, et al. CT and MR imaging findings of endocrine tumor of the pancreas according to WHO classification. Eur J Radiol, 2007, 62(3):371-377.
17. Bettini R, Partelli S, Boninsegna L, et al. Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor. Surgery, 2011, 150(1):75-82.
18. Osawa A, Sumiyama Y, Watanabe M, et al. Single case of renalcell carcinoma and endocrine pancreation head cancer occurring with von Hippel-Lindau disease. J Hepatobiliary Pancreat Surg, 2006, 13(2):174-180.
19. Gr?zinger G, Gr?zingger A, Horger M. The role of volume perfusion CT in the diagnosis of pathologies of the pancreas. Rofo, 2014, 186(12):1082-1093.
20. Worhunsky DJ, Krampitz GW, Poullos PD, et al. Pancreatic neuroen-docrine tumours:hypoenhancement on arterial phase computed tomography predicts biological aggressiveness. HPB (Oxford), 2014, 16(4):304-311.

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Correlation of MSCT Imaging Feature with Pathologic Grading of Pancreatic Neuroen-docrine Neoplasm

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