Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 GONGXiao-jun , MAOHong-yan , LIUHui-min ,  BAIHai-ya , YANGPing

Department of Breast, Maternal and Child Care Service Centre of Gansu Province, Lanzhou 730050, Gansu Province, China;

Corresponding?author：

BAIHai-ya, Email: gsbhy@sina.cn

Keywords：

Breast cancer; Sentinel lymph node biopsy; Indocyanine green; Methylene blue dye

DOI：

10.7507/1007-9424.20160057

Video：

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Objective To evaluate clinical value of indocyanine green (ICG) fluorescence in sentinel lymph node (SLN) biopsy (SLNB) for breast cancer. Method The SLNBs were performed in 66 patients with breast cancer,who were divided into ICG group (n=34) and methylene blue dye group (n=32) according to the tracing method. Results The SLNs were found in 59 patients,the detection rate was 89.39%(59/66).One hundred and sixty-two SLNs in 59 patients were detected,the average number of detected SLNs was 2.75.The SLNs detection rate was 97.06%(33/34) and 81.25%(26/32) in the ICG group and in the methylene blue dye group,respectively,which in the ICG group was significantly higher than that in the methylene blue dye group (P<0.05).The positive SLNs were found in 32 cases,within which was 20 cases in the ICG group,12 cases in the methylene blue dye group.The axillary lymph node metastases were found in 35 of 66 cases,within which was 21 cases in the ICG group,14 cases in the methylene blue dye group.The sensitivity and false negative rate had no significant differences between the ICG group and the methylene blue dye group (sensitivity:95.2% versus 85.7%,P>0.05;false negative rate:4.8% versus 14.3%,P>0.05). Conclusion The ICG fluorescence in SLNB for breast cancer has many advantages,including shorter time,simple operation,high sensitivity,and high detection rate as compared with methylene blue dye.

Citation： GONGXiao-jun, MAOHong-yan, LIUHui-min, BAIHai-ya, YANGPing. Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 221-224. doi: 10.7507/1007-9424.20160057 Copy

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3.	Lyman GH, Giuliano AE, Somerfield MR, et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol, 2005, 23(30):7703-7720.
4.	顏寧, 劉少杰, 彭偉強, 等. 早期乳腺癌前哨淋巴結活檢對預測腋窩淋巴結狀態的臨床探討. 當代醫學, 2013, 1(1):107-108.
5.	郭嘉嘉, 楊厚圃, 周禮馨, 等. 自發熒光物質在前哨淋巴結活檢中的應用. 中國腫瘤臨床, 2011, 3(22):1397-1399.
6.	陳國際, 張保寧, 邵永孚, 等. 前哨淋巴結活檢在乳腺癌治療中的應用價值. 實用腫瘤雜志, 2004, 1(3):226-228.
7.	Martin RC, Chagpar A, Scoggins CR, et al. Clinicopathologic factors associated with false-negative sentinel lymph-node biopsy in breast cancer. Ann Surg, 2005, 241(6):1005-1015.
8.	崔一堯, 王水. 前哨淋巴結活檢在乳腺癌治療中的意義. 醫學與哲學:臨床決策論壇版, 2011, 32(8):41-42, 76.
9.	吳祥德. 乳腺疾病診治. 第2版. 北京:人民衛生出版社, 2009:151.
10.	Dauphine CE, Khalkhali I, Vargas MP, et al. Intraoperative injection of technetium-99m Sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer. Am J Surg, 2006, 192(4):423-426.
11.	中國抗癌協會乳腺癌專業委員會. 中國抗癌協會乳腺癌診治指南與規范(2013). 中國癌癥雜志, 2013, 23(8):637-685.
12.	Moody LC, Wen X, Mcknight T, et al. Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer. Surgery, 2012, 152(3):389-396.
13.	林文旭, 黃兩喜, 謝春發, 等. 熒光探測技術在乳腺癌前哨淋巴結活檢中的應用. 中國煤炭工業醫學雜志, 2014, 17(3):421-422.
14.	張雅媛, 周冬仙, 丁雪青. 美藍在乳癌前哨淋巴結定位活檢中的應用研究. 當代醫學, 2012, 9(1):69-70.
15.	王永勝. 乳腺癌前哨淋巴結活檢:共識與展望. 中國普外基礎與臨床雜志, 2009, 16(7):505-509..
16.	Tagaya N, Yamazaki R, Nakagawa A, et al. Intraoperative identifi-cation of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg, 2008, 195(6):850-853.

1. ?Theriault RL, Carlson RW, Allred C, et al. Breast cancer, version 3.2013:featured updates to the NCCN guidelines. J Natl Compr Canc Netw, 2013, 11(7):753-761.
2. 中國抗癌協會乳腺癌專業委員會. 中國抗癌協會乳腺癌診治指南與規范(2013版). 中國癌癥雜志, 2013, 23(8):637-693.
3. Lyman GH, Giuliano AE, Somerfield MR, et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol, 2005, 23(30):7703-7720.
4. 顏寧, 劉少杰, 彭偉強, 等. 早期乳腺癌前哨淋巴結活檢對預測腋窩淋巴結狀態的臨床探討. 當代醫學, 2013, 1(1):107-108.
5. 郭嘉嘉, 楊厚圃, 周禮馨, 等. 自發熒光物質在前哨淋巴結活檢中的應用. 中國腫瘤臨床, 2011, 3(22):1397-1399.
6. 陳國際, 張保寧, 邵永孚, 等. 前哨淋巴結活檢在乳腺癌治療中的應用價值. 實用腫瘤雜志, 2004, 1(3):226-228.
7. Martin RC, Chagpar A, Scoggins CR, et al. Clinicopathologic factors associated with false-negative sentinel lymph-node biopsy in breast cancer. Ann Surg, 2005, 241(6):1005-1015.
8. 崔一堯, 王水. 前哨淋巴結活檢在乳腺癌治療中的意義. 醫學與哲學:臨床決策論壇版, 2011, 32(8):41-42, 76.
9. 吳祥德. 乳腺疾病診治. 第2版. 北京:人民衛生出版社, 2009:151.
10. Dauphine CE, Khalkhali I, Vargas MP, et al. Intraoperative injection of technetium-99m Sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer. Am J Surg, 2006, 192(4):423-426.
11. 中國抗癌協會乳腺癌專業委員會. 中國抗癌協會乳腺癌診治指南與規范(2013). 中國癌癥雜志, 2013, 23(8):637-685.
12. Moody LC, Wen X, Mcknight T, et al. Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer. Surgery, 2012, 152(3):389-396.
13. 林文旭, 黃兩喜, 謝春發, 等. 熒光探測技術在乳腺癌前哨淋巴結活檢中的應用. 中國煤炭工業醫學雜志, 2014, 17(3):421-422.
14. 張雅媛, 周冬仙, 丁雪青. 美藍在乳癌前哨淋巴結定位活檢中的應用研究. 當代醫學, 2012, 9(1):69-70.
15. 王永勝. 乳腺癌前哨淋巴結活檢:共識與展望. 中國普外基礎與臨床雜志, 2009, 16(7):505-509..
16. Tagaya N, Yamazaki R, Nakagawa A, et al. Intraoperative identifi-cation of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg, 2008, 195(6):850-853.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer

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