The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIPei-wu , WANGXian-kun , FUXu , WANGBin-jun , YANBo , CUIHong-bing , BAITian-shuo

The Trauma Surgery of Emergency Center, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China;

Corresponding?author：

LIPei-wu, Email: wuzi360@126.com

Keywords：

Somatostatin; Abdominal injury; Gastrointestinal function

DOI：

10.7507/1007-9424.20160015

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the role of somatostatin in gastrointestinal function after operation for treatment of abdominal injury patients. Methods Sixty patients with abdominal trauma were divided into somatostatin in treatment group (n=30) and the conventional treatment control group (n=30). The amount of gastrointestinal decompression drainage, bowel sounds recovery time, exhaust time, defecation time, and the levels of serum C reactive protein, TNF-α, IL-6, and IL-8 after operation in two groups were observed. Results Somatostatin treatment group recovery time of bowel sounds, exhaust time, and defecation time were earlier than the control group, hospitalization time shortened, and the amount of gastrointestinal decompression drainage reduced (P < 0.05), The levels of serum C reactive protein, TNF-α, IL-6 and IL-8 of somatostatin treatment group were lower than those in control group (P < 0.05), and the magnitude of decline above index in the somatostatin treatment group were greater than that in the control group (P < 0.05). Conclusion Somatostatin can promote the recovery of gastrointestinal function in patients after operation in abdominal injury.

Citation： LIPei-wu, WANGXian-kun, FUXu, WANGBin-jun, YANBo, CUIHong-bing, BAITian-shuo. The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(1): 56-59. doi: 10.7507/1007-9424.20160015 Copy

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5.	Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation:a systematic review. Surgery, 2015, 157(2):362-380.
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7.	Wehner S, Vilz TO, Stoffels B, et al. Immune mediators of posto-perative ileus. Langenbecks Arch Surg, 2012, 397(4):591-601.
8.	Rai U, Thrimawithana TR, Valery C, et al. Therapeutic uses of somatostatin and its analogues:Current view and potential applica-tions. Pharmacol Ther, 2015, 152:98-110.
9.	Tostivint H, Ocampo Daza D, Bergqvist CA, et al. Molecular evolution of GPCRs:Somatostatin/urotensinⅡreceptors. J Mol Endocrinol, 2014, 52(3):T61-86.
10.	Abdel-Rahman O, Lamarca A, Valle JW, et al. Somatostatin receptor expression in hepatocellular carcinoma:prognostic and therapeutic considerations. Endocr Relat Cancer, 2014, 21(6):R485-R493.
11.	郭景財, 張愛軍, 鄭向紅, 等.腹部手術后腸蠕動功能變化的實驗性研究.中國誤診學雜志, 2007, 7(13):2946-2948.
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13.	Schroeder JE, Weiss YG, Mosheiff R. The current state in the evalua-tion and treatment of ARDS and SIRS. Injury, 2009, 40(Suppl 4):S82-S89.
14.	Dimopoulou I, Orfanos S, Kotanidou A, et al. Plasma pro-and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients. Cytokine, 2008, 41(3):263-267.
15.	馮德元, 劉江偉, 呂月濤, 等. TNF-α和IL-6在腹部腸管火器傷后血清中的變化.臨床軍醫雜志, 2009, 37(2):168-170.
16.	Buttenschoen K, Fathimani K, Buttenschoen DC. Effect of major abdominal surgery on the host immune response to infection. Curr Opin Infect Dis, 2010, 23(3):259-267.
17.	李之拓, 杜建波, 韓冰, 等.生長抑素聯合抗生素對急性膽囊炎家兔血清腫瘤壞死因子-α和C反應蛋白的影響.中國普外基礎與臨床雜志, 2011, 18(8):835-839.
18.	Karnes JM, Daffner SD, Watkins CM. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone, 2015, 78:87-93.
19.	Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br, 2004, 86(3):313-323.
20.	Ozturk H, Yagmur Y, Ozturk H. The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-αlevels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int, 2008, 24(2):235-239.
21.	朱紅, 郭永章, 楊鴻煒, 等.血管生長抑素基因聯合生長抑素治療人胰腺癌的體外研究.中國普外基礎與臨床雜志, 2009, 16(6):460-465.
22.	楊澤權. C反應蛋白水平對判斷炎癥和創傷及心肌梗死轉歸的臨床價值.國際檢驗醫學雜志, 2013, 34(7):880-881.
23.	黃津, 白雪, 張凱, 等.白細胞計數和C-反應蛋白對創傷患者細菌感染的診斷價值.鄭州大學學報:醫學版, 2011, 46(5):800-801.
24.	Mosli MH, Zou G, Garg SK et al. C-Reactive protein, fecal calpro-tectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients:a systematic review and meta-analysis. Am J Gastroenterol, 2015, 110(6):802-819.
25.	Stone PA, Kazil J. The relationships between serum C-reactive protein level and risk and progression of coronary and carotid atherosclerosis. Semin Vasc Surg, 2014, 27(3-4):138-142.

1. 黃小蘭, 陳仿, 代喆, 等. 2200例腹部創傷住院患者流行病學分析.四川醫學, 2012, 33(8):1471-1473.
2. Murphy KP, Maher MM, O'Connor OJ. Abdominal ablation techniques. Am J Roentgenol, 2015, 204(5):W495-W502.
3. Yuan W, Yu X, Liu F, et al. Effects of trac element supplementation on the inflammatory response in a rabbit model of major trauma. J Trace Elem Med Biol, 2010, 24(1):36-41.
4. Barbi? J, Ivi? D, Alkhamis T, et al. Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C-reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? Coll Antropol, 2013, 37(1):195-203.
5. Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation:a systematic review. Surgery, 2015, 157(2):362-380.
6. Shirah GR, O'Neill PJ. Intra-abdominal Infections. Surg Clin North Am, 2014, 94(6):1319-1333.
7. Wehner S, Vilz TO, Stoffels B, et al. Immune mediators of posto-perative ileus. Langenbecks Arch Surg, 2012, 397(4):591-601.
8. Rai U, Thrimawithana TR, Valery C, et al. Therapeutic uses of somatostatin and its analogues:Current view and potential applica-tions. Pharmacol Ther, 2015, 152:98-110.
9. Tostivint H, Ocampo Daza D, Bergqvist CA, et al. Molecular evolution of GPCRs:Somatostatin/urotensinⅡreceptors. J Mol Endocrinol, 2014, 52(3):T61-86.
10. Abdel-Rahman O, Lamarca A, Valle JW, et al. Somatostatin receptor expression in hepatocellular carcinoma:prognostic and therapeutic considerations. Endocr Relat Cancer, 2014, 21(6):R485-R493.
11. 郭景財, 張愛軍, 鄭向紅, 等.腹部手術后腸蠕動功能變化的實驗性研究.中國誤診學雜志, 2007, 7(13):2946-2948.
12. Kirchhoff C, Biberthaler P, Mutschler WE, et al. Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury:a cohort study. Crit Care, 2009, 13(3):R88.
13. Schroeder JE, Weiss YG, Mosheiff R. The current state in the evalua-tion and treatment of ARDS and SIRS. Injury, 2009, 40(Suppl 4):S82-S89.
14. Dimopoulou I, Orfanos S, Kotanidou A, et al. Plasma pro-and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients. Cytokine, 2008, 41(3):263-267.
15. 馮德元, 劉江偉, 呂月濤, 等. TNF-α和IL-6在腹部腸管火器傷后血清中的變化.臨床軍醫雜志, 2009, 37(2):168-170.
16. Buttenschoen K, Fathimani K, Buttenschoen DC. Effect of major abdominal surgery on the host immune response to infection. Curr Opin Infect Dis, 2010, 23(3):259-267.
17. 李之拓, 杜建波, 韓冰, 等.生長抑素聯合抗生素對急性膽囊炎家兔血清腫瘤壞死因子-α和C反應蛋白的影響.中國普外基礎與臨床雜志, 2011, 18(8):835-839.
18. Karnes JM, Daffner SD, Watkins CM. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone, 2015, 78:87-93.
19. Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br, 2004, 86(3):313-323.
20. Ozturk H, Yagmur Y, Ozturk H. The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-αlevels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int, 2008, 24(2):235-239.
21. 朱紅, 郭永章, 楊鴻煒, 等.血管生長抑素基因聯合生長抑素治療人胰腺癌的體外研究.中國普外基礎與臨床雜志, 2009, 16(6):460-465.
22. 楊澤權. C反應蛋白水平對判斷炎癥和創傷及心肌梗死轉歸的臨床價值.國際檢驗醫學雜志, 2013, 34(7):880-881.
23. 黃津, 白雪, 張凱, 等.白細胞計數和C-反應蛋白對創傷患者細菌感染的診斷價值.鄭州大學學報:醫學版, 2011, 46(5):800-801.
24. Mosli MH, Zou G, Garg SK et al. C-Reactive protein, fecal calpro-tectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients:a systematic review and meta-analysis. Am J Gastroenterol, 2015, 110(6):802-819.
25. Stone PA, Kazil J. The relationships between serum C-reactive protein level and risk and progression of coronary and carotid atherosclerosis. Semin Vasc Surg, 2014, 27(3-4):138-142.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury

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