Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CAOZi-long ^1,2 , ZHANGZhuo ^1,2 , HUJian-li ^1,2 ,  SHENXuan-san ¹

1. Department of General Surgery, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, China;
2. Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, China;

Corresponding?author：

SHENXuan-san, Email: xuansanshen@163.com

Keywords：

Breast carcinoma; Naked cuticle homolog 1; Adenomatouspolyposis coli; Immunohistochemistry

DOI：

10.7507/1007-9424.20150317

Video：

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Objective To detect the expressions of NKD1 and APC in breast carcinoma tissues and to explore the clinical significance of their existence and their correlation. Methods The study selected 75 patients with breast carcinoma as the observation group, and their corresponding normal breast tissues from the breast carcinoma tissues more than 5 cm as the control group. The expressions of two proteins were detected by immunohistochemistry. Their relationship with the pathological characteristics of breast carcinoma and the correlation of the two proteins were analyzed. Results The positive expression rates of NKD1 and APC in normal breast tissues were significantl higher than those in breast carcinoma tissues (82.67% vs. 36.00%, 89.33% vs. 45.33%, P < 0.05). The expression of NKD1 was not correlated with the age of patients with breast carcinoma (P > 0.05), while correlated with the degree of differentiation, TNM stage, lymph node metastasis, and remote organ metastasis of breast carcinoma (P < 0.05). The expression of APC was not correlated with the age of patients with breast carcinoma, the degree of differentiation and lymph node metastasis of breast carcinoma (P > 0.05), while correlated with the TNM stage and remote organ metastasis of breast carcinoma (P < 0.05). The expressions of NKD1 and APC in breast carcinoma was positively correlated (r=0.609, P < 0.05). Conclusion NKD1 and APC may be involved in the development and remote organ metastasis of breast carcinoma, and the two proteins may have a synergistic role in breast carcinoma.

Citation： CAOZi-long, ZHANGZhuo, HUJian-li, SHENXuan-san. Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1226-1229. doi: 10.7507/1007-9424.20150317 Copy

1.	鄭瑩, 吳春曉, 張敏璐.乳腺癌在中國的流行狀況和疾病特征.中國癌癥雜志, 2013, 23(8):561-569.
2.	Borer JS, Hochrcitcr CA, Supino PG, et al. Importance of right ventricu-lar performance measurement in selecting asymptomatic patients with mtral regurgitation for valve surger. Adv Cardio1, 2002, 39:144-152.
3.	唐金海, 姚宇鋒.早期乳腺癌的診斷和外科治療進展.中國普外基礎與臨床雜志, 2011, 18(9):913-916.
4.	李汛, 孟文勃, 白仲添, 等.信號通路在肝細胞癌發展中的作用.中國普外基礎與臨床雜志, 2014, 21(7):916-920.
5.	陳瑩摘譯.根據解剖位置以及遺傳不穩定類型, 大腸癌的典型Wnt信號通路表現出不同的突變譜.中國普外基礎與臨床雜志, 2011, 18(11):1211.
6.	Ono M, Yin P, Navarro A, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril, 2014, 101(5):1441-1449.
7.	趙靜, 張春雷, 房興堂, 等. WNT信號通路的研究進展.中國牛業科學, 2012, 38(1):33-37.
8.	Larraguibel J, Weiss AR, Pasula DJ, et al. Wnt-ligand dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell, 2015, 26(12):2375-2384.
9.	王亞紅, 孫興華, 朱志圖, 等. BUB1與APC蛋白在不同乳腺組織中的表達及臨床意義.中國癌癥雜志, 2008, 18(12):888-892.
10.	McEwen DG, Peifer M. Wnt signaling:the naked truth? Curr Biol, 2001, 11(13):8524-8526.
11.	GaliatsatosP, Foulkes D. Familial adenomatous polyposis. Am J Gastroenterol, 2006, 101(2):385-398.
12.	余澤兵, 舒亦斌, 雷慧慧.胃腺癌組織Naked1和MMP-9表達及其相關性研究.浙江中西醫結合雜志, 2013, 23(1):9-11.
13.	陳巍, 王成盛, 章蔚.乳腺癌組織中NKD1和β-catenin蛋白的表達及對預后判斷價值的研究.中國現代醫生, 2012, 50(31):62-63.
14.	趙婧, 荊洋, 呂宗舜, 等.有大腸癌家族史的大腸多發性腺瘤患者瘤組織中APC, Survivin蛋白的表達及意義.山東醫藥, 2015, 55(6):24-27.
15.	Zhang S, Wang Y, Dai SD, et al. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer, 2011, 11:186.
16.	Wharton KA Jr, Zimmermann G, Rousset R, et al. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol, 2001, 234(1):93-106.
17.	閆康. NKD1參與介導miR-195對骨肉瘤轉移的抑制作用.第四軍醫大學, 2013.
18.	李玉婷. NKD1, Wnt2b在胃癌組織及癌前病變中的表達及其相互關系.蘭州大學, 2011.
19.	趙月, 孫波, 張盛, 等.非小細胞肺癌中Naked1的表達及意義.臨床與實驗病理學雜志, 2012, 28(3):257-260.
20.	Lapierre M, Bonnet S, Bascoul-Mollevi C, et al. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest, 2014, 124(5):1899-1913.
21.	肖忠盛, 梁慶模. APC的結構與功能的研究進展.現代醫藥衛生, 2010, 26(4):535-537.
22.	戴越盟, 嚴律南.β-連環蛋白及APC基因與腫瘤.中國普外基礎與臨床志, 2002, 9(4):291-293.
23.	孫政, 曹杰, 梁立源, 等. CCN2及APC蛋白在結直腸癌組織中的表達及意義.廣東醫學, 2012, 33(11):1556-1559.
24.	Van Noort M, Meeldijk J, van der Zee R, et al. Wnt si gnaling controls the phosphorylation status of beta-catenin. J Biol Chem, 2002, 277(20):17901-17905.
25.	Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell, 2012, 149(6):1192-1205.

1. 鄭瑩, 吳春曉, 張敏璐.乳腺癌在中國的流行狀況和疾病特征.中國癌癥雜志, 2013, 23(8):561-569.
2. Borer JS, Hochrcitcr CA, Supino PG, et al. Importance of right ventricu-lar performance measurement in selecting asymptomatic patients with mtral regurgitation for valve surger. Adv Cardio1, 2002, 39:144-152.
3. 唐金海, 姚宇鋒.早期乳腺癌的診斷和外科治療進展.中國普外基礎與臨床雜志, 2011, 18(9):913-916.
4. 李汛, 孟文勃, 白仲添, 等.信號通路在肝細胞癌發展中的作用.中國普外基礎與臨床雜志, 2014, 21(7):916-920.
5. 陳瑩摘譯.根據解剖位置以及遺傳不穩定類型, 大腸癌的典型Wnt信號通路表現出不同的突變譜.中國普外基礎與臨床雜志, 2011, 18(11):1211.
6. Ono M, Yin P, Navarro A, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril, 2014, 101(5):1441-1449.
7. 趙靜, 張春雷, 房興堂, 等. WNT信號通路的研究進展.中國牛業科學, 2012, 38(1):33-37.
8. Larraguibel J, Weiss AR, Pasula DJ, et al. Wnt-ligand dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell, 2015, 26(12):2375-2384.
9. 王亞紅, 孫興華, 朱志圖, 等. BUB1與APC蛋白在不同乳腺組織中的表達及臨床意義.中國癌癥雜志, 2008, 18(12):888-892.
10. McEwen DG, Peifer M. Wnt signaling:the naked truth? Curr Biol, 2001, 11(13):8524-8526.
11. GaliatsatosP, Foulkes D. Familial adenomatous polyposis. Am J Gastroenterol, 2006, 101(2):385-398.
12. 余澤兵, 舒亦斌, 雷慧慧.胃腺癌組織Naked1和MMP-9表達及其相關性研究.浙江中西醫結合雜志, 2013, 23(1):9-11.
13. 陳巍, 王成盛, 章蔚.乳腺癌組織中NKD1和β-catenin蛋白的表達及對預后判斷價值的研究.中國現代醫生, 2012, 50(31):62-63.
14. 趙婧, 荊洋, 呂宗舜, 等.有大腸癌家族史的大腸多發性腺瘤患者瘤組織中APC, Survivin蛋白的表達及意義.山東醫藥, 2015, 55(6):24-27.
15. Zhang S, Wang Y, Dai SD, et al. Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer, 2011, 11:186.
16. Wharton KA Jr, Zimmermann G, Rousset R, et al. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol, 2001, 234(1):93-106.
17. 閆康. NKD1參與介導miR-195對骨肉瘤轉移的抑制作用.第四軍醫大學, 2013.
18. 李玉婷. NKD1, Wnt2b在胃癌組織及癌前病變中的表達及其相互關系.蘭州大學, 2011.
19. 趙月, 孫波, 張盛, 等.非小細胞肺癌中Naked1的表達及意義.臨床與實驗病理學雜志, 2012, 28(3):257-260.
20. Lapierre M, Bonnet S, Bascoul-Mollevi C, et al. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest, 2014, 124(5):1899-1913.
21. 肖忠盛, 梁慶模. APC的結構與功能的研究進展.現代醫藥衛生, 2010, 26(4):535-537.
22. 戴越盟, 嚴律南.β-連環蛋白及APC基因與腫瘤.中國普外基礎與臨床志, 2002, 9(4):291-293.
23. 孫政, 曹杰, 梁立源, 等. CCN2及APC蛋白在結直腸癌組織中的表達及意義.廣東醫學, 2012, 33(11):1556-1559.
24. Van Noort M, Meeldijk J, van der Zee R, et al. Wnt si gnaling controls the phosphorylation status of beta-catenin. J Biol Chem, 2002, 277(20):17901-17905.
25. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell, 2012, 149(6):1192-1205.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma

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