Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUYan ¹ , LIQing-chun ² ,  HOURui-zhi ²

1. Department of Ultrosonography, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
2. Department of Gastrointestinal Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China;

Corresponding?author：

HOURui-zhi, Email: houruizhi821023@126.com

Keywords：

¹²⁵I radioactive particle; Interstitial permanent implantation; Colorectal cancer; Ultrasound

DOI：

10.7507/1007-9424.20150316

Video：

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Objective To evaluate the viability, short-term clinical efficacy, and safety of ultrasound-guided radioactive seed ¹²⁵I permanent implantation in tissue in patients with advanced colorectal cancer. Methods A total of 9 patients were recruited in this study. All of the patients came from China-Japan Union Hospital of Jilin University from October 2012 to October 2014, which had been selected after strict screening. Five cases of male patients, 4 cases of female patients; the age was between 46-78 years old, the median age was 54 years old. There were 5 cases of patients with pain. There were 14 lesions in total, 1 lesion was local tumor recurrence, 2 lesions were pelvic metastasis, 8 lesions were liver metastases, and 3 lesions were abdominal lymph node metastasis. CEA increased in 6 cases before implantation. All patients were confirmed metastasis by CT, MRI examination or pathology. The ¹²⁵I radioactive seed implantation was guided by real-time ultrasound. CT scanning was taken in two months after treatment. The degree of pain relief, tumor local control, and the occurrence of complications were observed. Results In 2 months after implantation of ¹²⁵I radioactive particles, the CT scanning results showed that 2 cases obtained complete response (CR), 5 cases obtained partial response (PR), 1 case got stable disease (SD), and 1 case got progress disease (PD). Total effective was 7/9, and disease control was 8/9. Five cases with pain symptoms were relieved after treatment. One walk metal particle in the abdominal cavity was found by abdominal CT scanning in 1 case. There were no serious complications intraoperative and postoperative. Conclusions Ultrasound guided radioactive seeds ¹²⁵I implantation in the treatment of advanced colorectal cancer can significantly relieve the clinical symptoms, improve the quality of life, and can effectively control the metastasis. It is safe and feasible, and the postoperative hospitalization time is short, it has the avantages of safety, effectiveness, and low incidence of complications.

Citation： LIUYan, LIQing-chun, HOURui-zhi. Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1222-1225. doi: 10.7507/1007-9424.20150316 Copy

1.	車薛華, 梁偉民. NCCN成人癌痛控制指南解讀.中國醫藥指南, 2010, 8(13):84-85.
2.	Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours:revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45(2):228-247.
3.	梁寒, 郝希山, 王曉娜, 等. 723例結腸癌患者術后多因素分析.中國腫瘤臨床, 2004, 31(6):343-348.
4.	趙全德, 董靈, 李向東, 等.吉西他濱聯合表柔星治療移性肝癌的臨床研究.現代腫瘤醫學, 2011, 19(1):116-117.
5.	Tveit KM, Wiig JN, Clsen DR, et al. Combinedmodality treatment in cluding intraoperative radiotherapy in locally advancedand recurrent rectal cancer. Radiother Oncol, 1997, 44(3):277-282.
6.	Kim SY, Yang ES, Lee J, et al. Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis. Biochimie, 2011, 93(2):269-276.
7.	莊洪卿, 王俊杰, 趙勇, 等. ¹²⁵I粒子對大腸癌CLl87細胞殺傷作用的實驗研究.中華放射醫學與防護雜志, 2008, 28(2):148-151.
8.	Koutrouvelis PG. Computed tomography-guided salvage brachytherapy of recurrent large non-Resectable familial colo-rectal cancer in the pelvis:case report. Technol Cancer Res Treat, 2002, 1(1):61-64.
9.	Goes RN, Beart RW Jr, Simons AJ, et al. Use of brachytherapy in management of locally recurrent rectal cancer. Dis Colon Rectum, 1997, 40(10):1177-1179.
10.	吳同勝, 韓潞, 譚衛林. ¹²⁵I組織間插植放射治療腹腔內惡性腫瘤的探討.中國癌癥雜志, 2009, 19(12):947-949.
11.	Wang Z, Lu J, Liu L, et al. Clinical application of CT-guided (125) I seed interstitial implan tatIon for local recurrent rectal carcinoma. Radiat Oncol, 2011, 6:138.
12.	Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy. Med Oncol, 2010, 27(2):421-429.
13.	張亮, 范衛君, 黃金華, 等. CT導向下¹²⁵I粒子植入治療直腸癌術后局部復發.中華醫學雜志, 2008, 88(19):1335-1338.
14.	張開賢, 李苓, 邢超, 等. CT引導¹²⁵I放射性粒子植入治療復發性直腸癌32例報告.當代醫學, 2009, 15(36):13-15.
15.	吳越竇, 新民, 曲金榮.放射性¹²⁵I粒子植入術治療直腸癌的臨床研究.當代醫學, 2009, 10(15):564-565.
16.	柳晨, 袁慧書, 王俊杰.復發性直腸癌:CT引導下植入放射性粒子組織間近距離放療的療效.中國介入影像與治療學, 2012, 9(2):94-98.
17.	元云飛, 李斌奎, 李錦清, 等.巨大肝癌手術切除治療的遠期療效.癌癥, 2004, 23(7):821-824.
18.	芮靜安, 王少斌, 陳曙光.肝三葉切除術治療肝臟巨大腫瘤29例.中華外科雜志, 2001, 39(10):759-763.
19.	Lee SG, Hwang S, Jung JP, et al. Outcome of patients with huge hepatocellular carcinoma after primary resection and treatment of recurrent lesions. Br J Surg, 2007, 94(3):320-326.
20.	Chung GE, Lee JH, Kim HY, et al. Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology, 2011, 258(2):627-634.
21.	Xu LT, Zhou ZH, Lin JH, et al. Clinical study of transarterial chemoembolization combined with 3-dimensional conformal radiotherapy for hepatocellular carcinoma. Eur J Surg Oncol, 2011, 37(3):245-251.
22.	Merle P, Mornex F. Transarterial chemoembolization and conformal radiotherapy for heaptocellular carcinoma. Cancer Radiother, 2011, 15(1):69-71.
23.	范新華, 金利盛. CT引導下125 I粒子永久植入治療肝轉移癌.醫學影像學雜志, 2012, 22(4):581-584.
24.	王建新, 王貴吉, 吳洋東. ¹²⁵I粒子植入治療胃癌肝轉移的臨床療效.河南醫學研究, 2012, 21(3):321-323.
25.	王俊杰.放射性粒子組織間永久植入治療肝轉移癌.癌癥進展, 2009, 7(3):286-290.

1. 車薛華, 梁偉民. NCCN成人癌痛控制指南解讀.中國醫藥指南, 2010, 8(13):84-85.
2. Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours:revised RECIST guideline (version 1.1). Eur J Cancer, 2009, 45(2):228-247.
3. 梁寒, 郝希山, 王曉娜, 等. 723例結腸癌患者術后多因素分析.中國腫瘤臨床, 2004, 31(6):343-348.
4. 趙全德, 董靈, 李向東, 等.吉西他濱聯合表柔星治療移性肝癌的臨床研究.現代腫瘤醫學, 2011, 19(1):116-117.
5. Tveit KM, Wiig JN, Clsen DR, et al. Combinedmodality treatment in cluding intraoperative radiotherapy in locally advancedand recurrent rectal cancer. Radiother Oncol, 1997, 44(3):277-282.
6. Kim SY, Yang ES, Lee J, et al. Sensitive to apoptosis gene protein regulates ionizing radiation-induced apoptosis. Biochimie, 2011, 93(2):269-276.
7. 莊洪卿, 王俊杰, 趙勇, 等. ¹²⁵I粒子對大腸癌CLl87細胞殺傷作用的實驗研究.中華放射醫學與防護雜志, 2008, 28(2):148-151.
8. Koutrouvelis PG. Computed tomography-guided salvage brachytherapy of recurrent large non-Resectable familial colo-rectal cancer in the pelvis:case report. Technol Cancer Res Treat, 2002, 1(1):61-64.
9. Goes RN, Beart RW Jr, Simons AJ, et al. Use of brachytherapy in management of locally recurrent rectal cancer. Dis Colon Rectum, 1997, 40(10):1177-1179.
10. 吳同勝, 韓潞, 譚衛林. ¹²⁵I組織間插植放射治療腹腔內惡性腫瘤的探討.中國癌癥雜志, 2009, 19(12):947-949.
11. Wang Z, Lu J, Liu L, et al. Clinical application of CT-guided (125) I seed interstitial implan tatIon for local recurrent rectal carcinoma. Radiat Oncol, 2011, 6:138.
12. Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy. Med Oncol, 2010, 27(2):421-429.
13. 張亮, 范衛君, 黃金華, 等. CT導向下¹²⁵I粒子植入治療直腸癌術后局部復發.中華醫學雜志, 2008, 88(19):1335-1338.
14. 張開賢, 李苓, 邢超, 等. CT引導¹²⁵I放射性粒子植入治療復發性直腸癌32例報告.當代醫學, 2009, 15(36):13-15.
15. 吳越竇, 新民, 曲金榮.放射性¹²⁵I粒子植入術治療直腸癌的臨床研究.當代醫學, 2009, 10(15):564-565.
16. 柳晨, 袁慧書, 王俊杰.復發性直腸癌:CT引導下植入放射性粒子組織間近距離放療的療效.中國介入影像與治療學, 2012, 9(2):94-98.
17. 元云飛, 李斌奎, 李錦清, 等.巨大肝癌手術切除治療的遠期療效.癌癥, 2004, 23(7):821-824.
18. 芮靜安, 王少斌, 陳曙光.肝三葉切除術治療肝臟巨大腫瘤29例.中華外科雜志, 2001, 39(10):759-763.
19. Lee SG, Hwang S, Jung JP, et al. Outcome of patients with huge hepatocellular carcinoma after primary resection and treatment of recurrent lesions. Br J Surg, 2007, 94(3):320-326.
20. Chung GE, Lee JH, Kim HY, et al. Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology, 2011, 258(2):627-634.
21. Xu LT, Zhou ZH, Lin JH, et al. Clinical study of transarterial chemoembolization combined with 3-dimensional conformal radiotherapy for hepatocellular carcinoma. Eur J Surg Oncol, 2011, 37(3):245-251.
22. Merle P, Mornex F. Transarterial chemoembolization and conformal radiotherapy for heaptocellular carcinoma. Cancer Radiother, 2011, 15(1):69-71.
23. 范新華, 金利盛. CT引導下125 I粒子永久植入治療肝轉移癌.醫學影像學雜志, 2012, 22(4):581-584.
24. 王建新, 王貴吉, 吳洋東. ¹²⁵I粒子植入治療胃癌肝轉移的臨床療效.河南醫學研究, 2012, 21(3):321-323.
25. 王俊杰.放射性粒子組織間永久植入治療肝轉移癌.癌癥進展, 2009, 7(3):286-290.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Radioactive Seeds Iodine-125 Implantation in Treatment of Advanced Colorectal Cancer: Report of Nine Cases

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