甲狀腺癌術后再發甲狀旁腺癌1例診治分析并文獻復習_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 張廣 , 宋靈敏 , 周樂 , 劉曉莉 , 于天宇 , 雒毅強 ,  孫輝

吉林大學中日聯誼醫院甲狀腺外科吉林省外科轉化醫學中心實驗室（吉林長春 130033）;

Corresponding?author：

孫輝, Email: sunhui1229@163.com

Keywords：

甲狀旁腺癌; 甲狀腺癌; 診療; 高鈣血癥

DOI：

10.7507/1007-9424.20150293

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的探討甲狀旁腺癌的臨床診療經驗。方法回顧性分析筆者所在醫院收治的1例甲狀腺癌術后再發甲狀旁腺癌病例的臨床資料和診療經過，并進行文獻復習。結果患者第1次因甲狀腺癌行手術治療，術前甲狀旁腺素（PTH）及血鈣水平輕度升高，但未見甲狀旁腺腫瘤，術后PTH及血鈣降至正常水平。患者第2次以頸部腫物、甲狀旁腺功能亢進癥、高鈣血癥入院行手術治療后，PTH及血鈣再次降至正常水平，石蠟切片病理標本經專家會診明確甲狀旁腺癌的診斷。第2次術后1年患者的甲狀旁腺癌復發，行微創消融治療，術后PTH及血鈣有所下降，但未達理想范圍，現仍在隨訪中。結論甲狀腺癌并發甲狀旁腺癌臨床罕見，其術前診斷困難，根據術后石蠟病理檢查及免疫組化檢查可以確診。手術是其最有效的治療方法，術后局部復發率較高，故術后應長期監測血鈣和血PTH水平，盡早發現腫瘤復發或轉移情況，盡早治療，以求提高生存率和延長無瘤生存期。

Citation： 張廣, 宋靈敏, 周樂, 劉曉莉, 于天宇, 雒毅強, 孫輝. 甲狀腺癌術后再發甲狀旁腺癌1例診治分析并文獻復習. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(9): 1127-1129. doi: 10.7507/1007-9424.20150293 Copy

1.	?Lee PK, Jarosek SL, Virnig BA, et al. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer, 2007, 109(9):1736-1741.
2.	Basceken SI, Genc V, Ersoz S, et al. Is local resection sufficient for parathyroid carcinoma?. Clinics (Sao Paulo), 2015, 70(4):247-249.
3.	Schaapveld M, Jorna FH, Aben KK, et al. Incidence and prognosis of parathyroid gland carcinoma:a population-based study in The Netherlands estimating the preoperative diagnosis. Am J Surg, 2011, 202(5):590-597.
4.	Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol, 2010, 37(6):580-590.
5.	Witteveen JE, Haak HR, Kievit J, et al. Challenges and pitfalls in the management of parathyroid carcinoma:17-year follow-up of a case and review of the literature. Horm Cancer, 2010, 1(4):205-214.
6.	Korpi-Hy?v?lti E, Cranston T, Ryh?nen E, et al. CDC73 intragenic deletion in familial primary hyperparathyroidism associated with parathyroid carcinoma. J Clin Endocrinol Metab, 2014, 99(9):3044-3048.
7.	Sulaiman L, Haglund F, Hashemi J, et al. Genome-wide and locus specific alterations in CDC73/HRPT2-mutated parathyroid tumors. PLoS One, 2012, 7(9):e46325.
8.	Wang O, Wang C, Nie M, et al. Novel HRPT2/CDC73 gene muta-tions and loss of expression of parafibromin in Chinese patients with clinically sporadic parathyroid carcinomas. PLoS One, 2012, 7(9):e45567.
9.	Milas M, Mensah A, Alghoul M, et al. The impact of office neck ultrasonography on reducing unnecessary thyroid surgery in patients undergoing parathyroidectomy. Thyroid, 2005, 15(9):1055-1059.
10.	徐少明, 鄭毅雄, 王平, 等. 原發性甲狀旁腺功能亢進癥并發甲狀腺疾病21例臨床分析. 中華普通外科雜志, 2007, 22(2):81-84.
11.	Sidhu S, Campbell P. Thyroid pathology associated with primary hyperparathyroidism. Aust N Z J Surg, 2000, 70(4):285-287.
12.	Javadi H, Jallalat S, Farrokhi S, et al. Concurrent papillary thyroid cancer and parathyroid adenoma as a rare condition:a case report. Nucl Med Rev Cent East Eur, 2012, 15(2):153-155.
13.	崔愛民, 柏楠, 張自琴, 等. 原發性甲狀旁腺功能亢進合并甲狀腺病變的臨床病因分析. 山東醫藥, 2011, 51(40):91-93.
14.	Sturniolo G, Gagliano E, Tonante A, et al. Parathyroid carcinoma:case report. G Chir, 2013, 34(5-6):170-172.
15.	徐藝桐, 張觀宇, 許立莉, 等. 無功能性甲狀旁腺癌一例報道及文獻復習. 中華臨床醫師雜志:電子版, 2012, 6(10):2807-2808.
16.	陳超, 陳紅, 劉寶瑞, 等. 非功能性甲狀旁腺癌1例. 臨床腫瘤學雜志, 2011, 16(10):959-960.
17.	Gao WC, Ruan CP, Zhang JC, et al. Nonfunctional parathyroid carcinoma. J Cancer Res Clin Oncol, 2010, 136(7):969-974.
18.	Kebebew E, Arici C, Duh QY, et al. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg, 2001, 136(8):878-885.
19.	Sriphrapradang C, Sornmayura P, Chanplakorn N, et al. Fine-needle aspiration cytology of parathyroid carcinoma mimic hürthle cell thyroid neoplasm. Case Rep Endocrinol, 2014, 2014:680876.
20.	Agarwal G, Dhingra S, Mishra SK, et al. Implantation of parathyroid carcinoma along fine needle aspiration track. Langenbecks Arch Surg, 2006, 391(6):623-626.
21.	Delellis RA. Parathyroid carcinoma:an overview. Adv Anat Pathol, 2005, 12(2):53-61.
22.	Schulte KM, Talat N. Diagnosis and management of parathyroid cancer. Nat Rev Endocrinol, 2012, 8(10):612-622.
23.	Owen RP, Silver CE, Pellitteri PK, et al. Parathyroid carcinoma:a review. Head Neck, 2011, 33(3):429-436.
24.	Campenni A, Ruggeri RM, Sindoni A, et al. Parathyroid carcinoma as a challenging diagnosis:report of three cases. Hormones (Athens), 2012, 11(3):368-376.
25.	Montenegro FL, Chammas MC, Juliano AG, et al. Ethanol injection under ultrasound guidance to palliate unresectable parathyroid carcinoma. Arq Bras Endocrinol Metabol, 2008, 52(4):707-711.
26.	Tochio M, Takaki H, Yamakado K, et al. A case report of 20 lung radiofrequency ablation sessions for 50 lung metastases from parathyroid carcinoma causing hyperparathyroidism. Cardiovasc Intervent Radiol, 2010, 33(3):657-659.
27.	Shane E. Clinical review 122:parathyroid carcinoma. J Clin Endo-crinol Metab, 2001, 86(2):485-493.
28.	胡琳, 崔愛民, 柏楠, 等. 甲狀旁腺癌的診斷和治療(附7例報道). 中國普外基礎與臨床雜志, 2015, 22(1):75-80.
29.	Kleinpeter KP, Lovato JF, Clark PB, et al. Is parathyroid carcinoma indeed a lethal disease?. Ann Surg Oncol, 2005, 12(3):260-266.

1. ?Lee PK, Jarosek SL, Virnig BA, et al. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer, 2007, 109(9):1736-1741.
2. Basceken SI, Genc V, Ersoz S, et al. Is local resection sufficient for parathyroid carcinoma?. Clinics (Sao Paulo), 2015, 70(4):247-249.
3. Schaapveld M, Jorna FH, Aben KK, et al. Incidence and prognosis of parathyroid gland carcinoma:a population-based study in The Netherlands estimating the preoperative diagnosis. Am J Surg, 2011, 202(5):590-597.
4. Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol, 2010, 37(6):580-590.
5. Witteveen JE, Haak HR, Kievit J, et al. Challenges and pitfalls in the management of parathyroid carcinoma:17-year follow-up of a case and review of the literature. Horm Cancer, 2010, 1(4):205-214.
6. Korpi-Hy?v?lti E, Cranston T, Ryh?nen E, et al. CDC73 intragenic deletion in familial primary hyperparathyroidism associated with parathyroid carcinoma. J Clin Endocrinol Metab, 2014, 99(9):3044-3048.
7. Sulaiman L, Haglund F, Hashemi J, et al. Genome-wide and locus specific alterations in CDC73/HRPT2-mutated parathyroid tumors. PLoS One, 2012, 7(9):e46325.
8. Wang O, Wang C, Nie M, et al. Novel HRPT2/CDC73 gene muta-tions and loss of expression of parafibromin in Chinese patients with clinically sporadic parathyroid carcinomas. PLoS One, 2012, 7(9):e45567.
9. Milas M, Mensah A, Alghoul M, et al. The impact of office neck ultrasonography on reducing unnecessary thyroid surgery in patients undergoing parathyroidectomy. Thyroid, 2005, 15(9):1055-1059.
10. 徐少明, 鄭毅雄, 王平, 等. 原發性甲狀旁腺功能亢進癥并發甲狀腺疾病21例臨床分析. 中華普通外科雜志, 2007, 22(2):81-84.
11. Sidhu S, Campbell P. Thyroid pathology associated with primary hyperparathyroidism. Aust N Z J Surg, 2000, 70(4):285-287.
12. Javadi H, Jallalat S, Farrokhi S, et al. Concurrent papillary thyroid cancer and parathyroid adenoma as a rare condition:a case report. Nucl Med Rev Cent East Eur, 2012, 15(2):153-155.
13. 崔愛民, 柏楠, 張自琴, 等. 原發性甲狀旁腺功能亢進合并甲狀腺病變的臨床病因分析. 山東醫藥, 2011, 51(40):91-93.
14. Sturniolo G, Gagliano E, Tonante A, et al. Parathyroid carcinoma:case report. G Chir, 2013, 34(5-6):170-172.
15. 徐藝桐, 張觀宇, 許立莉, 等. 無功能性甲狀旁腺癌一例報道及文獻復習. 中華臨床醫師雜志:電子版, 2012, 6(10):2807-2808.
16. 陳超, 陳紅, 劉寶瑞, 等. 非功能性甲狀旁腺癌1例. 臨床腫瘤學雜志, 2011, 16(10):959-960.
17. Gao WC, Ruan CP, Zhang JC, et al. Nonfunctional parathyroid carcinoma. J Cancer Res Clin Oncol, 2010, 136(7):969-974.
18. Kebebew E, Arici C, Duh QY, et al. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg, 2001, 136(8):878-885.
19. Sriphrapradang C, Sornmayura P, Chanplakorn N, et al. Fine-needle aspiration cytology of parathyroid carcinoma mimic hürthle cell thyroid neoplasm. Case Rep Endocrinol, 2014, 2014:680876.
20. Agarwal G, Dhingra S, Mishra SK, et al. Implantation of parathyroid carcinoma along fine needle aspiration track. Langenbecks Arch Surg, 2006, 391(6):623-626.
21. Delellis RA. Parathyroid carcinoma:an overview. Adv Anat Pathol, 2005, 12(2):53-61.
22. Schulte KM, Talat N. Diagnosis and management of parathyroid cancer. Nat Rev Endocrinol, 2012, 8(10):612-622.
23. Owen RP, Silver CE, Pellitteri PK, et al. Parathyroid carcinoma:a review. Head Neck, 2011, 33(3):429-436.
24. Campenni A, Ruggeri RM, Sindoni A, et al. Parathyroid carcinoma as a challenging diagnosis:report of three cases. Hormones (Athens), 2012, 11(3):368-376.
25. Montenegro FL, Chammas MC, Juliano AG, et al. Ethanol injection under ultrasound guidance to palliate unresectable parathyroid carcinoma. Arq Bras Endocrinol Metabol, 2008, 52(4):707-711.
26. Tochio M, Takaki H, Yamakado K, et al. A case report of 20 lung radiofrequency ablation sessions for 50 lung metastases from parathyroid carcinoma causing hyperparathyroidism. Cardiovasc Intervent Radiol, 2010, 33(3):657-659.
27. Shane E. Clinical review 122:parathyroid carcinoma. J Clin Endo-crinol Metab, 2001, 86(2):485-493.
28. 胡琳, 崔愛民, 柏楠, 等. 甲狀旁腺癌的診斷和治療(附7例報道). 中國普外基礎與臨床雜志, 2015, 22(1):75-80.
29. Kleinpeter KP, Lovato JF, Clark PB, et al. Is parathyroid carcinoma indeed a lethal disease?. Ann Surg Oncol, 2005, 12(3):260-266.

Previous Article
小切口直接甲狀旁腺腺瘤切除術治療原發性甲狀旁腺功能亢進18例報道
Next Article
成人胰腺體尾部海綿狀血管瘤1例報道并文獻復習

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

甲狀腺癌術后再發甲狀旁腺癌1例診治分析并文獻復習

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content