亞甲基四氫葉酸還原酶基因C677T和A1298C位點多態性與胃癌易感性的相關性分析_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 沈宏 , 張寧

武警后勤學院附屬醫院普通外科（天津 300162）;

Corresponding?author：

沈宏, Email: shenhonng@126.com

Keywords：

亞甲基四氫葉酸還原酶基因; 胃癌; C677T位點; A1298C位點; 基因多態性; 易感性

DOI：

10.7507/1007-9424.20150094

Video：

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目的探討亞甲基四氫葉酸還原酶（MTHFR）基因C677T和A1298C位點多態性與胃癌易感性的相關性。方法回顧性收集2008年1月至2014年1月期間在筆者所在醫院住院的、行MTHFR基因C677T和A1298C位點檢測的160例胃癌患者作為胃癌組，收集同期160名自愿接受上述基因檢測的健康體檢人員作為對照組，比較2組2種位點基因型的分布情況。結果胃癌組患者MTHFR基因C677T位點的基因型為：CC 72例，CT 64例，TT 24例；對照組為：CC 78例，CT 69例，TT 13例。胃癌組患者MTHFR基因A1298C位點的基因型為：AA 58例，AC 84例，CC 18例；對照組為：AA 62例，AC 77例，CC 21例。2組C677T位點及A1298C位點的基因型分布比較差異均無統計學意義（P>0.05）。結論 MTHFR基因C677T位點和A1298C位點多態性與胃癌的易感性無明顯相關性。

Citation： 沈宏, 張寧. 亞甲基四氫葉酸還原酶基因C677T和A1298C位點多態性與胃癌易感性的相關性分析. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 351-353. doi: 10.7507/1007-9424.20150094 Copy

1.	?Engin AB, Karahalil B, Karakaya AE, et al. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol, 2011, 62(3):207-214.
2.	Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2):170-174.
3.	Woo HD, Lee J, Choi IJ, et al. Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients, 2014, 6(11):4961-4973.
4.	Yoon H, Kim N. Diagnosis and management of high risk group for gastric cancer. Gut Liver, 2015, 9(1):5-17.
5.	Huang GL, Wang SK, Su M, et al. Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk. Biomed Environ Sci, 2013, 26(12):1008-1012.
6.	宋潔云, 劉芳宏, 馬軍, 等. 酚/氯仿法和鹽析法提取人類外周血基因組DNA方法的比較. 中國實驗診斷學, 2013, 17(5):802-805.
7.	Wen YY, Pan XF, Loh M, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 2012, 13(5):2139-2144.
8.	文拓. 胃癌外科治療的現狀與進展. 中國衛生產業, 2013, 2(4):191.
9.	Zhang Y, Wang M, Gu D, et al. Association of XRCC1 gene polymor-phisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3):111-118.
10.	Wu YL, Hu CY, Lu SS, et al. Association between methylenetetrahy-drofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension:a systematic review and meta-analysis. Metabolism, 2014, 63(12):1503-1511.
11.	馬利敏, 趙小強, 劉洪超, 等. 亞甲基四氫葉酸還原酶基因多態性與中國兒童急性淋巴細胞白血病關系的Meta分析. 醫學研究雜志, 2014, 43(4):87-90.
12.	Zhou BS, Bu GY, Li M, et al. Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population. Int J Mol Sci, 2014, 15(5):8931-8940.
13.	宋姍姍, 楊博逸, 孫貴范. 中國人群中亞甲基四氫葉酸還原酶C677T和A1298C基因多態性與乳腺癌相關性的Meta分析. 中國慢性病預防與控制, 2013, 21(5):560-564.
14.	張軍喜, 郭愛葉, 李宗輝, 等. TNF-α-308基因多態性與胃癌的關系研究. 中國現代藥物應用, 2014, 8(10):1-2.
15.	劉暢, 張玲, 姜政, 等. TNF-β基因+252A/G多態性與胃癌易感性Meta分析. 重慶醫科大學學報, 2014, 39(3):284-289.
16.	司君利, 亓玉琴, 紀麗莎, 等. hTERT基因多態性與胃癌易感性的研究. 胃腸病學, 2014, 19(5):270-274.
17.	小紅逄, 李效良, 張國琴. IGF2R基因多態性與胃癌易感性的相關性. 泰山醫學院學報, 2013, 34(11):805-807.
18.	王曉龍, 張成武, 劉寧, 等. P53基因Arg72Pro單核苷酸多態性與青海地區人群胃癌易感性的相關性分析. 中國免疫學雜志, 2014, 30(2):178-181.
19.	李丹萍, 侯慧, 徐昌青, 等. xpc 基因多態性與胃癌發生風險的關系. 山東醫藥, 2014, 54(13):24-26.
20.	Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015,[Epub ahead of print].
21.	Liu NB, Li J, Qi JF, et al. Methylenetetrahydrofolate reductase 677TT genotype may be associated with an increased lung cancer risk in North China:an updated meta-analysis. Med Sci Monit, 2014, 20:2817-2823.
22.	Rai V. Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations. Asian Pac J Cancer Prev, 2014, 15(21):9259-9264.

1. ?Engin AB, Karahalil B, Karakaya AE, et al. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol, 2011, 62(3):207-214.
2. Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2):170-174.
3. Woo HD, Lee J, Choi IJ, et al. Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients, 2014, 6(11):4961-4973.
4. Yoon H, Kim N. Diagnosis and management of high risk group for gastric cancer. Gut Liver, 2015, 9(1):5-17.
5. Huang GL, Wang SK, Su M, et al. Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk. Biomed Environ Sci, 2013, 26(12):1008-1012.
6. 宋潔云, 劉芳宏, 馬軍, 等. 酚/氯仿法和鹽析法提取人類外周血基因組DNA方法的比較. 中國實驗診斷學, 2013, 17(5):802-805.
7. Wen YY, Pan XF, Loh M, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 2012, 13(5):2139-2144.
8. 文拓. 胃癌外科治療的現狀與進展. 中國衛生產業, 2013, 2(4):191.
9. Zhang Y, Wang M, Gu D, et al. Association of XRCC1 gene polymor-phisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3):111-118.
10. Wu YL, Hu CY, Lu SS, et al. Association between methylenetetrahy-drofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension:a systematic review and meta-analysis. Metabolism, 2014, 63(12):1503-1511.
11. 馬利敏, 趙小強, 劉洪超, 等. 亞甲基四氫葉酸還原酶基因多態性與中國兒童急性淋巴細胞白血病關系的Meta分析. 醫學研究雜志, 2014, 43(4):87-90.
12. Zhou BS, Bu GY, Li M, et al. Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population. Int J Mol Sci, 2014, 15(5):8931-8940.
13. 宋姍姍, 楊博逸, 孫貴范. 中國人群中亞甲基四氫葉酸還原酶C677T和A1298C基因多態性與乳腺癌相關性的Meta分析. 中國慢性病預防與控制, 2013, 21(5):560-564.
14. 張軍喜, 郭愛葉, 李宗輝, 等. TNF-α-308基因多態性與胃癌的關系研究. 中國現代藥物應用, 2014, 8(10):1-2.
15. 劉暢, 張玲, 姜政, 等. TNF-β基因+252A/G多態性與胃癌易感性Meta分析. 重慶醫科大學學報, 2014, 39(3):284-289.
16. 司君利, 亓玉琴, 紀麗莎, 等. hTERT基因多態性與胃癌易感性的研究. 胃腸病學, 2014, 19(5):270-274.
17. 小紅逄, 李效良, 張國琴. IGF2R基因多態性與胃癌易感性的相關性. 泰山醫學院學報, 2013, 34(11):805-807.
18. 王曉龍, 張成武, 劉寧, 等. P53基因Arg72Pro單核苷酸多態性與青海地區人群胃癌易感性的相關性分析. 中國免疫學雜志, 2014, 30(2):178-181.
19. 李丹萍, 侯慧, 徐昌青, 等. xpc 基因多態性與胃癌發生風險的關系. 山東醫藥, 2014, 54(13):24-26.
20. Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015,[Epub ahead of print].
21. Liu NB, Li J, Qi JF, et al. Methylenetetrahydrofolate reductase 677TT genotype may be associated with an increased lung cancer risk in North China:an updated meta-analysis. Med Sci Monit, 2014, 20:2817-2823.
22. Rai V. Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations. Asian Pac J Cancer Prev, 2014, 15(21):9259-9264.

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亞甲基四氫葉酸還原酶基因C677T和A1298C位點多態性與胃癌易感性的相關性分析

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