Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIHao ¹ , YAOMeng-jie ¹ , ZOUBo-yuan ² , XUJian ¹ ,  DUXiao-hui ^1,3

1. Department of General Surgery, PLA General Hospital, Beijing 100853, China;
2. Clinical Medicine College, Medical College of Nankai University, Tianjin 300071, China;
3. Department of General Surgery, Hainan Branch of PLA General Hospital, Sanya 572013, Hainan Province, China;

Corresponding?author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Low density lipoprotein cholesterol; High density lipoprotein cholesterol; Colorectal cancer; Tumor staging; Lymph node metastasis; Distant metastasis

DOI：

10.7507/1007-9424.20150078

Video：

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Objective To evaluate the relationship between low density lipoprotein cholesterol (LDL-C)/high density lipoprotein cholesterol (HDL-C) of preoperation (L/H value for short) and the pathological staging of colorectal cancer. Methods The clinical data of 187 patients with colorectal cancer who treated in PLA General Hospital from July 2009 to June 2014 were analyzed retrospectively. Results There were statistical significance in L/H value among different TNM stagings, N stagings, and M stagings (P<0.05):L/H value of TNM Ⅳ staging was higher than those of TNM Ⅰ, Ⅱ, and Ⅲ staging, L/H values of N1 staging and N0 staging were lower than that of N2 staging, L/H value of M1 staging was higher than that of M0 staging. However, there was no statistical significance in L/H value among different T stagings of colorectal cancer (P>0.05). Logistic regression results showed that L/H value were positively associated with TNM staging (OR=4.34, 95% CI:2.837-6.644, P<0.000 1), T staging (OR=1.72, 95% CI:1.175-2.512, P=0.005 3), N staging (OR=2.15, 95% CI:1.422-3.254, P=0.000 3), and M staging (OR=3.04, 95% CI:1.733-5.332, P=0.000 1) of colorectal cancer, and patient with higher L/H value took more risk of progression of tumor, lymph node metastases, and distant metastasis. Conclusions Raise of preoperative L/H value is an independent risk factor for the progression of TNM staging, T staging, N staging, and M staging in colorectal cancer.

Citation： LIHao, YAOMeng-jie, ZOUBo-yuan, XUJian, DUXiao-hui. Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 289-292. doi: 10.7507/1007-9424.20150078 Copy

1.	?全國腫瘤防治研究辦公室,全國腫瘤登記中心, 衛生部疾病預防控制局. 中國腫瘤登記年報(2009). 北京:中國協和醫科大學出版社, 2012:335-442.
2.	Grosman H, Fabre B, Mesch V, et al. Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer. Aging Male, 2010, 13(2):87-92.
3.	Kuliszkiewicz-Janus M, Ma?ecki R, Mohamed AS. Lipid changes occuring in the course of hematological cancers. Cell Mol Biol Lett, 2008, 13(3):465-474.
4.	Shah FD, Shukla SN, Shah PM, et al. Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther, 2008, 7(1):33-41.
5.	劉業六, 錢海鑫, 秦磊, 等. 血脂相與乳腺癌遠處轉移的關系. 中華腫瘤雜志, 2012, 34(2): 129-131.
6.	Yang MH, Rampal S, Sung J, et al. The association of serum lipids with colorectal adenomas. Am J Gastroenterol, 2013, 108(5):833-841.
7.	詹建民, 趙先文, 劉東博, 等. 結直腸癌患者脂類水平的改變及其臨床意義. 中華胃腸外科雜志, 2009, 12(2): 205-206.
8.	van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, et al. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into cancer and nutrition. Gut, 2011, 60(8):1094-1102.
9.	Stephen B, April G, David R, et al. The AJCC cancer staging manual and handbook (7th edition). Heidelberg:Springer-verlag, 2010:143-164.
10.	王玉欣, 路國濤, 肖煒明, 等. 血脂水平與結直腸腫瘤關系的研究. 胃腸病學, 2014, 19(4):229-232.
11.	何勇山, 金黑鷹, 章蓓, 等. 脂代謝與結直腸腫瘤關系的研究進展. 世界華人消化雜志, 2012, 20(6):486-490.
12.	楊永濤, 盛華, 李志文, 等. 膽固醇代謝與結直腸癌的關系及其機制. 中華內分泌代謝雜志, 2014, 30(3):254-257.
13.	Notarnicola M, Altomare DF, Correale M, et al. Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases. Oncology, 2005, 68(4-6):371-374.
14.	Liu YL, Qian HX, Qin L, et al. Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology, 2011, 58(106):383-387.
15.	Carreras F, Sarli L, Pietra N, et al. A critical review of the history of the systems for staging colorectal cancer. G Chir, 1992, 13(5):287-292.
16.	Singh H, Mahmud SM, Turner D, et al. Long-term use of statins and risk of colorectal cancer:a population-based study. Am J Gastroenterol, 2009, 104(12):3015-3023.
17.	Méndez Mora JL, Ortega Calvo M, Cayuela Domínguez A, et al. CA 19.9 and HDL-cholesterol behaviour in a sporadic colorectal carcinoma sample. An Med Interna, 2004, 21(5):227-230.
18.	呂炳建, 來茂德. 代謝綜合征、胰島素抵抗與結直腸癌. 中華病理學雜志, 2006, 35(2):110-112.
19.	Vitols S, Norgren S, Juliusson G, et al. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood, 1994, 84(8):2689-2698.
20.	Bigler RD, Khoo M, Lund-Katz S, et al. Identification of low density lipoprotein as a regulator of Fc receptor-mediated phagocytosis. Proc Natl Acad Sci U S A, 1990, 87(13):4981-4985.
21.	Mccarthy BM, Okano Y, Nakayasu T, et al. Plasma lipoproteins and transferrin regulate the proliferation of a continuous T lymphocyte cell line. J Lipid Res, 1987, 28(9):1067-1077.
22.	馬愛迪, 王彩蓮, 閔捷, 等. 血清脂質水平與結直腸癌遠處轉移的相關性分析. 東南大學學報:醫學版, 2012, 31(4):471-473.
23.	彭心昭, 李健, 葉漢深, 等. 結直腸癌遠處轉移與血脂變化的關系研究. 臨床腫瘤學雜志, 2008, 13(1):64-66.
24.	Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer. Mol Cancer Ther, 2012, 11(6):1311-1319.
25.	李祖國, 趙亮, 劉莉, 等. 結直腸癌轉移動物模型血清中幾種蛋白變化的觀察. 中華病理學雜志, 2007, 36(1):48-52.
26.	梁振濤, 王憲沛, 曾秋棠, 等. 冠心病合并結直腸癌對血脂水平的影響及他汀類藥物調脂的意義. 南方醫科大學學報, 2008, 28(5):863-865.

1. ?全國腫瘤防治研究辦公室,全國腫瘤登記中心, 衛生部疾病預防控制局. 中國腫瘤登記年報(2009). 北京:中國協和醫科大學出版社, 2012:335-442.
2. Grosman H, Fabre B, Mesch V, et al. Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer. Aging Male, 2010, 13(2):87-92.
3. Kuliszkiewicz-Janus M, Ma?ecki R, Mohamed AS. Lipid changes occuring in the course of hematological cancers. Cell Mol Biol Lett, 2008, 13(3):465-474.
4. Shah FD, Shukla SN, Shah PM, et al. Significance of alterations in plasma lipid profile levels in breast cancer. Integr Cancer Ther, 2008, 7(1):33-41.
5. 劉業六, 錢海鑫, 秦磊, 等. 血脂相與乳腺癌遠處轉移的關系. 中華腫瘤雜志, 2012, 34(2): 129-131.
6. Yang MH, Rampal S, Sung J, et al. The association of serum lipids with colorectal adenomas. Am J Gastroenterol, 2013, 108(5):833-841.
7. 詹建民, 趙先文, 劉東博, 等. 結直腸癌患者脂類水平的改變及其臨床意義. 中華胃腸外科雜志, 2009, 12(2): 205-206.
8. van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, et al. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into cancer and nutrition. Gut, 2011, 60(8):1094-1102.
9. Stephen B, April G, David R, et al. The AJCC cancer staging manual and handbook (7th edition). Heidelberg:Springer-verlag, 2010:143-164.
10. 王玉欣, 路國濤, 肖煒明, 等. 血脂水平與結直腸腫瘤關系的研究. 胃腸病學, 2014, 19(4):229-232.
11. 何勇山, 金黑鷹, 章蓓, 等. 脂代謝與結直腸腫瘤關系的研究進展. 世界華人消化雜志, 2012, 20(6):486-490.
12. 楊永濤, 盛華, 李志文, 等. 膽固醇代謝與結直腸癌的關系及其機制. 中華內分泌代謝雜志, 2014, 30(3):254-257.
13. Notarnicola M, Altomare DF, Correale M, et al. Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases. Oncology, 2005, 68(4-6):371-374.
14. Liu YL, Qian HX, Qin L, et al. Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer. Hepatogastroenterology, 2011, 58(106):383-387.
15. Carreras F, Sarli L, Pietra N, et al. A critical review of the history of the systems for staging colorectal cancer. G Chir, 1992, 13(5):287-292.
16. Singh H, Mahmud SM, Turner D, et al. Long-term use of statins and risk of colorectal cancer:a population-based study. Am J Gastroenterol, 2009, 104(12):3015-3023.
17. Méndez Mora JL, Ortega Calvo M, Cayuela Domínguez A, et al. CA 19.9 and HDL-cholesterol behaviour in a sporadic colorectal carcinoma sample. An Med Interna, 2004, 21(5):227-230.
18. 呂炳建, 來茂德. 代謝綜合征、胰島素抵抗與結直腸癌. 中華病理學雜志, 2006, 35(2):110-112.
19. Vitols S, Norgren S, Juliusson G, et al. Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood, 1994, 84(8):2689-2698.
20. Bigler RD, Khoo M, Lund-Katz S, et al. Identification of low density lipoprotein as a regulator of Fc receptor-mediated phagocytosis. Proc Natl Acad Sci U S A, 1990, 87(13):4981-4985.
21. Mccarthy BM, Okano Y, Nakayasu T, et al. Plasma lipoproteins and transferrin regulate the proliferation of a continuous T lymphocyte cell line. J Lipid Res, 1987, 28(9):1067-1077.
22. 馬愛迪, 王彩蓮, 閔捷, 等. 血清脂質水平與結直腸癌遠處轉移的相關性分析. 東南大學學報:醫學版, 2012, 31(4):471-473.
23. 彭心昭, 李健, 葉漢深, 等. 結直腸癌遠處轉移與血脂變化的關系研究. 臨床腫瘤學雜志, 2008, 13(1):64-66.
24. Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer. Mol Cancer Ther, 2012, 11(6):1311-1319.
25. 李祖國, 趙亮, 劉莉, 等. 結直腸癌轉移動物模型血清中幾種蛋白變化的觀察. 中華病理學雜志, 2007, 36(1):48-52.
26. 梁振濤, 王憲沛, 曾秋棠, 等. 冠心病合并結直腸癌對血脂水平的影響及他汀類藥物調脂的意義. 南方醫科大學學報, 2008, 28(5):863-865.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Ratio of Serum Low Density Lipoprotein Cholesterol to High Density Lipoprotein Cholesterol and Pathological Staging of Colorectal Cancer

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