Clinical Application of Hemodilution Autotransfusion in Liver Resection for Patients with Hepatic Echinococcosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LUOXiao-qin ¹ ,  YANGKang-ming ² , ZHANGTan ¹ , LIUQing ¹ , GESang-qu-zhen ¹ , YANGXue-mei ¹ , ZOUGuo-ling ¹ , LUOYan ¹ , LIXin-mei ¹ , JIANGChao-pin ¹ , CHENZhe-yu ³

1. Operation Room, Ganzi Prefecture People's Hospital, Kangding 626000, Sichuan Province, China;
2. Department of General Surgery, Ganzi Prefecture People's Hospital, Kangding 626000, Sichuan Province, China;
3. Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

YANGKang-ming, Email: ykm@163.com

Keywords：

Hemodilution; Autotransfusion; Liver hydatid disease

DOI：

10.7507/1007-9424.20150042

Video：

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Objective To evaluate the effect of dilute autotransfusion in liver resection for patients with hepatic hydatid disease. Method Thirty patients with hepatic hydatid disease met the inclusion criteria were included. The changes of intraoperative hemodynamics, internal environment, and each system functions at different time point were observed. Results ①There were no significant differences among mean arterial pressure, central venous pressure, heart rate in all the patients at each time point (P > 0.05), while, the other indexes including the concentrations of hemoglobin (Hb), hematocrit (Hct) after blood collection were all greatly lower than those before blood collection (P < 0.05), Na⁺, K⁺, Cl^-, pH, and base excess after blood collection were all greatly lower than those before blood collection (P < 0.05). But all the indexes above mentioned (except for ph and base excess) returned to normal.②Compared with these indicators before surgery, the blood concentrations of AST, ALT, cardiac troponin I, and creatinin were all greatly increased (P < 0.05), the blood concentrations of Hb, Hct, platelet were all decreased apparently after surgery 1 day (P < 0.05). The prothrombin time and activated partial thromboplastin time were all prolonged (P < 0.05). But after surgery one week, those indicators had rebounded to the normal range. Conclusion The application of dilute autotransfusion in liver surgery for patients with hepatic hydatid disease is safe, feasible, and saving.

Citation： LUOXiao-qin, YANGKang-ming, ZHANGTan, LIUQing, GESang-qu-zhen, YANGXue-mei, ZOUGuo-ling, LUOYan, LIXin-mei, JIANGChao-pin, CHENZhe-yu. Clinical Application of Hemodilution Autotransfusion in Liver Resection for Patients with Hepatic Echinococcosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(2): 154-158. doi: 10.7507/1007-9424.20150042 Copy

1.	?梁兵, 田兆嵩.稀釋式自身輸血.中國輸血雜志, 2005, 18(6): 520-524.
2.	李長龍, 景鴻恩.肝包蟲病的診斷與治療現狀.中外醫學研究, 2012, 10(5): 158-160.
3.	溫浩.肝包蟲病診斷和手術治療新進展.中華消化外科雜志, 2011, 10(4): 290-292.
4.	鄔露丹, 徐煒峰, 郭建榮, 等.急性等容血液稀釋對老年肝切除術患者血漿蛋白、凝血功能的影響.現代實用醫學, 2008, 20(2): 86-87, 91.
5.	陶紅斌, 黃煥娟, 詹鴻, 等.回收式自體輸血聯合血液稀釋應用于骨科手術的研究.熱帶醫學雜志, 2010, 3(3): 333.
6.	林健清, 林財珠, 楊慶.急性等容性血液稀釋對肝臟手術纖維蛋白降解產物D-二聚體和凝血功能的影響.臨床麻醉學雜志, 2006, 22(5): 324-326.
7.	夏曉峰, 錢寶華.術中回收式自身輸血的研究進展.中國輸血雜志, 2008, 21(4): 310-314.
8.	Valter C, Giovanni S, Da CR, et al. Intraoperative low-volume acute normovolemic hemodilution in adult open-heart surgery. Anesthesiology, 2002, 97(2): 367-373.
9.	譚麗莉, 王海燕, 張樹超, 等.急性等容稀釋性自身輸血在心臟外科手術中的應用.中國輸血雜志, 2009, 22(10): 820-821.
10.	Bennett J, Haynes S, Torella F, et al. Acute normovolemic hemodilution in moderate blood loss surgery: a randomized controlled trial. Transfusion, 2006, 46(7): 1097-1103.
11.	徐彬.血液稀釋研究的若干進展.內蒙古中醫藥, 2013, 32(18): 155-156.
12.	趙桂軍, 孫莉, 邵永孚.急性等容血液稀釋自身輸血應用于腹部腫瘤患者手術的可行性.中華醫學雜志, 2003, 83(11): 1000-1001.
13.	Matot I, Scheinin O, Jurim O, et al. Effectiveness of acute normovolemic hemodilution to minimize allogeneic blood transfusion in major liver resections. Anesthesiology, 2002, 97(4): 794-800.
14.	Guo JR, Jin XJ, Yu J, et al. Acute normovolemic hemodilution effects on perioperative coagulation and fibrinolysis in elderly patients undergoing hepatic carcinectomy. Chin Med Sci, 2010, 25(3): 146-150.
15.	Saricaoglu F, Akinci SB, Celiker V, et al. The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion. Saudi Med J, 2005, 26(5): 792-798.

1. ?梁兵, 田兆嵩.稀釋式自身輸血.中國輸血雜志, 2005, 18(6): 520-524.
2. 李長龍, 景鴻恩.肝包蟲病的診斷與治療現狀.中外醫學研究, 2012, 10(5): 158-160.
3. 溫浩.肝包蟲病診斷和手術治療新進展.中華消化外科雜志, 2011, 10(4): 290-292.
4. 鄔露丹, 徐煒峰, 郭建榮, 等.急性等容血液稀釋對老年肝切除術患者血漿蛋白、凝血功能的影響.現代實用醫學, 2008, 20(2): 86-87, 91.
5. 陶紅斌, 黃煥娟, 詹鴻, 等.回收式自體輸血聯合血液稀釋應用于骨科手術的研究.熱帶醫學雜志, 2010, 3(3): 333.
6. 林健清, 林財珠, 楊慶.急性等容性血液稀釋對肝臟手術纖維蛋白降解產物D-二聚體和凝血功能的影響.臨床麻醉學雜志, 2006, 22(5): 324-326.
7. 夏曉峰, 錢寶華.術中回收式自身輸血的研究進展.中國輸血雜志, 2008, 21(4): 310-314.
8. Valter C, Giovanni S, Da CR, et al. Intraoperative low-volume acute normovolemic hemodilution in adult open-heart surgery. Anesthesiology, 2002, 97(2): 367-373.
9. 譚麗莉, 王海燕, 張樹超, 等.急性等容稀釋性自身輸血在心臟外科手術中的應用.中國輸血雜志, 2009, 22(10): 820-821.
10. Bennett J, Haynes S, Torella F, et al. Acute normovolemic hemodilution in moderate blood loss surgery: a randomized controlled trial. Transfusion, 2006, 46(7): 1097-1103.
11. 徐彬.血液稀釋研究的若干進展.內蒙古中醫藥, 2013, 32(18): 155-156.
12. 趙桂軍, 孫莉, 邵永孚.急性等容血液稀釋自身輸血應用于腹部腫瘤患者手術的可行性.中華醫學雜志, 2003, 83(11): 1000-1001.
13. Matot I, Scheinin O, Jurim O, et al. Effectiveness of acute normovolemic hemodilution to minimize allogeneic blood transfusion in major liver resections. Anesthesiology, 2002, 97(4): 794-800.
14. Guo JR, Jin XJ, Yu J, et al. Acute normovolemic hemodilution effects on perioperative coagulation and fibrinolysis in elderly patients undergoing hepatic carcinectomy. Chin Med Sci, 2010, 25(3): 146-150.
15. Saricaoglu F, Akinci SB, Celiker V, et al. The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion. Saudi Med J, 2005, 26(5): 792-798.

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Clinical Application of Hemodilution Autotransfusion in Liver Resection for Patients with Hepatic Echinococcosis

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