Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGPan ¹ , SUNYing-he ² ,  MABu-yun ¹ , JINYa ¹ , ZHOUJie-hong ¹ , PENGYu-lan ¹

1. Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
2. Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

MABu-yun, Email: ws_mby@126.com

Keywords：

Thyroid non-hodgkin lymphoma; Primary neoplasm; Ultrasonography

DOI：

10.7507/1007-9424.20140263

Video：

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Objective To investigate ultrasonography features of primary thyroid non-Hodgkin lymphoma (PT-NHL). Methods Ultrasonographic data of patients with PT-NHL(PT-NHL group) and non-Hodgkin lymphoma (control group) who were treated in our hospital from May. 2002 to Jul. 2014 were collected and analyzed. Results Compared with control group, enhancement of posterior echoes was more common in PT-NHL group (P=0.000), and difference values of transverse diameters, anteroposterior diameters, and sagittal diameters of more involved lobe to another lobe were bigger(P < 0.05), but echo pattern of gland, ultrasonographic classification of lesions, classification of vascularity, and condition of cervical lymph nodes were found no statistical difference(P > 0.05). In patients with nodular-type lesions(37 patients in PT-NHL group and 12 patients in control group), length of nodule lesions was larger in PT-NHL group (P=0.000), but there was no statistical difference in shape, boundary, orientation, and echoes of nodules between 2 groups(P > 0.05). In Pulsed-Wave(PW) Doppler between 2 groups(17 patients in PT-NHL group and 4 patients in control group), vascular resistance index(RI) was higher in PT-NHL group than those of control group (P=0.024). Conclusion The enhancement of posterior echoes was a feature in ultrasonography images of PT-NHL. Asymmetrical volume, high value of RI, and big nodule might link to PT-NHL, but diffuse heterogeneous echo with hypoechoic lesions might result in wrong diagnosis as PT-NHL.

Citation： YANGPan, SUNYing-he, MABu-yun, JINYa, ZHOUJie-hong, PENGYu-lan. Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(9): 1092-1096. doi: 10.7507/1007-9424.20140263 Copy

1.	岑溪南, 馬明信, 郭輝, 等.原發結外淋巴瘤139例臨床及誤診分析[J]. 北京大學學報:醫學版, 2003, 35(2):143-145.
2.	Al Diab AR, Aleem A, Qayum A, et al.Clinico-pathological pattern of extranodal non-Hodgkin's lymphoma in Saudi Arabia[J]. Asian Pac J Cancer Prev, 2011, 12(12):3277-3282.
3.	徐義全, 青曉艷, 樊晉川, 等.四川省腫瘤醫院2002至2011年全身麻醉甲狀腺惡性腫瘤患者臨床病理學分析[J/CD]. 中華臨床醫師雜志:電子版, 2013, 7(7):2842-2846.
4.	崔俊生, 陳桂秋, 倪勁松, 等.不同年代甲狀腺惡性腫瘤構成分析(附1011例病理報告)[J]. 中國實用外科雜志, 2004, 24(10):600-602.
5.	Dayan CM, Daniels GH.Chronic autoimmune thyroiditis[J]. N Eng J Med, 1996, 335(2):99-107.
6.	喻建軍, 曾亮, 周曉, 等.原發性甲狀腺淋巴瘤誤診分析[J]. 中國耳鼻咽喉頭頸外科, 2008, 15(1):25-27.
7.	Campo E, Swerdlow SH, Harris NL, et al.The 2008 WHO classification of lymphoid neoplasms and beyond:evolving concepts and practical applications[J]. Blood, 2011, 117(19):5019-5032.
8.	Ota H, Ito Y, Matsuzuka F, et al.Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid[J]. Thyroid, 2006, 16(10):983-987.
9.	Ma B, Jia Y, Wang Q, et al.Ultrasound of primary thyroid non-Hodgkin's lymphoma[J]. Clin Imaging, 2014, 38(5):621-626.
10.	Walsh S, Lowery AJ, Evoy D, et al.Thyroid lymphoma:recent advances in diagnosis and optimal management strategies[J]. Oncologist, 2013, 18(9):994-1003.
11.	張廷令.原發性甲狀腺淋巴瘤:Mayo臨床中心到1978年的經驗復習[J]. 國外醫學外科學分冊, 1981, (4):225-226.
12.	Sarinah B, Hisham AN.Primary lymphoma of the thyroid:diagnostic and therapeutic considerations[J]. Asian J Surg, 2010, 33(1):20-24.
13.	Ahmed R, Al-Shaikh S, Akhtar M.Hashimoto thyroiditis:a century later[J]. Adv Anat Pathol, 2012, 19(3):181-186.
14.	李昌幼, 羅佐杰.原發性甲狀腺淋巴瘤的發病機制及診治現狀[J]. 實用醫學雜志, 2013, 29(3):341-342.
15.	Ben-Ezra J, Wu A, Sheibani K.Hashimoto's thyroiditis lacks detectable clonal immunoglobulin and T cell receptor gene rearrangements[J]. Hum Pathol, 1988, 19(12):1444-1448.
16.	Stein SA, Wartofsky L.Primary thyroid lymphoma:a clinical review[J]. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
17.	Watanabe N, Noh JY, Narimatsu H, et al.Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease[J]. Br J Haematol, 2011, 153(2):236-243.
18.	Green LD, Mack L, Pasieka JL.Anaplastic thyroid cancer and primary thyroid lymphoma:a review of these rare thyroid malignancies[J]. J Surg Oncol, 2006, 94(8):725-736.
19.	Meusers P, Elo B, Wittig A, et al.Diagnosis and treatment of primary malignant lymphoma of the thyroid gland[J].Chinese-German J Clin Oncol,2003,2(4):219-223.
20.	Sun TQ, Zhu XL, Wang ZY, et al.Characteristics and prognosis of primary thyroid non-Hodgkin's lymphoma in Chinese patients[J]. J Surg Oncol, 2010, 101(7):545-550.
21.	朱堅, 費健.原發性甲狀腺淋巴瘤的診斷和治療分析[J]. 外科理論與實踐, 2013, 18(2):156-158.
22.	孫治君, 姚榛祥, 管小琴.甲狀腺原發性惡性淋巴瘤的診斷與治療(附7例報告)[J]. 中國普外基礎與臨床雜志, 2003, 10(4):393-394.
23.	章美武, 陳賽君.原發性甲狀腺淋巴瘤的超聲表現[J]. 現代實用醫學, 2012, 24(12):1377-1378.
24.	楊麗娟, 母義明, 胡翠寧, 等.11例原發性甲狀腺淋巴瘤的超聲表現[J]. 中國病案, 2013, 14(11):74-75.
25.	駱驚濤, 魏璽, 張侖.原發性甲狀腺淋巴瘤的超聲表現病理及其他影像學特征分析[J]. 中國腫瘤臨床, 2014, 41(2):123-126.
26.	彭曉瓊, 蘇新良, 蒲大容, 等.原發性甲狀腺惡性淋巴瘤的常規超聲及超聲造影表現[J]. 臨床超聲醫學雜志, 2013, 15(7):488-490.
27.	宋琳琳, 詹維偉, 周建橋, 等.淺表器官結外淋巴瘤的超聲表現[J]. 診斷學理論與實踐, 2012, 11(5):471-475.
28.	李鵬, 張惠.高頻超聲診斷原發性甲狀腺淋巴瘤[J]. 中國醫學影像技術, 2012, 28(12):2269-2270.

1. 岑溪南, 馬明信, 郭輝, 等.原發結外淋巴瘤139例臨床及誤診分析[J]. 北京大學學報:醫學版, 2003, 35(2):143-145.
2. Al Diab AR, Aleem A, Qayum A, et al.Clinico-pathological pattern of extranodal non-Hodgkin's lymphoma in Saudi Arabia[J]. Asian Pac J Cancer Prev, 2011, 12(12):3277-3282.
3. 徐義全, 青曉艷, 樊晉川, 等.四川省腫瘤醫院2002至2011年全身麻醉甲狀腺惡性腫瘤患者臨床病理學分析[J/CD]. 中華臨床醫師雜志:電子版, 2013, 7(7):2842-2846.
4. 崔俊生, 陳桂秋, 倪勁松, 等.不同年代甲狀腺惡性腫瘤構成分析(附1011例病理報告)[J]. 中國實用外科雜志, 2004, 24(10):600-602.
5. Dayan CM, Daniels GH.Chronic autoimmune thyroiditis[J]. N Eng J Med, 1996, 335(2):99-107.
6. 喻建軍, 曾亮, 周曉, 等.原發性甲狀腺淋巴瘤誤診分析[J]. 中國耳鼻咽喉頭頸外科, 2008, 15(1):25-27.
7. Campo E, Swerdlow SH, Harris NL, et al.The 2008 WHO classification of lymphoid neoplasms and beyond:evolving concepts and practical applications[J]. Blood, 2011, 117(19):5019-5032.
8. Ota H, Ito Y, Matsuzuka F, et al.Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid[J]. Thyroid, 2006, 16(10):983-987.
9. Ma B, Jia Y, Wang Q, et al.Ultrasound of primary thyroid non-Hodgkin's lymphoma[J]. Clin Imaging, 2014, 38(5):621-626.
10. Walsh S, Lowery AJ, Evoy D, et al.Thyroid lymphoma:recent advances in diagnosis and optimal management strategies[J]. Oncologist, 2013, 18(9):994-1003.
11. 張廷令.原發性甲狀腺淋巴瘤:Mayo臨床中心到1978年的經驗復習[J]. 國外醫學外科學分冊, 1981, (4):225-226.
12. Sarinah B, Hisham AN.Primary lymphoma of the thyroid:diagnostic and therapeutic considerations[J]. Asian J Surg, 2010, 33(1):20-24.
13. Ahmed R, Al-Shaikh S, Akhtar M.Hashimoto thyroiditis:a century later[J]. Adv Anat Pathol, 2012, 19(3):181-186.
14. 李昌幼, 羅佐杰.原發性甲狀腺淋巴瘤的發病機制及診治現狀[J]. 實用醫學雜志, 2013, 29(3):341-342.
15. Ben-Ezra J, Wu A, Sheibani K.Hashimoto's thyroiditis lacks detectable clonal immunoglobulin and T cell receptor gene rearrangements[J]. Hum Pathol, 1988, 19(12):1444-1448.
16. Stein SA, Wartofsky L.Primary thyroid lymphoma:a clinical review[J]. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
17. Watanabe N, Noh JY, Narimatsu H, et al.Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease[J]. Br J Haematol, 2011, 153(2):236-243.
18. Green LD, Mack L, Pasieka JL.Anaplastic thyroid cancer and primary thyroid lymphoma:a review of these rare thyroid malignancies[J]. J Surg Oncol, 2006, 94(8):725-736.
19. Meusers P, Elo B, Wittig A, et al.Diagnosis and treatment of primary malignant lymphoma of the thyroid gland[J].Chinese-German J Clin Oncol,2003,2(4):219-223.
20. Sun TQ, Zhu XL, Wang ZY, et al.Characteristics and prognosis of primary thyroid non-Hodgkin's lymphoma in Chinese patients[J]. J Surg Oncol, 2010, 101(7):545-550.
21. 朱堅, 費健.原發性甲狀腺淋巴瘤的診斷和治療分析[J]. 外科理論與實踐, 2013, 18(2):156-158.
22. 孫治君, 姚榛祥, 管小琴.甲狀腺原發性惡性淋巴瘤的診斷與治療(附7例報告)[J]. 中國普外基礎與臨床雜志, 2003, 10(4):393-394.
23. 章美武, 陳賽君.原發性甲狀腺淋巴瘤的超聲表現[J]. 現代實用醫學, 2012, 24(12):1377-1378.
24. 楊麗娟, 母義明, 胡翠寧, 等.11例原發性甲狀腺淋巴瘤的超聲表現[J]. 中國病案, 2013, 14(11):74-75.
25. 駱驚濤, 魏璽, 張侖.原發性甲狀腺淋巴瘤的超聲表現病理及其他影像學特征分析[J]. 中國腫瘤臨床, 2014, 41(2):123-126.
26. 彭曉瓊, 蘇新良, 蒲大容, 等.原發性甲狀腺惡性淋巴瘤的常規超聲及超聲造影表現[J]. 臨床超聲醫學雜志, 2013, 15(7):488-490.
27. 宋琳琳, 詹維偉, 周建橋, 等.淺表器官結外淋巴瘤的超聲表現[J]. 診斷學理論與實踐, 2012, 11(5):471-475.
28. 李鵬, 張惠.高頻超聲診斷原發性甲狀腺淋巴瘤[J]. 中國醫學影像技術, 2012, 28(12):2269-2270.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma

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