Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HUANGQiu-shi , WEITao , ZHUXin-xin ,  DUZhen-hong , ZHUJing-qiang

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

DUZhen-hong, Email: zjq-wkys@163.com

Keywords：

Ectopic thyroid gland; Diagnosis; Treatment

DOI：

10.7507/1007-9424.20140107

Video：

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Objective To explore the clinical characteristics, diagnosis and treatment of ectopic thyroid gland (ETG) so as to reduce the misdiagnosis and improper treatment. Methods According to the patients who were definitely diagnosed ETG by pathology from 2002 to 2010 in our hospital, their clinical and pathological data were retrospectively analyzed. Results There were 14 patients, 4 cases of male and 10 cases of female. Five patients had clinical symptoms. Eight cases were diagnosed before operation and six cases were diagnosed by pathology after operation. There were 4 cases were malignancy and 10 were benign. Three cases of differentiated ectopic thyroid carcinoma patients and 1 normal position's thyroid had papillary carcinoma patient accepted TSH suppression treatment after operation, 4 benign patients and 1 ectopic thyroid medullary carcinoma patient accepted levothyroxine substitution treatment after operation, and the other 5 benign patients did not accept any treatment after operation. Nine patients who accepted follow-up in 1-10 years had orthobiosis, and the malignancy patients without recurrence and metastasis. Conclusions ETG usually reveal no any special clinical features. For any masses from root of tongue to mediastinum, especially cervical masses, should be carefully check whether there are thyroid in normal position, and to exclude ETG. The color Doppler ultrasound, thyroid radioactive scanning, thyroid function tests, computed tomography, and fine needle aspiration cytology are all important examination measures. Due to the ETG may occur the same lesions as the normal position's thyroid, so once it is be definitly diagnosed, the treatment should be based on patient's age, position, size, and type of ETG, and nature of the lesions to select follow-up observation, operative treatment, levothyroxine replacement or therapeutic inhibition of TSH, and ¹³¹I therapy.

Citation： HUANGQiu-shi, WEITao, ZHUXin-xin, DUZhen-hong, ZHUJing-qiang. Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 442-447. doi: 10.7507/1007-9424.20140107 Copy

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2.	徐峰, 田景琦, 黃黎明.異位甲狀腺臨床診治分析[J].中國耳鼻咽喉頭頸外科, 2013, 20(4):221-222.
3.	Kozol RA, Geelhoed GW, Flynn SD, et al. Management of ectopic thyroid nodules[J]. Surgery, 1993, 114(6):1103-1106.
4.	王宏, 孫瑩, 賈靜, 等.國內近30年報道的198例異位甲狀腺病例的文獻分析[J].臨床耳鼻咽喉頭頸外科雜志, 2012, 26(18):814-816.
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6.	李思源, 吳新淮, 李珍紅.迷走型舌根異位甲狀腺1例[J].中國醫學影像技術, 2005, 21(7):1077.
7.	Ulug T, Ulubil SA, Alagol F. Dual ectopic thyroid:report of a case[J]. J Laryngol Otol, 2003, 117(7):574-576.
8.	李向東, 鄭艷, 劉世喜.頸部異位甲狀腺臨床分析[J].中國耳鼻咽喉頭頸外科, 2008, 15(7):388-390.
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10.	李軍, 孫堅.舌異位甲狀腺1例報告[J].口腔頜面外科雜志, 2000, 10(4):370.
11.	Batsakis JG, EL-Naggar AK, Luna MA. Thyroid gland ectopias[J]. Ann Otol Rhinol Laryngol, 1996, 105(12):996-1000.
12.	黃選兆, 汪吉寶.實用耳鼻喉科學[M].北京:人民衛生出版社, 1998:39.
13.	趙華, 陳剛, 李亮, 等.異位甲狀腺診治分析[J].中國耳鼻咽喉頭頸外科, 2008, 15(6):327-329.
14.	Williams JD, Sclafani AP, Slupchinskij O, et al. Evaluation and management of the lingual thyroid gland[J]. Ann Otol Rhinol Laryngol, 1996, 105(4):312-316.
15.	Sood A, Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management[J]. Hell J Nucl Med, 2008, 11(3):168-171.
16.	Gkeli MG, Apergis S, Klapsinou E, et al. Submandibular ectopic thyroid tissue diagnosed by ultrasound-guided fine needle biopsy[J]. J Oral Sci, 2011, 53(2):249-252.
17.	甄宏韜, 劉秋潤, 崔永華, 等.提高異位甲狀腺診斷符合率的方法[J].臨床耳鼻咽喉科雜志, 2002, 16(5):265-266.
18.	Bukachevsky RP, Casler JD, Oliver J, et al. Squamous cell carc-inoma and lingual thyroid[J]. Ear NoseThroat J, 1991, 70(8):505-507.
19.	張云宏, 王廣軍, 賈氫, 等.罕見異位甲狀腺腺瘤誤診切除引發醫療糾紛的思考[J].法律與醫學雜志, 2006, 13(2):88-89.
20.	徐雅男, 王家東.隱匿性甲狀腺癌的外科治療[J].臨床耳鼻咽喉科雜志, 2006, 20(24):1150-1152.
21.	Abdul-Jabar HB, Lynn J. The surgical management of thyroid cancer[J]. Nuel Med Commun, 2004, 25(9):869-872.

1. Amoodi HA, Makki F, Taylor M, et al. Lateral ectopic thyroid goiter with a normally located thyroid[J]. Thyroid, 2010, 20(2):217-220.
2. 徐峰, 田景琦, 黃黎明.異位甲狀腺臨床診治分析[J].中國耳鼻咽喉頭頸外科, 2013, 20(4):221-222.
3. Kozol RA, Geelhoed GW, Flynn SD, et al. Management of ectopic thyroid nodules[J]. Surgery, 1993, 114(6):1103-1106.
4. 王宏, 孫瑩, 賈靜, 等.國內近30年報道的198例異位甲狀腺病例的文獻分析[J].臨床耳鼻咽喉頭頸外科雜志, 2012, 26(18):814-816.
5. 蘭新海.舌根異位甲狀腺診治分析[J].臨床耳鼻咽喉頭頸外科雜志, 2011, 25(22):1044-1045.
6. 李思源, 吳新淮, 李珍紅.迷走型舌根異位甲狀腺1例[J].中國醫學影像技術, 2005, 21(7):1077.
7. Ulug T, Ulubil SA, Alagol F. Dual ectopic thyroid:report of a case[J]. J Laryngol Otol, 2003, 117(7):574-576.
8. 李向東, 鄭艷, 劉世喜.頸部異位甲狀腺臨床分析[J].中國耳鼻咽喉頭頸外科, 2008, 15(7):388-390.
9. Prasad KC, Bhat V. Surgical management of lingual thyroid:a report of four cases[J]. J Oral Maxillofac Surg, 2000, 58(2):223-227.
10. 李軍, 孫堅.舌異位甲狀腺1例報告[J].口腔頜面外科雜志, 2000, 10(4):370.
11. Batsakis JG, EL-Naggar AK, Luna MA. Thyroid gland ectopias[J]. Ann Otol Rhinol Laryngol, 1996, 105(12):996-1000.
12. 黃選兆, 汪吉寶.實用耳鼻喉科學[M].北京:人民衛生出版社, 1998:39.
13. 趙華, 陳剛, 李亮, 等.異位甲狀腺診治分析[J].中國耳鼻咽喉頭頸外科, 2008, 15(6):327-329.
14. Williams JD, Sclafani AP, Slupchinskij O, et al. Evaluation and management of the lingual thyroid gland[J]. Ann Otol Rhinol Laryngol, 1996, 105(4):312-316.
15. Sood A, Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management[J]. Hell J Nucl Med, 2008, 11(3):168-171.
16. Gkeli MG, Apergis S, Klapsinou E, et al. Submandibular ectopic thyroid tissue diagnosed by ultrasound-guided fine needle biopsy[J]. J Oral Sci, 2011, 53(2):249-252.
17. 甄宏韜, 劉秋潤, 崔永華, 等.提高異位甲狀腺診斷符合率的方法[J].臨床耳鼻咽喉科雜志, 2002, 16(5):265-266.
18. Bukachevsky RP, Casler JD, Oliver J, et al. Squamous cell carc-inoma and lingual thyroid[J]. Ear NoseThroat J, 1991, 70(8):505-507.
19. 張云宏, 王廣軍, 賈氫, 等.罕見異位甲狀腺腺瘤誤診切除引發醫療糾紛的思考[J].法律與醫學雜志, 2006, 13(2):88-89.
20. 徐雅男, 王家東.隱匿性甲狀腺癌的外科治療[J].臨床耳鼻咽喉科雜志, 2006, 20(24):1150-1152.
21. Abdul-Jabar HB, Lynn J. The surgical management of thyroid cancer[J]. Nuel Med Commun, 2004, 25(9):869-872.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease

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