Clinical Efficacy of Early Enteral Nutrition on Patients with Gastric Cancer after Radical Operation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 FENGLi ^1,2 ,  WANGFeng ¹ , DONGPei-de ¹ , HAOQin ¹ , SONGWei-dong ²

1. Department of Gastrointestinal Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China;
2. Department of General Surgery, Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot 010020, Inner Mongolia Autonomous Region, China;

Corresponding?author：

WANGFeng, Email: wangfeng_nm@126.com

Keywords：

Enteral nutrition; Parenteral nutrition; Gastric cancer; Clinical effect

DOI：

10.7507/1007-9424.20140076

Video：

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Objective To explore the clinical efficacy and security of early enteral nutrition (EN) on patients with gastric cancer after radical operation. Methods Seventy cases who treated in Affiliated Hospital of Inner Mongolia Medical University from Dec. 2008 to Apr. 2013 were randomly divided into EN group (n=35) and parenteral nutrition (PN) group (n=35), analysis and comparison of nutrition indicators and recovery indicators between 2 groups were performed. Results There were no significant differences on levels of count of white blood cell (WBC), serum albumin (ALB), prealbumin (PA), and transferring (TRF) before operation between the 2 groups (P > 0.05). On 3 and 7 days after operation, the levels of ALB, PA, and TRF were all higher in EN group (P < 0.05) besides level of count of WBC. In addition, hospital stay and hospitalization cost were both lower in EN group (P < 0.05), but there was no significant difference on postoperative exhaust time and complication incidence (P > 0.05). Conclusions EN is a safe, effective, and economical method of nutritional supplements, and it is a preferred method of nutritional support for patients with advanced gastric cancer after operation at prophase, which is worthy to apply widely in clinical.

Citation： FENGLi, WANGFeng, DONGPei-de, HAOQin, SONGWei-dong. Clinical Efficacy of Early Enteral Nutrition on Patients with Gastric Cancer after Radical Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(3): 325-329. doi: 10.7507/1007-9424.20140076 Copy

1.	?Wilmore DW, Kehlet H. Management of patients in fast track surgery[J]. BMJ, 2001, 322(7284):473-476.
2.	黎介壽.胃腸手術的"圍手術期營養處理"[J].腸外與腸內營養, 2013, 20(2):65-67.
3.	Karcz W, G?uszek S, Kot M, et al. Influence of nutritional treatment on the postoperative course in patients with gastric cancer[J]. Adv Med Sci, 2006, 51(1):278-282.
4.	李維勤, 李寧.外科病人的代謝改變和圍手術期營養支持[J].中國實用外科雜志, 2001, 21(7):442-448.
5.	Gallagher-Allred CR, Voss AC, Finn SC, et al. Malnutrition and clinical outcomes:the case for medical nutrition therapy[J]. J Am Diet Assoc, 1996, 96(4):361-366.
6.	Hermsen JL, Sano Y, Kudsk KA. Food fight!Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity[J]. Langenbecks Arch Surg, 2009, 394(1):17-30.
7.	Mosenthal AC, Xu D, Deitch EA. Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber[J]. Crit Care Med, 2002, 30(2):396-402.
8.	Dervenis C, Smailis D, Hatzitheoklitos E. Bacterial translocation and its prevention in acute pancreatitis[J]. J Hepatobiliary Pancreat Surg, 2003, 10(6):415-418.
9.	Peter JV, Moran JL, Phillips-Hughes J. A meta analysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients[J]. Crit Care Med, 2005, 33(1):213-220.
10.	Kamei H, Hachisuka T, Nakao M, et al. Quick recovery of serum diamine oxidase activity in patients undergoing total gastr-ectomy by oral enteral nutrition[J]. Am J Surg, 2005, 189(1):38-43.
11.	張秀雄, 羅小軍.自制非要素膳在食管、賁門癌術后早期腸內營養中的運用[J].中國現代醫藥雜志, 2012, 14(1):29-32.
12.	Kehlet H. Fast-track surgery-an update on physiological care principles to enhance recovery[J]. Langenbecks Arch Surg, 2011, 396(5):585-590.
13.	Krenk L, Rasmussen LS, Kehlet H. Delirium in the fast-track surgery setting[J]. Best Pract Res Clin Anaesthesiol, 2012, 26(3):345-353.
14.	江志偉, 黎介壽, 汪志明, 等.加速康復外科用于直腸癌前切除病人價值探討[J].中國實用外科雜志, 2008, 28(1):59-61.
15.	袁琮韡, 李俊生, 嵇振嶺, 等.全腸外營養及早期腸內營養在胃癌全胃切除術后患者中的對比研究[J].中國普外基礎與臨床雜志, 2010, 17(4):357-361.
16.	Andreyev HJ, Norman AR, Oates J, et al. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?[J]. Eur J Cancer, 1998, 34(4):503-509.
17.	祝中年.早期胃腸營養改善患者營養狀況及預防腸道術后醫源性腸饑餓綜合征[J].中國普通外科雜志, 2013, 22(4):527-529.
18.	Sedman PC, MacFie J, Palmer MD, et al. Preoperative total parenteral nutrition is not associated with mucosal atrophy or bact-erial translocation in humans[J]. Br J Surg, 1995, 82(12):1663-1667.
19.	李卡, 肖雪玲, 劉爽, 等.胃癌患者術后早期腸內營養的療效評估[J].中國普外基礎與臨床雜志, 2013, 20(2):174-177.
20.	Lewis SJ, Egger M, Sylvester PA, et al. Early enteral feeding versus "nil by mouth" after gastrointestinal surgery:systematic review and meta-analysis of controlled trials[J]. BMJ, 2001, 323(7316):773-776.
21.	陳玉民.腸內營養在術后早期的應用[J].中國臨床營養雜志, 2003, 11(3):216-218.
22.	宋延強, 呂文平, 龐新建.老年胃癌患者術后早期腸內營養與腸外營養療效的比較[J].中華普通外科雜志, 2004, 19(2):97-99.
23.	Huang J, Zhou H, Mahavadi S, et al. Signaling pathways medi-ating gastrointestinal smooth muscle contraction and MLC20 phos-phorylation by motilin receptors[J]. Am J Physiol Gastrointest Liver Physiol, 2005, 288(1):G23-G31.
24.	Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery:a systematic review and meta-analysis of randomized controlled trials in the English literature[J]. J Gastrointest Surg, 2008, 12(4):739-755.
25.	韋京豫.血清轉鐵蛋白和前白蛋白作為營養參數的比較[J].解放軍預防醫學雜志, 1988, 6(3):93-94.
26.	魏琳, 武梅, 朱紅芳.能全力用于老年臥床患者腸內營養80例臨床分析[J].中國藥業, 2013, 22(7):81.
27.	蔡青山, 樸文花, 馬德強, 等.早期腸內與腸外營養對進展期胃癌術后患者的支持效果[J].寧夏醫學雜志, 2010, 32(6):501-503.
28.	莢從正, 張建群, 譚林, 等.食管癌術后早期腸內營養的臨床應用[J].安徽醫學, 2013, 34(4):426-428.

1. ?Wilmore DW, Kehlet H. Management of patients in fast track surgery[J]. BMJ, 2001, 322(7284):473-476.
2. 黎介壽.胃腸手術的"圍手術期營養處理"[J].腸外與腸內營養, 2013, 20(2):65-67.
3. Karcz W, G?uszek S, Kot M, et al. Influence of nutritional treatment on the postoperative course in patients with gastric cancer[J]. Adv Med Sci, 2006, 51(1):278-282.
4. 李維勤, 李寧.外科病人的代謝改變和圍手術期營養支持[J].中國實用外科雜志, 2001, 21(7):442-448.
5. Gallagher-Allred CR, Voss AC, Finn SC, et al. Malnutrition and clinical outcomes:the case for medical nutrition therapy[J]. J Am Diet Assoc, 1996, 96(4):361-366.
6. Hermsen JL, Sano Y, Kudsk KA. Food fight!Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity[J]. Langenbecks Arch Surg, 2009, 394(1):17-30.
7. Mosenthal AC, Xu D, Deitch EA. Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber[J]. Crit Care Med, 2002, 30(2):396-402.
8. Dervenis C, Smailis D, Hatzitheoklitos E. Bacterial translocation and its prevention in acute pancreatitis[J]. J Hepatobiliary Pancreat Surg, 2003, 10(6):415-418.
9. Peter JV, Moran JL, Phillips-Hughes J. A meta analysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients[J]. Crit Care Med, 2005, 33(1):213-220.
10. Kamei H, Hachisuka T, Nakao M, et al. Quick recovery of serum diamine oxidase activity in patients undergoing total gastr-ectomy by oral enteral nutrition[J]. Am J Surg, 2005, 189(1):38-43.
11. 張秀雄, 羅小軍.自制非要素膳在食管、賁門癌術后早期腸內營養中的運用[J].中國現代醫藥雜志, 2012, 14(1):29-32.
12. Kehlet H. Fast-track surgery-an update on physiological care principles to enhance recovery[J]. Langenbecks Arch Surg, 2011, 396(5):585-590.
13. Krenk L, Rasmussen LS, Kehlet H. Delirium in the fast-track surgery setting[J]. Best Pract Res Clin Anaesthesiol, 2012, 26(3):345-353.
14. 江志偉, 黎介壽, 汪志明, 等.加速康復外科用于直腸癌前切除病人價值探討[J].中國實用外科雜志, 2008, 28(1):59-61.
15. 袁琮韡, 李俊生, 嵇振嶺, 等.全腸外營養及早期腸內營養在胃癌全胃切除術后患者中的對比研究[J].中國普外基礎與臨床雜志, 2010, 17(4):357-361.
16. Andreyev HJ, Norman AR, Oates J, et al. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?[J]. Eur J Cancer, 1998, 34(4):503-509.
17. 祝中年.早期胃腸營養改善患者營養狀況及預防腸道術后醫源性腸饑餓綜合征[J].中國普通外科雜志, 2013, 22(4):527-529.
18. Sedman PC, MacFie J, Palmer MD, et al. Preoperative total parenteral nutrition is not associated with mucosal atrophy or bact-erial translocation in humans[J]. Br J Surg, 1995, 82(12):1663-1667.
19. 李卡, 肖雪玲, 劉爽, 等.胃癌患者術后早期腸內營養的療效評估[J].中國普外基礎與臨床雜志, 2013, 20(2):174-177.
20. Lewis SJ, Egger M, Sylvester PA, et al. Early enteral feeding versus "nil by mouth" after gastrointestinal surgery:systematic review and meta-analysis of controlled trials[J]. BMJ, 2001, 323(7316):773-776.
21. 陳玉民.腸內營養在術后早期的應用[J].中國臨床營養雜志, 2003, 11(3):216-218.
22. 宋延強, 呂文平, 龐新建.老年胃癌患者術后早期腸內營養與腸外營養療效的比較[J].中華普通外科雜志, 2004, 19(2):97-99.
23. Huang J, Zhou H, Mahavadi S, et al. Signaling pathways medi-ating gastrointestinal smooth muscle contraction and MLC20 phos-phorylation by motilin receptors[J]. Am J Physiol Gastrointest Liver Physiol, 2005, 288(1):G23-G31.
24. Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery:a systematic review and meta-analysis of randomized controlled trials in the English literature[J]. J Gastrointest Surg, 2008, 12(4):739-755.
25. 韋京豫.血清轉鐵蛋白和前白蛋白作為營養參數的比較[J].解放軍預防醫學雜志, 1988, 6(3):93-94.
26. 魏琳, 武梅, 朱紅芳.能全力用于老年臥床患者腸內營養80例臨床分析[J].中國藥業, 2013, 22(7):81.
27. 蔡青山, 樸文花, 馬德強, 等.早期腸內與腸外營養對進展期胃癌術后患者的支持效果[J].寧夏醫學雜志, 2010, 32(6):501-503.
28. 莢從正, 張建群, 譚林, 等.食管癌術后早期腸內營養的臨床應用[J].安徽醫學, 2013, 34(4):426-428.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Efficacy of Early Enteral Nutrition on Patients with Gastric Cancer after Radical Operation

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