Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 QIAOWen-hui , YAONan ,  WANGJun

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;

Corresponding?author：

WANGJun, Email: juan_phd@163.com

Keywords：

Octamer-binding transcription factor 4; Gastric cancer; Cancer stem cell; Meta-analysis

DOI：

10.7507/1007-9424.20140015

Video：

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Objective To investigate the expression and clinical significance of octamer-binding transcription factor 4(Oct-4) in gastric cancer (GC) tissues with meta-analysis. Methods PubMed, EMBASE, Web of Science, CBM, VIP, CNKI, and WanFang Database were searched from their establishment to Oct.2012 for related studies, to investigate the relationship between expression of Oct-4 and the clinicopathological characteristics of GC.After evaluating methodo-logical quality of studies that met the inclusion criteria, RevMan 5.1 software was used to data analysis. Results Eight studies which enrolled 623 cases of GC were identified.The results of the meta-analysis showed that, as for the positive expression rate of Oct-4, there were significant differences between GC tissues and normal stomach tissues (OR=37.50, 95% CI: 4.76-295.51, P < 0.01), as well as the cell differentiation (OR=0.27, 95% CI: 0.16-0.45, P < 0.01), for that the positive expression rate of Oct-4 in low differentiation of gastric cancer tissues was higher than those of moderate-high differentation group.But there were no significant differences between GC tissues with lymph node metastasis and non-lymph node metastasis (OR=2.09, 95% CI: 0.63-6.94, P=0.23), as well as Ⅰ-Ⅱ stage and Ⅲ-Ⅳ stage (OR=0.62, 95% CI: 0.25-1.54, P=0.30) of GC tissues. Conclusions Oct-4 may participate in the whole course of carcinogenesis of GC, but the relationship between expression of Oct-4 and lymph node metastasis as well as the TNM stage of GC is unclear, which needs more high quality studies to explore the question clearly.

Citation： QIAOWen-hui, YAONan, WANGJun. Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(1): 76-81. doi: 10.7507/1007-9424.20140015 Copy

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4.	秦薇, 張曉偉, 章莉, 等.Oct-4在胃癌組織中的表達及臨床意義[J].上海交通大學學報:醫學版, 2009, 29(6):733-736.
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8.	Atlasi Y, Mowla SJ, Ziaee SA, et al.OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer[J].Int J Cancer, 2007, 120(7):1598-1602.
9.	Ezeh UI, Turek PJ, Reijo RA, et al.Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma[J].Cancer, 2005, 104(10):2255-2265.
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13.	曹夢苒, 謝劍明, 劉斐燁.轉錄因子Oct-4在胃癌中的表達及意義[J].山東醫藥, 2012, 52(32):78-80.
14.	邱江鋒, 張志奇, 尤俊, 等.胃癌組織中Oct4表達及其臨床病理意義的探討[J].中華腫瘤防治雜志, 2011, 18(5):342-344.
15.	翁厚光, 曹維克, 張鐵成, 等.Oct4蛋白在胃癌及癌旁組織中的表達及其意義[J].江蘇醫藥, 2011, 37(1):71-73.
16.	姚宏亮, 楊竹林, 李永國.胃良惡性病變組織中PSCA和Oct-4的表達及意義[J].中南大學學報:醫學版, 2008, 33(7):623-627.
17.	張金龍, 王海娟, 路中, 等.Oct4在多種人腺癌組織中表達水平的研究[J].中國醫藥導報, 2011, 8(8):17-20.
18.	Lichtenstein MJ, Mulrow CD, Elwood PC.Guidelines for reading case-control studies[J].J Chronic Dis, 1987, 40(9):893-903.
19.	Yeom YI, Ha HS, Balling R, et al.Structure, expression and chromosomal location of the Oct-4 gene[J].Mech Dev, 1991, 35(3):171-179.
20.	Pan GJ, Pei DQ.Identification of two distinct transactivation dom-ains in the pluripotency sustaining factor nanog[J].Cell Res, 2003, 13(6):499-502.
21.	周一葉, 曾凡一.維持胚胎干細胞多能性和自我更新的轉錄因子Oct-4/Nanog以及相關的調控網絡[J].遺傳, 2008, 30(5):529-536.
22.	Ezashi T, Ghosh D, Roberts RM.Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J].Mol Cell Biol, 2001, 21(23):7883-7891.
23.	Guo Y, Costa R, Ramsey H, et al.The embryonic stem cell tran-scription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression[J].Proc Natl Acad Sci U S A, 2002, 99(6):3663-3667.
24.	Grinnell KL, Yang B, Eckert RL, et al.De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4[J].J Invest Dermatol, 2007, 127(2):372-380.
25.	Buitrago W, Roop DR.Oct-4:the almighty POUripotent regulator?[J].J Invest Dermatol, 2007, 127(2):260-262.

1. Brenner H, Rothenbacher D, Arndt V.Epidemiology of stomach cancer[J].Methods Mol Biol, 2009, 472(1):467-477.
2. Han ME, Lee YS, Baek SY, et al.Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2[J].Int J Mol Sci, 2009, 10(7):3033-3043.
3. Parker SL, Tong T, Bolden S, et al.Cancer statistics, 1997[J].CA Cancer J Clin, 1997, 47(1):5-27.
4. 秦薇, 張曉偉, 章莉, 等.Oct-4在胃癌組織中的表達及臨床意義[J].上海交通大學學報:醫學版, 2009, 29(6):733-736.
5. Soltysova A, Altanerova V, Altaner C.Cancer stem cells[J].Neoplasma, 2005, 52(6):435-440.
6. Reya T, Morrison SJ, Clarke MF, et al.Stem cells, cancer, and cancer stem cells[J].Nature, 2001, 414(6859):105-111.
7. Tai MH, Chang CC, Kiupel M, et al.Oct4 expression in adult human stem cells:evidence in support of the stem cell theory of carcinogenesis[J].Carcinogenesis, 2005, 26(2):495-502.
8. Atlasi Y, Mowla SJ, Ziaee SA, et al.OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer[J].Int J Cancer, 2007, 120(7):1598-1602.
9. Ezeh UI, Turek PJ, Reijo RA, et al.Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma[J].Cancer, 2005, 104(10):2255-2265.
10. Iki K, Pour PM.Expression of Oct4, a stem cell marker, in the hamster pancreatic cancer model[J].Pancreatology, 2006, 6(4):406-413.
11. Chen Z, Xu WR, Qian H, et al.Oct4, a novel marker for human gastric cancer[J].J Surg Oncol, 2009, 99(7):414-419.
12. Matsuoka J, Yashiro M, Sakurai K, et al.Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma[J].J Surg Res, 2012, 174(1):130-135.
13. 曹夢苒, 謝劍明, 劉斐燁.轉錄因子Oct-4在胃癌中的表達及意義[J].山東醫藥, 2012, 52(32):78-80.
14. 邱江鋒, 張志奇, 尤俊, 等.胃癌組織中Oct4表達及其臨床病理意義的探討[J].中華腫瘤防治雜志, 2011, 18(5):342-344.
15. 翁厚光, 曹維克, 張鐵成, 等.Oct4蛋白在胃癌及癌旁組織中的表達及其意義[J].江蘇醫藥, 2011, 37(1):71-73.
16. 姚宏亮, 楊竹林, 李永國.胃良惡性病變組織中PSCA和Oct-4的表達及意義[J].中南大學學報:醫學版, 2008, 33(7):623-627.
17. 張金龍, 王海娟, 路中, 等.Oct4在多種人腺癌組織中表達水平的研究[J].中國醫藥導報, 2011, 8(8):17-20.
18. Lichtenstein MJ, Mulrow CD, Elwood PC.Guidelines for reading case-control studies[J].J Chronic Dis, 1987, 40(9):893-903.
19. Yeom YI, Ha HS, Balling R, et al.Structure, expression and chromosomal location of the Oct-4 gene[J].Mech Dev, 1991, 35(3):171-179.
20. Pan GJ, Pei DQ.Identification of two distinct transactivation dom-ains in the pluripotency sustaining factor nanog[J].Cell Res, 2003, 13(6):499-502.
21. 周一葉, 曾凡一.維持胚胎干細胞多能性和自我更新的轉錄因子Oct-4/Nanog以及相關的調控網絡[J].遺傳, 2008, 30(5):529-536.
22. Ezashi T, Ghosh D, Roberts RM.Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J].Mol Cell Biol, 2001, 21(23):7883-7891.
23. Guo Y, Costa R, Ramsey H, et al.The embryonic stem cell tran-scription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression[J].Proc Natl Acad Sci U S A, 2002, 99(6):3663-3667.
24. Grinnell KL, Yang B, Eckert RL, et al.De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4[J].J Invest Dermatol, 2007, 127(2):372-380.
25. Buitrago W, Roop DR.Oct-4:the almighty POUripotent regulator?[J].J Invest Dermatol, 2007, 127(2):260-262.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis

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