Analysis on Epidemiological and Clinical Characteristics of 818 Cases of Hepatic Hemangioma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 MUGuang-chuan , SUKa , HEWen-xing , LIJia , LINDe-an , HUWu-jie , WUSi-min , QUANJun-li ,  LIUZhi-ming

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;

Corresponding?author：

LIUZhi-ming, Email: liuzhiminggy@163.com

Keywords：

Hepatic hemangioma; Autoimmune diseases; Epidemiology; Clinical analysis

DOI：

10.7507/1007-9424.20140011

Video：

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Objective To explore the epidemiological and clinical features of hepatic hemangioma. Methods The clinical data of patients with hepatic hemangioma who were diagnosed in the First Affiliated Hospital of Guangxi Medical University from 2003 to 2011 were retrospectively analyzed, and then analyzed the epidemiological and clinical characteristics of hepatic hemangioma. Results Eight hundreds and eighteen patients with hepatic hemangioma were included in the study.Among them, 398 cases (48.7%) were male, 420 cases (51.3%) were female, and there were no significant differences in constitute of gender for each year (χ²=9.912, P=0.271), but there were significant differences in constitute of gender between different age groups (χ²=18.791, P=0.000 1), male patients were more than female in the group of aged over 60 years old.There was no special clinical manifestations of hepatic hemangioma.There were 75 patients (9.2%) combined autoimmune diseases in this group.The size of hepatic hemangioma ranged from 0.5-39.0 cm, the median diameter was 3.0 cm.There were significant differences between different gender, the tumor size of female patients were larger than male's (P < 0.05).The tumor happened mostly in the right hepatic lobe (57.2%), and there were no significant differences of the tumor location in different gender (P > 0.05).Hepatic hemangioma with a single lesion was most common (70.0%), and the right lobe lesions were more common than the left lobe lesions in single lesion group, multiple lesions in double lobes were most common in multiple lesion group. Conclusions Hepatic hemangioma has a certain distribution pattern in gender, age, size, position, and so on, further research in prevention and controlled strategy need to be carried out in the future.At the same time, more in-depth research in the related factors participated in occurrence and development of hepatic hemangioma also need to be carried out, especially for the relationship between gender, age, autoimmune diseases, and hepatic hemangioma, which is worthy to be discussed.

Citation： MUGuang-chuan, SUKa, HEWen-xing, LIJia, LINDe-an, HUWu-jie, WUSi-min, QUANJun-li, LIUZhi-ming. Analysis on Epidemiological and Clinical Characteristics of 818 Cases of Hepatic Hemangioma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(1): 55-59. doi: 10.7507/1007-9424.20140011 Copy

1.	Tsai HP, Jeng LB, Lee WC, et al.Clinical experience of hepatic hemangioma undergoing hepatic resection[J].Dig Dis Sci, 2003, 48(5):916-920.
2.	Jhaveri KS, Vlachou PA, Guindi M, et al.Association of hepatic hemangiomatosis with giant cavernous hemangioma in the adult population:prevalence, imaging appearance, and relevance[J].AJR Am J Roentgenol, 2011, 196(4):809-815.
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6.	Ishak KG, Rabin L.Benign tumors of the liver[J].Med Clin North Am, 1975, 59(4):995-1013.
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8.	Berzigotti A, Frigato M, Manfredini E, et al.Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus[J].World J Gastroenterol, 2011, 17(40):4503-4508.
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11.	Schnelldorfer T, Ware AL, Smoot R, et al.Management of giant hemangioma of the liver:resection versus observation[J].J Am Coll Surg, 2010, 211(6):724-730.
12.	Bioulac-Sage P, Laumonier H, Laurent C, et al.Benign and malignant vascular tumors of the liver in adults[J].Semin Liver Dis, 2008, 28(3):302-314.
13.	Zhu H, Obeidat K, Ouyang J, et al.Recurrent giant hemangiomas of liver:Report of two rare cases with literature review[J].World J Gastrointest Surg, 2012, 4(11):262-266.
14.	Kochin IN, Miloh TA, Arnon R, et al.Benign liver masses and lesions in children:53 cases over 12 years[J].Isr Med Assoc J, 2011, 13(9):542-547.
15.	Etemadi A, Golozar A, Ghassabian A, et al.Cavernous hemangioma of the liver:factors affecting disease progression in general hepatology practice[J].Eur J Gastroenterol Hepatol, 2011, 23(4):354-358.
16.	張志偉, 陳孝平.134例肝血管瘤的臨床分析[J].肝膽外科雜志, 2004, 12(5):341-343.
17.	Reddy KR, Kligerman S, Levi J, et al.Benign and solid tumors of the liver:relationship to sex, age, size of tumors, and outcome[J].Am Surg, 2001, 67(2):173-178.
18.	韓玥, 石景森, 孫學軍, 等.肝血管瘤的診斷治療:附50例報告[J].中國普通外科雜志, 2004, 13(8):609-611.
19.	Conter RL, Longmire WP Jr.Recurrent hepatic hemangiomas:possible association with estrogen therapy[J].Ann Surg, 1988, 207(2):115-119.
20.	Feurle GE.Arteriovenous shunting and cholestasis in hepatic hemangiomatosis associated with metoclopramide[J].Gastroenterology, 1990, 99(1):258-262.
21.	王開陽, 傅華群.肝血管瘤的外科治療現狀及手術指征[J].中華肝膽外科雜志, 2011, 17(9):701-702.

1. Tsai HP, Jeng LB, Lee WC, et al.Clinical experience of hepatic hemangioma undergoing hepatic resection[J].Dig Dis Sci, 2003, 48(5):916-920.
2. Jhaveri KS, Vlachou PA, Guindi M, et al.Association of hepatic hemangiomatosis with giant cavernous hemangioma in the adult population:prevalence, imaging appearance, and relevance[J].AJR Am J Roentgenol, 2011, 196(4):809-815.
3. Herman P, Costa ML, Machado MA, et al.Management of hepatic hemangiomas:a 14-year experience[J].J Gastrointest Surg, 2005, 9(6):853-859.
4. Choi J, Lee YJ, Hwang DW, et al.Surgical treatment of giant hepatic hemangiomas:technical point of view[J].Am Surg, 2011, 77(1):48-54.
5. Weimann A, Ringe B, Klempnauer J, et al.Benign liver tumors:differential diagnosis and indications for surgery[J].World J Surg, 1997, 21(9):983-990.
6. Ishak KG, Rabin L.Benign tumors of the liver[J].Med Clin North Am, 1975, 59(4):995-1013.
7. Yoon SS, Charny CK, Fong Y, et al.Diagnosis, management, and outcomes of 115 patients with hepatic hemangioma[J].J Am Coll Surg, 2003, 197(3):392-402.
8. Berzigotti A, Frigato M, Manfredini E, et al.Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus[J].World J Gastroenterol, 2011, 17(40):4503-4508.
9. Youssef WI, Tavill AS.Connective tissue diseases and the liver[J].J Clin Gastroenterol, 2002, 35(4):345-349.
10. Zviniene K, Zaboriene I, Basevicius A, et al.Comparative diag-nostic value of contrast-enhanced ultrasonography, computed tomography, and magnetic resonance imaging in diagnosis of hepatic hemangiomas[J].Medicina (Kaunas), 2010, 46(5):329-335.
11. Schnelldorfer T, Ware AL, Smoot R, et al.Management of giant hemangioma of the liver:resection versus observation[J].J Am Coll Surg, 2010, 211(6):724-730.
12. Bioulac-Sage P, Laumonier H, Laurent C, et al.Benign and malignant vascular tumors of the liver in adults[J].Semin Liver Dis, 2008, 28(3):302-314.
13. Zhu H, Obeidat K, Ouyang J, et al.Recurrent giant hemangiomas of liver:Report of two rare cases with literature review[J].World J Gastrointest Surg, 2012, 4(11):262-266.
14. Kochin IN, Miloh TA, Arnon R, et al.Benign liver masses and lesions in children:53 cases over 12 years[J].Isr Med Assoc J, 2011, 13(9):542-547.
15. Etemadi A, Golozar A, Ghassabian A, et al.Cavernous hemangioma of the liver:factors affecting disease progression in general hepatology practice[J].Eur J Gastroenterol Hepatol, 2011, 23(4):354-358.
16. 張志偉, 陳孝平.134例肝血管瘤的臨床分析[J].肝膽外科雜志, 2004, 12(5):341-343.
17. Reddy KR, Kligerman S, Levi J, et al.Benign and solid tumors of the liver:relationship to sex, age, size of tumors, and outcome[J].Am Surg, 2001, 67(2):173-178.
18. 韓玥, 石景森, 孫學軍, 等.肝血管瘤的診斷治療:附50例報告[J].中國普通外科雜志, 2004, 13(8):609-611.
19. Conter RL, Longmire WP Jr.Recurrent hepatic hemangiomas:possible association with estrogen therapy[J].Ann Surg, 1988, 207(2):115-119.
20. Feurle GE.Arteriovenous shunting and cholestasis in hepatic hemangiomatosis associated with metoclopramide[J].Gastroenterology, 1990, 99(1):258-262.
21. 王開陽, 傅華群.肝血管瘤的外科治療現狀及手術指征[J].中華肝膽外科雜志, 2011, 17(9):701-702.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis on Epidemiological and Clinical Characteristics of 818 Cases of Hepatic Hemangioma

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