Insights into the clinical studies related to cardiovascular surgery from the American Heart Association’s Scientific Sessions 2021: Part one_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YANG Yi , ZHU Jiaxi , ZHU Yunpeng ,  ZHAO Qiang

Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China;

Corresponding?author：

ZHAO Qiang, Email: zq11607@rjh.com.cn

Keywords：

American Heart Association; atrial fibrillation; vascular endothelial growth factor; external stent for vein graft; interpretation

DOI：

10.7507/1007-4848.202112090

Video：

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Abstract Full text Figures/Tables Video References Cited by

In the American Heart Association’s Scientific Sessions 2021, the results of six clinical trials related to cardiovascular surgery were revealed. The PALACS trial demonstrated that posterior left pericardiotomy during open heart surgery was associated with a significant reduction in postoperative atrial fibrillation; the EPICCURE study found that injection of mRNA encoding vascular endothelial growth factor (VEGF-A mRNA) directly into the myocardium of patients undergoing elective coronary artery bypass grafting (CABG) improved patients’ heart function; the VEST trial once again proved the safety and potential value of external stent for vein graft. This article will interpret the above-mentioned three studies.

Citation： YANG Yi, ZHU Jiaxi, ZHU Yunpeng, ZHAO Qiang. Insights into the clinical studies related to cardiovascular surgery from the American Heart Association’s Scientific Sessions 2021: Part one. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022, 29(4): 407-410. doi: 10.7507/1007-4848.202112090 Copy

1.	Late-Breaking Science abstracts and Featured Science abstracts from the American Heart Association's Scientific Sessions 2021 and Late-Breaking abstracts in Resuscitation Science from the Resuscitation Science Symposium 2021. Circulation, 2021, 144(25): e564-e593.
2.	Gaudino M, Sanna T, Ballman KV, et al. Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: An adaptive, single-centre, single-blind, randomised, controlled trial. Lancet, 2021, 398(10316): 2075-2083.
3.	Pepi M, Muratori M, Barbier P, et al. Pericardial effusion after cardiac surgery: Incidence, site, size, and haemodynamic consequences. Br Heart J, 1994, 72(4): 327-331.
4.	St-Onge S, Perrault LP, Demers P, et al. Pericardial blood as a trigger for postoperative atrial fibrillation after cardiac surgery. Ann Thorac Surg, 2018, 105(1): 321-328.
5.	Greenberg JW, Lancaster TS, Schuessler RB, et al. Postoperative atrial fibrillation following cardiac surgery: A persistent complication. Eur J Cardiothorac Surg, 2017, 52(4): 665-672.
6.	Eikelboom R, Sanjanwala R, Le ML, et al. Postoperative atrial fibrillation after cardiac surgery: A systematic review and meta-analysis. Ann Thorac Surg, 2021, 111(2): 544-554.
7.	Biancari F, Mahar MA. Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg, 2010, 139(5): 1158-1161.
8.	Hu XL, Chen Y, Zhou ZD, et al. Posterior pericardiotomy for the prevention of atrial fibrillation after coronary artery bypass grafting: A meta-analysis of randomized controlled trials. Int J Cardiol, 2016, 215: 252-256.
9.	Ekim H, Kutay V, Hazar A, et al. Effects of posterior pericardiotomy on the incidence of pericardial effusion and atrial fibrillation after coronary revascularization. Med Sci Monit, 2006, 12(10): CR431-CR434.
10.	Zangi L, Lui KO, von Gise A, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol, 2013, 31(10): 898-907.
11.	Zhang Y, Zhang J, Butler J, et al. Contemporary epidemiology, management, and outcomes of patients hospitalized for heart failure in China: Results from the China Heart Failure (China-HF) Registry. J Card Fail, 2017, 23(12): 868-875.
12.	Velazquez EJ, Lee KL, Deja MA, et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med, 2011, 364(17): 1607-1616.
13.	Carlsson L, Clarke JC, Yen C, et al. Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine. Mol Ther Methods Clin Dev, 2018, 9: 330-346.
14.	Gan LM, Lagerstr?m-Fermér M, Carlsson LG, et al. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nat Commun, 2019, 10(1): 871.
15.	Goldstein DJ. Device profile of the VEST for external support of SVG coronary artery bypass grafting: Historical development, current status, and future directions. Expert Rev Med Devices, 2021, 18(10): 921-931.
16.	Mawhinney JA, Mounsey CA, Taggart DP. The potential role of external venous supports in coronary artery bypass graft surgery. Eur J Cardiothorac Surg, 2018, 53(6): 1127-1134.
17.	Taggart DP, Webb CM, Desouza A, et al. Long-term performance of an external stent for saphenous vein grafts: The VEST Ⅳ trial. J Cardiothorac Surg, 2018, 13(1): 117.

1. Late-Breaking Science abstracts and Featured Science abstracts from the American Heart Association's Scientific Sessions 2021 and Late-Breaking abstracts in Resuscitation Science from the Resuscitation Science Symposium 2021. Circulation, 2021, 144(25): e564-e593.
2. Gaudino M, Sanna T, Ballman KV, et al. Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: An adaptive, single-centre, single-blind, randomised, controlled trial. Lancet, 2021, 398(10316): 2075-2083.
3. Pepi M, Muratori M, Barbier P, et al. Pericardial effusion after cardiac surgery: Incidence, site, size, and haemodynamic consequences. Br Heart J, 1994, 72(4): 327-331.
4. St-Onge S, Perrault LP, Demers P, et al. Pericardial blood as a trigger for postoperative atrial fibrillation after cardiac surgery. Ann Thorac Surg, 2018, 105(1): 321-328.
5. Greenberg JW, Lancaster TS, Schuessler RB, et al. Postoperative atrial fibrillation following cardiac surgery: A persistent complication. Eur J Cardiothorac Surg, 2017, 52(4): 665-672.
6. Eikelboom R, Sanjanwala R, Le ML, et al. Postoperative atrial fibrillation after cardiac surgery: A systematic review and meta-analysis. Ann Thorac Surg, 2021, 111(2): 544-554.
7. Biancari F, Mahar MA. Meta-analysis of randomized trials on the efficacy of posterior pericardiotomy in preventing atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg, 2010, 139(5): 1158-1161.
8. Hu XL, Chen Y, Zhou ZD, et al. Posterior pericardiotomy for the prevention of atrial fibrillation after coronary artery bypass grafting: A meta-analysis of randomized controlled trials. Int J Cardiol, 2016, 215: 252-256.
9. Ekim H, Kutay V, Hazar A, et al. Effects of posterior pericardiotomy on the incidence of pericardial effusion and atrial fibrillation after coronary revascularization. Med Sci Monit, 2006, 12(10): CR431-CR434.
10. Zangi L, Lui KO, von Gise A, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol, 2013, 31(10): 898-907.
11. Zhang Y, Zhang J, Butler J, et al. Contemporary epidemiology, management, and outcomes of patients hospitalized for heart failure in China: Results from the China Heart Failure (China-HF) Registry. J Card Fail, 2017, 23(12): 868-875.
12. Velazquez EJ, Lee KL, Deja MA, et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med, 2011, 364(17): 1607-1616.
13. Carlsson L, Clarke JC, Yen C, et al. Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1 week post-myocardial infarction in swine. Mol Ther Methods Clin Dev, 2018, 9: 330-346.
14. Gan LM, Lagerstr?m-Fermér M, Carlsson LG, et al. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nat Commun, 2019, 10(1): 871.
15. Goldstein DJ. Device profile of the VEST for external support of SVG coronary artery bypass grafting: Historical development, current status, and future directions. Expert Rev Med Devices, 2021, 18(10): 921-931.
16. Mawhinney JA, Mounsey CA, Taggart DP. The potential role of external venous supports in coronary artery bypass graft surgery. Eur J Cardiothorac Surg, 2018, 53(6): 1127-1134.
17. Taggart DP, Webb CM, Desouza A, et al. Long-term performance of an external stent for saphenous vein grafts: The VEST Ⅳ trial. J Cardiothorac Surg, 2018, 13(1): 117.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Insights into the clinical studies related to cardiovascular surgery from the American Heart Association’s Scientific Sessions 2021: Part one

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