Transapical mitral valve repair with LifeClip system: Early outcome of a single center_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YANG Hang , ZHENG Huiping , FENG Haibo , ZHAO Hong ,  LING Yunpeng

Department of Cardiac Surgery, Peking University Third Hospital, Beijing, 100191, P. R. China;

Corresponding?author：

LING Yunpeng, Email: micsling@pku.edu.cn

Keywords：

Mitral regurgitation; transapical mitral valve repair; LifeClip system

DOI：

10.7507/1007-4848.202112085

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the safety and efficacy of transapical mitral valve repair with moderate-to-severe or severe mitral regurgitation (MR) by using LifeClip system. Methods We retrospectively analyzed the clinical data of 7 symptomatic patients with moderate-to-severe or severe MR who received transapical mitral valve repair by using the LifeClip system in our hospital from July to November 2021. There were 5 males and 2 females with an average age of 76.0±7.5 years. Results There were 2 patients with degenerative MR and 5 patients with functional MR. All of the procedures were successful and 6 patients received 1 LifeClip while the other one patient received 2. The operation time was 135.7±46.9 min, the mechanical ventilation time was 12 (3, 14) h, and the hospital stay time was 18.1±4.1 d. No serious complications or death occurred during the perioperative or follow-up period. MR reduction by ≥2 grades was achieved in all the patients at the one-month follow-up. The classification of cardiac function was improved in varying degrees. Conclusion Transapical mitral valve repair using the LifeClip system shows good safety and efficacy for severe MR patients, and MR degree is significantly improved at early follow-up. However, the benefit of LifeClip should be validated in a larger sample size of Chinese population and through long-term follow-up.

Citation： YANG Hang, ZHENG Huiping, FENG Haibo, ZHAO Hong, LING Yunpeng. Transapical mitral valve repair with LifeClip system: Early outcome of a single center. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022, 29(5): 572-576. doi: 10.7507/1007-4848.202112085 Copy

1.	Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: A population-based study. Lancet, 2006, 368(9540): 1005-1011.
2.	Taramasso M, Candreva A, Pozzoli A, et al. Current challenges in interventional mitral valve treatment. J Thorac Dis, 2015, 7(9): 1536-1542.
3.	Head SJ, van Leeuwen WJ, Van Mieghem NM, et al. Surgical or transcatheter mitral valve intervention: Complex disease requires complex decisions. EuroIntervention, 2014, 9(10): 1133-1135.
4.	Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med, 2018, 379(24): 2307-2318.
5.	Chiarito M, Pagnesi M, Martino EA, et al. Outcome after percutaneous edge-to-edge mitral repair for functional and degenerative mitral regurgitation: A systematic review and meta-analysis. Heart, 2018, 104(4): 306-312.
6.	Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol, 2021, 77(4): e25-e197.
7.	Feldman T, Wasserman HS, Herrmann HC, et al. Percutaneous mitral valve repair using the edge-to-edge technique: Six-month results of the EVEREST phase Ⅰ clinical trial. J Am Coll Cardiol, 2005, 46(11): 2134-2140.
8.	Mauri L, Garg P, Massaro JM, et al. The EVEREST Ⅱ Trial: Design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation. Am Heart J, 2010, 160(1): 23-29.
9.	Feldman T, Kar S, Elmariah S, et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST Ⅱ. J Am Coll Cardiol, 2015, 66(25): 2844-2854.
10.	Maisano F, Franzen O, Baldus S, et al. Percutaneous mitral valve interventions in the real world: Early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol, 2013, 62(12): 1052-1061.
11.	Bail DH. (Meta)-analysis of safety and efficacy following edge-to-edge mitral valve repair using the MitraClip system. J Interv Cardiol, 2015, 28(1): 69-75.
12.	Andalib A, Mamane S, Schiller I, et al. A systematic review and meta-analysis of surgical outcomes following mitral valve surgery in octogenarians: Implications for transcatheter mitral valve interventions. EuroIntervention, 2014, 9(10): 1225-1234.
13.	Nickenig G, Estevez-Loureiro R, Franzen O, et al. Percutaneous mitral valve edge-to-edge repair: In-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry. J Am Coll Cardiol, 2014, 64(9): 875-884.
14.	譚冠昶, 盧志南, 梁逸倫, 等. 經皮MitraClip介入治療二尖瓣反流1年隨訪報道. 中國介入心臟病學雜志, 2021, 29(10): 564-569.
15.	Goel S, Pasam RT, Wats K, et al. Mitraclip plus medical therapy versus medical therapy alone for functional mitral regurgitation: A meta-analysis. Cardiol Ther, 2020, 9(1): 5-17.

1. Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: A population-based study. Lancet, 2006, 368(9540): 1005-1011.
2. Taramasso M, Candreva A, Pozzoli A, et al. Current challenges in interventional mitral valve treatment. J Thorac Dis, 2015, 7(9): 1536-1542.
3. Head SJ, van Leeuwen WJ, Van Mieghem NM, et al. Surgical or transcatheter mitral valve intervention: Complex disease requires complex decisions. EuroIntervention, 2014, 9(10): 1133-1135.
4. Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med, 2018, 379(24): 2307-2318.
5. Chiarito M, Pagnesi M, Martino EA, et al. Outcome after percutaneous edge-to-edge mitral repair for functional and degenerative mitral regurgitation: A systematic review and meta-analysis. Heart, 2018, 104(4): 306-312.
6. Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol, 2021, 77(4): e25-e197.
7. Feldman T, Wasserman HS, Herrmann HC, et al. Percutaneous mitral valve repair using the edge-to-edge technique: Six-month results of the EVEREST phase Ⅰ clinical trial. J Am Coll Cardiol, 2005, 46(11): 2134-2140.
8. Mauri L, Garg P, Massaro JM, et al. The EVEREST Ⅱ Trial: Design and rationale for a randomized study of the evalve mitraclip system compared with mitral valve surgery for mitral regurgitation. Am Heart J, 2010, 160(1): 23-29.
9. Feldman T, Kar S, Elmariah S, et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST Ⅱ. J Am Coll Cardiol, 2015, 66(25): 2844-2854.
10. Maisano F, Franzen O, Baldus S, et al. Percutaneous mitral valve interventions in the real world: Early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe. J Am Coll Cardiol, 2013, 62(12): 1052-1061.
11. Bail DH. (Meta)-analysis of safety and efficacy following edge-to-edge mitral valve repair using the MitraClip system. J Interv Cardiol, 2015, 28(1): 69-75.
12. Andalib A, Mamane S, Schiller I, et al. A systematic review and meta-analysis of surgical outcomes following mitral valve surgery in octogenarians: Implications for transcatheter mitral valve interventions. EuroIntervention, 2014, 9(10): 1225-1234.
13. Nickenig G, Estevez-Loureiro R, Franzen O, et al. Percutaneous mitral valve edge-to-edge repair: In-hospital results and 1-year follow-up of 628 patients of the 2011-2012 Pilot European Sentinel Registry. J Am Coll Cardiol, 2014, 64(9): 875-884.
14. 譚冠昶, 盧志南, 梁逸倫, 等. 經皮MitraClip介入治療二尖瓣反流1年隨訪報道. 中國介入心臟病學雜志, 2021, 29(10): 564-569.
15. Goel S, Pasam RT, Wats K, et al. Mitraclip plus medical therapy versus medical therapy alone for functional mitral regurgitation: A meta-analysis. Cardiol Ther, 2020, 9(1): 5-17.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Transapical mitral valve repair with LifeClip system: Early outcome of a single center

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content