Synchronous biopsy followed by radiofrequency ablation in lung tumors: A clinical analysis of a single center_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIU Qin ¹ , WANG Qingbing ¹ , SUN Yawen ² , GUO Xiaoxia ¹ , HUANG Wei ¹ , XIAO Dingyi ¹ , WANG Zhongmin ¹ , DING Xiaoyi ¹ ,  WU Zhiyuan ¹

1. Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R.China;
2. Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R.China;

Corresponding?author：

WU Zhiyuan, Email: wuzhiyuan@shsmu.edu.cn

Keywords：

Lung tumors; ablation; biopsy; intervention therapy

DOI：

10.7507/1007-4848.202103020

Video：

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Objective To explore the application value of synchronous CT-guided percutaneous biopsy followed by radiofrequency ablation in the diagnosis and treatment of lung tumors. Methods The clinical data of 21 patients with lung tumors were retrospectively analyzed. There were 8 males and 13 females aged 68 (51, 73) years. A total of 24 lesions underwent CT-guided percutaneous biopsy and concurrent radiofrequency ablation. The effectiveness and safety of this protocol were analyzed. Results All 21 patients successfully completed the procedures. The diameter of 24 lesions was 17.0 (13.3, 19.0) mm. Biopsy specimens met the requirements of pathological diagnosis, and the effectiveness of specimens was 100.0%. The incidence of small amount of pneumothorax/pleural shrinkage after procedures was 19.0% (4/21) and the incidence of tension pneumothorax was 4.7% (1/21). There was no obvious bleeding or other complications.Conclusion Synchronous CT-guided percutaneous biopsy followed by radiofrequency ablation combines two interventional techniques, which is safe and effective in the diagnosis and treatment of lung tumors, and it is worthy of popularization and application in clinic.

Citation： LIU Qin, WANG Qingbing, SUN Yawen, GUO Xiaoxia, HUANG Wei, XIAO Dingyi, WANG Zhongmin, DING Xiaoyi, WU Zhiyuan. Synchronous biopsy followed by radiofrequency ablation in lung tumors: A clinical analysis of a single center. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(11): 1305-1309. doi: 10.7507/1007-4848.202103020 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: Good or bad news from the 2018 global cancer statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3.	中國抗癌協會腫瘤介入學專業委員會, 中國抗癌協會腫瘤介入學專業委員會胸部腫瘤診療專家委員會. 胸部腫瘤經皮穿刺活檢中國專家共識(2020版). 中華醫學雜志, 2021, 101(3): 185-198.
4.	王芬, 俞同福, 趙欣, 等. 孤立性肺結節CT引導下微波消融術后近期療效分析. 中國胸心血管外科臨床雜志, 2021, 28(8): 928-934.
5.	Tselikas L, de Baere T, Deschamps F, et al. Diagnostic yield of a biopsy performed immediately after lung radiofrequency ablation. Eur Radiol, 2017, 27(3): 1211-1217.
6.	Schwartz LH, Litière S, de Vries E, et al. RECIST 1.1-Update and clarification: From the RECIST committee. Eur J Cancer, 2016, 62: 132-137.
7.	Alberg AJ, Brock MV, Ford JG, et al. Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(5 Suppl): e1S-e29S.
8.	Kong F, Wang C, Li Y, et al. Advances in study of the sequence of lung tumor biopsy and thermal ablation. Thorac Cancer, 2021, 12(3): 279-286.
9.	Nour-Eldin NE, Alsubhi M, Emam A, et al. Pneumothorax complicating coaxial and non-coaxial CT-guided lung biopsy: Comparative analysis of determining risk factors and management of pneumothorax in a retrospective review of 650 patients. Cardiovasc Intervent Radiol, 2016, 39(2): 261-270.
10.	Zhang L, Shi L, Xiao Z, et al. Coaxial technique-promoted diagnostic accuracy of CT-guided percutaneous cutting needle biopsy for small and deep lung lesions. PLoS One, 2018, 13(2): e0192920.
11.	Liu BD, Ye X, Fan WJ, et al. Expert consensus on image-guided radiofrequency ablation of pulmonary tumors: 2018 edition. Thorac Cancer, 2018, 9(9): 1194-1208.
12.	Tselikas L, Garzelli L, Mercier O, et al. Radiofrequency ablation versus surgical resection for the treatment of oligometastatic lung disease. Diagn Interv Imaging, 2021, 102(1): 19-26.
13.	Iezzi R, Cioni R, Basile D, et al. Standardizing percutaneous microwave ablation in the treatment of lung tumors: A prospective multicenter trial (MALT study). Eur Radiol, 2021, 31(4): 2173-2182.
14.	Huang G, Yang X, Li W, et al. A feasibility and safety study of computed tomography-guided percutaneous microwave ablation: A novel therapy for multiple synchronous ground-glass opacities of the lung. Int J Hyperthermia, 2020, 37(1): 414-422.
15.	Yuan Z, Wang Y, Zhang J, et al. A meta-analysis of clinical outcomes after radiofrequency ablation and microwave ablation for lung cancer and pulmonary metastases. J Am Coll Radiol, 2019, 16(3): 302-314.
16.	Sun D, Sui P, Zhang W, et al. Cerebral air embolism during percutaneous computed tomography scan-guided liver biopsy. J Cancer Res Ther, 2018, 14(7): 1650-1654.
17.	Yun S, Kang H, Park S, et al. Diagnostic accuracy and complications of CT-guided core needle lung biopsy of solid and part-solid lesions. Br J Radiol, 2018, 91(1088): 20170946.
18.	Schneider T, Puderbach M, Kunz J, et al. Simultaneous computed tomography-guided biopsy and radiofrequency ablation of solitary pulmonary malignancy in high-risk patients. Respiration, 2012, 84(6): 501-508.
19.	Wang D, Li B, Bie Z, et al. Synchronous core-needle biopsy and microwave ablation for highly suspicious malignant pulmonary nodule via a coaxial cannula. J Cancer Res Ther, 2019, 15(7): 1484-1489.
20.	Wangüemert Pérez AL, González Expósito H, Pascual Fernández L. Assessment of midazolam sedation in ultrasound-guided percutaneous biopsy of peripheral lung lesions. Arch Bronconeumol (Engl Ed), 2018, 54(6): 342-343.
21.	Azrumelashvili T, Mizandari M, Dundua T. Imaging guided percutaneal core biopsy of pulmonary and pleural masses-technique and complications. Georgian Med News, 2016, (250): 25-33.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Feng RM, Zong YN, Cao SM, et al. Current cancer situation in China: Good or bad news from the 2018 global cancer statistics? Cancer Commun (Lond), 2019, 39(1): 22.
3. 中國抗癌協會腫瘤介入學專業委員會, 中國抗癌協會腫瘤介入學專業委員會胸部腫瘤診療專家委員會. 胸部腫瘤經皮穿刺活檢中國專家共識(2020版). 中華醫學雜志, 2021, 101(3): 185-198.
4. 王芬, 俞同福, 趙欣, 等. 孤立性肺結節CT引導下微波消融術后近期療效分析. 中國胸心血管外科臨床雜志, 2021, 28(8): 928-934.
5. Tselikas L, de Baere T, Deschamps F, et al. Diagnostic yield of a biopsy performed immediately after lung radiofrequency ablation. Eur Radiol, 2017, 27(3): 1211-1217.
6. Schwartz LH, Litière S, de Vries E, et al. RECIST 1.1-Update and clarification: From the RECIST committee. Eur J Cancer, 2016, 62: 132-137.
7. Alberg AJ, Brock MV, Ford JG, et al. Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(5 Suppl): e1S-e29S.
8. Kong F, Wang C, Li Y, et al. Advances in study of the sequence of lung tumor biopsy and thermal ablation. Thorac Cancer, 2021, 12(3): 279-286.
9. Nour-Eldin NE, Alsubhi M, Emam A, et al. Pneumothorax complicating coaxial and non-coaxial CT-guided lung biopsy: Comparative analysis of determining risk factors and management of pneumothorax in a retrospective review of 650 patients. Cardiovasc Intervent Radiol, 2016, 39(2): 261-270.
10. Zhang L, Shi L, Xiao Z, et al. Coaxial technique-promoted diagnostic accuracy of CT-guided percutaneous cutting needle biopsy for small and deep lung lesions. PLoS One, 2018, 13(2): e0192920.
11. Liu BD, Ye X, Fan WJ, et al. Expert consensus on image-guided radiofrequency ablation of pulmonary tumors: 2018 edition. Thorac Cancer, 2018, 9(9): 1194-1208.
12. Tselikas L, Garzelli L, Mercier O, et al. Radiofrequency ablation versus surgical resection for the treatment of oligometastatic lung disease. Diagn Interv Imaging, 2021, 102(1): 19-26.
13. Iezzi R, Cioni R, Basile D, et al. Standardizing percutaneous microwave ablation in the treatment of lung tumors: A prospective multicenter trial (MALT study). Eur Radiol, 2021, 31(4): 2173-2182.
14. Huang G, Yang X, Li W, et al. A feasibility and safety study of computed tomography-guided percutaneous microwave ablation: A novel therapy for multiple synchronous ground-glass opacities of the lung. Int J Hyperthermia, 2020, 37(1): 414-422.
15. Yuan Z, Wang Y, Zhang J, et al. A meta-analysis of clinical outcomes after radiofrequency ablation and microwave ablation for lung cancer and pulmonary metastases. J Am Coll Radiol, 2019, 16(3): 302-314.
16. Sun D, Sui P, Zhang W, et al. Cerebral air embolism during percutaneous computed tomography scan-guided liver biopsy. J Cancer Res Ther, 2018, 14(7): 1650-1654.
17. Yun S, Kang H, Park S, et al. Diagnostic accuracy and complications of CT-guided core needle lung biopsy of solid and part-solid lesions. Br J Radiol, 2018, 91(1088): 20170946.
18. Schneider T, Puderbach M, Kunz J, et al. Simultaneous computed tomography-guided biopsy and radiofrequency ablation of solitary pulmonary malignancy in high-risk patients. Respiration, 2012, 84(6): 501-508.
19. Wang D, Li B, Bie Z, et al. Synchronous core-needle biopsy and microwave ablation for highly suspicious malignant pulmonary nodule via a coaxial cannula. J Cancer Res Ther, 2019, 15(7): 1484-1489.
20. Wangüemert Pérez AL, González Expósito H, Pascual Fernández L. Assessment of midazolam sedation in ultrasound-guided percutaneous biopsy of peripheral lung lesions. Arch Bronconeumol (Engl Ed), 2018, 54(6): 342-343.
21. Azrumelashvili T, Mizandari M, Dundua T. Imaging guided percutaneal core biopsy of pulmonary and pleural masses-technique and complications. Georgian Med News, 2016, (250): 25-33.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Synchronous biopsy followed by radiofrequency ablation in lung tumors: A clinical analysis of a single center

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