Localization of small pulmonary nodules with magnetic beads: An animal experiment_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LV Lu ^1,2 , SHI Aihua ³ , YAN Xiaopeng ^3,4 , ZHANG Zhixuan ^1,5 , ZHOU Guxiang ⁵ , FU Junke ¹ , MA Feng ³ , WANG Haohua ^3,4 , LV Yi ^3,4 ,  ZHANG Yong ^1,3

1. Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
2. Zonglian College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
3. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
4. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
5. Qide College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;

Corresponding?author：

ZHANG Yong, Email: zhangyongyang05@163.com

Keywords：

Magnetic beads; small pulmonary nodules; rabbit; magnetic tracer technique; animal experiment

DOI：

10.7507/1007-4848.202009014

Video：

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Objective To investigate the feasibility of using magnetic beads to locate small pulmonary nodules.Methods Twelve rabbits were randomly divided into two groups, 6 in each group. One group underwent thoracotomy after anesthesia and the other group underwent percutaneous puncture under the guidance of X-ray. One and two cylindrical tracer magnets (magnetic beads) with a diameter of 1 mm and a height of 3 mm were injected adjacent to the imaginary pulmonary nodules in left lung in each group. The magnetic beads beside the imaginary nodules were attracted by a pursuit magnet with a diameter of 9 mm and a height of 19 mm. The effectiveness of localization by magnetic beads were determined by attraction between tracer and pursuit magnets.Results All processes were uneven in 12 rabbits. There was micro hemorrhage and no hematoma in the lung tissue at the injection site of the magnetic beads. When tracked with the pursuit magnets, there was one bead divorce in cases that one bead was injected, but no migration or divorce of the magnetic beads in cases that two magnetic beads were simultaneously injected to localize the small pulmonary nodules.Conclusion The feasibility of using magnetic beads to locate small pulmonary nodules has been preliminarily verified.

Citation： LV Lu, SHI Aihua, YAN Xiaopeng, ZHANG Zhixuan, ZHOU Guxiang, FU Junke, MA Feng, WANG Haohua, LV Yi, ZHANG Yong. Localization of small pulmonary nodules with magnetic beads: An animal experiment. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(11): 1360-1364. doi: 10.7507/1007-4848.202009014 Copy

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13.	Tsutsui H, Kinouchi Y, Sasaki H, et al. Studies on the Sm-Co magnet as a dental material. J Dent Res, 1979, 58(6): 1597-1606.
14.	劉豪, 付珊, 付琴琴. 醫用釹鐵硼體內植入表面改性研究現狀. 現代生物醫學進展, 2019, 19(1): 175-179.
15.	Klima U, MacVaugh H 3rd, Bagaev E, et al. Magnetic vascular port in minimally invasive direct coronary artery bypass grafting. Circulation, 2004, 110(11 Suppl 1): Ⅱ55-Ⅱ60.
16.	Graves CE, Co C, Hsi RS, et al. Magnetic compression anastomosis (magnamosis): First-in-human trial. J Am Coll Surg, 2017, 225(5): 676-681.
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18.	Chen CK, Chang HT, Chen YC, et al. Utilization and safety of percutaneous lung biopsy: A 10-year nationwide population-based study. Int J Environ Res Public Health, 2019, 16(8): 1316.

1. 中華醫學會呼吸病學分會肺癌學組, 中國肺癌防治聯盟專家組. 肺結節診治中國專家共識(2018 年版). 中華結核和呼吸雜志, 2018, 41(10): 763-771.
2. Liu Q, Huang Y, Chen H, et al. Computed tomography-based radiomic features for diagnosis of indeterminate small pulmonary nodules. J Comput Assist Tomogr, 2020, 44(1): 90-94.
3. 呂璐, 嚴小鵬, 張至軒, 等. 肺小結節定位研究進展. 國際外科學雜志, 2020, 47(3): 197-201, 封四.
4. Iacovacci V, Lucarini G, Innocenti C, et al. Polydimethylsiloxane films doped with NdFeB powder: Magnetic characterization and potential applications in biomedical engineering and microrobotics. Biomed Microdevices, 2015, 17(6): 112.
5. 黃濤, 王向東, 石曉寧, 等. 釹鐵硼稀土永磁材料腐蝕防護技術的研究進展. 中國稀土學報, 2018, 36(4): 394-405.
6. 嚴小鵬, 商澎, 史愛華, 等. 磁外科學體系的探索與建立. 科學通報, 2019, 64(8): 815-826.
7. 中華醫學會放射學分會心胸學組. 低劑量螺旋 CT 肺癌篩查專家共識. 中華放射學雜志, 2015, 49(5): 328-335.
8. Mao Y, Yang D, He J, et al. Epidemiology of lung cancer. Surg Oncol Clin N Am, 2016, 25(3): 439-445.
9. 中華醫學會, 中華醫學會腫瘤學分會, 中華醫學會雜志社. 中華醫學會肺癌臨床診療指南(2019 版). 中華腫瘤雜志, 2020, 42(4): 257-287.
10. Zheng RS, Sun KX, Zhang SW, et al. Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi, 2019, 41(1): 19-28.
11. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin, 2018, 68(1): 7-30.
12. Thistlethwaite PA, Gower JR, Hernandez M, et al. Needle localization of small pulmonary nodules: Lessons learned. J Thorac Cardiovasc Surg, 2018, 155(5): 2140-2147.
13. Tsutsui H, Kinouchi Y, Sasaki H, et al. Studies on the Sm-Co magnet as a dental material. J Dent Res, 1979, 58(6): 1597-1606.
14. 劉豪, 付珊, 付琴琴. 醫用釹鐵硼體內植入表面改性研究現狀. 現代生物醫學進展, 2019, 19(1): 175-179.
15. Klima U, MacVaugh H 3rd, Bagaev E, et al. Magnetic vascular port in minimally invasive direct coronary artery bypass grafting. Circulation, 2004, 110(11 Suppl 1): Ⅱ55-Ⅱ60.
16. Graves CE, Co C, Hsi RS, et al. Magnetic compression anastomosis (magnamosis): First-in-human trial. J Am Coll Surg, 2017, 225(5): 676-681.
17. Matsuzaki I, Hattori M, Hirose K, et al. Magnetic anchor-guided endoscopic submucosal dissection for gastric lesions (with video). Gastrointest Endosc, 2018, 87(6): 1576-1580.
18. Chen CK, Chang HT, Chen YC, et al. Utilization and safety of percutaneous lung biopsy: A 10-year nationwide population-based study. Int J Environ Res Public Health, 2019, 16(8): 1316.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Localization of small pulmonary nodules with magnetic beads: An animal experiment

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