Association between baseline SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIN Dong , WANG Shuai , CHEN Xiaosang ,  TAN Lijie

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P.R.China;

Corresponding?author：

TAN Lijie, Email: tan.lijie@zs-hospital.sh.cn

Keywords：

Peripheral type; lung adenocarcinoma; PET/CT; histological subtype

DOI：

10.7507/1007-4848.202002120

Video：

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Objective To investigate the association between the baseline ¹⁸F-FDG PET/CT SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma (cN0).Methods We retrospectively reviewed the clinical data of consecutive patients who received baseline ¹⁸F-FDG PET/CT and underwent anatomic lung resection for ≤2 cm early peripheral lung adenocarcinoma from 2011 to 2014 in our institute.Results A total of 195 patients were enrolled in this study, including 86 males and 109 females, with an average age of 59.96±9.19 years. Twenty-two patients were pathologically confirmed with lymph node metastasis. One hundred and fifty-seven patients were in the subtype group 1, which included lepidic, acinar, and papillary predominant tumors. Thirty-eight patients were in the subtype group 2, which included solid and micropapillary predominant tumors. The 5-year survival rate was 79.0% and 58.0% in the subtype group 1 and subtype group 2, respectively (P=0.006). The median SUVmax was 2.00 (0.30-13.10) and 4.15 (1.20-17.90) in the subtype group 1 and subtype group 2, respectively (P=0.000). Logistic regression suggested that baseline SUVmax≥2.5 was an independent risk factor for the subtype group 2 (OR=6.635, 95%CI 2.510-17.545, P=0.000). The receiver operating characteristic curve suggested that the continuous SUVmax had an moderate predictive value for subtypes (area under the curve was 0.792, 95%CI 0.717-0.866).Conclusion Baseline ¹⁸F-FDG PET/CT SUVmax has certain predictive value for histological subtypes of ≤2 cm early peripheral lung adenocarcinoma.

Citation： LIN Dong, WANG Shuai, CHEN Xiaosang, TAN Lijie. Association between baseline SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(10): 1182-1186. doi: 10.7507/1007-4848.202002120 Copy

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18.	Song CY, Kimura D, Sakai T, <italic>et al</italic>. Novel approach for predicting occult lymph node metastasis in peripheral clinical stage Ⅰ lung adenocarcinoma. J Thorac Dis, 2019, 11(4): 1410-1420.

1. Bray F, Ferlay J, Soerjomataram I, <italic>et al</italic>. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Chen W, Zheng R, Baade PD, <italic>et al</italic>. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3. Macmahon H, Naidich DP, Goo JM, <italic>et al</italic>. Guidelines for management of incidental pulmonary nodules detected on CT images: From the Fleischner Society 2017. Radiology, 2017, 284(1): 228-243.
4. Horeweg N, Van Rosmalen J, Heuvelmans MA, <italic>et al</italic>. Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening. Lancet Oncol, 2014, 15(12): 1332-1341.
5. Dai C, Shen J, Ren Y, <italic>et al</italic>. Choice of surgical procedure for patients with non-small-cell lung cancer ≤ 1 cm or > 1 to 2 cm among lobectomy, segmentectomy, and wedge resection: A population-based study. J Clin Oncol, 2016, 34(26): 3175-3182.
6. Schneider BJ, Daly ME, Kennedy EB, <italic>et al</italic>. Stereotactic body radiotherapy for early-stage non-small-cell lung cancer: American Society of Clinical Oncology endorsement of the American Society for Radiation Oncology evidence-based guideline. J Clin Oncol, 2018, 36(7): 710-719.
7. Travis WD, Brambilla E, Noguchi M, <italic>et al</italic>. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol, 2011, 6(2): 244-285.
8. Yu Y, Jian H, Shen L, <italic>et al</italic>. Lymph node involvement influenced by lung adenocarcinoma subtypes in tumor size ≤3 cm disease: A study of 2268 cases. Eur J Surg Oncol, 2016, 42(11): 1714-1719.
9. Murakami S, Ito H, Tsubokawa N, <italic>et al</italic>. Prognostic value of the new IASLC/ATS/ERS classification of clinical stageⅠA lung adenocarcinoma. Lung Cancer, 2015, 90(2): 199-204.
10. Yoshiya T, Mimae T, Tsutani Y, <italic>et al</italic>. Prognostic role of subtype classification in small-sized pathologic N0 invasive lung adenocarcinoma. Ann Thorac Surg, 2016, 102(5): 1668-1673.
11. Liu S, Wang R, Zhang Y, <italic>et al</italic>. Precise diagnosis of intraoperative frozen section is an effective method to guide resection strategy for peripheral small-sized lung adenocarcinoma. J Clin Oncol, 2016, 34(4): 307-313.
12. Boellaard R, Delgado-bolton R, Oyen WJ, <italic>et al</italic>. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging, 2015, 42(2): 328-354.
13. Chiu CH, Yeh YC, Lin KH, <italic>et al</italic>. Histological subtypes of lung adenocarcinoma have differential <sup>18</sup>F-fluorodeoxyglucose uptakes on the positron emission tomography/computed tomography scan. J Thorac Oncol, 2011, 6(10): 1697-1703.
14. Nakamura H, Saji H, Shinmyo T, <italic>et al</italic>. Close association of IASLC/ATS/ERS lung adenocarcinoma subtypes with glucose-uptake in positron emission tomography. Lung Cancer, 2015, 87(1): 28-33.
15. Swets JA. Measuring the accuracy of diagnostic systems. Science, 1988, 240(4857): 1285-1293.
16. Lin JT, Yang XN, Zhong WZ, <italic>et al</italic>. Association of maximum standardized uptake value with occult mediastinal lymph node metastases in cN0 non-small cell lung cancer. Eur J Cardiothorac Surg, 2016, 50(5): 914-919.
17. Wang S, Lin D, Yang X, <italic>et al</italic>. Clinical significance of PET/CT uptake for peripheral clinical N0 non-small cell lung cancer. Cancer Med, 2020.
18. Song CY, Kimura D, Sakai T, <italic>et al</italic>. Novel approach for predicting occult lymph node metastasis in peripheral clinical stage Ⅰ lung adenocarcinoma. J Thorac Dis, 2019, 11(4): 1410-1420.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Association between baseline SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma

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