Influencing factors of postoperative cough after lung resection in patients with lung cancer by video-assisted thoracic surgery: a single centre prospective study_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIN Rongjia ,  CHE Guowei , XU Zhihua , WANG Mingming , LI Pengfei , YANG Mei

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding?author：

CHE Guowei, Email: guowei_che@yahoo.com

Keywords：

Influencing factor; pulmonary thoracoscope surgery; cough; lung cancer

DOI：

10.7507/1007-4848.201704008

Video：

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Objective To explore the factors of postoperative cough in lung cancer patients. Methods Totally 130 lung cancer patients of single medical team (average age of 58.75±9.34 years, 65 males and 65 females), from February 2016 to February 2017 in the Department of Thoracic Surgery of West China Hospital of Sichuan University, were investigated by Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC). We analyzed and calculated the preoperative and postoperative scores of LCQ-MC, Cronbach α and the influencing factor. Results The preoperative score of LCQ-MC's physiological dimension was significantly lower in the postoperative cough group (6.30±0.76) than that of the postoperative non-cough group (6.56±0.60,P=0.044), while the preoperative total score of LCQ-MC (19.53±1.78, 20.03±1.45) was not statistically different (P=0.080). The postoperative score of LCQ-MC was significantly lower in the postoperative cough group (17.32±2.79) than that of the postoperative non-cough group (19.70±1.39,P<0.001). And the scores of physiological, psychological and social dimension were significantly lower in the postoperative cough group (5.32 ±1.14, 5.73±1.14, 6.23±0.89) than those of the postoperative non-cough group (6.25±0.63, 6.67±0.54, 6.78±0.49) (P values were all less than 0.001). The result of multi-factor logistic regression analysis showed the condition of preoperative cough symptom (OR=0.354, 95%CI=0.126–0.994, P=0.049) and anesthesia time (OR=1.021, 95% CI=1.003–1.040, P=0.021) were the risk factors. Conclusion The risk factors of postoperative cough symptoms in lung cancer patients are the condition of preoperative cough symptoms and anesthesia time.

Citation： LIN Rongjia, CHE Guowei, XU Zhihua, WANG Mingming, LI Pengfei, YANG Mei. Influencing factors of postoperative cough after lung resection in patients with lung cancer by video-assisted thoracic surgery: a single centre prospective study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(10): 748-752. doi: 10.7507/1007-4848.201704008 Copy

1.	Lee KK, Matos S, Evans DH, et al. A longitudinal assessment of acute cough. Am J Respir Crit Care Med, 2013, 187(9): 991-997.
2.	Urso B, Michaels S. Differentiation of lung cancer, empyema, and abscess through the investigation of a dry cough. Cureus, 2016, 8(11): e896.
3.	Driessen AK, McGovern AE, Narula M, et al. Central mechanisms of airway sensation and cough hypersensitivity. Pulm Pharmacol Ther, 2017, S1094-5539(17)30016-0.
4.	Molassiotis A, Smith JA, Mazzone P, et al. Symptomatic treatment of cough among adult patients with lung cancer: chest guidelines and expert panel report. Chest, 2017, 151(4):861-874.
5.	車國衛, 劉倫旭, 石應康. 加速康復外科臨床應用現狀與思考. 中國胸心血管外科臨床雜志, 2016, 23(3): 211-215.0.
6.	車國衛, 李為民, 劉倫旭. 快速肺康復需要圍手術期流程優化. 中國胸心血管外科臨床雜志, 2016, 23(3): 216-220.0.
7.	Liu L, Che G, Pu Q, et al. A new concept of endoscopic lung cancer resection: Single-direction thoracoscopic lobectomy. Surg Oncol, 2010, 19(2): e71-e77.
8.	Zhi XY, Yu JM, Shi YK. Chinese guidelines on the diagnosis and treatment of primary lung cancer(2015 version). Cancer, 2015, 121(Suppl 17): 3165-3181.
9.	楊梅, 樊駿 ,周紅霞, 等. 胸腔鏡肺癌肺葉切除術后 16F 較 28F 胸腔引流管應用的臨床優勢. 中國肺癌雜志, 2015, 18(8): 512-517.0.
10.	Gao YH, Guan WJ, Xu G, et al. Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in bronchiectasis. Int J Tuberc Lung Dis, 2014, 18(12): 1431-1437.
11.	Raj AA, Pavord DI, Birring SS. Clinical cough IV:what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol, 2009, 187: 311-320.
12.	Yousaf N, Lee KK, Jayaraman B, et al. The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute). Cough, 2011, 7(1): 4.
13.	Molassiotis A, Smith JA, Bennett MI, et al. Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough, 2010, 6: 9. doi: 10.1186/1745-9974-6-9.
14.	Harle AS, Blackhall FH, Smith JA, et al. Understanding cough and its management in lung cancer. Curr Opin Support Palliat Care, 2012, 6(2): 153-162.
15.	Lee SY, Yoo JY, Kim JY, et al. Optimal effect-site concentration of remifentanil for preventing cough during removal of the double-lumen endotracheal tube from sevoflurane-remifentanil anesthesia: A prospective clinical trial. Medicine (Baltimore), 2016, 95(24): e3878.
16.	Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol, 2015, 22: 37-40.
17.	Wang K, Birring SS, Taylor K, et al. Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial. Lancet Respir Med, 2014, 2(1): 35-43.
18.	黃佳, 羅清泉, 申屠陽,等. 右肺癌系統性清掃淋巴結術后頑固性咳嗽防治方法的探討. 中國肺癌雜志, 2010, 13(10): 975-979.0.
19.	宋志芳, 韓兆杰, 林琳, 等. SF-36 量表評價胸外科住院患者生活質量的信度和效度. 中國胸心血管外科臨床雜志, 2014, 21(2):164-167.0.
20.	李斌愷, 賴克方, 王法霞, 等. 慢性咳嗽患者的生活質量調查. 國際呼吸雜志, 2011, 31(5): 326-329.0.

1. Lee KK, Matos S, Evans DH, et al. A longitudinal assessment of acute cough. Am J Respir Crit Care Med, 2013, 187(9): 991-997.
2. Urso B, Michaels S. Differentiation of lung cancer, empyema, and abscess through the investigation of a dry cough. Cureus, 2016, 8(11): e896.
3. Driessen AK, McGovern AE, Narula M, et al. Central mechanisms of airway sensation and cough hypersensitivity. Pulm Pharmacol Ther, 2017, S1094-5539(17)30016-0.
4. Molassiotis A, Smith JA, Mazzone P, et al. Symptomatic treatment of cough among adult patients with lung cancer: chest guidelines and expert panel report. Chest, 2017, 151(4):861-874.
5. 車國衛, 劉倫旭, 石應康. 加速康復外科臨床應用現狀與思考. 中國胸心血管外科臨床雜志, 2016, 23(3): 211-215.0.
6. 車國衛, 李為民, 劉倫旭. 快速肺康復需要圍手術期流程優化. 中國胸心血管外科臨床雜志, 2016, 23(3): 216-220.0.
7. Liu L, Che G, Pu Q, et al. A new concept of endoscopic lung cancer resection: Single-direction thoracoscopic lobectomy. Surg Oncol, 2010, 19(2): e71-e77.
8. Zhi XY, Yu JM, Shi YK. Chinese guidelines on the diagnosis and treatment of primary lung cancer(2015 version). Cancer, 2015, 121(Suppl 17): 3165-3181.
9. 楊梅, 樊駿 ,周紅霞, 等. 胸腔鏡肺癌肺葉切除術后 16F 較 28F 胸腔引流管應用的臨床優勢. 中國肺癌雜志, 2015, 18(8): 512-517.0.
10. Gao YH, Guan WJ, Xu G, et al. Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in bronchiectasis. Int J Tuberc Lung Dis, 2014, 18(12): 1431-1437.
11. Raj AA, Pavord DI, Birring SS. Clinical cough IV:what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol, 2009, 187: 311-320.
12. Yousaf N, Lee KK, Jayaraman B, et al. The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute). Cough, 2011, 7(1): 4.
13. Molassiotis A, Smith JA, Bennett MI, et al. Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough, 2010, 6: 9. doi: 10.1186/1745-9974-6-9.
14. Harle AS, Blackhall FH, Smith JA, et al. Understanding cough and its management in lung cancer. Curr Opin Support Palliat Care, 2012, 6(2): 153-162.
15. Lee SY, Yoo JY, Kim JY, et al. Optimal effect-site concentration of remifentanil for preventing cough during removal of the double-lumen endotracheal tube from sevoflurane-remifentanil anesthesia: A prospective clinical trial. Medicine (Baltimore), 2016, 95(24): e3878.
16. Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol, 2015, 22: 37-40.
17. Wang K, Birring SS, Taylor K, et al. Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial. Lancet Respir Med, 2014, 2(1): 35-43.
18. 黃佳, 羅清泉, 申屠陽,等. 右肺癌系統性清掃淋巴結術后頑固性咳嗽防治方法的探討. 中國肺癌雜志, 2010, 13(10): 975-979.0.
19. 宋志芳, 韓兆杰, 林琳, 等. SF-36 量表評價胸外科住院患者生活質量的信度和效度. 中國胸心血管外科臨床雜志, 2014, 21(2):164-167.0.
20. 李斌愷, 賴克方, 王法霞, 等. 慢性咳嗽患者的生活質量調查. 國際呼吸雜志, 2011, 31(5): 326-329.0.

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Influencing factors of postoperative cough after lung resection in patients with lung cancer by video-assisted thoracic surgery: a single centre prospective study

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