Correlation of Twist expression in esophageal squamous cell carcinomas with clinical prognosis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

GUO Hai ¹ , YUAN Yang ² , QIN Sheng ³ , HUANG Jianming ³ , XIAO Bo ³ , FANG Qiang ³ ,  REN Guangguo ³

1. Department of Postgraduate, Guangxi Medical University, Nanning, 530021, P.R.China;
2. Chengdu First People’s Hospital, Chengdu, 630041, P.R.China;
3. Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, 630041, P.R.China;

Corresponding?author：

REN Guangguo, Email: rengg2091@163.com

Keywords：

Esophageal squamous cell carcinoma; vascular tumor emboli; Twist; immunohistochemistry

DOI：

10.7507/1007-4848.201608037

Video：

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Objective To observe the expression of Twist in esophageal squamous cell carcinoma (ESCC) and analyze the relationship between positive expression of Twist and disease-free survival, and to provide clinical evidence for reducing tumor recurrence, prolonging disease-free survival and improving prognosis. Methods Retrospective analysis of 70 ESCC patients receiving thoracic surgery from June 2010 to June 2012 in the Department of Thoracic Surgery, Sichuan Cancer Hospital was done, including 39 males and 31 females with an average age of 63.6 years. The expression of Twist in normal esophageal tissue, tumor tissue and vascular tumor emboli was observed by immunohistochemical staining of paraffin specimens. Results The positive rate of Twist in normal esophageal tissues was 42.9%, and in tumor tissue was 77.1% (P<0.05). The positive expression rate of Twist in tumor cells was 74.3% in patients with vascular tumor emboli and 80.0% in patients without vascular tumor emboli (P>0.05). The positive expression rate of Twist in tumor cells and in vascular tumor emboli was 74.3% and 71.4%, respectively (P>0.05). The expression of Twist in lymphatic vessels and blood vessels of patients with vascular tumor emboli was 56.0% and 72.0%, respectively (P>0.05). Conclusion Twist expression in esophageal cancer tissues is significantly higher than that in normal tissues, but there is no significant difference in the positive expression of Twist between tumor cells and the mean disease-free survival (P>0.05). At present, Twist expression can not be used as a prognostic indicator of esophageal cancer, and more researches need be further implemented.

Citation： GUO Hai, YUAN Yang, QIN Sheng, HUANG Jianming, XIAO Bo, FANG Qiang, REN Guangguo. Correlation of Twist expression in esophageal squamous cell carcinomas with clinical prognosis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(11): 849-852. doi: 10.7507/1007-4848.201608037 Copy

1.	Chen MQ, Xu BH, Zhang YY. Analysis of prognostic factors for esophageal squamous cell carcinoma with distant organ metastasis at initial diagnosis. J Chin Med Assoc, 2014, 77(11): 562-566.
2.	Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol, 1995, 191(5): 381-396.
3.	Kwok WK, Ling MT, Lee TW, et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res, 2005, 65(12): 5153-5162．.
4.	Zhang X, Wang Q, Ling MT, et al. Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells. Int J Cancer, 2007, 120(9): 1891-1898．.
5.	Fidler IJ. The pathogenesis of cancer metastasis:the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer, 2003, 3(6): 453-458．.
6.	Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res, 2006, 66(9): 4549-4552.
7.	Zhang HL, Chen LQ, Liu RL, et al. The number of lymph node metastases influencs survival and International Union Against Cancer tumor-node-metastas is classification for esophageal squamous cell carcinoma. Dis Esophagus, 2010, 23 (1): 53-55.
8.	Parkin DM, Bray F, Ferlay J, et al. Global cancel statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
9.	Chuang WY, Yeh CJ, Wu YC, et al. Tumor cell expression of podoplanin correlates with nodalmetastasis in esophageal squamous cell carcinoma. Histol Histopathol, 2009, 24(8): 1021-1027.
10.	Xie F, Li K, Quyang X. Twist, an independent prognostic marker for predicting distant metastasis and survival rates of esophageal squamous cell carcinoma patients. Clin Exp Metastasis, 2009, 26(8): 1025-1032.
11.	Forghanifard MM, Moaven O, Farshchian M, et al. Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. Ann Surg Oncol, 2012, 19(3): 743-749.
12.	孫鳳丹, 崔演, 張佰玲, 等. 食管鱗癌組織中 Twist1 的表達及其臨床意義. 臨床與實驗病理學雜志, 2013, 29(8): 836-839.
13.	Wushou A, Hou J, Zhao YJ, et al. Twist-1 up-regulation in carcinoma correlates to poor survival. Int J Mol Sci, 2014, 15(12): 21621-21630.

1. Chen MQ, Xu BH, Zhang YY. Analysis of prognostic factors for esophageal squamous cell carcinoma with distant organ metastasis at initial diagnosis. J Chin Med Assoc, 2014, 77(11): 562-566.
2. Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol, 1995, 191(5): 381-396.
3. Kwok WK, Ling MT, Lee TW, et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res, 2005, 65(12): 5153-5162．.
4. Zhang X, Wang Q, Ling MT, et al. Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells. Int J Cancer, 2007, 120(9): 1891-1898．.
5. Fidler IJ. The pathogenesis of cancer metastasis:the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer, 2003, 3(6): 453-458．.
6. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res, 2006, 66(9): 4549-4552.
7. Zhang HL, Chen LQ, Liu RL, et al. The number of lymph node metastases influencs survival and International Union Against Cancer tumor-node-metastas is classification for esophageal squamous cell carcinoma. Dis Esophagus, 2010, 23 (1): 53-55.
8. Parkin DM, Bray F, Ferlay J, et al. Global cancel statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
9. Chuang WY, Yeh CJ, Wu YC, et al. Tumor cell expression of podoplanin correlates with nodalmetastasis in esophageal squamous cell carcinoma. Histol Histopathol, 2009, 24(8): 1021-1027.
10. Xie F, Li K, Quyang X. Twist, an independent prognostic marker for predicting distant metastasis and survival rates of esophageal squamous cell carcinoma patients. Clin Exp Metastasis, 2009, 26(8): 1025-1032.
11. Forghanifard MM, Moaven O, Farshchian M, et al. Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. Ann Surg Oncol, 2012, 19(3): 743-749.
12. 孫鳳丹, 崔演, 張佰玲, 等. 食管鱗癌組織中 Twist1 的表達及其臨床意義. 臨床與實驗病理學雜志, 2013, 29(8): 836-839.
13. Wushou A, Hou J, Zhao YJ, et al. Twist-1 up-regulation in carcinoma correlates to poor survival. Int J Mol Sci, 2014, 15(12): 21621-21630.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Correlation of Twist expression in esophageal squamous cell carcinomas with clinical prognosis

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