Progress in Diagnosis and Treatment of Double Primary Lung Cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANGHui , WANGXiao-jun , CHENShu ,  GUOXi-ping

Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun 130021, P. R. China;

Corresponding?author：

GUOXi-ping, Email: 3399787213@qq.com

Keywords：

Double primary lung cancer; Video-assisted thoracoscopic surgery; Radiotherapy alone

DOI：

10.7507/1007-4848.20160173

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the continuous development of living standards, medical imageology, pathology and the technique of cell biology, the morbidity of double primary lung cancer (DPLC) grows rapidly in recent years. The thoracic surgeons have constantly improved its standard of diagnosis and treatment. At the present, union diagnosis of multiple indexes, defining clinical stage based on a single leision, and the early surgery have been accepted by most of the thoracic surgeons. The video-assisted thoracoscopic surgery (VATS), for its advantage of small trauma, has been accepted by thoracic surgeons and been widely used now. It's a promising treatment for DPLC and other chest diseases. In addition, it has been proved that there was no statistical diffence in prognosis between the simple radiotherapy and surgical treatment. The traditional concept of thoracic surgery is facing severe challenges. Therefore, we review the clinical diagnosis and treatment progress of DPLC as follows.

Citation： WANGHui, WANGXiao-jun, CHENShu, GUOXi-ping. Progress in Diagnosis and Treatment of Double Primary Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(7): 724-727. doi: 10.7507/1007-4848.20160173 Copy

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5.	Beyreuther H. Multiplicitat von canciinomen bei einem Fall von sog. "Schenecberger" Lungenkrebs mit tuberkulose. Virchows Arch, 1924, 250(5):230-243.
6.	Biuroth T, Fukuda M, Soda H, et al. Clinical pattern and patholo-gicstage but not histologic features predict outcome for bronchioloal-veolarcarcinoma. Ann ThoracSurg, 2002, 74(8):1640-1647.
7.	Rea F, Zuin A, Callegaro D, et al. Surgical results for multiple primary lung cancers. Eur J Cardiothorac Surg, 2001, 20(3):489-495.
8.	Luraghi P, Schelter F, Kruger A, et al. The MET oncogene as a therapeutical target in cancer invasive growth. Front Pharmacol, 2012, 3(2):164.
9.	Schmid F, Wang Q, Huska MR, et al. A target genef MACC1, conter-butes to colorectal cancer metastasis. Proc Am Ass Res, 2012, 54 (10):416.
10.	Shiro F, Katsuhiro M. Multiple primary malignancies in patients with non-small cell lung cancer. Intern Med, 2015, 54(3):325-331.
11.	Vineis P, Alavanja M, Buffler P, et al. Tobacco and cancer:recent epidemiological evidence. J Natl Cancer Inst, 2004, 96(2):99-106.
12.	張國欽, 王寧, 王濤,等. 北京市城區居民煙草消費和大氣污染對肺癌死亡率的影響. 環境與健康雜志, 2009, 26(8):666-669.
13.	Adams AM, Berg CD. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med, 2011, 365(9):395-409.
14.	Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer:a systematic review. JAMA, 2012, 307 (22):2418-2429.
15.	Hellwig D, Baum RP, Kirsch C. FDG, PET, PET/CT and conven-tional nuclear medicine procedures in the evaluation of lung cancer:a systematic review. Nuklearmedizin, 2009, 48(2):59-69.
16.	馮飛躍, 張德超, 劉向陽, 等. 31例同期雙原發肺癌的手術方式和患者生存情況分析. 癌癥雜志, 2005, 24(2):215-218.
17.	Antakli T, Schaefer RF, Rutherford JE, et al. Second primary lung cancer. Ann Thorac Surg, 1995, 59(4):863-866.
18.	Martini N, Melamed MR. Multiple primary lung cancer. J Thorac Cardiovas Surg, 2005, 70(5):606-612.
19.	Kozower BD, Larner JM, Detterbeck FC, et al. Special treatment issues in non-small cell lung cancer:Diagnosis and management of lung cancer:American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(5 Suppl):e369-e399.
20.	董賀, 孫青. 分子病理學技術在腫瘤診治中的應用. 分子診斷與治療雜志, 2015, 7(2):73-77, 82.
21.	Kontic M, Stevic R, Stojsic J, et al. Synchronous primary lung cancers:a muhidisciplinary approach in diagnosis. Tumori, 2011, 97(4):e16-19.
22.	Stella GM, Cemmi F, Inghilleri S, et al. Synchronous lung cancers:when saine histological types feature different molecular profiles and response phenotypes. J Cancer, 2011, 2(2):474-477.
23.	Graziano P, Cardillo G, Mancuse A, et al. Long-term disease free survival of a patient with synchronous bilateral lung adenecareinoma displaying different EGFR and C-MYC molecular characteristics. Chest, 2011, 140(5):1354-1356.
24.	Hayes JL, Tzeuka A, Thygesen H, et al. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics, 2013, 102(3):174-181.
25.	張洋, 蘇玉虹, 巴彩鳳, 等. 流式細胞微球芯片捕獲技術在醫學領域中的應用價值. 中國臨床康復, 2006, 37:129-131.
26.	Ichinose X, Hara N, Ohta M, et al. DNA ploidypat-terns of tumors diagnosed as metachronous or recurrent lung cancers. Ann Thorac Surg, 1991, 52(4):496-473.
27.	姚健. MACC1和c-Met在同期多發肺癌中的表達及臨床意義. 長春:吉林大學, 2014.13-105.
28.	Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer:an increasing clinicaloc-currence repuiring multidisciplinary management. J Thorac Cardiovasc Surg, 2007, 133(5):1193-1200.
29.	廖虎. 劉倫旭教授成功開展國際首例雙側單孔胸腔鏡手術同期治療多原發肺癌. 中國胸心血管外科臨床雜志, 2014, 21(2):177.
30.	Niessen RC, Berends MJ, Wu Y, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary nonpolyposis colorectal cancer. Gut, 2006, 55(12):1781-1788.
31.	Landreneau RJ. Sugarbaker DJ, Mack MJ, et al. Wedge resection versuslobect my for stage 1 (T₁N₀M₀) Non small cell lung cancer. J Thorac Cardiovasc surg, 1997, 113(5):691-700.
32.	Kobayashi S, Okada S, Hasumi T, et al. Long-term survival of a poor risk octogenarian following wedge resetion under AVTS for small cell lung cancer:report of a case. Surg Today, 2000, 30(3):286-290.
33.	Johnson BE. Second lung in patients after treatment for an mutal lung cancer. J Natl Cancer Inst, 1998, 90(2):1335-1345.
34.	Gold DR, Bloomberg GR, Gruikshank WW, et al. Parental charac-teristics,somatic fetal growth and season of birth influence innate and adaptive cord.blood cyctokine responses. J Allergy Clin Immunol, 2009, 124(5):1078-1087.
35.	Yoshizawa A, Sumiyoshi N, Sonobe M, et a1. Validation of the lst. C/ATS/ERS lung adenoearcinoma classification for prognosis and association with EGFR and KRASgene mutations:analysis of 440 Japanese patients. J Thorac Oncol, 2013, 8:52-61.
36.	Tsuta K, Kawago M, Inoue E, et al. The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung cancer, 2013, 81(1):371-376.
37.	Woo T, Okudela K, Mitsui H, et al. Prognostic value of the IASLC/ATS/ERS classification of lung adenocarcinoma in stage 1 disease of Japanese cases. Pathol Int, 2012, 62(3):785-791.
38.	Naohiro T, Tsutomu K. A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. Am J Case Rep, 2014, 15(7):576-579.
39.	Depierre A, Westeel V. Overview of the role of neoadjuvant therapy for early stage non-small cell lung cancer. Sein Oncol, 2001, 28 (4Suppl 14):29-36.
40.	Matthiesen C, Thompson JS, De La Fuente HT, et a1. Use of stereo-tactic body radiation therapy for medically inoperable multiple pfimary lung cancer. J Med Imaging Radiat Oncol, 2012, 56(5):56l-566.
41.	初向陽,薛志強,劉毅, 等. 單操作孔電視胸腔鏡肺葉切除術治療早期肺癌的臨床研究. 中國胸心血管外科臨床雜志, 2012, 19(2):113-115.

1. Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin, 2014, 64(1):9-29.
2. 羅汶鑫, 周萍, 李為民.多原發性肺癌的診治進展.中國肺癌雜志, 2015, 18(10):640-643.
3. 張雷, 李文濤, 丁嘉安, 等. 多原發性肺癌的外科治療. 中華胸心血管外科雜志, 2004, 20(1):63.
4. 付強, 李欽, 劉涌. 同時性多原發性肺癌的外科治療. 四川醫學, 2007, 28(2):188-189.
5. Beyreuther H. Multiplicitat von canciinomen bei einem Fall von sog. "Schenecberger" Lungenkrebs mit tuberkulose. Virchows Arch, 1924, 250(5):230-243.
6. Biuroth T, Fukuda M, Soda H, et al. Clinical pattern and patholo-gicstage but not histologic features predict outcome for bronchioloal-veolarcarcinoma. Ann ThoracSurg, 2002, 74(8):1640-1647.
7. Rea F, Zuin A, Callegaro D, et al. Surgical results for multiple primary lung cancers. Eur J Cardiothorac Surg, 2001, 20(3):489-495.
8. Luraghi P, Schelter F, Kruger A, et al. The MET oncogene as a therapeutical target in cancer invasive growth. Front Pharmacol, 2012, 3(2):164.
9. Schmid F, Wang Q, Huska MR, et al. A target genef MACC1, conter-butes to colorectal cancer metastasis. Proc Am Ass Res, 2012, 54 (10):416.
10. Shiro F, Katsuhiro M. Multiple primary malignancies in patients with non-small cell lung cancer. Intern Med, 2015, 54(3):325-331.
11. Vineis P, Alavanja M, Buffler P, et al. Tobacco and cancer:recent epidemiological evidence. J Natl Cancer Inst, 2004, 96(2):99-106.
12. 張國欽, 王寧, 王濤,等. 北京市城區居民煙草消費和大氣污染對肺癌死亡率的影響. 環境與健康雜志, 2009, 26(8):666-669.
13. Adams AM, Berg CD. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med, 2011, 365(9):395-409.
14. Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer:a systematic review. JAMA, 2012, 307 (22):2418-2429.
15. Hellwig D, Baum RP, Kirsch C. FDG, PET, PET/CT and conven-tional nuclear medicine procedures in the evaluation of lung cancer:a systematic review. Nuklearmedizin, 2009, 48(2):59-69.
16. 馮飛躍, 張德超, 劉向陽, 等. 31例同期雙原發肺癌的手術方式和患者生存情況分析. 癌癥雜志, 2005, 24(2):215-218.
17. Antakli T, Schaefer RF, Rutherford JE, et al. Second primary lung cancer. Ann Thorac Surg, 1995, 59(4):863-866.
18. Martini N, Melamed MR. Multiple primary lung cancer. J Thorac Cardiovas Surg, 2005, 70(5):606-612.
19. Kozower BD, Larner JM, Detterbeck FC, et al. Special treatment issues in non-small cell lung cancer:Diagnosis and management of lung cancer:American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(5 Suppl):e369-e399.
20. 董賀, 孫青. 分子病理學技術在腫瘤診治中的應用. 分子診斷與治療雜志, 2015, 7(2):73-77, 82.
21. Kontic M, Stevic R, Stojsic J, et al. Synchronous primary lung cancers:a muhidisciplinary approach in diagnosis. Tumori, 2011, 97(4):e16-19.
22. Stella GM, Cemmi F, Inghilleri S, et al. Synchronous lung cancers:when saine histological types feature different molecular profiles and response phenotypes. J Cancer, 2011, 2(2):474-477.
23. Graziano P, Cardillo G, Mancuse A, et al. Long-term disease free survival of a patient with synchronous bilateral lung adenecareinoma displaying different EGFR and C-MYC molecular characteristics. Chest, 2011, 140(5):1354-1356.
24. Hayes JL, Tzeuka A, Thygesen H, et al. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics, 2013, 102(3):174-181.
25. 張洋, 蘇玉虹, 巴彩鳳, 等. 流式細胞微球芯片捕獲技術在醫學領域中的應用價值. 中國臨床康復, 2006, 37:129-131.
26. Ichinose X, Hara N, Ohta M, et al. DNA ploidypat-terns of tumors diagnosed as metachronous or recurrent lung cancers. Ann Thorac Surg, 1991, 52(4):496-473.
27. 姚健. MACC1和c-Met在同期多發肺癌中的表達及臨床意義. 長春:吉林大學, 2014.13-105.
28. Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer:an increasing clinicaloc-currence repuiring multidisciplinary management. J Thorac Cardiovasc Surg, 2007, 133(5):1193-1200.
29. 廖虎. 劉倫旭教授成功開展國際首例雙側單孔胸腔鏡手術同期治療多原發肺癌. 中國胸心血管外科臨床雜志, 2014, 21(2):177.
30. Niessen RC, Berends MJ, Wu Y, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary nonpolyposis colorectal cancer. Gut, 2006, 55(12):1781-1788.
31. Landreneau RJ. Sugarbaker DJ, Mack MJ, et al. Wedge resection versuslobect my for stage 1 (T₁N₀M₀) Non small cell lung cancer. J Thorac Cardiovasc surg, 1997, 113(5):691-700.
32. Kobayashi S, Okada S, Hasumi T, et al. Long-term survival of a poor risk octogenarian following wedge resetion under AVTS for small cell lung cancer:report of a case. Surg Today, 2000, 30(3):286-290.
33. Johnson BE. Second lung in patients after treatment for an mutal lung cancer. J Natl Cancer Inst, 1998, 90(2):1335-1345.
34. Gold DR, Bloomberg GR, Gruikshank WW, et al. Parental charac-teristics,somatic fetal growth and season of birth influence innate and adaptive cord.blood cyctokine responses. J Allergy Clin Immunol, 2009, 124(5):1078-1087.
35. Yoshizawa A, Sumiyoshi N, Sonobe M, et a1. Validation of the lst. C/ATS/ERS lung adenoearcinoma classification for prognosis and association with EGFR and KRASgene mutations:analysis of 440 Japanese patients. J Thorac Oncol, 2013, 8:52-61.
36. Tsuta K, Kawago M, Inoue E, et al. The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung cancer, 2013, 81(1):371-376.
37. Woo T, Okudela K, Mitsui H, et al. Prognostic value of the IASLC/ATS/ERS classification of lung adenocarcinoma in stage 1 disease of Japanese cases. Pathol Int, 2012, 62(3):785-791.
38. Naohiro T, Tsutomu K. A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. Am J Case Rep, 2014, 15(7):576-579.
39. Depierre A, Westeel V. Overview of the role of neoadjuvant therapy for early stage non-small cell lung cancer. Sein Oncol, 2001, 28 (4Suppl 14):29-36.
40. Matthiesen C, Thompson JS, De La Fuente HT, et a1. Use of stereo-tactic body radiation therapy for medically inoperable multiple pfimary lung cancer. J Med Imaging Radiat Oncol, 2012, 56(5):56l-566.
41. 初向陽,薛志強,劉毅, 等. 單操作孔電視胸腔鏡肺葉切除術治療早期肺癌的臨床研究. 中國胸心血管外科臨床雜志, 2012, 19(2):113-115.

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