Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

CHENJia-kuan ¹ ,  YANGBo ² , WANGJian ¹ , LIJian-zhong ³ , ZHOULin ¹ , ZHANGHong ¹ , XIAYan-min ¹ , WANGWen-chen ¹ ,  JIANGTao ¹

1. Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, P. R. China;
2. Department of Thoracic Surgery, Tianjin First Central Hospital, Tianjin 300192, P. R. China;
Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding?author：

YANGBo, Email: yangbochest@126.com; JIANGTao, Email: jiangtaochest@163.com

Keywords：

Digitalis; Pneumonectomy; Cardiac function

DOI：

10.7507/1007-4848.20160109

Video：

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Objective To investigate the clinical significance of applying digitalis preparations after pneumonec-tomy. Methods We retrospectively analyzed the clinical data of 78 patients who underwent pneumonectomy in the Tangdu Hospital of The Fourth Military Medical University from August 2010 to August 2013. The patients were divided into a control group (39 patients with 27 males and 12 females at a mean age of 56.8±14.8 years) and a trial group (39 patients with 24 males and 15 females at a mean age of 57.4±10.1 years). After pneumonectomy, the trial group received low dose of digitalis treatment. On 3, 5, and 7 days, the arterial partial pressure of oxygen (PaO₂), systolic pulmonary artery pressure (SPAP), mean arterial pressure (MAP), diastolic pulmonary artery pressure (DPAP), and the rate of complications were examined. Results After treatment with the low dose of digitalis, the SPAP, MAP, DPAP of the trial group were statistically lower than those of the control group (P < 0.05). Incidence of arrhythmia in the trial group was statistically lower than that of the control group (P < 0.05). There was no statistical difference between the two groups in the PaO₂, the incidence of pulmonary infection, and circulation disorder (P > 0.05). Conclusion Low dose of digitalis preparations can improve cardiac function after pneumonectomy.

Citation： CHENJia-kuan, YANGBo, WANGJian, LIJian-zhong, ZHOULin, ZHANGHong, XIAYan-min, WANGWen-chen, JIANGTao. Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(5): 463-466. doi: 10.7507/1007-4848.20160109 Copy

1.	Thomas PA, Berbis J, Baste JM, et al. Pneumonectomy for lung cancer:contemporary national early morbidity and mortality outcomes. J Thorac Cardiovasc Surg, 2015, 149(1):73-82.
2.	Xiong F, Wang S, Kai J. Video-assisted thoracic surgery right sleeve lobectomy. J Thorac Dis, 2014, 6(12):1831-1833.
3.	Safi S, Benner A, Walloschek J, et al. Development and validation of a risk score for predicting death after pneumonectomy. PLoS One, 2015, 10(4):1-12.
4.	雷藝炎, 陳振光, 羅紅鶴, 等. 肺癌患者圍術期并發癥發生的危險因素分析. 中國胸心血管外科臨床雜志, 2008, 15(4):268-271.
5.	Harpole DH, Liptay MJ, DeCamp MM Jr, et al. Prospective analysis of pneumonectomy:risk factors for major morbidity and cardiac dysrhythmias. Ann Thrac Surg, 1996, 61(3):977-982.
6.	Stolz AJ, Harustiak T, Simonek J, et al. Pneumonectomy for non-small cell lung cancer:predictors of early mortality and morbidity. Acta chirurgica Belgica, 2013, 114(1):25-30.
7.	段孝鳳, 傅承麗, 高曉旭, 等. 全肺切除治療晚期肺癌420例臨床分析. 現代腫瘤醫學, 2014, 22(2):363-366.
8.	崔玉尚, 張志庸, 阿布都熱伊木阿伊都. 開胸術后早期肺功能的變化規律及影響因素分析. 中華外科雜志, 2003, 41(12):909-912.
9.	武艷. 肺癌術后心律失常的危險因素分析. 腫瘤學雜志, 2012, 17(12):917-919.
10.	Koh WJ, Kim YH, Kwon OJ, et al. Surgical treatment of pulmonary diseases due to nontuberculous mycobacteria. J Korean Med Sci, 2008, 23(3):397-401.
11.	Pop D, Nadeemy AS, Venissac N, et al. Bronchopleural fistula:the Damocles sword of all pneumonectomies. Interact Cardiovasc Thrac Surg, 2011, 13(1):107-108.
12.	Ishikawa K, Kato T, Aragaki M, et al. Endobronchial closure of a bronchopleural fitula using a firin glue-coated collagen patch and firin glue. Ann Thrac Cardiovasc Surg, 2013, 19(6):423-427.
13.	楊波, 張志培, 姜鵬, 等. N-myc下游調節基因-2在大鼠腸缺血再灌注肺損傷中的表達及其與NF-kBp65的相關研究. 創傷外科雜志, 2012, 14(6):543-546.
14.	Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
15.	Yang B, Li XP, Ni YF, et al. Protective effect of isorhamnetin on lipopolysac charide-induced acute lung injury in mice. Inflammation, 2016, 39(1):129-137.
16.	Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
17.	Sharifpour M, Bittner EA. Postpneumonectomy syndrome:a case of shiftng priorities. Anesthesiol, 2014, 121(6):1334.
18.	支修益. 胸外科圍手術期氣道管理專家共識(2012年版). 中國胸心血管外科臨床雜志, 2013, 20(3):251-255.
19.	Pricopi C, Mordant P, Rivera C, et al. Postoperative morbidity and mortality after pneumonectomy:a 30-year experience of 2064 consecutive patients. Interact Cardiovasc Thorac Surg, 2015, 20(3):316-321.
20.	Chandrashekhara SH, Bhalla AS, Sharma R, et al. Imaging in postpneumonectomy complications:a pictorial review. J Cancer Res Ther, 2011, 7(1):3-10.
21.	汪志海, 孫曉雁, 郭明. 全肺切除術后并發癥的防治進展.中國胸心血管外科臨床雜志, 2015, 22(4):380-384.
22.	Fan Y, Zhang AM, Xiao YB. Glucose-insulin-potassium therapy in adult patients undergoing cardiac surgery a meta-analysis. Eur J Cardiothorac Surg, 2011, 40(1):192-199.
23.	翁毅敏, 廖洪映, 李昀, 等. 肺癌全肺切除術后心肺并發癥的防治. 中山大學學報(醫學科學版), 2007, 28(B06):89-91.
24.	李學昌, 王偉, 尚立群, 等. 高齡患者全肺切除術后心律失常發生. 山東醫藥, 2013, 53(6):83-85.
25.	甄福喜, 趙欣, 張偉, 等. 肺癌全肺切除術后早期右心功能不全的危險因素分析. 臨床腫瘤學雜志, 2013, 17(11):1006-1008.
26.	呂卓人, 薛小臨, 姜馨, 等. 洋地黃在治療慢性心力衰竭中地位的再評價. 中華心血管病雜志, 2002, 30(3):185-186.

1. Thomas PA, Berbis J, Baste JM, et al. Pneumonectomy for lung cancer:contemporary national early morbidity and mortality outcomes. J Thorac Cardiovasc Surg, 2015, 149(1):73-82.
2. Xiong F, Wang S, Kai J. Video-assisted thoracic surgery right sleeve lobectomy. J Thorac Dis, 2014, 6(12):1831-1833.
3. Safi S, Benner A, Walloschek J, et al. Development and validation of a risk score for predicting death after pneumonectomy. PLoS One, 2015, 10(4):1-12.
4. 雷藝炎, 陳振光, 羅紅鶴, 等. 肺癌患者圍術期并發癥發生的危險因素分析. 中國胸心血管外科臨床雜志, 2008, 15(4):268-271.
5. Harpole DH, Liptay MJ, DeCamp MM Jr, et al. Prospective analysis of pneumonectomy:risk factors for major morbidity and cardiac dysrhythmias. Ann Thrac Surg, 1996, 61(3):977-982.
6. Stolz AJ, Harustiak T, Simonek J, et al. Pneumonectomy for non-small cell lung cancer:predictors of early mortality and morbidity. Acta chirurgica Belgica, 2013, 114(1):25-30.
7. 段孝鳳, 傅承麗, 高曉旭, 等. 全肺切除治療晚期肺癌420例臨床分析. 現代腫瘤醫學, 2014, 22(2):363-366.
8. 崔玉尚, 張志庸, 阿布都熱伊木阿伊都. 開胸術后早期肺功能的變化規律及影響因素分析. 中華外科雜志, 2003, 41(12):909-912.
9. 武艷. 肺癌術后心律失常的危險因素分析. 腫瘤學雜志, 2012, 17(12):917-919.
10. Koh WJ, Kim YH, Kwon OJ, et al. Surgical treatment of pulmonary diseases due to nontuberculous mycobacteria. J Korean Med Sci, 2008, 23(3):397-401.
11. Pop D, Nadeemy AS, Venissac N, et al. Bronchopleural fistula:the Damocles sword of all pneumonectomies. Interact Cardiovasc Thrac Surg, 2011, 13(1):107-108.
12. Ishikawa K, Kato T, Aragaki M, et al. Endobronchial closure of a bronchopleural fitula using a firin glue-coated collagen patch and firin glue. Ann Thrac Cardiovasc Surg, 2013, 19(6):423-427.
13. 楊波, 張志培, 姜鵬, 等. N-myc下游調節基因-2在大鼠腸缺血再灌注肺損傷中的表達及其與NF-kBp65的相關研究. 創傷外科雜志, 2012, 14(6):543-546.
14. Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
15. Yang B, Li XP, Ni YF, et al. Protective effect of isorhamnetin on lipopolysac charide-induced acute lung injury in mice. Inflammation, 2016, 39(1):129-137.
16. Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
17. Sharifpour M, Bittner EA. Postpneumonectomy syndrome:a case of shiftng priorities. Anesthesiol, 2014, 121(6):1334.
18. 支修益. 胸外科圍手術期氣道管理專家共識(2012年版). 中國胸心血管外科臨床雜志, 2013, 20(3):251-255.
19. Pricopi C, Mordant P, Rivera C, et al. Postoperative morbidity and mortality after pneumonectomy:a 30-year experience of 2064 consecutive patients. Interact Cardiovasc Thorac Surg, 2015, 20(3):316-321.
20. Chandrashekhara SH, Bhalla AS, Sharma R, et al. Imaging in postpneumonectomy complications:a pictorial review. J Cancer Res Ther, 2011, 7(1):3-10.
21. 汪志海, 孫曉雁, 郭明. 全肺切除術后并發癥的防治進展.中國胸心血管外科臨床雜志, 2015, 22(4):380-384.
22. Fan Y, Zhang AM, Xiao YB. Glucose-insulin-potassium therapy in adult patients undergoing cardiac surgery a meta-analysis. Eur J Cardiothorac Surg, 2011, 40(1):192-199.
23. 翁毅敏, 廖洪映, 李昀, 等. 肺癌全肺切除術后心肺并發癥的防治. 中山大學學報(醫學科學版), 2007, 28(B06):89-91.
24. 李學昌, 王偉, 尚立群, 等. 高齡患者全肺切除術后心律失常發生. 山東醫藥, 2013, 53(6):83-85.
25. 甄福喜, 趙欣, 張偉, 等. 肺癌全肺切除術后早期右心功能不全的危險因素分析. 臨床腫瘤學雜志, 2013, 17(11):1006-1008.
26. 呂卓人, 薛小臨, 姜馨, 等. 洋地黃在治療慢性心力衰竭中地位的再評價. 中華心血管病雜志, 2002, 30(3):185-186.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Therapeutic Effect of Low Dose of Digitalis in Lung Cancer Patients After Pneumonectomy

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