Influence of Different Nutritional Approaches on Liver Function in Patients afer Esophagectomy_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIUGao-hua , WANGXiao-yong , ZHANFu-sheng ,  TANGXiao-jun

Department of Cardiothoracic Surgery, Afliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, P. R. China;

Corresponding?author：

TANGXiao-jun, Email: tangxiaojun73@163.com

Keywords：

Esophageal cancer; Liver function; Enteral nutrition; Total parenteral nutrition

DOI：

10.7507/1007-4848.20150120

Video：

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Objective To explore influence of different nutritional approaches on liver function in patients after esophagectomy. Methods A total of 160 patients with esophageal cancer who underwent surgical treatment were divided into a enteral nutrition (EN) group and a total parenteral nutrition (TPN) group according to different medical staff. There were 80 patients in each group. Two and 7 days postoperatively, albumin (ALB), prealbumin (PA), alanine aminotransferase (ALT) and total bilirubin (TB) of the 2 groups were examined to evaluate liver function. Results Abnormities in liver function (ALB, PA, ALT, TB) was common phenomenon in esophageal cancer patients, but there was no statistical difference in ALB, PA, ALT, TB on the 2nd postoperative day between the EN group and the TPN group (P > 0.05). On the 7th postoperative day, liver functions were improved than those on the 2nd postoperative day in the two groups. And frequencies of liver function abnormity in the EN group were significantly lower than those in the TNP group (P < 0.05). Conclusion Compared with TPN, EN has advantages in facilitating hepatic protein synthesis and recovery of liver function after esophagectomy.

Citation： LIUGao-hua, WANGXiao-yong, ZHANFu-sheng, TANGXiao-jun. Influence of Different Nutritional Approaches on Liver Function in Patients afer Esophagectomy. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(5): 459-462. doi: 10.7507/1007-4848.20150120 Copy

1.	欒正剛, 馬曉春.圍手術期肝功能障礙類型及處理.中國實用外科雜志, 2014, 34(2):123-126.
2.	Tsujinaka T, Kido Y, Ogawa Y, et al. Clinical analysis of postoperative hyperbilirubinemia following resection of esophageal cancer. Nihon Geka Gakkai Zasshi, 1987, 88(8):939-946.
3.	徐達夫, 尤振兵, 朱衛國, 等.快速康復外科對食管癌患者肝功能的影響.中華實驗外科雜志, 2012, 29(10):1920.
4.	Liu CL, Du Z, Lou C, et al. Enteral nutrition is superior to total parenteral nutrition for pancreatic cancer patients who underwent pancreaticoduodenectomy. Asia Pac J Clin Nutr, 2011, 20(2):154-160.
5.	Powell-Tuck J. Nutritional interventions in critical illness. Proc Nutr Soc, 2007, 66(1):16-24.
6.	徐洪波, 黃和平.食管癌術后早期腸內營養的臨床應用.腫瘤, 2007, 27(10):832-834.
7.	Baker A, Wooten LA, Malloy M. Nutritional considerations after gastrectomy and esophagectomy for malignancy. Curr Treat Options Oncol, 2011, 1(1):85-95.
8.	Seike J, Tangoku A, Yuasa Y, et al. Te effect of nutritional suport on the immune function in the acute postoperative period after esophageal cancer surgery:total parenteral nutrition versus enteral nutrition. J Med Invest, 2011, 58(1-2):75-80.
9.	謝天鵬, 趙雍凡, 彭林, 等.食管癌術后早期全腸內營養支持對肝功能的影響.中國臨床營養雜志, 2007, 15(2):95-98.
10.	Gabor S, Renner H, Matzi V, et al. Early enteral feeding compared with parenteral nutrition after oesophageal or oesophagogastric resection and reconstruction. Br J Nutr, 2005, 93(4):509-513.
11.	寧桂芝, 夏宏偉, 呂麗艷, 等.食道癌病人圍手術期腸內營養支持.齊齊哈爾醫學院學報, 2009, 30(15):1856-1857.
12.	魚曉波, 阮征, 黃海龍, 等.食管癌術后早期腸內營養對腸粘膜屏障功能及免疫功能的影響.臨床外科雜志, 2013, 21(1):39-42.
13.	李寧.腸功能障礙的腸內營養策略.腸外與腸內營養, 2010, 17(4):173-174.
14.	Soybel DI, Matthews JB, Silen W. Elemental diet and IV-TPNinduced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg, 1997, 225(2):238-239.
15.	Hong L, Wang X, Wu J, et al. Miochondria-initiated apoptosis triggered by oxidative injury play a role in total parenteral nutritionassociated liver dysfunction in infant rabbit model. J Pediatr Surg, 2009, 44(9):1712-1718.
16.	洪莉, 王翔, 吳江, 等.胃腸外營養相關肝損傷機制的實驗研究.上海交通大學學報(醫學版), 2006, 26(11):1201-1205.
17.	Tannuri U. Oxidative injury and hepatocyte apoptosis in total parenteral nutrition-associated liver dysfunction. J Pediatr Srug, 2007, 42(3):596.

1. 欒正剛, 馬曉春.圍手術期肝功能障礙類型及處理.中國實用外科雜志, 2014, 34(2):123-126.
2. Tsujinaka T, Kido Y, Ogawa Y, et al. Clinical analysis of postoperative hyperbilirubinemia following resection of esophageal cancer. Nihon Geka Gakkai Zasshi, 1987, 88(8):939-946.
3. 徐達夫, 尤振兵, 朱衛國, 等.快速康復外科對食管癌患者肝功能的影響.中華實驗外科雜志, 2012, 29(10):1920.
4. Liu CL, Du Z, Lou C, et al. Enteral nutrition is superior to total parenteral nutrition for pancreatic cancer patients who underwent pancreaticoduodenectomy. Asia Pac J Clin Nutr, 2011, 20(2):154-160.
5. Powell-Tuck J. Nutritional interventions in critical illness. Proc Nutr Soc, 2007, 66(1):16-24.
6. 徐洪波, 黃和平.食管癌術后早期腸內營養的臨床應用.腫瘤, 2007, 27(10):832-834.
7. Baker A, Wooten LA, Malloy M. Nutritional considerations after gastrectomy and esophagectomy for malignancy. Curr Treat Options Oncol, 2011, 1(1):85-95.
8. Seike J, Tangoku A, Yuasa Y, et al. Te effect of nutritional suport on the immune function in the acute postoperative period after esophageal cancer surgery:total parenteral nutrition versus enteral nutrition. J Med Invest, 2011, 58(1-2):75-80.
9. 謝天鵬, 趙雍凡, 彭林, 等.食管癌術后早期全腸內營養支持對肝功能的影響.中國臨床營養雜志, 2007, 15(2):95-98.
10. Gabor S, Renner H, Matzi V, et al. Early enteral feeding compared with parenteral nutrition after oesophageal or oesophagogastric resection and reconstruction. Br J Nutr, 2005, 93(4):509-513.
11. 寧桂芝, 夏宏偉, 呂麗艷, 等.食道癌病人圍手術期腸內營養支持.齊齊哈爾醫學院學報, 2009, 30(15):1856-1857.
12. 魚曉波, 阮征, 黃海龍, 等.食管癌術后早期腸內營養對腸粘膜屏障功能及免疫功能的影響.臨床外科雜志, 2013, 21(1):39-42.
13. 李寧.腸功能障礙的腸內營養策略.腸外與腸內營養, 2010, 17(4):173-174.
14. Soybel DI, Matthews JB, Silen W. Elemental diet and IV-TPNinduced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg, 1997, 225(2):238-239.
15. Hong L, Wang X, Wu J, et al. Miochondria-initiated apoptosis triggered by oxidative injury play a role in total parenteral nutritionassociated liver dysfunction in infant rabbit model. J Pediatr Surg, 2009, 44(9):1712-1718.
16. 洪莉, 王翔, 吳江, 等.胃腸外營養相關肝損傷機制的實驗研究.上海交通大學學報(醫學版), 2006, 26(11):1201-1205.
17. Tannuri U. Oxidative injury and hepatocyte apoptosis in total parenteral nutrition-associated liver dysfunction. J Pediatr Srug, 2007, 42(3):596.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Influence of Different Nutritional Approaches on Liver Function in Patients afer Esophagectomy

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