Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHENGXi , YUANYong , HUYang ,  ZHAOYong-fan

Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

ZHAOYong-fan, Email: doctorzhaoyongfan@hotmail.com

Keywords：

Esophageal carcinoma; Lymphatic chemotherapy; Immunoglobulin; T cell subgroup

DOI：

10.7507/1007-4848.20140067

Video：

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Objective To explore the effects of intraoperative lymphatic chemotherapy (LC) on immune functions of patients after esophageal carcinoma resection. Methods Patients who underwent intraoperative LC during esophageal carcinoma resection in the Department of Thoracic Surgery of West China Hospital from March to October,2013 were prospectively included in this study, and patients who underwent esophageal carcinoma resection without intraoperative LC during the same period were also included as the control group. All the patients were divided into a pacitaxel LC group,a fluorouracil LC group,and a control group without LC. A total of 37 patients were included in this study including 25 male and 12 female patients with their age of 42-76 (61.89±7.95) years. There were 15 patients in the pacitaxel LC group,15 patients in the fluorouracil LC group,and 7 patients in the control group. Representative indexes of humoral immunity and cellular immunity in peripheral blood of all the patients were examined preoperatively and on the third and seventh postoperative day, and then compared among the 3 groups. Results All the immune indexes of the 3 groups decreased after surgery to different extent. There was no statistical difference in preoperative and postoperative difference of immunoglobulin concentration between LC groups and the control group (P>0.05). CD8⁺ T cell count recovered more rapidly after surgery in LC groups than the control group. CD3⁺ T cells recovered most rapidly after surgery in the fluorouracil LC group. Conclusion LC is beneficial for the recovery of cytotoxic effects of T lymphocytes but may not promote humoral immunity for patients after esophageal carcinoma resection.

Citation： ZHENGXi, YUANYong, HUYang, ZHAOYong-fan. Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(2): 233-237. doi: 10.7507/1007-4848.20140067 Copy

1.	?孟強,李會晨,崔龍,等.消化道惡性腫瘤淋巴化療的現狀.中國實用外科雜志,2006,26 (2):145-147.
2.	紀志鵬,張建良.淋巴化療及其在消化道惡性腫瘤中的應用.中國現代普通外科進展,2008,11 (5):422-424.
3.	蔡長茂,李威.納米炭在普外科惡性腫瘤診治中的應用.中華實用診斷與治療雜志,2010,24 (9):833-834.
4.	Ortner MA,Taha AA,Schreiber S,et al.Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer:a pilot study.Endoscopy,2004,36 (5):421-425.
5.	楊凱,溫玉明.口腔癌淋巴化療.臨床口腔醫學雜志,2004,20 (1):59-60.
6.	高紅,鄭春雷,龐達.載藥國產納米活性炭在胃癌根治術中的應用.齊齊哈爾醫學院學報,2010,31 (18):2859-2861.
7.	李義生,王書奎,呂進,等.術前淋巴化療對乳腺癌的臨床治療研究.中國現代醫生,2011,49 (30):28-29.
8.	邵麗瑋,溫艷惠,李慧運,等.內鏡下淋巴化療對胃癌淋巴轉移的療效研究.現代腫瘤醫學,2011,19 (6):1153-1156.
9.	李義生,王書奎,王和明,等.術前聯合奧曲肽行淋巴化療對大腸癌的治療研究.中華臨床醫師雜志:電子版,2012,6 (11):203-204.
10.	程邦昌,梅強.食管癌患者外周血T淋巴細胞亞群、腫瘤壞死因子的改變及其相關因素研究.中華實驗外科雜志,1998,15 (3):226-228.
11.	張治,張偉,許林,等.食管癌、賁門癌患者T細胞亞群水平及臨床意義.江蘇醫藥,2007,33 (3):231-232.
12.	姜云,駱金華.食管癌免疫學研究現狀及進展.江蘇醫藥,2011,37 (3):341-343.
13.	孟強,孟榮貴,崔龍,等.直腸癌術前淋巴化療安全性分析.中華消化外科雜志,2008,7 (2):137-139.
14.	Edge SB,Compton CC.The American Joint Committee on Cancer:the 7th edition of the AJCC cancer staging manual and the future of TNM.Ann Surg Oncol,2010,17 (6):1471-1474.
15.	蒲敏,黃斌,任明揚,等.納米炭在腹腔鏡下食管胃交界腺癌手術中的應用.中國普外基礎與臨床雜志,2013,20 (2):147-151.
16.	吳三明,鄭國凡,蔣述均,等.AT-C型活性炭載附絲裂霉素對食管/胃癌的靶向化療.現代消化病及內鏡雜志,1997,2 (1):52-53.
17.	吳三明,鄭國凡,蔣述均,等.活性炭載附絲裂霉素內鏡下注射治療26例老年食管、胃癌患者療效分析.中國中西醫結合脾胃雜志,1997,5 (4):242-243.
18.	劉建芳,潘霞,王鐵武,等.內鏡下注射活性炭加絲裂霉素治療食道癌、胃癌42例報道.胃腸病學,2001,6 (增刊):151-152.
19.	周軍,辛旭,齊磊.白芨混合微粒在食道中下段癌術中淋巴化療的應用研究.陜西中醫,2004,25 (1):30-31.
20.	侯建民,陳克能,胡興云,等.全麻對食管癌手術患者體液免疫功能的影響.中華實驗外科雜志,1999,16 (6):587.
21.	邢翠燕,吳明毅,范海鵬.不同麻醉和鎮痛方法對食管癌手術患者細胞免疫功能及應激激素水平的影響.南方醫科大學學報,2010,30 (2):284-287.
22.	蒲強,馬林,梅建東,等.全胸腔鏡與后外側開胸對肺癌患者免疫功能影響的對比研究.四川大學學報:醫學版,2013,44 (1):126-129.
23.	韓東景,李偉,金哲,等.ω-3多不飽和脂肪酸及谷氨酰胺對食管癌手術患者免疫功能及營養狀況的影響.中華實用診斷與治療雜志,2013,27 (9):905-906.
24.	漆奮強,左傳田.影響食管癌圍手術期體液免疫變化的因素.中國癌癥防治雜志,2010,2 (3):236-238.
25.	王忠民,喬剛,李漢臣.食管癌切除患者胸導管預防性結扎的細胞免疫及臨床研究.中國醫師雜志,2003,5 (11):1506-1507.
26.	孫汶生,王福慶,主編.醫學免疫學.北京:高等教育出版社,2006.51-52,117-120,124.
27.	洪超群,陳炯玉,楊衛平,等.食管鱗癌患者手術前后外周血T細胞亞群與NK、NKT細胞檢測的臨床意義.現代腫瘤醫學,2010,18 (6):1113-1115.

1. ?孟強,李會晨,崔龍,等.消化道惡性腫瘤淋巴化療的現狀.中國實用外科雜志,2006,26 (2):145-147.
2. 紀志鵬,張建良.淋巴化療及其在消化道惡性腫瘤中的應用.中國現代普通外科進展,2008,11 (5):422-424.
3. 蔡長茂,李威.納米炭在普外科惡性腫瘤診治中的應用.中華實用診斷與治療雜志,2010,24 (9):833-834.
4. Ortner MA,Taha AA,Schreiber S,et al.Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer:a pilot study.Endoscopy,2004,36 (5):421-425.
5. 楊凱,溫玉明.口腔癌淋巴化療.臨床口腔醫學雜志,2004,20 (1):59-60.
6. 高紅,鄭春雷,龐達.載藥國產納米活性炭在胃癌根治術中的應用.齊齊哈爾醫學院學報,2010,31 (18):2859-2861.
7. 李義生,王書奎,呂進,等.術前淋巴化療對乳腺癌的臨床治療研究.中國現代醫生,2011,49 (30):28-29.
8. 邵麗瑋,溫艷惠,李慧運,等.內鏡下淋巴化療對胃癌淋巴轉移的療效研究.現代腫瘤醫學,2011,19 (6):1153-1156.
9. 李義生,王書奎,王和明,等.術前聯合奧曲肽行淋巴化療對大腸癌的治療研究.中華臨床醫師雜志:電子版,2012,6 (11):203-204.
10. 程邦昌,梅強.食管癌患者外周血T淋巴細胞亞群、腫瘤壞死因子的改變及其相關因素研究.中華實驗外科雜志,1998,15 (3):226-228.
11. 張治,張偉,許林,等.食管癌、賁門癌患者T細胞亞群水平及臨床意義.江蘇醫藥,2007,33 (3):231-232.
12. 姜云,駱金華.食管癌免疫學研究現狀及進展.江蘇醫藥,2011,37 (3):341-343.
13. 孟強,孟榮貴,崔龍,等.直腸癌術前淋巴化療安全性分析.中華消化外科雜志,2008,7 (2):137-139.
14. Edge SB,Compton CC.The American Joint Committee on Cancer:the 7th edition of the AJCC cancer staging manual and the future of TNM.Ann Surg Oncol,2010,17 (6):1471-1474.
15. 蒲敏,黃斌,任明揚,等.納米炭在腹腔鏡下食管胃交界腺癌手術中的應用.中國普外基礎與臨床雜志,2013,20 (2):147-151.
16. 吳三明,鄭國凡,蔣述均,等.AT-C型活性炭載附絲裂霉素對食管/胃癌的靶向化療.現代消化病及內鏡雜志,1997,2 (1):52-53.
17. 吳三明,鄭國凡,蔣述均,等.活性炭載附絲裂霉素內鏡下注射治療26例老年食管、胃癌患者療效分析.中國中西醫結合脾胃雜志,1997,5 (4):242-243.
18. 劉建芳,潘霞,王鐵武,等.內鏡下注射活性炭加絲裂霉素治療食道癌、胃癌42例報道.胃腸病學,2001,6 (增刊):151-152.
19. 周軍,辛旭,齊磊.白芨混合微粒在食道中下段癌術中淋巴化療的應用研究.陜西中醫,2004,25 (1):30-31.
20. 侯建民,陳克能,胡興云,等.全麻對食管癌手術患者體液免疫功能的影響.中華實驗外科雜志,1999,16 (6):587.
21. 邢翠燕,吳明毅,范海鵬.不同麻醉和鎮痛方法對食管癌手術患者細胞免疫功能及應激激素水平的影響.南方醫科大學學報,2010,30 (2):284-287.
22. 蒲強,馬林,梅建東,等.全胸腔鏡與后外側開胸對肺癌患者免疫功能影響的對比研究.四川大學學報:醫學版,2013,44 (1):126-129.
23. 韓東景,李偉,金哲,等.ω-3多不飽和脂肪酸及谷氨酰胺對食管癌手術患者免疫功能及營養狀況的影響.中華實用診斷與治療雜志,2013,27 (9):905-906.
24. 漆奮強,左傳田.影響食管癌圍手術期體液免疫變化的因素.中國癌癥防治雜志,2010,2 (3):236-238.
25. 王忠民,喬剛,李漢臣.食管癌切除患者胸導管預防性結扎的細胞免疫及臨床研究.中國醫師雜志,2003,5 (11):1506-1507.
26. 孫汶生,王福慶,主編.醫學免疫學.北京:高等教育出版社,2006.51-52,117-120,124.
27. 洪超群,陳炯玉,楊衛平,等.食管鱗癌患者手術前后外周血T細胞亞群與NK、NKT細胞檢測的臨床意義.現代腫瘤醫學,2010,18 (6):1113-1115.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection

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