Research progress on clinical transformation of Piezo1 in osteoarthritis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WANG Yiyang , WEI Ning ,  ZHENG Zhanle

Knee Joint Preservation Center, Hebei Medical University Third Hospital, Shijiazhuang Hebei, 050051, P. R. China;

Corresponding?author：

ZHENG Zhanle, Email: 38200671@hebmu.edu.cn

Keywords：

Piezo1; osteoarthritis; mechanosensitive ion channel; clinical transformation; research progress

DOI：

10.7507/1002-1892.202601058

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the role of the mechanosensitive ion channel Piezo1 in osteoarthritis (OA) pathogenesis and summarize recent advances in its clinical transformation as a potential therapeutic target. Methods The recent domestic and international research literature was reviewed. Recent studies on Piezo1 in chondrocyte injury, inflammation, extracellular matrix degradation, and osteophyte formation were analyzed, along with Piezo1-targeted inhibitors, activators, and modulators. Results Piezo1 senses abnormal mechanical stress and mediates Ca²⁺ influx, activating PI3K/AKT/mTOR and MAPK/ERK signaling pathways, thereby promoting chondrocyte apoptosis, impaired autophagy, and matrix degradation. Preclinical studies suggest that GsMTx4, Piezo1-siRNA, Dooku1, and artemisinin may confer chondroprotective effects, but their specificity, stability, delivery efficiency, and safety require further verification. Conclusion Piezo1 is a critical link between mechanical stress and OA progression, representing a potential therapeutic target. Future research should focus on elucidating mechanisms, developing highly specific modulators and targeted delivery systems, and conducting rigorous preclinical and clinical studies to promote clinical transformation.

Citation： WANG Yiyang, WEI Ning, ZHENG Zhanle. Research progress on clinical transformation of Piezo1 in osteoarthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2026, 40(7): 1142-1148. doi: 10.7507/1002-1892.202601058 Copy

1.	Tang S, Zhang C, Oo WM, et al. Osteoarthritis. Nat Rev Dis Primers, 2025, 11(1): 10. doi: 10.1038/s41572-025-00594-6.
2.	Han Y, Cheng F, Li X, et al. The mechanosensitive ion channel Piezo1 regulates Chondrocyte homeostasis through the PI3K/AKT/mTORC1 pathway in osteoarthritis. J Cell Mol Med, 2025, 29(15): e70734. doi: 10.1111/jcmm.70734.
3.	Wang Y, Liu G, Tao Z, et al. PIEZO1-mediated mechanotransduction in craniofacial biology. FASEB Journal, 2025, 39(16): e70937. doi: 10.1096/fj.202501130R.
4.	Xie B, He X, Guo Y, et al. Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells. Human Cell, 2024, 37(6): 1649-1662.
5.	Chen W, Zhang H. Elucidating the mechanism of IL-1β-mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway. Tissue Cell, 2024, 86: 102291. doi: 10.1016/j.tice.2023.102291.
6.	Chen S, Li Z, Zhang J, et al. Piezo1 at the crossroads: Mediating inflammation and mechanical stress in joint disorders. Joint Bone Spine, 2026, 93(2): 105953. doi: 10.1016/j.jbspin.2025.105953.
7.	Wang X, Wang J, Zhang Y, et al. Piezo1 regulates fibrocartilage stem cell in cartilage growth and osteoarthritis. Osteoarthritis Cartilage, 2025, 33(8): 980-991.
8.	Yuan G, Xiong Z, Ke X, et al. Exploring the multifactorial regulation of PIEZO1 in chondrocytes: Mechanisms and implications. Int J Med Sci, 2025, 22(13): 3393-3411.
9.	Sethi V, Anand C, Della Pasqua O. Clinical assessment of osteoarthritis pain: Contemporary scenario, challenges, and future perspectives. Pain Ther, 2024, 13(3): 391-408.
10.	Wang J, Sun YX, Li J. The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology. Developmental Biology, 2023, 493: 80-88.
11.	He D, Liu X, Yang W, et al. The role of mechanosensitive ion channel Piezo1 in knee osteoarthritis inflammation. Channels (Austin), 2024, 18(1): 2393088. doi: 10.1080/19336950.2024.2393088.
12.	Gan D, Tao C, Jin X, et al. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res, 2024, 62: 105-117.
13.	Brylka LJ, Alimy AR, Tschaffon-Müller MEA, et al. Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development. Bone Res. 2024, 12(1): 12. doi: 10.1038/s41413-024-00315-x.
14.	Yan Z, Wu D, Zhao H, et al. Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development. J Orthop Translat, 2026, 57: 101053. doi: 10.1016/j.jot.2026.101053.
15.	Lee W, Nims RJ, Savadipour A, et al. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proc Natl Acad Sci U S A, 2021, 118(13): e2001611118. doi: 10.1073/pnas.2001611118.
16.	Yu L, Su Z, Tian D, et al. Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis. Mol Med, 2025, 31(1): 272. doi: 10.1186/s10020-025-01335-x.
17.	Feng X, Li S, Wang S, et al. Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA. Oral Dis, 2024, 30(4): 2425-2438.
18.	Liu Y, Lu X, Zhang Z, et al. Lentivirus-mediated small interfering RNA targeting Piezo1 inhibits cartilage matrix degeneration in osteoarthritis chondrocytes[PP/OL]. Research Square, (2022-02-16)[2026-06-07]. https://doi.org/10.21203/rs.3.rs-1262556/v1.
19.	Ren X, Zhuang H, Li B, et al. Gsmtx4 alleviated osteoarthritis through Piezo1/Calcineurin/NFAT1 signaling axis under excessive mechanical strain. Int J Mol Sci, 2023, 24(4): 4022. doi: 10.3390/ijms24044022.
20.	Tadget T, Pattewar A, More N, et al. The role of Piezo1 and Piezo2 proteins in tissue engineering: A comprehensive review. Engineered Regeneration, 2024, 5(2): 170-185.
21.	Merten AL, Sch?ler U, Guo Y, et al. High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca²⁺ imaging applied to Piezo1 in cardiac HL-1 cells. Cell Mol Life Sci, 2024, 81(1): 140. doi: 10.1007/s00018-024-05159-6.
22.	Wu CB, Ma T, Ma L, et al. Piezo1 affects temporomandibular joint osteoarthritis by influencing pSmad3. Front Physiol, 2022, 13: 892089. doi: 10.3389/fphys.2022.892089.
23.	Liu Y, Zhang Z, Li J, et al. Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity. Mech Ageing Dev, 2023, 216: 111880. doi: 10.1016/j.mad.2023.111880.
24.	Yang Y, Wang D, Zhang C, et al. Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation. Human Cell, 2022, 35(1): 51-62.
25.	Yang Q, Li X, Xing Y, et al. Piezo1, a novel therapeutic target to treat pulmonary arterial hypertension. Front Physiol, 2023, 14: 1084921. doi: 10.3389/fphys.2023.1084921.
26.	He J, Shan S, Li Q, et al. Mechanical stretch triggers epithelial-mesenchymal transition in keratinocytes through Piezo1 channel. Front Physiol, 2022, 13: 745572. doi: 10.3389/fphys.2022.745572.
27.	Yang J, Xu C, Xie X, et al. Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment: Review. Mol Med Rep, 2025, 32(1): 200. doi: 10.3892/mmr.2025.13565.
28.	Lei L, Wen Z, Cao M, et al. The emerging role of Piezo1 in the musculoskeletal system and disease. Theranostics, 2024, 14(10): 3963-3983.
29.	Liu C, Li H, Hang L. The research progress into cellular mechanosensitive ion channels mediating cancer pain. Channels (Austin), 2025, 19(1): 2517109. doi: 10.1080/19336950.2025.2517109.
30.	Lin Y, Wen D, Chen K, et al. Piezo1 and tissue fibrosis: insights into its role and potential for modulation. Burns Trauma, 2025, 13: tkaf054. doi: 10.1093/burnst/tkaf054.
31.	Kinsella JA, Debant M, Parsonage G, et al. Pharmacology of PIEZO1 channels. Br J Pharmacol, 2024, 181(23): 4714-4732.
32.	Zhang Y, Gao C, Li Y, et al. Piezo-type mechanosensitive ion channel component 1: a mechano-bioenergetic transducer in the tumour microenvironment. Annals of Medicine, 2026, 58(1): 2603022. doi: 10.1080/07853890.2025.2603022.
33.	Ranade S, Qiu Z, Woo SH, et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences, 2014, 111(28): 10347-10352.
34.	Xiao B. Levering mechanically activated Piezo channels for potential pharmacological intervention. Annu Rev Pharmacol Toxicol, 2020, 60: 195-218.
35.	Bosutti A, Giniatullin A, Odnoshivkina Y, et al. “Time window” effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation. Acta Physiol (Oxf), 2021, 233(4): e13702. doi: 10.1111/apha.13702.
36.	Du Y, Xu B, Li Q, et al. The role of mechanically sensitive ion channel Piezo1 in bone remodeling. Front Bioeng Biotechnol, 2024, 12: 1342149. doi: 10.3389/fbioe.2024.1342149.
37.	Huynh TTT, Quang MT, Vu HYT. Modulation of inflammatory signaling pathways by natural products in osteoarthritis: Mechanisms, challenges, and future directions. Tropical Journal of Pharmaceutical Research, 2024, 23(8): 1387-1396.
38.	Henrotin Y, Mobasheri A. Natural products for promoting joint health and managing osteoarthritis. Current Rheumatology Reports, 2018, 20(11): 72. doi: 10.1007/s11926-018-0782-9.
39.	Santana éTN, Lima VNB, de Souza Siqueira Quintans J, et al. Management of pain and inflammation through natural products in individuals with knee osteoarthritis: A systematic review. Journal of Herbal Medicine, 2024, 45: 100851. doi: 10.1016/j.hermed.2024.100851.
40.	Pourteymour S, Fan J, Majhi RK, et al. PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis. Cell Mol Life Sci, 2024, 81(1): 331. doi: 10.1007/s00018-024-05372-3.
41.	He X, Liu Y, Dai Z, et al. Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission. J Nanobiotechnol, 2024, 22(1): 407. doi: 10.1186/s12951-024-02669-0.
42.	Jin C, Su S A, Yu S, et al. Essential roles of PIEZO1 in mammalian cardiovascular system: From development to diseases. Cells, 2024, 13(17): 1422. doi: 10.3390/cells13171422.
43.	Xing H, Liu H, Chang Z, et al. Research progress on the immunological functions of Piezo1, a receptor molecule that responds to mechanical force. International Immunopharmacology, 2024, 139: 112684. doi: 10.1016/j.intimp.2024.112684.
44.	Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis Cartilage, 2022, 30(2): 184-195.
45.	Ely EV, Lenz KL, Paradi SG, et al. Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice. Arthritis Res Ther, 2025, 27(1): 152. doi: 10.1186/s13075-025-03620-w.
46.	Zhang L, Li Y, Ma X, et al. Ginsenoside Rg1-notoginsenoside R1-protocatechuic aldehyde reduces atherosclerosis and attenuates low-shear stress-induced vascular endothelial cell dysfunction. Front Pharmacol, 2021, 11: 588259. doi: 10.3389/fphar.2020.588259.
47.	Scolnik M, Singh G. Combination therapy versus celecoxib, a single selective COX-2 agent, to reduce gastrointestinal toxicity in arthritic patients: Patient and cost-effectiveness considerations. Open Access Rheumatology: Research and Reviews, 2011, 3: 53-62.
48.	Foster NE, Eriksson L, Deveza L, et al. Osteoarthritis year in review 2022: Epidemiology & therapy. Osteoarthritis Cartilage, 2023, 31(7): 876-883.
49.	Lawrence KM, Jones RC, Jackson TR, et al. Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. Sci Rep, 2017, 7(1): 5147. doi: 10.1038/s41598-017-04367-4.

1. Tang S, Zhang C, Oo WM, et al. Osteoarthritis. Nat Rev Dis Primers, 2025, 11(1): 10. doi: 10.1038/s41572-025-00594-6.
2. Han Y, Cheng F, Li X, et al. The mechanosensitive ion channel Piezo1 regulates Chondrocyte homeostasis through the PI3K/AKT/mTORC1 pathway in osteoarthritis. J Cell Mol Med, 2025, 29(15): e70734. doi: 10.1111/jcmm.70734.
3. Wang Y, Liu G, Tao Z, et al. PIEZO1-mediated mechanotransduction in craniofacial biology. FASEB Journal, 2025, 39(16): e70937. doi: 10.1096/fj.202501130R.
4. Xie B, He X, Guo Y, et al. Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells. Human Cell, 2024, 37(6): 1649-1662.
5. Chen W, Zhang H. Elucidating the mechanism of IL-1β-mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway. Tissue Cell, 2024, 86: 102291. doi: 10.1016/j.tice.2023.102291.
6. Chen S, Li Z, Zhang J, et al. Piezo1 at the crossroads: Mediating inflammation and mechanical stress in joint disorders. Joint Bone Spine, 2026, 93(2): 105953. doi: 10.1016/j.jbspin.2025.105953.
7. Wang X, Wang J, Zhang Y, et al. Piezo1 regulates fibrocartilage stem cell in cartilage growth and osteoarthritis. Osteoarthritis Cartilage, 2025, 33(8): 980-991.
8. Yuan G, Xiong Z, Ke X, et al. Exploring the multifactorial regulation of PIEZO1 in chondrocytes: Mechanisms and implications. Int J Med Sci, 2025, 22(13): 3393-3411.
9. Sethi V, Anand C, Della Pasqua O. Clinical assessment of osteoarthritis pain: Contemporary scenario, challenges, and future perspectives. Pain Ther, 2024, 13(3): 391-408.
10. Wang J, Sun YX, Li J. The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology. Developmental Biology, 2023, 493: 80-88.
11. He D, Liu X, Yang W, et al. The role of mechanosensitive ion channel Piezo1 in knee osteoarthritis inflammation. Channels (Austin), 2024, 18(1): 2393088. doi: 10.1080/19336950.2024.2393088.
12. Gan D, Tao C, Jin X, et al. Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin. J Adv Res, 2024, 62: 105-117.
13. Brylka LJ, Alimy AR, Tschaffon-Müller MEA, et al. Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development. Bone Res. 2024, 12(1): 12. doi: 10.1038/s41413-024-00315-x.
14. Yan Z, Wu D, Zhao H, et al. Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development. J Orthop Translat, 2026, 57: 101053. doi: 10.1016/j.jot.2026.101053.
15. Lee W, Nims RJ, Savadipour A, et al. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proc Natl Acad Sci U S A, 2021, 118(13): e2001611118. doi: 10.1073/pnas.2001611118.
16. Yu L, Su Z, Tian D, et al. Piezo1 induces mitochondrial autophagy dysfunction leading to cartilage injury in knee osteoarthritis. Mol Med, 2025, 31(1): 272. doi: 10.1186/s10020-025-01335-x.
17. Feng X, Li S, Wang S, et al. Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion-induced TMJOA. Oral Dis, 2024, 30(4): 2425-2438.
18. Liu Y, Lu X, Zhang Z, et al. Lentivirus-mediated small interfering RNA targeting Piezo1 inhibits cartilage matrix degeneration in osteoarthritis chondrocytes[PP/OL]. Research Square, (2022-02-16)[2026-06-07]. https://doi.org/10.21203/rs.3.rs-1262556/v1.
19. Ren X, Zhuang H, Li B, et al. Gsmtx4 alleviated osteoarthritis through Piezo1/Calcineurin/NFAT1 signaling axis under excessive mechanical strain. Int J Mol Sci, 2023, 24(4): 4022. doi: 10.3390/ijms24044022.
20. Tadget T, Pattewar A, More N, et al. The role of Piezo1 and Piezo2 proteins in tissue engineering: A comprehensive review. Engineered Regeneration, 2024, 5(2): 170-185.
21. Merten AL, Sch?ler U, Guo Y, et al. High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca²⁺ imaging applied to Piezo1 in cardiac HL-1 cells. Cell Mol Life Sci, 2024, 81(1): 140. doi: 10.1007/s00018-024-05159-6.
22. Wu CB, Ma T, Ma L, et al. Piezo1 affects temporomandibular joint osteoarthritis by influencing pSmad3. Front Physiol, 2022, 13: 892089. doi: 10.3389/fphys.2022.892089.
23. Liu Y, Zhang Z, Li J, et al. Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity. Mech Ageing Dev, 2023, 216: 111880. doi: 10.1016/j.mad.2023.111880.
24. Yang Y, Wang D, Zhang C, et al. Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation. Human Cell, 2022, 35(1): 51-62.
25. Yang Q, Li X, Xing Y, et al. Piezo1, a novel therapeutic target to treat pulmonary arterial hypertension. Front Physiol, 2023, 14: 1084921. doi: 10.3389/fphys.2023.1084921.
26. He J, Shan S, Li Q, et al. Mechanical stretch triggers epithelial-mesenchymal transition in keratinocytes through Piezo1 channel. Front Physiol, 2022, 13: 745572. doi: 10.3389/fphys.2022.745572.
27. Yang J, Xu C, Xie X, et al. Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment: Review. Mol Med Rep, 2025, 32(1): 200. doi: 10.3892/mmr.2025.13565.
28. Lei L, Wen Z, Cao M, et al. The emerging role of Piezo1 in the musculoskeletal system and disease. Theranostics, 2024, 14(10): 3963-3983.
29. Liu C, Li H, Hang L. The research progress into cellular mechanosensitive ion channels mediating cancer pain. Channels (Austin), 2025, 19(1): 2517109. doi: 10.1080/19336950.2025.2517109.
30. Lin Y, Wen D, Chen K, et al. Piezo1 and tissue fibrosis: insights into its role and potential for modulation. Burns Trauma, 2025, 13: tkaf054. doi: 10.1093/burnst/tkaf054.
31. Kinsella JA, Debant M, Parsonage G, et al. Pharmacology of PIEZO1 channels. Br J Pharmacol, 2024, 181(23): 4714-4732.
32. Zhang Y, Gao C, Li Y, et al. Piezo-type mechanosensitive ion channel component 1: a mechano-bioenergetic transducer in the tumour microenvironment. Annals of Medicine, 2026, 58(1): 2603022. doi: 10.1080/07853890.2025.2603022.
33. Ranade S, Qiu Z, Woo SH, et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences, 2014, 111(28): 10347-10352.
34. Xiao B. Levering mechanically activated Piezo channels for potential pharmacological intervention. Annu Rev Pharmacol Toxicol, 2020, 60: 195-218.
35. Bosutti A, Giniatullin A, Odnoshivkina Y, et al. “Time window” effect of Yoda1-evoked Piezo1 channel activity during mouse skeletal muscle differentiation. Acta Physiol (Oxf), 2021, 233(4): e13702. doi: 10.1111/apha.13702.
36. Du Y, Xu B, Li Q, et al. The role of mechanically sensitive ion channel Piezo1 in bone remodeling. Front Bioeng Biotechnol, 2024, 12: 1342149. doi: 10.3389/fbioe.2024.1342149.
37. Huynh TTT, Quang MT, Vu HYT. Modulation of inflammatory signaling pathways by natural products in osteoarthritis: Mechanisms, challenges, and future directions. Tropical Journal of Pharmaceutical Research, 2024, 23(8): 1387-1396.
38. Henrotin Y, Mobasheri A. Natural products for promoting joint health and managing osteoarthritis. Current Rheumatology Reports, 2018, 20(11): 72. doi: 10.1007/s11926-018-0782-9.
39. Santana éTN, Lima VNB, de Souza Siqueira Quintans J, et al. Management of pain and inflammation through natural products in individuals with knee osteoarthritis: A systematic review. Journal of Herbal Medicine, 2024, 45: 100851. doi: 10.1016/j.hermed.2024.100851.
40. Pourteymour S, Fan J, Majhi RK, et al. PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis. Cell Mol Life Sci, 2024, 81(1): 331. doi: 10.1007/s00018-024-05372-3.
41. He X, Liu Y, Dai Z, et al. Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission. J Nanobiotechnol, 2024, 22(1): 407. doi: 10.1186/s12951-024-02669-0.
42. Jin C, Su S A, Yu S, et al. Essential roles of PIEZO1 in mammalian cardiovascular system: From development to diseases. Cells, 2024, 13(17): 1422. doi: 10.3390/cells13171422.
43. Xing H, Liu H, Chang Z, et al. Research progress on the immunological functions of Piezo1, a receptor molecule that responds to mechanical force. International Immunopharmacology, 2024, 139: 112684. doi: 10.1016/j.intimp.2024.112684.
44. Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthritis Cartilage, 2022, 30(2): 184-195.
45. Ely EV, Lenz KL, Paradi SG, et al. Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice. Arthritis Res Ther, 2025, 27(1): 152. doi: 10.1186/s13075-025-03620-w.
46. Zhang L, Li Y, Ma X, et al. Ginsenoside Rg1-notoginsenoside R1-protocatechuic aldehyde reduces atherosclerosis and attenuates low-shear stress-induced vascular endothelial cell dysfunction. Front Pharmacol, 2021, 11: 588259. doi: 10.3389/fphar.2020.588259.
47. Scolnik M, Singh G. Combination therapy versus celecoxib, a single selective COX-2 agent, to reduce gastrointestinal toxicity in arthritic patients: Patient and cost-effectiveness considerations. Open Access Rheumatology: Research and Reviews, 2011, 3: 53-62.
48. Foster NE, Eriksson L, Deveza L, et al. Osteoarthritis year in review 2022: Epidemiology & therapy. Osteoarthritis Cartilage, 2023, 31(7): 876-883.
49. Lawrence KM, Jones RC, Jackson TR, et al. Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1. Sci Rep, 2017, 7(1): 5147. doi: 10.1038/s41598-017-04367-4.

Chinese Journal of Reparative and Reconstructive Surgery

Research progress on clinical transformation of Piezo1 in osteoarthritis

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