Preliminary application of antibiotic bone cement directly inducing skin regeneration technology in repairing of wound in lateral toe flap donor area_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHOU Jian , ZHENG Yucen , CHEN Wei , CHANG Shusen ,  WEI Zairong , NIE Kaiyu , ZHANG Fang , LI Shujun , GONG Feiyu , ZHOU Jian , ZHENG Yucen , CHEN Wei , CHANG Shusen ,  WEI Zairong , NIE Kaiyu , ZHANG Fang , LI Shujun , GONG Feiyu

Department of Plastic Surgery and Burns, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P. R. China;

Corresponding?author：

WEI Zairong, Email: zairongwei@163.com; WEI Zairong, Email: zairongwei@163.com

Keywords：

Antibiotic bone cement; lateral toe; flap donor site; wound repair

DOI：

10.7507/1002-1892.202401054

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Objective To investigate the feasibility and effectiveness of antibiotic bone cement directly inducing skin regeneration technology in the repairing of wound in the lateral toe flap donor area. Methods Between June 2020 and February 2023, antibiotic bone cement directly inducing skin regeneration technology was used to repair lateral toe flap donor area in 10 patients with a total of 11 wounds, including 7 males and 3 females. The patients’ age ranged from 21 to 63 years, with an average of 40.6 years. There were 3 cases of the distal segment of the thumb, 2 cases of the distal segment of the index finger, 1 case of the middle segment of the index and middle fingers, 1 case of the distal segment of the middle finger, and 3 cases of the distal segment of the ring finger. The size of the skin defect of the hand ranged from 2.4 cm×1.8 cm to 4.3 cm×3.4 cm. The disease duration ranged from 1 to 15 days, with an average of 6.9 days. The flap donor sites were located at fibular side of the great toe in 5 sites, tibial side of the second toe in 5 sites, and tibial side of the third toe in 1 site. The skin flap donor site wounds could not be directly sutured, with 2 cases having exposed tendons, all of which were covered with antibiotic bone cement. Results All patients were followed up 6 months to 2 years, with an average of 14.7 months. All the 11 flaps survived and had good appearance. The wound healing time was 40-72 days, with an average of 51.7 days. There was no hypertrophic scar in the donor site, which was similar to the color of the surrounding normal skin; the appearance of the foot was good, and wearing shoes and walking of the donor foot were not affected. Conclusion It is a feasible method to repair the wound in the lateral foot flap donor area with the antibiotic bone cement directly inducing skin regeneration technology. The wound heals spontaneously, the operation is simple, and there is no second donor site injury.

Citation： ZHOU Jian, ZHENG Yucen, CHEN Wei, CHANG Shusen, WEI Zairong, NIE Kaiyu, ZHANG Fang, LI Shujun, GONG Feiyu. Preliminary application of antibiotic bone cement directly inducing skin regeneration technology in repairing of wound in lateral toe flap donor area. Chinese Journal of Reparative and Reconstructive Surgery, 2024, 38(4): 474-479. doi: 10.7507/1002-1892.202401054 Copy

1.	楊良軍, 孫良業, 王從虎, 等. 踇趾腓側或第2趾脛側皮瓣修復指腹軟組織缺損18例. 中華顯微外科雜志, 2020, 43(5): 504-507.
2.	楊良軍, 孫良業, 王從虎, 等. 踇趾腓側或第2趾脛側皮瓣修復指腹軟組織缺損18例. 中華顯微外科雜志, 2020, 43(5): 504-507.
3.	周建輝, 石惠文, 冷樹立, 等. 踇趾腓側折疊皮瓣修復拇指全指腹缺損. 中華手外科雜志, 2023, 39(2): 176-178.
4.	周建輝, 石惠文, 冷樹立, 等. 踇趾腓側折疊皮瓣修復拇指全指腹缺損. 中華手外科雜志, 2023, 39(2): 176-178.
5.	王玥, 趙玲瓏, 滕云升, 等. 改良踇趾腓背側皮瓣游離移植修復指背大面積軟組織缺損. 中華手外科雜志, 2018, 34(4): 308-309.
6.	王玥, 趙玲瓏, 滕云升, 等. 改良踇趾腓背側皮瓣游離移植修復指背大面積軟組織缺損. 中華手外科雜志, 2018, 34(4): 308-309.
7.	劉亦楊, 沈立鋒, 林炳遠, 等. 游離踇趾腓側皮瓣移植修復兒童手部創傷性軟組織缺損. 中華小兒外科雜志, 2020, 41(3): 262-267.
8.	劉亦楊, 沈立鋒, 林炳遠, 等. 游離踇趾腓側皮瓣移植修復兒童手部創傷性軟組織缺損. 中華小兒外科雜志, 2020, 41(3): 262-267.
9.	周健, 魏在榮, 孫廣峰, 等. 游離第3足趾脛側微型皮瓣修復手指末節指腹皮膚軟組織缺損. 中華燒傷雜志, 2019, 35(3): 205-208.
10.	周健, 魏在榮, 孫廣峰, 等. 游離第3足趾脛側微型皮瓣修復手指末節指腹皮膚軟組織缺損. 中華燒傷雜志, 2019, 35(3): 205-208.
11.	周健, 楊孝明, 周丕育, 等. 應用游離踇趾腓側皮瓣急診修復拇指指指腹創面. 中華整形外科雜志, 2014, 30(6): 264-465.
12.	周健, 楊孝明, 周丕育, 等. 應用游離踇趾腓側皮瓣急診修復拇指指指腹創面. 中華整形外科雜志, 2014, 30(6): 264-465.
13.	李海建, 李甲, 閆楊士, 等. 應用雙足踇趾腓側游離皮瓣同期修復雙手指遠節指腹缺損. 中華手外科雜志, 2023, 39(2): 129-132.
14.	李海建, 李甲, 閆楊士, 等. 應用雙足踇趾腓側游離皮瓣同期修復雙手指遠節指腹缺損. 中華手外科雜志, 2023, 39(2): 129-132.
15.	張偉, 程芳斌, 劉剛義, 等. 游離趾腓側皮瓣移植修復指腹缺失的臨床體會. 中華手外科雜志, 2022, 38(3): 241-242.
16.	張偉, 程芳斌, 劉剛義, 等. 游離趾腓側皮瓣移植修復指腹缺失的臨床體會. 中華手外科雜志, 2022, 38(3): 241-242.
17.	滕云升, 賈宗海, 梁高峰, 等. 人工真皮取合游離皮片在踇甲皮瓣供區修復中的臨床應用. 中華手外科雜志, 2017, 33(4): 318-319.
18.	滕云升, 賈宗海, 梁高峰, 等. 人工真皮取合游離皮片在踇甲皮瓣供區修復中的臨床應用. 中華手外科雜志, 2017, 33(4): 318-319.
19.	龍航, 吳奇, 陳廷剛, 等. 人工真皮修復兒童指端缺損. 中華手外科雜志, 2016, 32(2): 98-100.
20.	龍航, 吳奇, 陳廷剛, 等. 人工真皮修復兒童指端缺損. 中華手外科雜志, 2016, 32(2): 98-100.
21.	鐘少開, 汪慶紅, 曾德慶, 等. 第一跖背動脈遠端穿支蒂逆行島狀皮瓣修復踇趾皮瓣供區創面. 中華手外科雜志, 2016, 32(4): 266-267.
22.	鐘少開, 汪慶紅, 曾德慶, 等. 第一跖背動脈遠端穿支蒂逆行島狀皮瓣修復踇趾皮瓣供區創面. 中華手外科雜志, 2016, 32(4): 266-267.
23.	于勝軍, 馬振杰, 李曉, 等. 踇動脈蒂踇趾腓側島狀皮瓣修復第二足趾供區創面. 中華手外科雜志, 2012, 28(5): 310-312.
24.	于勝軍, 馬振杰, 李曉, 等. 踇動脈蒂踇趾腓側島狀皮瓣修復第二足趾供區創面. 中華手外科雜志, 2012, 28(5): 310-312.
25.	石磊, 趙光勛, 胡灃, 等. 臂橈側副動脈穿支皮瓣修復踇趾腓側皮瓣和踇甲瓣術后供區. 中華顯微外科雜志, 2019, 42(4): 396-399.
26.	石磊, 趙光勛, 胡灃, 等. 臂橈側副動脈穿支皮瓣修復踇趾腓側皮瓣和踇甲瓣術后供區. 中華顯微外科雜志, 2019, 42(4): 396-399.
27.	茍中坤, 吳泉玲, 趙崇偉, 等. 腓動脈穿支皮瓣修復踇趾腓側皮瓣供區九例. 中華顯微外科雜志, 2021, 44(6): 653-656.
28.	茍中坤, 吳泉玲, 趙崇偉, 等. 腓動脈穿支皮瓣修復踇趾腓側皮瓣供區九例. 中華顯微外科雜志, 2021, 44(6): 653-656.
29.	Hallock GG. Cosmetic trauma surgery. Plast Reconstr Surg, 1995, 95(2): 380-381.
30.	Hallock GG. Cosmetic trauma surgery. Plast Reconstr Surg, 1995, 95(2): 380-381.
31.	Liu C, You JX, Chen YX, et al. Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible. J Diabetes Res, 2019, 2019: 2429136. doi: 10.1155/2019/2429136.
32.	Liu C, You JX, Chen YX, et al. Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible. J Diabetes Res, 2019, 2019: 2429136. doi: 10.1155/2019/2429136.
33.	陳偉, 常樹森, 周健, 等. 抗生素骨水泥聯合游離股前外側組織瓣序貫治療糖尿病足潰瘍的臨床療效. 中華燒傷與創面修復雜志, 2023, 39(4): 319-324.
34.	陳偉, 常樹森, 周健, 等. 抗生素骨水泥聯合游離股前外側組織瓣序貫治療糖尿病足潰瘍的臨床療效. 中華燒傷與創面修復雜志, 2023, 39(4): 319-324.
35.	吳堯, 陳步國, 董自強, 等. 以動脈蒂遠端作為回流靜脈的改良踇趾腓側皮瓣修復手指遠節創面. 中國修復重建外科雜志, 2021, 35(2): 206-209.
36.	吳堯, 陳步國, 董自強, 等. 以動脈蒂遠端作為回流靜脈的改良踇趾腓側皮瓣修復手指遠節創面. 中國修復重建外科雜志, 2021, 35(2): 206-209.
37.	段永明, 巨積輝, 張廣亮, 等. 游離第二足趾脛側一蒂雙瓣修復兩指指端缺損. 中華手外科雜志, 2020, 36(1): 38-40.
38.	段永明, 巨積輝, 張廣亮, 等. 游離第二足趾脛側一蒂雙瓣修復兩指指端缺損. 中華手外科雜志, 2020, 36(1): 38-40.
39.	劉昌余, 周世文. 負壓封閉引流等技術在治療骨創傷創面軟組織損傷的療效. 現代養生 (下半月版), 2016,(11): 58.
40.	劉昌余, 周世文. 負壓封閉引流等技術在治療骨創傷創面軟組織損傷的療效. 現代養生 (下半月版), 2016,(11): 58.
41.	周翔, 李向榮, 秦軍, 等. 人工真皮聯合舌狀筋膜瓣修復手指遠端缺損骨外露創面的應用及療效. 中華手外科雜志, 2023, 39(4): 294-296.
42.	周翔, 李向榮, 秦軍, 等. 人工真皮聯合舌狀筋膜瓣修復手指遠端缺損骨外露創面的應用及療效. 中華手外科雜志, 2023, 39(4): 294-296.
43.	李一, 李學淵, 俞淼, 等. 雙層人工真皮移植與拇指橈背側島狀皮瓣轉移修復拇指末節缺損的療效比較. 中華手外科雜志, 2023, 39(4): 289-293.
44.	李一, 李學淵, 俞淼, 等. 雙層人工真皮移植與拇指橈背側島狀皮瓣轉移修復拇指末節缺損的療效比較. 中華手外科雜志, 2023, 39(4): 289-293.
45.	楊旅軍, 吳洪娟, 張明君, 等. 人羊膜活性皮膚替代物修復巨痣切除術后創面的可行性及療效研究. 中國修復重建外科雜志, 2017, 31(12): 1495-1499.
46.	楊旅軍, 吳洪娟, 張明君, 等. 人羊膜活性皮膚替代物修復巨痣切除術后創面的可行性及療效研究. 中國修復重建外科雜志, 2017, 31(12): 1495-1499.
47.	Weng T, Wang J, Yang M, et al. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing. Burns Trauma, 2022, 10: tkab049. doi: 10.1093/burnst/tkab049.
48.	Weng T, Wang J, Yang M, et al. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing. Burns Trauma, 2022, 10: tkab049. doi: 10.1093/burnst/tkab049.
49.	黃紅軍, 牛希華, 楊冠龍, 等. 抗生素骨水泥在糖尿病足潰瘍創面應用的臨床效果. 中華燒傷雜志, 2019, 35(6): 464-466.
50.	黃紅軍, 牛希華, 楊冠龍, 等. 抗生素骨水泥在糖尿病足潰瘍創面應用的臨床效果. 中華燒傷雜志, 2019, 35(6): 464-466.
51.	Mendame Ehya RE, Zhang H, Qi B, et al. Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial. J Diabetes Res, 2021, 2021: 9911072. doi: 10.1155/2021/9911072.
52.	Mendame Ehya RE, Zhang H, Qi B, et al. Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial. J Diabetes Res, 2021, 2021: 9911072. doi: 10.1155/2021/9911072.
53.	Morelli I, Drago L, George DA, et al. Masquelet technique: myth or reality? A systematic review and meta-analysis. Injury, 2016, 47 Suppl 6: S68-S76.
54.	Morelli I, Drago L, George DA, et al. Masquelet technique: myth or reality? A systematic review and meta-analysis. Injury, 2016, 47 Suppl 6: S68-S76.
55.	殷渠東, 顧三軍, 孫振中, 等. Masquelet技術體外制作骨水泥填塞物治療骨缺損的臨床應用. 中華創傷雜志, 2016, 32(4): 370-372.
56.	殷渠東, 顧三軍, 孫振中, 等. Masquelet技術體外制作骨水泥填塞物治療骨缺損的臨床應用. 中華創傷雜志, 2016, 32(4): 370-372.
57.	Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol, 2015, 25(6): 969-974.
58.	Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol, 2015, 25(6): 969-974.
59.	劉愛蓬, 劉衍松, 曹天勇. 糖尿病足潰瘍創面修復中抗生素骨水泥的應用分析. 糖尿病新世界, 2021, 24(2): 157-159.
60.	劉愛蓬, 劉衍松, 曹天勇. 糖尿病足潰瘍創面修復中抗生素骨水泥的應用分析. 糖尿病新世界, 2021, 24(2): 157-159.
61.	Komi-Kuramochi A, Kawano M, Oda Y, et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol, 2005, 186(2): 273-289.
62.	Komi-Kuramochi A, Kawano M, Oda Y, et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol, 2005, 186(2): 273-289.
63.	Wilkins RG, Unverdorben M. Wound cleaning and wound healing: a concise review. Adv Skin Wound Care, 2013, 26(4): 160-163.
64.	Wilkins RG, Unverdorben M. Wound cleaning and wound healing: a concise review. Adv Skin Wound Care, 2013, 26(4): 160-163.
65.	Kühn KD, Renz N, Trampuz A. Local antibiotic therapy. Unfallchirurg, 2017, 120(7): 561-572.
66.	Kühn KD, Renz N, Trampuz A. Local antibiotic therapy. Unfallchirurg, 2017, 120(7): 561-572.

1. 楊良軍, 孫良業, 王從虎, 等. 踇趾腓側或第2趾脛側皮瓣修復指腹軟組織缺損18例. 中華顯微外科雜志, 2020, 43(5): 504-507.
2. 楊良軍, 孫良業, 王從虎, 等. 踇趾腓側或第2趾脛側皮瓣修復指腹軟組織缺損18例. 中華顯微外科雜志, 2020, 43(5): 504-507.
3. 周建輝, 石惠文, 冷樹立, 等. 踇趾腓側折疊皮瓣修復拇指全指腹缺損. 中華手外科雜志, 2023, 39(2): 176-178.
4. 周建輝, 石惠文, 冷樹立, 等. 踇趾腓側折疊皮瓣修復拇指全指腹缺損. 中華手外科雜志, 2023, 39(2): 176-178.
5. 王玥, 趙玲瓏, 滕云升, 等. 改良踇趾腓背側皮瓣游離移植修復指背大面積軟組織缺損. 中華手外科雜志, 2018, 34(4): 308-309.
6. 王玥, 趙玲瓏, 滕云升, 等. 改良踇趾腓背側皮瓣游離移植修復指背大面積軟組織缺損. 中華手外科雜志, 2018, 34(4): 308-309.
7. 劉亦楊, 沈立鋒, 林炳遠, 等. 游離踇趾腓側皮瓣移植修復兒童手部創傷性軟組織缺損. 中華小兒外科雜志, 2020, 41(3): 262-267.
8. 劉亦楊, 沈立鋒, 林炳遠, 等. 游離踇趾腓側皮瓣移植修復兒童手部創傷性軟組織缺損. 中華小兒外科雜志, 2020, 41(3): 262-267.
9. 周健, 魏在榮, 孫廣峰, 等. 游離第3足趾脛側微型皮瓣修復手指末節指腹皮膚軟組織缺損. 中華燒傷雜志, 2019, 35(3): 205-208.
10. 周健, 魏在榮, 孫廣峰, 等. 游離第3足趾脛側微型皮瓣修復手指末節指腹皮膚軟組織缺損. 中華燒傷雜志, 2019, 35(3): 205-208.
11. 周健, 楊孝明, 周丕育, 等. 應用游離踇趾腓側皮瓣急診修復拇指指指腹創面. 中華整形外科雜志, 2014, 30(6): 264-465.
12. 周健, 楊孝明, 周丕育, 等. 應用游離踇趾腓側皮瓣急診修復拇指指指腹創面. 中華整形外科雜志, 2014, 30(6): 264-465.
13. 李海建, 李甲, 閆楊士, 等. 應用雙足踇趾腓側游離皮瓣同期修復雙手指遠節指腹缺損. 中華手外科雜志, 2023, 39(2): 129-132.
14. 李海建, 李甲, 閆楊士, 等. 應用雙足踇趾腓側游離皮瓣同期修復雙手指遠節指腹缺損. 中華手外科雜志, 2023, 39(2): 129-132.
15. 張偉, 程芳斌, 劉剛義, 等. 游離趾腓側皮瓣移植修復指腹缺失的臨床體會. 中華手外科雜志, 2022, 38(3): 241-242.
16. 張偉, 程芳斌, 劉剛義, 等. 游離趾腓側皮瓣移植修復指腹缺失的臨床體會. 中華手外科雜志, 2022, 38(3): 241-242.
17. 滕云升, 賈宗海, 梁高峰, 等. 人工真皮取合游離皮片在踇甲皮瓣供區修復中的臨床應用. 中華手外科雜志, 2017, 33(4): 318-319.
18. 滕云升, 賈宗海, 梁高峰, 等. 人工真皮取合游離皮片在踇甲皮瓣供區修復中的臨床應用. 中華手外科雜志, 2017, 33(4): 318-319.
19. 龍航, 吳奇, 陳廷剛, 等. 人工真皮修復兒童指端缺損. 中華手外科雜志, 2016, 32(2): 98-100.
20. 龍航, 吳奇, 陳廷剛, 等. 人工真皮修復兒童指端缺損. 中華手外科雜志, 2016, 32(2): 98-100.
21. 鐘少開, 汪慶紅, 曾德慶, 等. 第一跖背動脈遠端穿支蒂逆行島狀皮瓣修復踇趾皮瓣供區創面. 中華手外科雜志, 2016, 32(4): 266-267.
22. 鐘少開, 汪慶紅, 曾德慶, 等. 第一跖背動脈遠端穿支蒂逆行島狀皮瓣修復踇趾皮瓣供區創面. 中華手外科雜志, 2016, 32(4): 266-267.
23. 于勝軍, 馬振杰, 李曉, 等. 踇動脈蒂踇趾腓側島狀皮瓣修復第二足趾供區創面. 中華手外科雜志, 2012, 28(5): 310-312.
24. 于勝軍, 馬振杰, 李曉, 等. 踇動脈蒂踇趾腓側島狀皮瓣修復第二足趾供區創面. 中華手外科雜志, 2012, 28(5): 310-312.
25. 石磊, 趙光勛, 胡灃, 等. 臂橈側副動脈穿支皮瓣修復踇趾腓側皮瓣和踇甲瓣術后供區. 中華顯微外科雜志, 2019, 42(4): 396-399.
26. 石磊, 趙光勛, 胡灃, 等. 臂橈側副動脈穿支皮瓣修復踇趾腓側皮瓣和踇甲瓣術后供區. 中華顯微外科雜志, 2019, 42(4): 396-399.
27. 茍中坤, 吳泉玲, 趙崇偉, 等. 腓動脈穿支皮瓣修復踇趾腓側皮瓣供區九例. 中華顯微外科雜志, 2021, 44(6): 653-656.
28. 茍中坤, 吳泉玲, 趙崇偉, 等. 腓動脈穿支皮瓣修復踇趾腓側皮瓣供區九例. 中華顯微外科雜志, 2021, 44(6): 653-656.
29. Hallock GG. Cosmetic trauma surgery. Plast Reconstr Surg, 1995, 95(2): 380-381.
30. Hallock GG. Cosmetic trauma surgery. Plast Reconstr Surg, 1995, 95(2): 380-381.
31. Liu C, You JX, Chen YX, et al. Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible. J Diabetes Res, 2019, 2019: 2429136. doi: 10.1155/2019/2429136.
32. Liu C, You JX, Chen YX, et al. Effect of induced membrane formation followed by polymethylmethacrylate implantation on diabetic foot ulcer healing when revascularization is not feasible. J Diabetes Res, 2019, 2019: 2429136. doi: 10.1155/2019/2429136.
33. 陳偉, 常樹森, 周健, 等. 抗生素骨水泥聯合游離股前外側組織瓣序貫治療糖尿病足潰瘍的臨床療效. 中華燒傷與創面修復雜志, 2023, 39(4): 319-324.
34. 陳偉, 常樹森, 周健, 等. 抗生素骨水泥聯合游離股前外側組織瓣序貫治療糖尿病足潰瘍的臨床療效. 中華燒傷與創面修復雜志, 2023, 39(4): 319-324.
35. 吳堯, 陳步國, 董自強, 等. 以動脈蒂遠端作為回流靜脈的改良踇趾腓側皮瓣修復手指遠節創面. 中國修復重建外科雜志, 2021, 35(2): 206-209.
36. 吳堯, 陳步國, 董自強, 等. 以動脈蒂遠端作為回流靜脈的改良踇趾腓側皮瓣修復手指遠節創面. 中國修復重建外科雜志, 2021, 35(2): 206-209.
37. 段永明, 巨積輝, 張廣亮, 等. 游離第二足趾脛側一蒂雙瓣修復兩指指端缺損. 中華手外科雜志, 2020, 36(1): 38-40.
38. 段永明, 巨積輝, 張廣亮, 等. 游離第二足趾脛側一蒂雙瓣修復兩指指端缺損. 中華手外科雜志, 2020, 36(1): 38-40.
39. 劉昌余, 周世文. 負壓封閉引流等技術在治療骨創傷創面軟組織損傷的療效. 現代養生 (下半月版), 2016,(11): 58.
40. 劉昌余, 周世文. 負壓封閉引流等技術在治療骨創傷創面軟組織損傷的療效. 現代養生 (下半月版), 2016,(11): 58.
41. 周翔, 李向榮, 秦軍, 等. 人工真皮聯合舌狀筋膜瓣修復手指遠端缺損骨外露創面的應用及療效. 中華手外科雜志, 2023, 39(4): 294-296.
42. 周翔, 李向榮, 秦軍, 等. 人工真皮聯合舌狀筋膜瓣修復手指遠端缺損骨外露創面的應用及療效. 中華手外科雜志, 2023, 39(4): 294-296.
43. 李一, 李學淵, 俞淼, 等. 雙層人工真皮移植與拇指橈背側島狀皮瓣轉移修復拇指末節缺損的療效比較. 中華手外科雜志, 2023, 39(4): 289-293.
44. 李一, 李學淵, 俞淼, 等. 雙層人工真皮移植與拇指橈背側島狀皮瓣轉移修復拇指末節缺損的療效比較. 中華手外科雜志, 2023, 39(4): 289-293.
45. 楊旅軍, 吳洪娟, 張明君, 等. 人羊膜活性皮膚替代物修復巨痣切除術后創面的可行性及療效研究. 中國修復重建外科雜志, 2017, 31(12): 1495-1499.
46. 楊旅軍, 吳洪娟, 張明君, 等. 人羊膜活性皮膚替代物修復巨痣切除術后創面的可行性及療效研究. 中國修復重建外科雜志, 2017, 31(12): 1495-1499.
47. Weng T, Wang J, Yang M, et al. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing. Burns Trauma, 2022, 10: tkab049. doi: 10.1093/burnst/tkab049.
48. Weng T, Wang J, Yang M, et al. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing. Burns Trauma, 2022, 10: tkab049. doi: 10.1093/burnst/tkab049.
49. 黃紅軍, 牛希華, 楊冠龍, 等. 抗生素骨水泥在糖尿病足潰瘍創面應用的臨床效果. 中華燒傷雜志, 2019, 35(6): 464-466.
50. 黃紅軍, 牛希華, 楊冠龍, 等. 抗生素骨水泥在糖尿病足潰瘍創面應用的臨床效果. 中華燒傷雜志, 2019, 35(6): 464-466.
51. Mendame Ehya RE, Zhang H, Qi B, et al. Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial. J Diabetes Res, 2021, 2021: 9911072. doi: 10.1155/2021/9911072.
52. Mendame Ehya RE, Zhang H, Qi B, et al. Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial. J Diabetes Res, 2021, 2021: 9911072. doi: 10.1155/2021/9911072.
53. Morelli I, Drago L, George DA, et al. Masquelet technique: myth or reality? A systematic review and meta-analysis. Injury, 2016, 47 Suppl 6: S68-S76.
54. Morelli I, Drago L, George DA, et al. Masquelet technique: myth or reality? A systematic review and meta-analysis. Injury, 2016, 47 Suppl 6: S68-S76.
55. 殷渠東, 顧三軍, 孫振中, 等. Masquelet技術體外制作骨水泥填塞物治療骨缺損的臨床應用. 中華創傷雜志, 2016, 32(4): 370-372.
56. 殷渠東, 顧三軍, 孫振中, 等. Masquelet技術體外制作骨水泥填塞物治療骨缺損的臨床應用. 中華創傷雜志, 2016, 32(4): 370-372.
57. Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol, 2015, 25(6): 969-974.
58. Seligson D, Berling S. Antibiotic-laden PMMA bead chains for the prevention of infection in compound fractures: current state of the art. Eur J Orthop Surg Traumatol, 2015, 25(6): 969-974.
59. 劉愛蓬, 劉衍松, 曹天勇. 糖尿病足潰瘍創面修復中抗生素骨水泥的應用分析. 糖尿病新世界, 2021, 24(2): 157-159.
60. 劉愛蓬, 劉衍松, 曹天勇. 糖尿病足潰瘍創面修復中抗生素骨水泥的應用分析. 糖尿病新世界, 2021, 24(2): 157-159.
61. Komi-Kuramochi A, Kawano M, Oda Y, et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol, 2005, 186(2): 273-289.
62. Komi-Kuramochi A, Kawano M, Oda Y, et al. Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol, 2005, 186(2): 273-289.
63. Wilkins RG, Unverdorben M. Wound cleaning and wound healing: a concise review. Adv Skin Wound Care, 2013, 26(4): 160-163.
64. Wilkins RG, Unverdorben M. Wound cleaning and wound healing: a concise review. Adv Skin Wound Care, 2013, 26(4): 160-163.
65. Kühn KD, Renz N, Trampuz A. Local antibiotic therapy. Unfallchirurg, 2017, 120(7): 561-572.
66. Kühn KD, Renz N, Trampuz A. Local antibiotic therapy. Unfallchirurg, 2017, 120(7): 561-572.

Chinese Journal of Reparative and Reconstructive Surgery

Preliminary application of antibiotic bone cement directly inducing skin regeneration technology in repairing of wound in lateral toe flap donor area

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