Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LEI Shuting ^1,2,3 ,  HU Juanjuan ^1,2 , TANG Yingqi ⁴ , GAN Weigang ² , SONG Yuting ¹ , JIANG Yanlin ¹ , ZHANG Honghui ² , GAO Yaya ^1,2 , YANG Hui ² , XIE Huiqi ¹

1. Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
2. Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
3. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
4. West China School of Public Health, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding?author：

HU Juanjuan, Email: hujuanjuan2017@163.com

Keywords：

Atrophic rhinitis; tissue engineering technology; repair and reconstruction

DOI：

10.7507/1002-1892.202301064

Video：

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Objective To review the research progress of the feasibility of a new treatment method for atrophic rhinitis (ATR) based on tissue engineering technology (seed cells, scaffold materials, and growth factors), and provide new ideas for the treatment of ATR. Methods The literature related to ATR was extensively reviewed. Focusing on the three aspects of seed cells, scaffold materials, and growth factors, the recent research progress of ATR treatment was reviewed, and the future directions of tissue engineering technology to treat ATR were proposed. Results The pathogenesis and etiology of ATR are still unclear, and the effectiveness of the current treatments are still unsatisfactory. The construction of a cell-scaffold complex with sustained and controlled release of exogenous cytokines is expected to reverse the pathological changes of ATR, promoting the regeneration of normal nasal mucosa and reconstructing the atrophic turbinate. In recent years, the research progress of exosomes, three-dimensional printing, and organoids will promote the development of tissue engineering technology for ATR. Conclusion Tissue engineering technology can provide a new treatment method for ATR.

Citation： LEI Shuting, HU Juanjuan, TANG Yingqi, GAN Weigang, SONG Yuting, JIANG Yanlin, ZHANG Honghui, GAO Yaya, YANG Hui, XIE Huiqi. Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis. Chinese Journal of Reparative and Reconstructive Surgery, 2023, 37(6): 727-731. doi: 10.7507/1002-1892.202301064 Copy

1.	趙霞. 多方案聯合治療萎縮性鼻炎的臨床療效及安全性. 河南醫學研究, 2015, 24(3): 97-98.
2.	Pace-Balzan A, Shankar L, Hawke M. Computed tomographic findings in atrophic rhinitis. J Otolaryngol, 1991, 20(6): 428-432.
3.	Bunnag C, Jareoncharsri P, Tansuriyawong P, et al. Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital. Rhinology, 1999, 37(3): 125-130.
4.	Ghosh P. Vestibuloplasty (a new one-stage operation for atrophic rhinitis). J Laryngol Otol, 1987, 101(9): 905-909.
5.	Garcia GJ, Bailie N, Martins DA, et al. Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J Appl Physiol (1985), 2007, 103(3): 1082-1092.
6.	Medina L, Benazzo M, Bertino G, et al. Clinical, genetic and immunologic analysis of a family affected by ozena. Eur Arch Otorhinolaryngol, 2003, 260(7): 390-394.
7.	Fouad H, Afifi N, Fatt-Hi A, et al. Altered cell mediated immunity in atrophic rhinitis. J Laryngol Otol, 1980, 94(5): 507-514.
8.	李欣. 京萬紅軟膏治療萎縮性鼻炎100例臨床療效分析. 內蒙古中醫藥, 2017, 36(10): 110-111.
9.	Abdel-Naby Awad OG, Hasan MM. Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. Am J Otolaryngol, 2019, 40(2): 137-142.
10.	Testa D, Marcuccio G, Lombardo N, et al. Role of α-tocopherol acetate on nasal respiratory functions: Mucociliary clearance and rhinomanometric evaluations in primary atrophic rhinitis. Ear Nose Throat J, 2021, 100(6): NP290-NP295.
11.	Kang X, Sun Y, Yi B, et al. Based on network pharmacology and molecular dynamics simulations, baicalein, an active ingredient of Yiqi Qingre Ziyin method, potentially protects patients with atrophic rhinitis from cognitive impairment. Front Aging Neurosci, 2022, 14: 880794. doi: 10.3389/fnagi.2022.880794.
12.	Dutt SN, Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol, 2005, 119(11): 843-852.
13.	Park MJ, Jang YJ. Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. Auris Nasus Larynx, 2018, 45(3): 613-616.
14.	Hassan CH, Malheiro E, Béquignon E, et al. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique. Laryngoscope Investig Otolaryngol, 2021, 7(1): 6-11.
15.	劉文軍, 梁灼萍, 陳祖堯, 等. 萎縮性鼻炎治療及基礎研究現狀. 中國中西醫結合耳鼻咽喉科雜志, 2008, 16(5): 398-400,397.
16.	侯琳琳. 改良前鼻孔縮窄術聯合表皮生長因子治療萎縮性鼻炎患者的療效. 醫療裝備, 2018, 31(14): 20-21.
17.	殷曉雪, 陳仲強, 郭昭慶, 等. 人骨髓間充質干細胞定向誘導分化為成骨細胞及其鑒定. 中國修復重建外科雜志, 2004, 18(2): 88-91.
18.	楊大鑒, 黃定強, 何成松, 等. 組織工程骨技術在萎縮性鼻炎治療中的應用. 中國康復, 2006, 21(4): 225-226.
19.	Mende W, G?tzl R, Kubo Y, et al. The role of adipose stem cells in bone regeneration and bone tissue engineering. Cells, 2021, 10(5): 975.
20.	Friji MT, Gopalakrishnan S, Verma SK, et al. New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. Clin Otolaryngol, 2014, 39(5): 289-292.
21.	Hass R, Kasper C, B?hm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal, 2011, 9: 12. doi: 10.1186/1478-811X-9-12.
22.	董金輝, 任秀敏, 徐鷗, 等. 人臍血干細胞分化為鼻黏膜纖毛上皮細胞. 中國組織工程研究, 2016, 20(32): 4764-4770.
23.	Sun L, Sha J, Meng C, et al. Mesenchymal stem cell-based therapy for allergic rhinitis. Stem Cells Int, 2020, 2020: 2367524. doi: 10.1155/2020/2367524.
24.	Drela K, Stanaszek L, Nowakowski A, et al. Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes. Stem Cells Int, 2019, 2019: 7012692. doi: 10.1155/2019/7012692.
25.	陳曉旭, 羅雅馨, 畢浩然, 等. 脫細胞支架制備及其在組織工程和再生醫學中的應用. 中國組織工程研究, 2022, 26(4): 591-596.
26.	Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Semin Immunol, 2017, 29: 72-91.
27.	石潤杰, 吳晴偉, 趙影穎, 等. 自體骨髓基質干細胞構建下鼻甲. 中國耳鼻咽喉頭頸外科, 2009, 16(1): 13-16.
28.	許航, 何其澤, 黃為. 組織工程關節軟骨的研究進展. 中國骨與關節損傷雜志, 2022, 37(5): 558-560.
29.	Singh BN, Veeresh V, Mallick SP, et al. Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering. Int J Biol Macromol, 2019, 133: 817-830.
30.	Cakmak AM, Unal S, Sahin A, et al. 3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering. Polymers (Basel), 2020, 12(9): 1962. doi: 10.3390/polym12091962.
31.	Iglesias-Mejuto A, García-González CA. 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2021, 131: 112525. doi: 10.1016/j.msec.2021.112525.
32.	楊君英. 重組牛堿性成纖維細胞生長因子治療萎縮性鼻炎臨床觀察. 醫藥論壇雜志, 2013, 34(7): 115-116.
33.	尤景敏, 汪建, 彭華, 等. 表皮生長因子治療萎縮性鼻炎的效果觀察. 廣東醫學, 2003, 24(10): 1057.
34.	楊曉燕, 吳宏洲, 錢美. 鼻腔沖洗配合表皮生長因子治療萎縮性鼻炎56例體會. 中國醫學工程, 2010, 18(2): 152-153.
35.	張心如, 魯文龍, 馮超, 等. 血管內皮生長因子納米微球-細菌纖維素復合支架與多種細胞構建組織工程膀胱. 中國組織工程研究, 2016, 20(21): 3088-3096.
36.	張志文, 黃玉良, 張理選, 等. 堿性成纖維細胞生長因子復合脫細胞骨基質/殼聚糖支架修復骨缺損. 中國組織工程研究, 2021, 25(34): 5439-5444.
37.	劉士博, 劉顯. 不同源性外泌體在骨缺損修復中的研究進展. 華西口腔醫學雜志, 2020, 38(2): 193-197.
38.	Du YM, Zhuansun YX, Chen R, et al. Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Exp Cell Res, 2018, 363(1): 114-120.
39.	Li W, Liu Y, Zhang P, et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS Appl Mater Interfaces, 2018, 10(6): 5240-5254.
40.	蔡超瑩, 陳學鵬, 胡濟安. 外泌體復合支架用于口腔組織工程的研究進展. 國際口腔醫學雜志, 2022, 49(4): 489-496.
41.	Ganbold B, Heo SJ, Koak JY, et al. Human stem cell responses and surface characteristics of 3D printing co-cr dental material. Materials (Basel), 2019, 12(20): 3419. doi: 10.3390/ma12203419.
42.	徐晨陽, 李祎, 劉曉雯, 等. 3D打印技術在耳鼻咽喉科的應用進展. 中華耳科學雜志, 2022, 20(4): 645-648.
43.	孫開瑜, 徐銘恩, 周永勇. 基于3D打印的Ⅰ型膠原涂覆β-TCP骨組織工程支架研究. 中國生物醫學工程學報, 2018, 37(3): 335-343.
44.	路冬冬, 朱天峰, 張一健, 等. 3D生物打印甲基丙烯酰化明膠水凝膠支架促進軟骨下骨缺損的修復. 中國組織工程研究, 2022, 26(34): 5454-5460.
45.	李瀟萌, 管若羽, 高建軍, 等. 類器官在再生醫學中的應用. 中國細胞生物學學報, 2021, 43(6): 1120-1131.
46.	Park Y, Cheong E, Kwak JG, et al. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv, 2021, 7(4): eabd6495. doi: 10.1126/sciadv.abd6495.
47.	Chen S, Chen X, Geng Z, et al. The horizon of bone organoid: A perspective on construction and application. Bioact Mater, 2022, 18: 15-25.
48.	陳曉, 蘇佳燦. 骨缺損治療新技術: 骨類器官. 中華創傷雜志, 2022, 38(4): 293-296.

1. 趙霞. 多方案聯合治療萎縮性鼻炎的臨床療效及安全性. 河南醫學研究, 2015, 24(3): 97-98.
2. Pace-Balzan A, Shankar L, Hawke M. Computed tomographic findings in atrophic rhinitis. J Otolaryngol, 1991, 20(6): 428-432.
3. Bunnag C, Jareoncharsri P, Tansuriyawong P, et al. Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital. Rhinology, 1999, 37(3): 125-130.
4. Ghosh P. Vestibuloplasty (a new one-stage operation for atrophic rhinitis). J Laryngol Otol, 1987, 101(9): 905-909.
5. Garcia GJ, Bailie N, Martins DA, et al. Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J Appl Physiol (1985), 2007, 103(3): 1082-1092.
6. Medina L, Benazzo M, Bertino G, et al. Clinical, genetic and immunologic analysis of a family affected by ozena. Eur Arch Otorhinolaryngol, 2003, 260(7): 390-394.
7. Fouad H, Afifi N, Fatt-Hi A, et al. Altered cell mediated immunity in atrophic rhinitis. J Laryngol Otol, 1980, 94(5): 507-514.
8. 李欣. 京萬紅軟膏治療萎縮性鼻炎100例臨床療效分析. 內蒙古中醫藥, 2017, 36(10): 110-111.
9. Abdel-Naby Awad OG, Hasan MM. Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. Am J Otolaryngol, 2019, 40(2): 137-142.
10. Testa D, Marcuccio G, Lombardo N, et al. Role of α-tocopherol acetate on nasal respiratory functions: Mucociliary clearance and rhinomanometric evaluations in primary atrophic rhinitis. Ear Nose Throat J, 2021, 100(6): NP290-NP295.
11. Kang X, Sun Y, Yi B, et al. Based on network pharmacology and molecular dynamics simulations, baicalein, an active ingredient of Yiqi Qingre Ziyin method, potentially protects patients with atrophic rhinitis from cognitive impairment. Front Aging Neurosci, 2022, 14: 880794. doi: 10.3389/fnagi.2022.880794.
12. Dutt SN, Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol, 2005, 119(11): 843-852.
13. Park MJ, Jang YJ. Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. Auris Nasus Larynx, 2018, 45(3): 613-616.
14. Hassan CH, Malheiro E, Béquignon E, et al. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique. Laryngoscope Investig Otolaryngol, 2021, 7(1): 6-11.
15. 劉文軍, 梁灼萍, 陳祖堯, 等. 萎縮性鼻炎治療及基礎研究現狀. 中國中西醫結合耳鼻咽喉科雜志, 2008, 16(5): 398-400,397.
16. 侯琳琳. 改良前鼻孔縮窄術聯合表皮生長因子治療萎縮性鼻炎患者的療效. 醫療裝備, 2018, 31(14): 20-21.
17. 殷曉雪, 陳仲強, 郭昭慶, 等. 人骨髓間充質干細胞定向誘導分化為成骨細胞及其鑒定. 中國修復重建外科雜志, 2004, 18(2): 88-91.
18. 楊大鑒, 黃定強, 何成松, 等. 組織工程骨技術在萎縮性鼻炎治療中的應用. 中國康復, 2006, 21(4): 225-226.
19. Mende W, G?tzl R, Kubo Y, et al. The role of adipose stem cells in bone regeneration and bone tissue engineering. Cells, 2021, 10(5): 975.
20. Friji MT, Gopalakrishnan S, Verma SK, et al. New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. Clin Otolaryngol, 2014, 39(5): 289-292.
21. Hass R, Kasper C, B?hm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal, 2011, 9: 12. doi: 10.1186/1478-811X-9-12.
22. 董金輝, 任秀敏, 徐鷗, 等. 人臍血干細胞分化為鼻黏膜纖毛上皮細胞. 中國組織工程研究, 2016, 20(32): 4764-4770.
23. Sun L, Sha J, Meng C, et al. Mesenchymal stem cell-based therapy for allergic rhinitis. Stem Cells Int, 2020, 2020: 2367524. doi: 10.1155/2020/2367524.
24. Drela K, Stanaszek L, Nowakowski A, et al. Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes. Stem Cells Int, 2019, 2019: 7012692. doi: 10.1155/2019/7012692.
25. 陳曉旭, 羅雅馨, 畢浩然, 等. 脫細胞支架制備及其在組織工程和再生醫學中的應用. 中國組織工程研究, 2022, 26(4): 591-596.
26. Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Semin Immunol, 2017, 29: 72-91.
27. 石潤杰, 吳晴偉, 趙影穎, 等. 自體骨髓基質干細胞構建下鼻甲. 中國耳鼻咽喉頭頸外科, 2009, 16(1): 13-16.
28. 許航, 何其澤, 黃為. 組織工程關節軟骨的研究進展. 中國骨與關節損傷雜志, 2022, 37(5): 558-560.
29. Singh BN, Veeresh V, Mallick SP, et al. Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering. Int J Biol Macromol, 2019, 133: 817-830.
30. Cakmak AM, Unal S, Sahin A, et al. 3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering. Polymers (Basel), 2020, 12(9): 1962. doi: 10.3390/polym12091962.
31. Iglesias-Mejuto A, García-González CA. 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2021, 131: 112525. doi: 10.1016/j.msec.2021.112525.
32. 楊君英. 重組牛堿性成纖維細胞生長因子治療萎縮性鼻炎臨床觀察. 醫藥論壇雜志, 2013, 34(7): 115-116.
33. 尤景敏, 汪建, 彭華, 等. 表皮生長因子治療萎縮性鼻炎的效果觀察. 廣東醫學, 2003, 24(10): 1057.
34. 楊曉燕, 吳宏洲, 錢美. 鼻腔沖洗配合表皮生長因子治療萎縮性鼻炎56例體會. 中國醫學工程, 2010, 18(2): 152-153.
35. 張心如, 魯文龍, 馮超, 等. 血管內皮生長因子納米微球-細菌纖維素復合支架與多種細胞構建組織工程膀胱. 中國組織工程研究, 2016, 20(21): 3088-3096.
36. 張志文, 黃玉良, 張理選, 等. 堿性成纖維細胞生長因子復合脫細胞骨基質/殼聚糖支架修復骨缺損. 中國組織工程研究, 2021, 25(34): 5439-5444.
37. 劉士博, 劉顯. 不同源性外泌體在骨缺損修復中的研究進展. 華西口腔醫學雜志, 2020, 38(2): 193-197.
38. Du YM, Zhuansun YX, Chen R, et al. Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Exp Cell Res, 2018, 363(1): 114-120.
39. Li W, Liu Y, Zhang P, et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS Appl Mater Interfaces, 2018, 10(6): 5240-5254.
40. 蔡超瑩, 陳學鵬, 胡濟安. 外泌體復合支架用于口腔組織工程的研究進展. 國際口腔醫學雜志, 2022, 49(4): 489-496.
41. Ganbold B, Heo SJ, Koak JY, et al. Human stem cell responses and surface characteristics of 3D printing co-cr dental material. Materials (Basel), 2019, 12(20): 3419. doi: 10.3390/ma12203419.
42. 徐晨陽, 李祎, 劉曉雯, 等. 3D打印技術在耳鼻咽喉科的應用進展. 中華耳科學雜志, 2022, 20(4): 645-648.
43. 孫開瑜, 徐銘恩, 周永勇. 基于3D打印的Ⅰ型膠原涂覆β-TCP骨組織工程支架研究. 中國生物醫學工程學報, 2018, 37(3): 335-343.
44. 路冬冬, 朱天峰, 張一健, 等. 3D生物打印甲基丙烯酰化明膠水凝膠支架促進軟骨下骨缺損的修復. 中國組織工程研究, 2022, 26(34): 5454-5460.
45. 李瀟萌, 管若羽, 高建軍, 等. 類器官在再生醫學中的應用. 中國細胞生物學學報, 2021, 43(6): 1120-1131.
46. Park Y, Cheong E, Kwak JG, et al. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv, 2021, 7(4): eabd6495. doi: 10.1126/sciadv.abd6495.
47. Chen S, Chen X, Geng Z, et al. The horizon of bone organoid: A perspective on construction and application. Bioact Mater, 2022, 18: 15-25.
48. 陳曉, 蘇佳燦. 骨缺損治療新技術: 骨類器官. 中華創傷雜志, 2022, 38(4): 293-296.

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Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis

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