Application of medical biomaterials in prevention and treatment of tendon adhesion_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANG Mingmin ,  REN Gaohong

Department of Trauma Orthopedics, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou Guangdong, 510515, P.R.China;

Corresponding?author：

REN Gaohong, Email: doctor020@163.com

Keywords：

Biomaterials; tendon injury; tendon adhesion; repair; prevention

DOI：

10.7507/1002-1892.201910024

Video：

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Objective To review the research progress of medicine biomaterials in prevention and treatment of adhesion after tendon injury, and to provide reference for clinical treatment.Methods The literature on the application of medical biomaterials in the prevention and treatment of tendon adhesions in recent years was reviewed, and the biological process, treatment methods, and current status of tendon adhesions were summarized.Results Tendon adhesion as part of the healing process of the tendon is the biological response of the tendon to the injury and is also a common complication of joint dysfunction. Application of medical biomaterials can achieve better biological function of postoperative tendon by reducing the adhesion of peritendon tissues as far as possible without adversely affecting the tendon healing process.Conclusion The use of medical biomaterials is conducive to reduce the adhesion of tendon after operation, and the appropriate anti-adhesion material should be selected according to the patients’ condition and surgical needs.

Citation： ZHANG Mingmin, REN Gaohong. Application of medical biomaterials in prevention and treatment of tendon adhesion. Chinese Journal of Reparative and Reconstructive Surgery, 2020, 34(8): 1065-1070. doi: 10.7507/1002-1892.201910024 Copy

1.	姜士超, 劉坤, 范存義. 肌腱粘連機制及預防的研究進展. 中國修復重建外科雜志, 2013, 27(5): 633-636.
2.	Branford OA, Lee DA, Rolfe KJ, et al. The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. J Hand Surg (Eur Vol), 2012, 37(6): 564-572.
3.	de Jong JP, Nguyen JT, Sonnema AJ, et al. The incidence of acute traumatic tendon injuries in the hand and wrist: a 10-year population-based study. Clin Orthop Surg, 2014, 6(2): 196-202.
4.	Dy CJ, Hernandez-Soria A, Ma Y, et al. Complications after flexor tendon repair: a systematic review and meta-analysis. J Hand Surg (Am), 2012, 37(3): 543-551.
5.	Manske PR. Flexor tendon healing. J Hand Surg (Br), 1988, 13(3): 237-245.
6.	Leadbetter WB. Cell-matrix response in tendon injury. Clin Sports Med, 1992, 11(3): 533-578.
7.	Ishiyama N, Moro T, Ohe T, et al. Reduction of peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. J Bone Joint Surg (Am), 2011, 93(2): 142-149.
8.	Lundborg G. Experimental flexor tendon healing without adhesion formation—a new concept of tendon nutrition and intrinsic healing mechanisms. A preliminary report. Hand, 1976, 8(3): 235-238.
9.	Wu W, Cheng R, das Neves J, et al. Advances in biomaterials for preventing tissue adhesion. J Control Release, 2017, 261: 318-336.
10.	Tenenhaus M. The use of dehydrated human amnion/chorion membranes in the treatment of burns and complex wounds: current and future applications. Ann Plast Surg, 2017, 78(2 Suppl 1): S11-S13.
11.	Srinivasan R, T SS, Gupta A, et al. Hypopyon iritis after primary fresh amniotic membrane transplantation. Cornea, 2007, 26(10): 1275-1276.
12.	Duan-Arnold Y, Gyurdieva A, Johnson A, et al. Retention of endogenous viable cells enhances the anti-inflammatory activity of cryopreserved amnion. Adv Wound Care (New Rochelle), 2015, 4(9): 523-533.
13.	Jamil S, Mousavizadeh R, Roshan-Moniri M, et al. Angiopoietin-like 4 Enhances the Proliferation and Migration of Tendon Fibroblasts. Med Sci Sports Exerc, 2017, 49(9): 1769-1777.
14.	Melville JM, McDonald CA, Bischof RJ, et al. Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs. PLoS One, 2017, 12(3): e0173572.
15.	Shu J, He X, Zhang L, et al. Human amnion mesenchymal cells inhibit lipopolysaccharide-induced TNF-α and IL-1β production in THP-1 cells. Biol Res, 2015, 48: 69.
16.	Liu C, Yu K, Bai J, et al. Experimental study of tendon sheath repair via decellularized amnion to prevent tendon adhesion. PLoS One, 2018, 13(10): e0205811.
17.	Yang TH, Lu SC, Lin WJ, et al. Assessing finger joint biomechanics by applying equal force to flexor tendons in vitro using a novel simultaneous approach. PLoS One, 2016, 11(8): e0160301.
18.	Fouda MB, Thankam FG, Dilisio MF, et al. Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. Am J Transl Res, 2017, 9(10): 4341-4360.
19.	Kshersagar J, Kshirsagar R, Desai S, et al. Decellularized amnion scaffold with activated PRP: a new paradigm dressing material for burn wound healing. Cell Tissue Bank, 2018, 19(3): 423-436.
20.	Ryzhuk V, Zeng XX, Wang X, et al. Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Mater Sci Eng C Mater Biol Appl, 2018, 85: 191-202.
21.	Liu C, Bai J, Yu K, et al. Biological amnion prevents flexor tendon adhesion in zone Ⅱ: A controlled, multicentre clinical trial. Biomed Res Int, 2019, 2019: 2354325.
22.	Oei TS, Klopper PJ, Spaas JA, et al. Reconstruction of the flexor tendon sheath. An experimental study in rabbits. J Hand Surg (Br), 1996, 21(1): 72-83.
23.	Sungur N, Uysal A, Ko?er U, et al. Prevention of tendon adhesions by the reconstruction of the tendon sheath with solvent dehydrated bovine pericard: An experimental study. J Trauma, 2006, 61(6): 1467-1472.
24.	Irk?ren S, Demird?ver C, Akad BZ, et al. Use of a perichondrial autograft on the peritendinous adhesion: an experimental study in rabbits. Acta Orthop Traumatol Turc, 2012, 46(3): 208-214.
25.	Hanc? D, Altun H. Effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing: a prospective, double-blind, controlled clinical study. Int J Pediatr Otorhinolaryngol, 2015, 79(9): 1388-1392.
26.	Hagberg L, Gerdin B. Sodium hyaluronate as an adjunct in adhesion prevention after flexor tendon surgery in rabbits. J Hand Surg (Am), 1992, 17(5): 935-941.
27.	Chou PY, Chen SH, Chen CH, et al. Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative peritendinous adhesion. Acta Biomater, 2017, 63: 85-95.
28.	Shalumon KT, Sheu C, Chen CH, et al. Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation. Acta Biomater, 2018, 72: 121-136.
29.	Chen Q, Lu H, Yang H. Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway. Mol Med Rep, 2015, 12(3): 4598-4603.
30.	Shen Y, Tu T, Yi B, et al. Electrospun acid-neutralizing fibers for the amelioration of inflammatory response. Acta Biomater, 2019, 97: 200-215.
31.	任高宏, 張明敏, 崔壯, 等. 皮膚牽張器聯合膠原蛋白海綿修復軟組織缺損. 中華創傷骨科雜志, 2018, 20(8): 689-695.
32.	Zhao H, Guan HG, Gu J, et al. Collagen membrane alleviates peritendinous adhesion in the rat Achilles tendon injury model. Chin Med J (Engl), 2013, 126(4): 729-733.
33.	Tian F, Dou C, Qi S, et al. Preventive effect of dexamethasone gelatin sponge on the lumbosacral epidural adhesion. Int J Clin Exp Med, 2015, 8(4): 5478-5484.
34.	Wichelhaus DA, Beyersdoerfer ST, Gierer P, et al. The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model. Arch Orthop Trauma Surg, 2016, 136(7): 1021-1029.
35.	Ohata A, Tamura N, Iwata K, et al. Trehalose solution protects mesothelium and reduces bowel adhesions. J Surg Res, 2014, 191(1): 224-230.
36.	Bang S, Lee E, Ko YG, et al. Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion. Int J Biol Macromol, 2016, 87: 155-162.
37.	Fotiadis K, Filidou E, Arvanitidis K, et al. Intraperitoneal application of phospholipids for the prevention of postoperative adhesions: a possible role of myofibroblasts. J Surg Res, 2015, 197(2): 291-300.
38.	Chen SH, Chou PY, Chen ZY, et al. Electrospun water-borne polyurethane Nanofibrous Membrane as a Barrier for Preventing Postoperative Peritendinous Adhesion. Int J Mol Sci, 2019, 20(7): pii: E1625.
39.	Shi K, Wang YL, Qu Y, et al. Synthesis, characterization, and application of reversible PDLLA-PEG-PDLLA copolymer thermogels in vitro and in vivo. Sci Rep, 2016, 6: 19077.
40.	Yuan BM, He CL, Dong XM, et al. 5-fluorouracil loaded thermosensitive PLGA-PEG-PLGA hydrogels for preventing postoperative tendon adhesion. RSC Adv, 2015, 5(32): 25295-25303.
41.	Wu Q, Wang N, He T, et al. Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model. Sci Rep, 2015, 5: 13553.
42.	Kessler M, Esser E, Groll J, et al. Bilateral PLA/alginate membranes for the prevention of postsurgical adhesions. J Biomed Mater Res B Appl Biomater, 2016, 104(8): 1563-1570.
43.	Chen SH, Chen CH, Fong YT, et al. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta Biomater, 2014, 10(12): 4971-4982.
44.	Jiang S, Yan H, Fan D, et al. Multi-layer electrospun membrane mimicking tendon sheath for prevention of tendon adhesions. Int J Mol Sci, 2015, 16(4): 6932-6944.

1. 姜士超, 劉坤, 范存義. 肌腱粘連機制及預防的研究進展. 中國修復重建外科雜志, 2013, 27(5): 633-636.
2. Branford OA, Lee DA, Rolfe KJ, et al. The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. J Hand Surg (Eur Vol), 2012, 37(6): 564-572.
3. de Jong JP, Nguyen JT, Sonnema AJ, et al. The incidence of acute traumatic tendon injuries in the hand and wrist: a 10-year population-based study. Clin Orthop Surg, 2014, 6(2): 196-202.
4. Dy CJ, Hernandez-Soria A, Ma Y, et al. Complications after flexor tendon repair: a systematic review and meta-analysis. J Hand Surg (Am), 2012, 37(3): 543-551.
5. Manske PR. Flexor tendon healing. J Hand Surg (Br), 1988, 13(3): 237-245.
6. Leadbetter WB. Cell-matrix response in tendon injury. Clin Sports Med, 1992, 11(3): 533-578.
7. Ishiyama N, Moro T, Ohe T, et al. Reduction of peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. J Bone Joint Surg (Am), 2011, 93(2): 142-149.
8. Lundborg G. Experimental flexor tendon healing without adhesion formation—a new concept of tendon nutrition and intrinsic healing mechanisms. A preliminary report. Hand, 1976, 8(3): 235-238.
9. Wu W, Cheng R, das Neves J, et al. Advances in biomaterials for preventing tissue adhesion. J Control Release, 2017, 261: 318-336.
10. Tenenhaus M. The use of dehydrated human amnion/chorion membranes in the treatment of burns and complex wounds: current and future applications. Ann Plast Surg, 2017, 78(2 Suppl 1): S11-S13.
11. Srinivasan R, T SS, Gupta A, et al. Hypopyon iritis after primary fresh amniotic membrane transplantation. Cornea, 2007, 26(10): 1275-1276.
12. Duan-Arnold Y, Gyurdieva A, Johnson A, et al. Retention of endogenous viable cells enhances the anti-inflammatory activity of cryopreserved amnion. Adv Wound Care (New Rochelle), 2015, 4(9): 523-533.
13. Jamil S, Mousavizadeh R, Roshan-Moniri M, et al. Angiopoietin-like 4 Enhances the Proliferation and Migration of Tendon Fibroblasts. Med Sci Sports Exerc, 2017, 49(9): 1769-1777.
14. Melville JM, McDonald CA, Bischof RJ, et al. Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs. PLoS One, 2017, 12(3): e0173572.
15. Shu J, He X, Zhang L, et al. Human amnion mesenchymal cells inhibit lipopolysaccharide-induced TNF-α and IL-1β production in THP-1 cells. Biol Res, 2015, 48: 69.
16. Liu C, Yu K, Bai J, et al. Experimental study of tendon sheath repair via decellularized amnion to prevent tendon adhesion. PLoS One, 2018, 13(10): e0205811.
17. Yang TH, Lu SC, Lin WJ, et al. Assessing finger joint biomechanics by applying equal force to flexor tendons in vitro using a novel simultaneous approach. PLoS One, 2016, 11(8): e0160301.
18. Fouda MB, Thankam FG, Dilisio MF, et al. Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. Am J Transl Res, 2017, 9(10): 4341-4360.
19. Kshersagar J, Kshirsagar R, Desai S, et al. Decellularized amnion scaffold with activated PRP: a new paradigm dressing material for burn wound healing. Cell Tissue Bank, 2018, 19(3): 423-436.
20. Ryzhuk V, Zeng XX, Wang X, et al. Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Mater Sci Eng C Mater Biol Appl, 2018, 85: 191-202.
21. Liu C, Bai J, Yu K, et al. Biological amnion prevents flexor tendon adhesion in zone Ⅱ: A controlled, multicentre clinical trial. Biomed Res Int, 2019, 2019: 2354325.
22. Oei TS, Klopper PJ, Spaas JA, et al. Reconstruction of the flexor tendon sheath. An experimental study in rabbits. J Hand Surg (Br), 1996, 21(1): 72-83.
23. Sungur N, Uysal A, Ko?er U, et al. Prevention of tendon adhesions by the reconstruction of the tendon sheath with solvent dehydrated bovine pericard: An experimental study. J Trauma, 2006, 61(6): 1467-1472.
24. Irk?ren S, Demird?ver C, Akad BZ, et al. Use of a perichondrial autograft on the peritendinous adhesion: an experimental study in rabbits. Acta Orthop Traumatol Turc, 2012, 46(3): 208-214.
25. Hanc? D, Altun H. Effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing: a prospective, double-blind, controlled clinical study. Int J Pediatr Otorhinolaryngol, 2015, 79(9): 1388-1392.
26. Hagberg L, Gerdin B. Sodium hyaluronate as an adjunct in adhesion prevention after flexor tendon surgery in rabbits. J Hand Surg (Am), 1992, 17(5): 935-941.
27. Chou PY, Chen SH, Chen CH, et al. Thermo-responsive in-situ forming hydrogels as barriers to prevent post-operative peritendinous adhesion. Acta Biomater, 2017, 63: 85-95.
28. Shalumon KT, Sheu C, Chen CH, et al. Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation. Acta Biomater, 2018, 72: 121-136.
29. Chen Q, Lu H, Yang H. Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway. Mol Med Rep, 2015, 12(3): 4598-4603.
30. Shen Y, Tu T, Yi B, et al. Electrospun acid-neutralizing fibers for the amelioration of inflammatory response. Acta Biomater, 2019, 97: 200-215.
31. 任高宏, 張明敏, 崔壯, 等. 皮膚牽張器聯合膠原蛋白海綿修復軟組織缺損. 中華創傷骨科雜志, 2018, 20(8): 689-695.
32. Zhao H, Guan HG, Gu J, et al. Collagen membrane alleviates peritendinous adhesion in the rat Achilles tendon injury model. Chin Med J (Engl), 2013, 126(4): 729-733.
33. Tian F, Dou C, Qi S, et al. Preventive effect of dexamethasone gelatin sponge on the lumbosacral epidural adhesion. Int J Clin Exp Med, 2015, 8(4): 5478-5484.
34. Wichelhaus DA, Beyersdoerfer ST, Gierer P, et al. The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model. Arch Orthop Trauma Surg, 2016, 136(7): 1021-1029.
35. Ohata A, Tamura N, Iwata K, et al. Trehalose solution protects mesothelium and reduces bowel adhesions. J Surg Res, 2014, 191(1): 224-230.
36. Bang S, Lee E, Ko YG, et al. Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion. Int J Biol Macromol, 2016, 87: 155-162.
37. Fotiadis K, Filidou E, Arvanitidis K, et al. Intraperitoneal application of phospholipids for the prevention of postoperative adhesions: a possible role of myofibroblasts. J Surg Res, 2015, 197(2): 291-300.
38. Chen SH, Chou PY, Chen ZY, et al. Electrospun water-borne polyurethane Nanofibrous Membrane as a Barrier for Preventing Postoperative Peritendinous Adhesion. Int J Mol Sci, 2019, 20(7): pii: E1625.
39. Shi K, Wang YL, Qu Y, et al. Synthesis, characterization, and application of reversible PDLLA-PEG-PDLLA copolymer thermogels in vitro and in vivo. Sci Rep, 2016, 6: 19077.
40. Yuan BM, He CL, Dong XM, et al. 5-fluorouracil loaded thermosensitive PLGA-PEG-PLGA hydrogels for preventing postoperative tendon adhesion. RSC Adv, 2015, 5(32): 25295-25303.
41. Wu Q, Wang N, He T, et al. Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model. Sci Rep, 2015, 5: 13553.
42. Kessler M, Esser E, Groll J, et al. Bilateral PLA/alginate membranes for the prevention of postsurgical adhesions. J Biomed Mater Res B Appl Biomater, 2016, 104(8): 1563-1570.
43. Chen SH, Chen CH, Fong YT, et al. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta Biomater, 2014, 10(12): 4971-4982.
44. Jiang S, Yan H, Fan D, et al. Multi-layer electrospun membrane mimicking tendon sheath for prevention of tendon adhesions. Int J Mol Sci, 2015, 16(4): 6932-6944.

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Application of medical biomaterials in prevention and treatment of tendon adhesion

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